---
title: 'Associate Director / Director, Clinical Science at Immunome, Inc.'
canonical: 'https://feeny.ai/job/associate-director-director-clinical-science-immunome-inc-bothell-washington-494qmvx9sfw1'
type: 'job'
last_seen: '2026-09-12'
---

# Associate Director / Director, Clinical Science at Immunome, Inc.

- **Company:** Immunome, Inc.
- **Location:** Bothell Washington, United States
- **Compensation:** $178k–$263k
- **Posted:** 2026-08-21
- **Last confirmed live:** 2026-09-12
- **Apply:** https://job-boards.greenhouse.io/immunomeinc/jobs/5397105008

## Job description

Company Overview

Immunome is a clinical-stage targeted oncology company committed to developing first-in-class and best-in-class targeted cancer therapies. We are advancing an innovative portfolio of therapeutics, supported by a leadership team with deep experience in the design, development, and commercialization of cutting-edge therapies, including antibody-drug conjugates. Our pipeline includes varegacestat, an investigational gamma secretase inhibitor for which an NDA has been accepted by the U.S. FDA; IM-1021, a clinical-stage ROR1 ADC; IM-1617, a clinical-stage solid tumor ADC; and IM-3050, a clinical-stage FAP-targeted radioligand therapy. We are also advancing a broad portfolio of early-stage ADCs pursuing undisclosed solid tumor targets.

Position Overview

Immunome is seeking a highly experienced and strategic Associate Director / Director, Clinical Science to provide scientific leadership for clinical development programs across our oncology portfolio. This role will be responsible for shaping clinical strategy, authoring and reviewing key clinical documents, and ensuring scientific rigor in the design, conduct, analysis, and interpretation of clinical studies.

The successful candidate will bring deep expertise in oncology drug development, strong cross-functional leadership in a matrix organization, and the communication skills required to translate complex clinical data into clear recommendations. This position offers a highly visible opportunity to influence clinical development plans and help advance Immunome’s innovative targeted therapies.

## Responsibilities

Strategic Leadership

- Partner with Clinical Development leadership to define clinical strategy and contribute to integrated clinical development plans for assigned programs.
- Provide scientific leadership for clinical study design (Phase 1–3), including endpoints, eligibility criteria, dose and regimen rationale, and biomarker strategy.
- Serve as a key clinical development voice in program governance, enabling timely, data-driven decisions that balance patient safety, scientific value, and development timelines.

Program Oversight and Execution

- Lead the scientific execution of clinical studies, collaborating with Clinical Operations, Data Management, Biostatistics, Clinical Pharmacology, Translational Medicine, and Safety to ensure high-quality conduct.
- Support medical monitoring activities, including review of safety data, protocol deviations, and emerging risk/benefit considerations, in partnership with Medical Directors and Pharmacovigilance.
- Review and interpret clinical data (safety, efficacy, PK/PD, biomarkers), generate insights, and communicate results to internal teams and external stakeholders.

Vendor and Partner Management

- Provide clinical development oversight of CROs and vendors (e.g., central labs, imaging, biomarkers) to ensure alignment with protocol requirements and data quality expectations.
- Collaborate with external investigators, steering committees, and key opinion leaders to support study execution, recruitment, and scientific communication.

Regulatory and Documentation Support

- Author, review, and contribute to clinical protocols, amendments, investigator brochures, informed consent forms, statistical analysis plans (in partnership), clinical study reports, and regulatory submissions (IND/CTA, annual reports, briefing packages).
- Contribute to responses to health authority questions and support regulatory interactions by providing clear clinical development rationale and data interpretation.
- Ensure all clinical development activities comply with GCP, applicable regulations, and internal quality standards.

Leadership and Collaboration

- Lead, mentor, and develop clinical scientists and/or contractors, fostering a culture of scientific excellence, accountability, and collaboration.
- Drive alignment across cross-functional teams, proactively identifying risks, proposing mitigation plans, and ensuring clear communication of priorities and decisions.
- Support scientific dissemination through abstracts, manuscripts, presentations, and investigator meeting materials.

## Qualifications

- PhD, PharmD, MD, or equivalent advanced degree in a life science discipline with 5+ years of experience in clinical development (oncology preferred).
- Demonstrated experience designing and executing oncology clinical trials, including protocol development, endpoint selection, and operational feasibility considerations.
- Proven track record authoring and reviewing key clinical documents and contributing to regulatory submissions and/or health authority interactions.
- Experience interpreting clinical and translational data (safety, efficacy, PK/PD, biomarkers) and presenting findings to diverse audiences.
- Strong understanding of ICH/GCP and global clinical development regulations and guidance.
- Experience leading in a matrix environment and managing external vendors/partners; prior people management experience is a plus.

Knowledge and Skills

- Deep knowledge of clinical trial design and execution across phases, with a strong scientific foundation in oncology and targeted therapeutics.
- Expertise in writing, reviewing, and QC’ing clinical documents (protocols, ICFs, IBs, CSRs, briefing documents) with attention to detail and regulatory expectations.
- Ability to synthesize complex datasets and translate findings into clear scientific narratives and actionable recommendations.
- Strong cross-functional leadership and project management skills, with the ability to drive alignment and decision-making in a fast-paced environment.
- Excellent verbal and written communication skills, including experience presenting to internal governance and external scientific audiences.
- Collaborative, proactive working style with sound judgment, integrity, and a commitment to patient safety and data quality.
- Demonstrated ability to manage priorities across multiple programs and meet aggressive timelines.
- Experience mentoring and developing scientific staff, building strong internal and external networks.

Washington State Pay Range - Associate Director: $177,571 - $212,160

Washington State Pay Range - Director: $221,245 - $263,327

Washington State Pay Range $177,571—$263,327 USD

E/E/O

Immunome, Inc. is an equal opportunity employer. We celebrate diversity and are committed to creating an inclusive environment for all employees.

E-Verify

Immunome, Inc. is a participant in E-Verify. Please review the following notices: [E-Verify Participation Poster](https://immunome.box.com/s/bopxukipfidxjscs4bjxt75f90bvpppk) | https://immunome.box.com/s/r51g9subw1wqni9xkutbl6up635sjr8e | https://immunome.box.com/s/r3ekbimwh988my9vzl76tnlbg60zvh9u.

## About Immunome, Inc.

## Company Overview
- **One-liner**: Immunome is a clinical-stage oncology company developing first-in-class and best-in-class targeted cancer therapies, with a primary focus on antibody-drug conjugates (ADCs).
- **Entity Type**: Public (Nasdaq: IMNM)
- **Headquarters**: Bothell, Washington, United States
- **Founded**: The company was formed through a merger of Morphimmune and Immunome in October 2023.
- **Founders**: The company is led by Clay Siegall, Ph.D. (Chairman, CEO, and President), who co-founded Seagen. The original Immunome entity was founded earlier, but the current company structure dates to the 2023 merger.

## Core Business
- Primary industry/industries: Biotechnology, Oncology, Drug Discovery & Development
- Target customers: Patients with cancer, healthcare providers, and clinical trial sites. The company is a B2B/B2C entity in the healthcare and life sciences space.
- Mission or purpose statement: "Our mission is to improve outcomes for cancer patients by advancing and expanding a portfolio of first-in-class and best-in-class therapeutic candidates." [immunome.com](https://immunome.com/)

## Products & Services
- **Varegacestat (formerly AL102)**: A late-clinical stage gamma secretase inhibitor for the treatment of desmoid tumors. The company submitted a New Drug Application (NDA) to the U.S. FDA in April 2026. [investors.immunome.com](https://investors.immunome.com/)
- **IM-1021**: A ROR1-targeted antibody-drug conjugate (ADC) currently in a Phase 1 trial.
- **IM-3050**: A FAP-targeted radioligand which received IND clearance in Q1 2025.
- **Preclinical ADC Pipeline (IM-1617, IM-1340, IM-1335)**: ADCs pursuing undisclosed targets with expression in multiple solid tumors. IM-1617 had its first patient dosed in a Phase 1 trial in June 2026. [investors.immunome.com](https://investors.immunome.com/)

## Market Standing
- **Valuation/Market Cap**: Not publicly available in the search results. As a public company, this fluctuates. (Check recent filings for current data).
- **Key Metric**: The company is pre-revenue (clinical-stage) and has raised significant capital. Since the 2023 merger, CEO Clay Siegall has raised $355 million in equity financings. [immunome.com](https://immunome.com/about/)
- **Notable Investors/Partners**: The company is publicly traded. Key leadership previously worked at Seagen (acquired by Pfizer for $43 billion).
- **Growth Signals**: The company is rapidly advancing its pipeline. Key milestones include the NDA submission for varegacestat, first patient dosed for IM-1617, and positive Phase 3 data presented at ASCO 2026. The company currently lists 32 open positions on its careers page, indicating strong hiring momentum. [job-boards.greenhouse.io](http://job-boards.greenhouse.io/immunomeinc)

## Competitive Advantages
- **World-Class Leadership**: The executive team, led by Seagen co-founder Clay Siegall, has deep experience in designing, developing, and commercializing blockbuster ADCs (ADCETRIS, PADCEV, TIVDAK, TUKYSA). [immunome.com](https://immunome.com/about/)
- **Proprietary ADC Platform**: A systematic, data-driven process for optimizing antibodies, linkers, and payloads to create differentiated ADCs. [immunome.com](https://immunome.com/)
- **Near-Term Catalyst**: The NDA submission for varegacestat provides a potential near-term commercial opportunity.
- **Strong Financial Backing**: Raised $355M in equity since the merger, providing a solid runway for pipeline advancement.

## Strategic Focus
- **Advancing the Pipeline**: The primary focus is on executing clinical trials for varegacestat (Phase 3), IM-1021 (Phase 1), and IM-3050 (Phase 1), and advancing preclinical ADCs into the clinic.
- **Regulatory Filing**: Successfully navigating the FDA NDA submission and potential approval for varegacestat.
- **Discovery & Expansion**: Using their ADC discovery platform to generate new candidates and identify and acquire targeted oncology assets to expand the portfolio. [immunome.com](https://immunome.com/about/)

## Why Work Here
- **Mission-Driven**: The work directly impacts the lives of cancer patients, with a stated goal of developing transformative therapies. [immunome.com](https://immunome.com/about/)
- **High-Impact Team**: Opportunity to work with "some of the brightest and most experienced minds in ADC development," including leaders who have brought multiple drugs to market. [immunome.com](https://immunome.com/careers/)
- **Growth Stage**: With 32 open roles, the company is in a rapid growth phase, offering significant career advancement opportunities. [job-boards.greenhouse.io](http://job-boards.greenhouse.io/immunomeinc)
- **Comprehensive Benefits**: Includes 100% company-paid medical premiums for employees, a 401(k) with employer match, paid parental leave, and a week-long winter break. [immunome.com](https://immunome.com/careers/)
- **Location & Culture**: Based in Bothell, WA. The company describes a culture of "innovative, collaborative environment where employees are empowered to do their best work." [immunome.com](https://immunome.com/careers/)

## Sources
1. [Immunome Official Website](https://immunome.com/)
2. [Immunome About Page](https://immunome.com/about/)
3. [Immunome Investor Relations](https://investors.immunome.com/)
4. [Immunome Careers Page](https://immunome.com/careers/)
5. [Immunome Jobs on Greenhouse](http://job-boards.greenhouse.io/immunomeinc)

## Other roles at Immunome, Inc.

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- [Senior In-House Clinical Research Associate](https://feeny.ai/job/senior-in-house-clinical-research-associate-immunome-inc-bothell-washington-xd757hs9sz89) — Bothell Washington, United States
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