--- title: 'Associate Director, Clinical Data Management at Relay Therapeutics' canonical: 'https://feeny.ai/job/associate-director-clinical-data-management-relay-therapeutics-cambridge-2jdbj5fhjawe' type: 'job' last_seen: '2026-11-10' --- # Associate Director, Clinical Data Management at Relay Therapeutics - **Company:** Relay Therapeutics - **Location:** Cambridge, MA - **Posted:** 2026-11-09 - **Last confirmed live:** 2026-11-10 - **Apply:** https://job-boards.greenhouse.io/relaytherapeutics/jobs/6251831004 ## Job description Associate Director, Clinical Data Management As Associate Director, Data Management, you will be accountable for delivery, integrity, and quality of Relay’s clinical data across the clinical studies. You will be an integrated member of the Relay Tx Clinical Data Management Team, responsible for the in-house data management expertise for the execution of clinical studies that will translate Relay’s innovative science into impactful medicines for patients. You will report to the Executive Director, Clinical Data Management. Your Role: - You will be responsible for oversight and execution of data management activities for the assigned clinical study including data timelines and key deliverables. - You will work directly with and oversee CROs and vendors for outsourced Data Management activities. Is responsible for CRO performance and data management metrics for assigned programs. - You will lead database development and eCRF design, UAT, data import specifications, Case Report Form completion guidelines, data entry guidelines and related operations manuals. - You will lead data validation specifications and programs for assuring the accuracy of clinical trial data, e.g., manual data review guidelines, computerized edit check programs, Data Management Plans (DMP). - You will be responsible for executing or overseeing data cleaning activities through to database lock: includes generating and managing clinical trial data queries, data review listings, reconciling serious adverse events, coding, central and local lab data, and external data. - You will collaborate with a dynamic Relay cross-functional team to ensure timeliness and quality of data deliverables. - You will ensure compliance with global regulatory requirements and quality standards. - You will contribute to data standards including CRF and participate in data system development initiatives and database integration projects. - You will participate in SOP development, training of junior data managers, process mapping, and other departmental activities. Your Background: - You should ideally have 7+ years of experience in the pharmaceutical / biotechnology industry as a Data Manager.  Sponsor experience is strongly preferred. - You have advanced experience with data collection and cleaning covering Phase I, II and III studies. Oncology experience is preferred. - You have experience in executing clinical studies across various phases is desirable.  Expertise in oncology drug development is preferred. - You have a strong and current knowledge in global regulatory and compliance requirements including but not limited to US CFR, EU CTD, ICH GCP, and CDISC. - You have experience in CRO and vendor oversight. - You are a motivated self-starter who is capable of flourishing in a fast-paced small company environment and able to work independently. - You are a creative problem-solver with excellent communication and public speaking skills. - You have strong interpersonal and organizational skills, with a high degree of attention to detail. - You are pragmatic and able to manage multiple projects and needs effectively. Estimated Salary Range: [$147,000 - $210,000]. The range provided above is based on what we believe to be a reasonable estimate for this job at the time of posting. Actual base salary will depend on a number of factors, including but not limited to, a candidate’s education, experience, skills and location. #JO1 ## About Relay Therapeutics Relay Therapeutics is a clinical-stage precision medicines company transforming the drug discovery process with the goal of bringing life-changing therapies to patients. Built on unparalleled insights into protein motion and how this dynamic behavior relates to protein function, we aim to effectively drug protein targets that have previously been intractable, with an initial focus on enhancing small molecule therapeutic discovery in targeted oncology. Our Dynamo platform integrates an array of leading-edge experimental and computational approaches to provide a differentiated understanding of protein structure and motion to drug these targets. We have built a world-class team of leading experts from each of these disciplines, and they are driven by a deep collaboration at every step of our drug discovery process. Our team is equal parts fearless and relentless, with a shared passion for working collaboratively in intellectually stimulating environments. If you’re excited by the challenge of putting protein motion at the heart of drug discovery and passionate about making a difference in the lives of patients, join us! ## About Relay Therapeutics ## Company Overview - **One-liner**: Relay Therapeutics is a clinical-stage precision medicines company that uses its Dynamo® platform to visualize protein motion and drug previously intractable targets, with an initial focus on precision oncology and genetic disease. - **Entity Type**: Public (NASDAQ: RLAY) - **Headquarters**: Cambridge, Massachusetts, United States - **Founded**: 2016 - **Founders**: Not publicly listed as individual founders; the company was launched by Third Rock Ventures. ## Core Business - **Primary industry/industries**: Biotechnology, Precision Oncology, Genetic Disease Therapeutics - **Target customers**: Patients with specific cancer mutations (e.g., PI3Kα, FGFR2, NRAS) and rare genetic diseases (e.g., Fabry disease, PROS); partners are healthcare providers, clinical trial sites, and regulatory bodies. - **Mission or purpose statement**: "We aim to drug the undruggable." The company is laser-focused on bringing life-changing medicines to patients by visualizing protein motion to discover new therapeutics. ## Products & Services - **Dynamo® Platform**: A proprietary drug discovery platform that integrates long-timescale molecular dynamics (MD) simulations, cryo-electron microscopy (cryo-EM), and other biophysical techniques to visualize protein motion and identify novel drug binding sites. This is the core technology enabling all pipeline programs. - **Zovegalisib (RLY-2608)**: A clinical-stage, allosteric, pan-mutant and isoform-selective PI3Kα inhibitor. It is designed to overcome the toxicity of orthosteric inhibitors by sparing wild-type PI3Kα. Currently in a Phase 3 trial (ReDiscover-2) for HR+/HER2- PI3Kα-mutated advanced breast cancer and a Phase 1/2 trial for PROS and vascular anomalies. - **Lirafugratinib (RLY-4008)**: A selective FGFR2 inhibitor. In December 2024, global development and commercialization rights were out-licensed to Elevar Therapeutics. - **RLY-8161**: A first-in-class, NRAS-selective inhibitor designed to address the liabilities of pan-RAS inhibitors. Currently in a Phase 1/2 trial for NRAS-mutant melanoma and other solid tumors. - **Fabry Disease Program**: An investigational non-inhibitory chaperone designed to stabilize the αGal enzyme without inhibiting its activity, potentially offering a chronic treatment option for Fabry disease. Currently in IND-enabling studies. ## Market Standing - **Valuation/Market Cap**: $909.1 million (as of mid-2026) [linkedin.com](https://www.linkedin.com/company/relay-therapeutics-inc.) - **Key Metric**: Annual Revenue of $15.4 million (pre-commercial, primarily from collaboration/grants) [linkedin.com](https://www.linkedin.com/company/relay-therapeutics-inc.) - **Total Funding**: $1.8 billion (including IPO and follow-on offerings) [linkedin.com](https://www.linkedin.com/company/relay-therapeutics-inc.) - **Notable Investors/Partners**: Third Rock Ventures (founding investor), Nextech Invest, Elevar Therapeutics (out-license partner for lirafugratinib). - **Growth Signals**: Initiation of the Phase 3 ReDiscover-2 trial for zovegalisib in mid-2025; out-license of lirafugratinib to Elevar Therapeutics in December 2024; advancement of RLY-8161 into Phase 1/2 for NRAS-mutant cancers; expansion of the pipeline into genetic diseases (Fabry). ## Competitive Advantages - **Dynamo® Platform Moat**: The company's core differentiator is its ability to use long-timescale molecular dynamics simulations to visualize protein motion. This allows them to drug targets (like allosteric sites on PI3Kα and NRAS) that are "undruggable" with traditional static-structure approaches. - **Selectivity & Tolerability**: Their lead asset, zovegalisib, is designed to be a pan-mutant, isoform-selective PI3Kα inhibitor. This selectivity for mutant over wild-type PI3Kα is a key advantage over first-generation orthosteric inhibitors, potentially offering better efficacy and chronic tolerability. - **First-in-Class Potential**: RLY-8161 is described as the first NRAS-selective inhibitor, addressing a major unmet need in NRAS-mutant cancers by sparing KRAS and HRAS, which are responsible for the toxicity of pan-RAS inhibitors. ## Strategic Focus - **Advancing Late-Stage Pipeline**: The primary focus is on executing the Phase 3 ReDiscover-2 trial for zovegalisib in breast cancer and expanding its potential in vascular anomalies (PROS). - **Expanding Pipeline**: Advancing RLY-8161 (NRAS) through Phase 1/2 and moving the Fabry disease program toward clinical trials. - **Platform Validation**: Continuing to use the Dynamo® platform to discover new drug candidates for previously intractable targets, thereby validating the platform's broader potential beyond current pipeline assets. ## Why Work Here - **Culture**: The company describes its culture as "highly integrated, collaborative and entrepreneurial." Employees emphasize that the team is "equal parts bright and bold" and that the work is a "personal mission" driven by a desire to help patients. The culture values candor, quirkiness, and sweating the details. [relaytx.com](https://relaytx.com/careers/) - **Work Environment**: Based in Cambridge, MA (Kendall Square area). The company is on-site/hybrid, typical for a biotech R&D environment. The team is described as "world-class" and "highly integrated." - **Notable Perks**: The company offers competitive benefits and perks, investing in employee well-being, financial health, and family support. [relaytx.com](https://relaytx.com/careers/) - **Engineering & Science Culture**: The company emphasizes a highly collaborative environment where computational scientists (cheminformatics, computational architecture) work side-by-side with experimental biologists, chemists, and structural biologists. The focus on "protein motion" creates a unique intellectual challenge. ## Sources 1. [relaytx.com](https://relaytx.com/) 2. [relaytx.com](https://relaytx.com/pipeline/) 3. [relaytx.com](https://relaytx.com/careers/) 4. [linkedin.com](https://www.linkedin.com/company/relay-therapeutics-inc.) 5. [greenhouse.io](http://job-boards.greenhouse.io/relaytherapeutics) ## Other roles at Relay Therapeutics - [Manager, Clinical Supply Chain](https://feeny.ai/job/manager-clinical-supply-chain-relay-therapeutics-cambridge-5tg4ssv59zzb) — Cambridge, MA - [Associate Director, Drug Substance](https://feeny.ai/job/associate-director-drug-substance-relay-therapeutics-cambridge-wg1mp3ks5hhe) — Cambridge, MA - [Medical Director](https://feeny.ai/job/medical-director-relay-therapeutics-cambridge-dqfwq8bjw6gh) — Cambridge, MA - [Associate Director, Biostatistics](https://feeny.ai/job/associate-director-biostatistics-relay-therapeutics-cambridge-ykyy55zptr84) — Cambridge, MA - [Associate Director, Regulatory Project Manager](https://feeny.ai/job/associate-director-regulatory-project-manager-relay-therapeutics-cambridge-jhp36tb9dz27) — Cambridge, MA - [Medical Director/Senior Medical Director, Patient Safety & Risk Management](https://feeny.ai/job/medical-director-senior-medical-director-patient-safety-risk-management-relay-kq6nb9077wvg) — Cambridge, MA - [Associate Director/Director, CMC Regulatory](https://feeny.ai/job/associate-director-director-cmc-regulatory-relay-therapeutics-cambridge-fxx1zz50mb8r) — Cambridge, MA - [Medical Science Liaison - Southeast](https://feeny.ai/job/medical-science-liaison-southeast-relay-therapeutics-southeast-d8fmt3fthtgp) — Southeast - [Senior Manager, Clinical Business Operations](https://feeny.ai/job/senior-manager-clinical-business-operations-relay-therapeutics-cambridge-9c91kbpgewjr) — Cambridge, MA - [Senior Manager/Associate Director, Portfolio & Strategy Operations](https://feeny.ai/job/senior-manager-associate-director-portfolio-strategy-operations-relay-efqrqwcpnyq1) — Cambridge, MA