---
title: 'Associate Director, CMC Project Management at Maze Therapeutics'
canonical: 'https://feeny.ai/job/associate-director-cmc-project-management-maze-therapeutics-south-san-francisco-7wqp0jppgr7v'
type: 'job'
last_seen: '2026-10-18'
---

# Associate Director, CMC Project Management at Maze Therapeutics

- **Company:** Maze Therapeutics
- **Location:** South San Francisco, CA
- **Posted:** 2026-09-17
- **Last confirmed live:** 2026-10-18
- **Apply:** http://www.mazetx.com/careers/?gh_jid=8815264002

## Job description

The Position

Join Maze Therapeutics as our Associate Director, CMC Project Management. In this highly visible role within Technical Operations, you will drive cross-functional planning and execution across our pipeline programs while managing development and manufacturing timelines in collaboration with our CMOs. Reporting to the VP, Technical Operations, you will partner closely with CMC, Quality, and key internal stakeholders to enable program milestones, support regulatory success, and ultimately help bring potential medicines to patients.

The Impact You’ll Have

- Provide end-to-end CMC project management support across the drug development lifecycle.
- Lead cross-functional teams (Chemical Development, Pharmaceutical Development, CMC Analytical, QA, CMC Regulatory, and Clinical Supply Chain) to plan and execute CMC activities aligned with corporate goals.
- Serve as the point of contact to facilitate the meeting discussions with the CMOs and follow up on the action items.
- Own risk management for assigned programs — establishing risk registries, identifying and mitigating risks, and escalating issues before they impact timelines or objectives.
- Serve as the primary CMC project management point of contact to collaborate with the Program Management team, maintaining full command of CMC scope, status, and key risks while coordinating interdependencies across workstreams.
- Facilitate governance and decision-making by preparing proposals, analyses, and recommendations for senior leadership review, and resolving cross-team conflicts that could impede progress.
- Contribute to the planning and preparation of regulatory filings (e.g., IND, IMPD, etc.) in close partnership with Regulatory CMC and other functional teams.
- Drive clear, consistent communication through dashboards, status reports, and meeting operations (agendas, minutes, action-item follow-up) for stakeholders ranging from project teams to senior leadership.
- Cultivate strong working relationships across functions and with external partners to foster a collaborative, high-performing team environment and enable timely issue resolution.
- Champion continuous improvement of project management processes, tools, and governance frameworks, and support program-level budget tracking and financial forecasting.

As an Associate Director, we also expect our leaders to demonstrate the following Leadership Competencies:

Leadership Competencies

- Communication and Influence
- Communicates the reasoning behind decisions to appropriate stakeholders
- Promotes open communication with internal and external stakeholders
- Fosters healthy and respectful debate
- Teamwork and Collaboration
- Creates opportunities for team members to connect with others outside the team
- Manages conflict effectively between teams
- Openly values thoughts, opinions and contributions of employees
- Execution and Results
- Exercises astute judgement to make decisions with only the necessary amount of data
- Supports team members in creating their own resolutions to challenges and problems
- Works with others to reinforce process compliance, what good looks like, and risk mitigation
- Develop Others and Self
- Articulate what good looks like throughout Maze
- Pursues development activities for continuous improvement of self and team

## What We’re Looking For

- Bachelor's degree in life sciences, scientific, technical, engineering, or business discipline required (or equivalent relevant experience); advanced degree preferred.
- Minimum of 10 years total professional experience, including at least 5 years in project management within the pharmaceutical, biotechnology, or medical device industry.
- At least 3 years directly managing cross-functional teams in a matrixed organization, with demonstrated success driving complex programs to completion in fast-paced environments.
- Working knowledge of CMC and drug development functions such as process development, analytical development, formulation, manufacturing, quality systems, supply chain, packaging, and regulatory CMC requirements.
- Understanding of the drug development lifecycle from Pre-IND through NDA/commercialization, including clinical development processes; experience with late-stage or commercial programs is a plus.
- Familiarity with GMP/GxP-regulated environments and quality management systems, ideally within small molecule modalities.
- Proficiency with project management and collaboration platforms (e.g., Smart-sheet, Microsoft Project, SharePoint, Microsoft Office Suite); PMP certification preferred but not required.
- Strong organizational, prioritization, and time-management skills, with the ability to adapt to shifting priorities and manage multiple projects simultaneously.
- Excellent verbal and written communication skills, with the ability to build effective relationships and influence outcomes across teams without formal authority.
- Ability to work both independently and collaboratively, ideally with prior exposure to start-up or growth-stage biotech settings; must be authorized to work in the U.S.

## About Maze Therapeutics

Maze Therapeutics is a clinical-stage biopharmaceutical company harnessing human genetics to develop precision medicines for patients with kidney and metabolic diseases. Our clinical pipeline is anchored by two small molecule programs: MZE829, an APOL1 inhibitor for patients with APOL1‑mediated kidney disease, and MZE782, which targets genetic drivers of disease in phenylketonuria (PKU) and chronic kidney disease. We are also advancing a preclinical pipeline through our Compass platform, which links human genetic variants to the biological pathways that drive disease.

Our People

Maze is comprised of a team of passionate and creative professionals committed to discovering and delivering transformative medicines to patients suffering from both rare and common genetic diseases. We are fostering a culture that encourages vision, initiative and the development of talent. Our supportive work environment inspires creative thinking and freedom of expression, resulting in a stimulating atmosphere where people enjoy coming to work. While we have a passion for advanced science and pride ourselves on excellence in execution, ultimately, everything we do is about patients.

Our Core Values

Further Together – Our path is paved with challenges, but with resilience and a team-first mentality, we’ll achieve our mission.

Impact Obsessed – We embrace the bold, take calculated risks, and learn from our mistakes to improve the lives of others.

Stand True – Our integrity is foundational; it guides us no matter the obstacle.

The expected annual salary range for employees located in the San Francisco Bay Area is $193,500 - $236,500. Additionally, this position is eligible for an annual performance bonus.

Maze performs position-based compensation benchmarking to industry market data to ensure we pay competitive wages. Determination of starting salary will depend upon a variety of job-related factors, which may include professional experience, skills, and job location. The expected salary range for this role may be modified in the future.

Maze offers a robust benefits package to our eligible employees including competitive medical, dental, and vision insurance, mental health offerings, equity incentive plan, 401(k) program with employer match and a generous holiday and PTO policy.

#LI-Hybrid

## About Maze Therapeutics

## Company Overview
- **One-liner**: Maze Therapeutics is a clinical-stage biopharmaceutical company developing small molecule precision medicines for common diseases, primarily kidney disease, by leveraging human genetics and its proprietary Compass platform.
- **Entity Type**: Public (NASDAQ: MAZE)
- **Headquarters**: South San Francisco, California, United States
- **Founded**: 2018
- **Founders**: Not publicly listed as individual founders; the company was established by a team of geneticists and industry veterans.

## Core Business
- **Primary industry/industries**: Biotechnology / Biopharmaceuticals (Precision Medicine)
- **Target customers**: B2B (partners and investors), B2C (patients with APOL1-mediated kidney disease, chronic kidney disease, and phenylketonuria)
- **Mission or purpose statement**: "Harnessing the power of genetics to transform the lives of patients" by translating genetic insights into effective precision medicines.

## Products & Services
- **MZE829 (Lead Program)**: An oral, small molecule, dual-mechanism APOL1 inhibitor for the treatment of APOL1-mediated kidney disease (AMKD). Recently reported positive topline Phase 2 HORIZON trial data.
- **MZE782 (SLC6A19 Inhibitor)**: A precision medicine in development for chronic kidney disease (CKD) and phenylketonuria (PKU), currently in clinical trials.
- **Maze Compass™ Platform**: A proprietary platform that leverages variant functionalization to link genetic variants to disease pathways, enabling the discovery and design of precision medicines.
- **Other Pipeline Programs**: Several additional programs in drug discovery targeting renal, cardiovascular, and metabolic diseases.

## Market Standing
- **Valuation/Market Cap**: Approximately **$1.48 Billion** (as of mid-2026, per CB Insights market cap data).
- **Key Metric**: **Total Raised** (including IPO): **$496 Million**. The company also announced a **$150 Million registered offering** in 2026.
- **Notable Investors/Partners**: Key investors include **Third Rock Ventures**, **Gilead Sciences**, **Genentech**, **Denali Therapeutics**, and **Calico Life Sciences** (as top talent sources and likely institutional backers). The company went public via a PIPE/IPO structure.
- **Growth Signals**: 
    - Positive topline data from the Phase 2 HORIZON trial of MZE829 (announced March 2026).
    - Three clinical-stage programs and several discovery-stage programs.
    - Active job postings increased by **120% year-over-year**.
    - Headcount of approximately 150 employees (based on LinkedIn data showing ~150 total employees).

## Competitive Advantages
- **Proprietary Compass Platform**: A unique, data-driven platform that functionally validates genetic variants, giving Maze a differentiated ability to identify and target disease-causing pathways that are often overlooked.
- **Focus on Common Diseases**: Unlike many precision medicine companies that focus on rare diseases, Maze targets large, unmet medical needs (e.g., chronic kidney disease), which represents a massive market opportunity.
- **Strong Genetic Foundation**: The company’s entire strategy is built on robust human genetic evidence, reducing the risk of late-stage clinical failures and increasing the probability of success.
- **Experienced Leadership Team**: The team includes veterans from leading biotech and pharma companies (Gilead, Genentech, Amgen), providing deep industry expertise in drug development and commercialization.

## Strategic Focus
- **Advance Lead Programs**: Primary focus is on progressing MZE829 through Phase 2/3 trials for APOL1-mediated kidney disease and advancing MZE782 for CKD and PKU.
- **Expand Pipeline**: Leveraging the Compass platform to identify and develop additional precision medicines for renal, cardiovascular, and metabolic diseases.
- **Clinical Data Generation**: Delivering key clinical readouts to support regulatory filings and potential partnerships.
- **Commercial Preparation**: Building the infrastructure and team (e.g., Senior Director, Talent Acquisition; Senior Director, Pharmaceutical Development) to prepare for potential late-stage success and launch.

## Why Work Here
- **Mission-Driven Culture**: The company is deeply committed to "harnessing the power of genetics to transform the lives of patients," with core values of "Impact Obsessed," "Stand True" (integrity), and "Further Together" (teamwork and resilience).
- **Supportive Work Environment**: Maze promotes a culture that encourages "vision, initiative, and the development of talent," with a "stimulating atmosphere where people enjoy coming to work."
- **Comprehensive Benefits**: Offers "comprehensive and competitive health, financial, paid time off and many other benefits designed to promote the health and financial well-being of employees and their families."
- **Equal Opportunity Employer**: Committed to diversity and non-discrimination.
- **Growth Trajectory**: As a public clinical-stage company with positive clinical data and a 120% increase in job postings year-over-year, there are significant opportunities for career growth and impact.
- **Location**: Based in South San Francisco (a major biotech hub), though specific remote/hybrid policy is not publicly detailed.

## Sources
1. [mazetx.com](https://mazetx.com/)
2. [mazetx.com](https://mazetx.com/about-us/)
3. [mazetx.com](https://mazetx.com/careers/)
4. [cbinsights.com](https://www.cbinsights.com/company/maze-therapeutics)
5. [linkedin.com](https://www.linkedin.com/company/mazetx)

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