--- title: 'Associate Director/Director, Computational Test Development at Precede' canonical: 'https://feeny.ai/job/associate-director-director-computational-test-development-precede-cambridge-vax7530xbk3b' type: 'job' last_seen: '2026-11-04' --- # Associate Director/Director, Computational Test Development at Precede - **Company:** Precede - **Location:** Cambridge, MA - **Compensation:** $180k–$240k - **Employment:** full-time - **Work type:** hybrid - **Posted:** 2026-10-19 - **Last confirmed live:** 2026-11-04 - **Apply:** https://jobs.lever.co/precede/8d245f18-19ef-49f0-942c-67d08d4d1cc2 ## Job description The Opportunity We are seeking a Director-level computational scientist to drive the analytical and regulatory dimensions of diagnostic test development at Precede Biosciences. Reporting to the Senior Director of Computational Test Development, this role sits at the center of our effort to bring a novel epigenomics-based liquid biopsy platform from late-stage development through FDA regulatory submission. You will lead the analytical strategy and bioinformatics infrastructure verification that underlies our validation programs. You will drive the interpretation of complex data, guide pipeline execution, and author critical regulatory documentation in close partnership with laboratory, clinical, and regulatory teams. ## About Us We are pioneering an advanced, minimally invasive, comprehensive epigenomics platform with the potential to profoundly impact the research and development of new medicines and the use of approved medicines in clinical practice across a number of conditions, including cancer. More information on our company and platform can be found on our company website and in our seminal publication in Nature Medicine. We care deeply about creating a place where folks can do their best work from the start and have intentionally created an environment that is defined by purpose, teamwork, and excellence. This means nurturing team spirit, facing challenges together, and collaboratively solving complex problems, while also ensuring a strong focus on individual initiative, accountability, and delivery. ## What You'll Do Analytical Validation & Regulatory Execution - Design and develop computational approaches for characterizing the performance of existing and new epigenomic tests. - Define and implement metrics and analyses to assess NGS and epigenomic data quality to enable coordinated optimization of assay and diagnostic performance. - Lead the computational execution of verification and validation protocols, statistical analysis plans (SAPs), and performance summary reports to meet FDA evidentiary standards. - Translate complex computational results into clear, well-organized regulatory documentation for FDA submissions. - Stay current on FDA guidance for IVDs, companion diagnostics, and evolving LDT oversight to actively inform study design decisions. Statistical & Bioinformatics Analysis - Develop and apply statistical methods for diagnostic characterization, including LOD/LOQ, reproducibility, thresholding, gaurdbanding, and clinical utility endpoints. - Support and optimize robust, reproducible analysis pipelines—ensuring code traceability and standardization from raw NGS data through regulatory-grade outputs. - Identify and systematically address sources of variability, bias, and technical confounding across the computational workflow. Cross-Functional Collaboration - Partner closely with laboratory development, clinical operations, and regulatory affairs to ensure absolute scientific and regulatory alignment across programs. - Contribute to clinical study design—including sample size calculations, endpoint selection, and pre-specified SAPs using data-driven insights from analytical validation pilots. ## Who You Are - PhD in computational biology, bioinformatics, biostatistics, or a closely related quantitative field. Direct experience with advanced NGS modalities (e.g., cell-free DNA, ChIP-Seq, or epigenomic signal processing) is highly preferred. - 4–9 years of industry experience in regulated diagnostics, liquid biopsy, or IVD development, ideally within a fast-paced, cross-functional R&D environment. - Proven track record working under a formal Quality Management System (ISO 13485, 21 CFR Part 820). - Hands-on experience contributing to regulatory submissions (such as Pre-Subs, De Novo, or 510(k) tracks). Please describe your specific role and submission type in your cover letter or CV. - Solid grasp of analytical validation frameworks, including CLSI EP guidelines, FDA IVD/CDx guidance, and CAP/CLIA requirements. - Fluency in R and/or Python for robust statistical modeling, data analysis, and reproducible reporting. - Strong communication skills with a demonstrated ability to present and defend analytical validation strategies to internal leadership, scientific advisors, and regulatory stakeholders. - Startup mindset: You thrive when taking autonomous ownership of projects, remain adaptive under evolving information, and execute effectively in an entrepreneurial environment. We believe in building an inclusive and balanced team. We also know meeting every single-exact-criteria can get in the way of meeting stellar folks. Please don’t hesitate to apply! Precede Biosciences is an equal opportunity employer. We do not discriminate in regard to race, color, religion, national origin, age, sex, sexual orientation, gender identity, marital status, ancestry, physical or mental disability, veteran status, or any other legally protected. Please note that we do not accept unsolicited resumes from recruitment agencies and external recruiters. No fees will be paid for such submissions. ## About Precede ## Company Overview - **One-liner**: Precede Biosciences decodes genome-wide transcriptional biology from a simple blood test to enable precision medicine and accelerate drug development. - **Entity Type**: Private (Series B) - **Headquarters**: Boston, Massachusetts, United States - **Founded**: 2021 - **Founders**: Rehan Verjee (CEO) ## Core Business - **Primary industry**: Biotechnology / Precision Diagnostics - **Target customers**: Biopharmaceutical companies (drug developers), clinical researchers, and diagnostic partners (B2B) - **Mission or purpose**: To create a world where new medicine development succeeds more frequently and where anyone can receive a minimally invasive diagnosis and treatment precise to the biology of their disease. ## Products & Services - **Precede Bio Insight™**: A first-of-its-kind liquid biopsy product that profiles circulating chromatin and the DNA methylome from just 1 mL of plasma. It enables quantitative inference of gene expression, pathway activity, and cell states – providing a functional, systems-level view of tumor biology. Used for therapeutic target discovery, patient selection, and understanding treatment resistance. (SaaS-like platform service for biopharma partners) - **Custom Diagnostic Development**: Partnering with medicine developers to design and validate diagnostic tests that reveal target expression and pathway biology relevant to next-generation precision medicines (e.g., ADCs, protein degraders). ## Market Standing - **Valuation/Market Cap**: Not publicly disclosed. Total funding raised: **$140.5M** (as of January 2026). - **Key Metric**: Total funding of $140.5M across Series A, Series B, and debt financing. Estimated annual revenue of ~$8M (third-party estimate). - **Notable Investors/Partners**: 5AM Ventures, Lilly Asia Ventures, Illumina Ventures, Bristol Myers Squibb, Osage University Partners, Binney Street Capital, Labcorp Venture Fund, UPMC Enterprises, Mirae Asset Capital Life Science, 28 Capital LLC, Alexandria Venture Investments. Strategic partnership with SVB for non-dilutive financing. - **Growth Signals**: 55 employees (+17.3% YoY); 4 active job postings; launched Precede Bio Insight™ in April 2026; strong commercial traction with leading biopharma developers; presented data at major conferences (ESMO 2024, ASCO 2024, ECTRIMS 2024). ## Competitive Advantages - **Unique platform**: Profiles circulating chromatin and DNA methylome at genome-wide scale (~20K gene promoters, ~1M enhancers, ~50K CpG islands) from a single 1 mL blood sample, providing resolution into individual gene and pathway activation that tissue biopsies cannot easily capture. - **Actionable readouts**: Uses proprietary machine learning to deliver interpretable, quantitative data on therapeutic targets, resistance pathways, and tumor lineage – directly relevant to next-generation precision medicines. - **Minimally invasive**: Simple blood draw replaces invasive tissue biopsies, enabling longitudinal monitoring and broader patient access. ## Strategic Focus - Scale the Precede Bio Insight™ platform for broader biopharma adoption. - Expand partnerships with drug developers to co-develop companion diagnostics. - Advance internal diagnostic tests for specific oncology indications. - Continue building a world-class team in computational biology, epigenomics, and translational sciences. ## Why Work Here - **Mission-driven**: Tackle hard problems in precision medicine with a team that values trust, collaboration, and impact. - **Hybrid work**: Offices in Boston, MA (1 Design Center Place) with hybrid flexibility for most roles. - **Small but growing**: 55 employees with a flat structure – every person has the potential to shape the company. - **Culture**: Emphasis on mutual care, intellectual curiosity, and a “one team” mentality. Recent job postings include roles in computational test development, project management, and translational oncology. - **Perks**: Not explicitly listed, but the environment is typical of a well-funded biotech startup with opportunities for rapid growth and influence. ## Sources 1. [precede.bio](https://www.precede.bio/) 2. [jobs.lever.co/precede](https://jobs.lever.co/precede) 3. [linkedin.com/company/precedebiosciences](https://linkedin.com/company/precedebiosciences) 4. [cbinsights.com/company/precede-biosciences](https://www.cbinsights.com/company/precede-biosciences) 5. [builtin.com/company/precede-biosciences](https://builtin.com/company/precede-biosciences) ## Other roles at Precede - [Scientist / Senior Scientist, Computational Biology](https://feeny.ai/job/scientist-senior-scientist-computational-biology-precede-boston-m9pf6akf73sj) — Boston, MA - [Associate Director, Alliance and Project Management](https://feeny.ai/job/associate-director-alliance-and-project-management-precede-cambridge-zftv1qwegjaj) — Cambridge, MA - [Associate Director, Regulatory Affairs (IVD)](https://feeny.ai/job/associate-director-regulatory-affairs-ivd-precede-cambridge-aj3fke22z1rx) — Cambridge, MA - [Associate Scientist / Scientist I, Computational Test Development](https://feeny.ai/job/associate-scientist-scientist-i-computational-test-development-precede-boston-c7pmhcxnr9pt) — Boston, MA