--- title: 'Associate, Clinical Trial Management at Lyell Immunopharma' canonical: 'https://feeny.ai/job/associate-clinical-trial-management-lyell-immunopharma-seattle-6q7xywjd148z' type: 'job' last_seen: '2026-10-18' --- # Associate, Clinical Trial Management at Lyell Immunopharma - **Company:** Lyell Immunopharma - **Location:** Seattle, WA - **Posted:** 2026-10-14 - **Last confirmed live:** 2026-10-18 - **Apply:** https://job-boards.greenhouse.io/lyellimmunopharma/jobs/6089622003 ## Job description Using living cells to treat – and sometimes even cure – cancer is one of the most dramatic advances in modern medicine. Patients with hematologic malignancies have been successfully treated with cell therapies. However, these profound results have not yet been achieved in patients with solid tumors, representing approximately 90% of all cancers. And for patients with hematologic malignancies, there is a need for next-generation cell therapies that can deliver increased response rates and longer duration of response.  We are a clinical-stage company advancing a pipeline of next-generation CAR T-cell therapies for patients with solid tumors or hematologic malignancies. Lyell’s product candidates are enhanced with novel technology designed to generate T cells that resist exhaustion and have qualities of durable stemness in order to drive durable tumor cytotoxicity and achieve consistent and long-lasting clinical response. We were founded by cell therapy pioneers whose decades of research elevated the broader understanding of T-cell biology and its interaction with cancer. In our quest to advance next-generation CAR T-cell therapies, we have built a fully integrated company capable of discovering new technologies, translating science into therapies, manufacturing cell therapy products, and clinically evaluating them in patients. Our culture is based on Science, Respect, Collaboration, and Courage and reflects who we are, the environment we create, and our mission's urgency. The incumbent is responsible for conducting tasks related to the trial, as assigned; escalates issues and recommends solutions to address concerns; with the guidance from the Director/Associate Director Clinical Operations/Senior Clinical Trial Manager. ## KEY ROLE AND RESPONSIBILITIES: - Conducts tasks related to the trial as assigned; escalates issues and recommends solutions to address concerns - Develops tactical plans, detailed process steps and creates forms as needed for efficient trial execution; collaborates and seeks feedback from broader study team stakeholders to improve/optimize recommendations - Responsible for oversight of defined tasks with CRO partners; ensures deliverables are conducted on a timely, quality basis. Raises issues quickly to CTM/Sr CTM for resolution; makes recommendations on how to address concerns - Tracks inputs and deliverables day-to-day in partnership with the Clinical Operations team; identifies ways to improve the way we track study progress, reaches out to cross-functional partners for follow up and pull through. - Collaborates effectively; operates as a mentor and subject matter expert for more junior clinical team members - Supports TMF maintenance activities through timely filing of study and vendor documents, assisting with TMF review, reporting findings to CTM - Continues to learn and apply ICH GCP guidelines; stays current with evolving expectations and applies new protocols as required; recommends processes and procedures that support effective trial management - Tracks study expenses, as directed by Associate Director or Sr CTM, tracks vendor invoices, routes invoices for approval. ## PREFERRED EDUCATION: - BS in Life Sciences, or related discipline ## PREFERRED EXPERIENCE: - Minimum 4 years ## KNOWLEDGE, SKILLS AND ABILITIES: - Experience in Oncology clinical trial programs required - Proven support of clinical studies for 2+ years; early phase and start-ups a plus - Field/site monitoring experience a plus; sponsor in-house experience a plus, Oncology drug development experience a plus - Track record of collaborating and managing CROs and other external vendors to deliver successful trial outcomes - Operates effectively in cross-functional, multi-disciplinary teams - Understands FDA regulations and ICH GCP guidelines; learns how to successfully apply these to studies to drive effective, efficient and timely strategies The salary range for this position is $100,000 to $130,000, annually, with the opportunity to earn an annual bonus. The salary range is an estimate, and the actual salary may vary based on Lyell’s compensation practices and an applicant’s qualifications and experience. Employees are also eligible to participate in Lyell’s Equity Incentive Plan. At Lyell, we believe that highest performing teams include people from a wide variety of backgrounds and experiences who respectfully challenge each other. We are committed to building an open, diverse and inclusive culture for all employees. Lyell is proud to be an equal opportunity employer and does not discriminate on the basis of race, color, citizenship status, national origin, ancestry, sex, sexual orientation, age, religion, creed, physical or mental disability, medical condition, marital status, veteran status or any other characteristics protected under applicable federal, state and local laws. We’ve learned from experience that some of the best people don’t always match our requirements perfectly - if you’re interested and think you could fit, please don’t hesitate to apply. ## About Lyell Immunopharma ## Company Overview - **One-liner**: Lyell Immunopharma is a clinical-stage biotechnology company advancing next-generation CAR T-cell therapies designed to deliver durable remissions for patients with cancer. - **Entity Type**: Public (ticker not explicitly confirmed in provided sources; investor relations page indicates public reporting) - **Headquarters**: South San Francisco, California, United States - **Founded**: Not publicly available from provided sources - **Founders**: Rick Klausner, M.D. (Founder & Chairman), Crystal Mackall, M.D. (Founder), Stan Riddell, M.D. (Founder) ## Core Business - **Primary industry**: Biotechnology – Cell Therapy / Oncology - **Target customers**: B2B (healthcare providers, clinical trial sites, and patients seeking one-time cell therapies) - **Mission / purpose**: “To fully realize the curative potential of cell therapy for patients with cancer” – advancing next-generation CAR T cells that provide potent, long-lasting responses in both hematologic malignancies and solid tumors. ## Products & Services - **Ronde-Cel (LYL797)**: A next-generation CAR T-cell product candidate targeting ROR1 in solid tumors; currently presenting clinical and translational data at conferences like ASH 2025. - **Other pipeline candidates**: Multiple undisclosed product candidates for hematologic malignancies and solid tumors, designed with novel CAR constructs, T-cell exhaustion‑resistance technologies, and proprietary manufacturing protocols. ## Market Standing - **Valuation / Market Cap**: Not publicly available from provided sources - **Key Metric**: Clinical-stage; no approved product yet. Most recent disclosed financing is a $50 million tranche of equity private placement (closed April 2026). - **Notable Investors / Partners**: Not explicitly listed in provided data; investors likely include those from private placements and institutional holders (details not available). - **Growth Signals**: - Clinical progress with Ronde-Cel in solid tumors - State-of-the-art manufacturing facility in Bothell, WA, approved for clinical and commercial production - Active pipeline across hematologic and solid tumor indications - Establishment of three West Coast hubs (South San Francisco HQ, Seattle, Bothell) ## Competitive Advantages - **Proprietary T-cell biology**: Pioneering approaches to prevent T-cell exhaustion, enabling longer‑lived and more potent cancer killing. - **End‑to‑end control**: Own and operate a dedicated manufacturing facility, ensuring supply chain control and product quality. - **Founding by cell‑therapy pioneers**: Founders (Klausner, Mackall, Riddell) are leaders in the field, providing deep scientific expertise. ## Strategic Focus - **Pipeline advancement**: Progress next‑generation CAR T candidates through clinical trials, aiming to improve outcomes over first‑generation CAR T therapies. - **Solid tumor expansion**: Aggressively develop therapies for solid tumors where current cell therapies have limited efficacy. - **Manufacturing scale‑up**: Leverage internal manufacturing to accelerate development and eventual commercialization. ## Why Work Here - **Culture**: Described as “grounded in science, infused with courage, and powered by respect and collaboration.” Employees report feeling welcomed and able to contribute, with diverse perspectives valued. - **Work model**: Hybrid – in‑office collaboration days and weekly lunches; offices in South San Francisco, Seattle (South Lake Union), and Bothell. - **Benefits**: - Comprehensive medical, dental, vision (up to 100% premium for employees, 85% for dependents) - Employee Stock Purchase Plan (ESPP) with 15% discount - 401(k) matching - FSA/HSA options - Company‑sponsored life insurance, short‑ and long‑term disability - Paid vacation and sick time - Commuter benefit - Wellness program (mental health, physical fitness, financial wellness) ## Sources 1. [Lyell.com – Company Overview](https://www.lyell.com/) 2. [Lyell.com – Careers](https://www.lyell.com/careers/) 3. [Lyell.com – Job Openings](https://www.lyell.com/careers/job-openings/) 4. [Lyell.com – Investor Relations](https://ir.lyell.com/investor-relations) 5. [Lyell.com – Leadership](https://www.lyell.com/about/leadership/) ## Other roles at Lyell Immunopharma - [Director, Medical Writing](https://feeny.ai/job/director-medical-writing-lyell-immunopharma-united-states-vhfy2mbbyfy2) — United States - [Associate Director, FP&A](https://feeny.ai/job/associate-director-fp-a-lyell-immunopharma-united-states-xv34y6x78vjv) — United States - [Associate Director, Clinical Development Program Management](https://feeny.ai/job/associate-director-clinical-development-program-management-lyell-immunopharma-p0yy7kq7ngdh) — South San Francisco, CA - [Director or Senior Director, Investor Relations and Corporate Communications](https://feeny.ai/job/director-or-senior-director-investor-relations-and-corporate-communications-e9h5mes0s5ce) — United States - [Director, Regulatory Affairs](https://feeny.ai/job/director-regulatory-affairs-lyell-immunopharma-united-states-79r3gcjrr7eh) — United States - [Director, Medical Affairs Operations](https://feeny.ai/job/director-medical-affairs-operations-lyell-immunopharma-united-states-2yw8q0bfn11t) — United States