---
title: 'Associate Director, Operational Excellence at Tango Therapeutics'
canonical: 'https://feeny.ai/job/associate-director-operational-excellence-tango-therapeutics-boston-at4qdd9qfq1w'
type: 'job'
last_seen: '2026-10-20'
---

# Associate Director, Operational Excellence at Tango Therapeutics

- **Company:** Tango Therapeutics
- **Location:** Boston, MA
- **Compensation:** $164k–$246k
- **Posted:** 2026-10-15
- **Last confirmed live:** 2026-10-20
- **Apply:** https://job-boards.greenhouse.io/tangotherapeutics/jobs/8031566003

## Job description

Company Overview

Tango Therapeutics is a biotechnology company dedicated to discovering novel drug targets and delivering the next generation of precision medicine for the treatment of cancer.

Using an approach that starts and ends with patients, Tango leverages the genetic principle of synthetic lethality to discover and develop therapies that take aim at critical targets in cancer.

This includes expanding the universe of precision oncology targets into novel areas such as tumor suppressor gene loss and their contribution to the ability of cancer cells to evade immune cell killing.

The Tango labs and offices are located at 201 Brookline Avenue, in the Fenway area of Boston, Massachusetts.

Summary

The Operational Excellence and Training Lead enables scalable, efficient, and inspection‑ready execution across Development by designing standardized processes, building operational capabilities through training, and driving consistent adoption and continuous improvement.

Your Role:

- Own and lead end‑to‑end design, implementation, and optimization of assigned process and system across Development
- Translate strategic objectives into fit‑for‑purpose, standardized processes that are efficient, scalable, and inspection‑ready
- Define process standards, guidance, and performance measures, ensuring clarity of roles and accountability
- Develop and deliver training on new/changed processes incl. compliance expectations, and inspection readiness behavior
- Design and maintain role‑based and process‑based curricula, including onboarding
- Identify inefficiencies, risks, and variability through data analysis and stakeholder input, and lead targeted improvement initiatives
- Support functions in adopting new or improved processes through change management, training inputs, and practical guidance
- Ensure processes are well documented, consistently applied, and auditable, supporting inspection readiness
- Track and report process performance, improvement outcomes, and residual risks to Operational Excellence & Clinical Compliance leadership
- Act as a subject‑matter expert and trusted advisor to functional teams on process excellence and operational rigor
- Support Leadership in defining and executing the learning and capability‑building strategy for Development functions
- Support leadership in building a learning culture that reinforces accountability, consistency, and continuous improvement

What You Bring:

Required Qualifications

- Bachelor’s degree required (Life Sciences, or related field)
- Advanced degree preferred (e.g., MBA, MSc)
- Certification or formal training in Operational Excellence, Lean, Six Sigma, or Process Improvement preferred

Required Experience

- 8–10+ years’ experience in operational excellence, process improvement, training, or operational leadership within a regulated life sciences or clinical development environment
- Proven experience owning and implementing end‑to‑end processes or systems across multiple functions
- Hands‑on experience designing and delivering process and role‑based training
- Experience supporting audit and inspection readiness, including documentation and behavioral readiness

Required Competencies

- End‑to‑end process design, standardization, and optimization
- Lean / continuous improvement methodologies
- Training design, curriculum development, and adult learning principles
- Process documentation (SOPs, guidance, work instructions)
- Process performance metrics, KPIs, and dashboarding
- Understanding compliance and inspection expectations in regulated environments.
- Strong systems thinker able to translate strategy into execution
- Excellent facilitation, communication, and stakeholder‑engagement skills
- Ability to influence and drive adoption without direct authority
- Pragmatic change leader with strong execution discipline
- Trusted advisor mindset with high credibility and accountability
- Collaborative, service‑oriented, and improvement‑focused

We are an equal opportunity employer and value diversity at our company. We do not discriminate on the basis of race, religion, color, national origin, gender, sexual orientation, age, marital status, veteran status, or disability status.

Salary range $164,000—$246,000 USD

## About Tango Therapeutics

## Company Overview
- **One-liner**: Tango Therapeutics is a clinical-stage biotechnology company leveraging the principle of synthetic lethality to discover and develop next-generation precision cancer medicines for genetically defined patient populations.
- **Entity Type**: Public (NASDAQ: TNGX)
- **Headquarters**: Boston, Massachusetts, United States
- **Founded**: 2017
- **Founders**: Not publicly disclosed (launched by Third Rock Ventures)

## Core Business
- **Primary industry/industries**: Biotechnology, Precision Oncology, Drug Discovery & Development
- **Target customers**: B2B (pharma partnerships, clinical trial sites); ultimate customers are cancer patients with specific genetic tumor profiles
- **Mission or purpose statement**: "Discover transformative drugs for people with cancer by leveraging the classic principles of synthetic lethality in innovative ways… building a road map to cures that will transform the lives of patients and their families." [tangotx.com](https://www.tangotx.com/join-us/)

## Products & Services
- **Vopimetostat (PRMT5 inhibitor)**: A clinical-stage, wholly-owned program targeting MTAP-deleted cancers, including pancreatic, lung, and glioblastoma. Currently in Phase 1/2 trials. [tangotx.com](https://www.tangotx.com/pipeline/)
- **TNG456 (PRMT5 inhibitor)**: A next-generation PRMT5 inhibitor for MTAP-deleted cancers, currently in pre-clinical development.
- **Daraxonrasib (RAS inhibitor)**: A combination therapy (with vopimetostat) for MTAPdel/RASmut pancreatic and lung cancers. Recently reported a 92% objective response rate in pancreatic cancer in a Phase 1/2 trial. [tangotx.com](https://www.tangotx.com/)
- **CRISPR-based Target Discovery Engine**: A proprietary platform for identifying novel synthetic lethal targets, enabling a robust pipeline of wholly-owned programs.

## Market Standing
- **Valuation/Market Cap**: ~$1.05 billion (as of mid-2026) [linkedin.com](https://www.linkedin.com/company/tango-therapeutics)
- **Key Metric**: Annual Revenue of ~$62.4 million; Total Funding raised ~$901 million (including post-IPO). [linkedin.com](https://www.linkedin.com/company/tango-therapeutics)
- **Notable Investors/Partners**: Third Rock Ventures (lead Series A), Boxer Capital (lead Series B), BCTG Acquisition Corp (parent). Strategic partners include pharma and biotech companies (collaborations under active exploration). [linkedin.com](https://www.linkedin.com/company/tango-therapeutics)
- **Growth Signals**: Completed a $600 million upsized public offering in June 2026; strong clinical data (92% ORR in pancreatic cancer); pipeline expanding into glioblastoma; headcount growth in job postings (+400% YoY in active roles). [tangotx.com](https://www.tangotx.com/)

## Competitive Advantages
- **Synthetic Lethality Expertise**: A deep, proprietary understanding of CRISPR-based target discovery to identify novel vulnerabilities in cancers with tumor suppressor gene loss, undruggable oncogenes, and immune evasion mechanisms.
- **Genetically Defined Patient Selection**: All programs are designed for well-defined patient populations with clear biomarkers, increasing the probability of clinical success and reducing trial risk.
- **Wholly-Owned Pipeline**: Unlike many biotechs that license out rights, Tango retains full ownership of its lead programs, capturing maximum value.
- **Strong Financial Position**: With over $1B in market cap and a recent $600M offering, the company is well-capitalized to advance its pipeline through pivotal trials.

## Strategic Focus
- **Current priorities**: Advancing vopimetostat and daraxonrasib into Phase 3 trials for pancreatic and lung cancers; expanding the pipeline into glioblastoma; continuing to discover and validate new synthetic lethal targets; building out commercial manufacturing and clinical operations infrastructure.
- **Direction for growth**: Becoming a fully-integrated biotechnology company capable of bringing its own medicines to market, while selectively pursuing strategic collaborations to expand reach.

## Why Work Here
- **Culture highlights**: Emphasizes "urgency + compassion," "courage + leadership," "spirit + resilience," and "embrace individuality and face challenges together." Described as a team of "passionate problem solvers" who are "all in for exciting science and changing lives." [tangotx.com](https://www.tangotx.com/join-us/)
- **Remote/hybrid/office policy**: Primarily on-site at Boston HQ (201 Brookline Ave, Suite 901, Boston, MA). Roles appear to be Boston-based, though some field-based positions (e.g., Medical Science Liaisons) are remote.
- **Notable perks or engineering culture**: High scientific ambition with a clear patient-first mission; strong leadership team with deep oncology experience; active hiring across clinical operations, biostatistics, medical affairs, and legal/compliance; 15+ active job postings with significant YoY growth in roles. [greenhouse.io](http://job-boards.greenhouse.io/tangotherapeutics)
- **Workforce**: ~129 employees, with a mix of research (26%), medical (12%), and operations roles. Notable alumni from Novartis, Vertex, Takeda, and Broad Institute. [linkedin.com](https://www.linkedin.com/company/tango-therapeutics)

## Sources
1. [Tango Therapeutics Official Website](https://www.tangotx.com/)
2. [Tango Therapeutics Careers Page (Greenhouse)](http://job-boards.greenhouse.io/tangotherapeutics)
3. [Tango Therapeutics LinkedIn Profile](https://www.linkedin.com/company/tango-therapeutics)
4. [Tango Therapeutics Pipeline Page](https://www.tangotx.com/pipeline/)
5. [Tango Therapeutics Join Us Page](https://www.tangotx.com/join-us/)

## Other roles at Tango Therapeutics

- [Senior Vice President, Medical Affairs](https://feeny.ai/job/senior-vice-president-medical-affairs-tango-therapeutics-boston-yphb7g2va8xb) — Boston, MA
- [Associate Director, Statistical Programming](https://feeny.ai/job/associate-director-statistical-programming-tango-therapeutics-boston-dkt87pa41pb6) — Boston, MA
- [Executive Director, Commercial Law/Commercial Contracts](https://feeny.ai/job/executive-director-commercial-law-commercial-contracts-tango-therapeutics-boston-4rgpv55eb66w) — Boston, MA
- [Director, Intellectual Property](https://feeny.ai/job/director-intellectual-property-tango-therapeutics-boston-pesyhn9k10dj) — Boston, MA
- [Senior Clinical Data Manager](https://feeny.ai/job/senior-clinical-data-manager-tango-therapeutics-boston-xk614h7zhf91) — Boston, MA
- [Manager, GMP Quality](https://feeny.ai/job/manager-gmp-quality-tango-therapeutics-boston-70t57986x902) — Boston, MA
- [Executive Director, Commercial Strategy & Execution](https://feeny.ai/job/executive-director-commercial-strategy-execution-tango-therapeutics-boston-y7x7vkeeenkd) — Boston, MA
- [Head of Marketing & Sales](https://feeny.ai/job/head-of-marketing-sales-tango-therapeutics-boston-ex81335qs4hc) — Boston, MA
- [Head of Insights & Analytics](https://feeny.ai/job/head-of-insights-analytics-tango-therapeutics-boston-4f5kkx80kztw) — Boston, MA
- [Senior Vice President, Market Access](https://feeny.ai/job/senior-vice-president-market-access-tango-therapeutics-boston-47tt1fw4qxxq) — Boston, MA