---
title: 'Associate Scientist, Bioanalytical Assays at Serif Biomedicines, Inc.'
canonical: 'https://feeny.ai/job/associate-scientist-bioanalytical-assays-serif-biomedicines-inc-cambridge-7e493d7k67nb'
type: 'job'
last_seen: '2026-11-04'
---

# Associate Scientist, Bioanalytical Assays at Serif Biomedicines, Inc.

- **Company:** Serif Biomedicines, Inc.
- **Location:** Cambridge, MA
- **Posted:** 2026-10-28
- **Last confirmed live:** 2026-11-04
- **Apply:** https://job-boards.greenhouse.io/serif/jobs/8922114002

## Job description

Company Summary:

Serif Biomedicines is a privately held, early-stage biotechnology company developing a novel approach to gene therapy that can address currently untreatable diseases.

Serif Biomedicines was founded by Flagship Pioneering, an innovation enterprise that conceives, creates, resources, and grows first-in-category life sciences companies. Flagship Pioneering has created over 100 groundbreaking companies over the past twenty years, all of which are pioneering novel and proprietary biological, industrial, and engineering approaches to solve major needs in human health and sustainability. These companies include Moderna (MRNA), Syros Pharmaceuticals (SYRS), Seres Therapeutics (NASDAQ:MCRB), Generate Biomedicines, Tessera Tx, Evelo Biosciences (EVLO), and Indigo Agriculture.

Position Summary:

We are searching for an experienced Associate Scientist to drive bio-analytical assays for a novel DNA platform. More broadly, we are looking for an individual who enjoys working with in vitro and in vivo assays, and brings scientific rigor, intellectual curiosity, enthusiasm, and a desire to innovate new nucleic acid therapeutics. This individual will have the opportunity to work in a dynamic and fast-paced entrepreneurial environment, working both independently and as part of a highly collaborative and rapidly growing team.

Key Responsibilities:

- Execution and analysis of bioassays, to assess efficacy, safety and biodistribution of novel nucleic acid therapeutics in rodents and NHPs
- Contribute to scientific and technical perspectives to advance platform development.
- Develop, optimize, and execute ligand binding assays   to support studies in-house and  at CROs.
- Effectively communicate experimental findings in oral, written, and visual formats.
- Work independently and collaboratively in a multidisciplinary team environment.

Qualifications:

- Masters or BS in relevant discipline with 6+ years of industry experience. Level will be based on experience.
- Deep expertise in ex-vivo analytical assays such as ELISA, MSD, qPCR, ddPCR,  etc.
- Hands-on experience with multi-parameter flow-cytometry, including panel design, compensation, and analysis.
- Experience with various transfection methods in human and NHP PBMCs is preferred
- Proficiency in processing tissues and isolation of various cell types (hepatocytes, immune cells etc.) from mice and NHPs
- Prior experience in nucleic acid therapeutics or LNPs is a plus
- Experience with histological techniques (IHC/IF, ISH, H&E, etc.) analysis is a plus.
- Strong communication, interpersonal, organizational, analytical, and problem-solving skills.
- The successful candidate will be expected to demonstrate flexibility in supporting the accelerated timelines associated with data generation, analysis, and reporting for in vivo studies.
- Ability to thrive in a fast-paced, multidisciplinary, and rapidly growing biotech environment.

At Flagship, we recognize there is no perfect candidate. If you have some of the experience listed above but not all, please apply anyway. Experience comes in many forms, skills are transferable, and passion goes a long way. We are dedicated to building diverse and inclusive teams and look forward to learning more about your unique background.

Recruitment & Staffing Agencies: Flagship Pioneering and its affiliated Flagship Lab companies (collectively, “FSP”) do not accept unsolicited resumes from any source other than candidates. The submission of unsolicited resumes by recruitment or staffing agencies to FSP or its employees is strictly prohibited unless contacted directly by Flagship Pioneering’s internal Talent Acquisition team. Any resume submitted by an agency in the absence of a signed agreement will automatically become the property of FSP, and FSP will not owe any referral or other fees with respect thereto.

Privacy Notice for Applicants: When you apply for a role at Flagship Pioneering or one of its portfolio companies, we collect and use personal information you provide (such as your name, contact details, work history, and application materials) to evaluate your application, communicate with you, and comply with legal obligations. Your application data is processed through Greenhouse, our applicant tracking system, and may also be reviewed using AI-assisted screening tools. We do not sell your personal information. California residents have rights under the CCPA/CPRA including to know, delete, and opt out of the sharing of their personal information. If you are located in the EU or UK, we process your data under GDPR and you have rights to access, rectify, and erase your data. To exercise your rights or for questions, contact privacy@flagshippioneering.com.

The salary range for this role is $96,000 - $126,500. Compensation for the role will depend on a number of factors, including a candidate’s qualifications, skills, competencies, and experience. Serif Biomedicines currently offers healthcare coverage, annual incentive program, retirement benefits and a broad range of other benefits. Compensation and benefits information is based on Serif Biomedicines's good faith estimate as of the date of publication and may be modified in the future. Privacy Notice for Applicants: When you apply for a role at Serif Biomedicines, Inc., a Flagship Pioneering portfolio company, we collect and use personal information you provide (such as your name, contact details, work history, and application materials) to evaluate your application, communicate with you, and comply with legal obligations. Your application data is processed through Greenhouse, our applicant tracking system, and may also be reviewed using AI-assisted screening tools. We do not sell your personal information. California residents have rights under the CCPA/CPRA including to know, delete, and opt out of the sharing of their personal information. If you are located in the EU or UK, we process your data under GDPR and you have rights to access, rectify, and erase your data. To exercise your rights or for questions, contact privacy@flagshippioneering.com.

## About Serif Biomedicines, Inc.

## Company Overview
- **One-liner**: Serif Biomedicines is pioneering Modified DNA as a new class of genetic medicine, using nucleic acid chemistry, synthetic biology, delivery science, and AI to create programmable, durable, and redosable DNA therapeutics.
- **Entity Type**: Private (Founded by Flagship Pioneering)
- **Headquarters**: Cambridge, MA, USA
- **Founded**: 2026 (public launch in April 2026)
- **Founders**: Originated at Flagship Pioneering; Founding team includes Jacob (Jake) Rubens, PhD (CEO), Matt Kennedy, PhD (CSO), and others.

## Core Business
- **Primary industry**: Biotechnology / Genetic Medicines
- **Target customers**: B2B (pharma/biotech partnerships) and B2G (therapeutic development for rare diseases and immune programming)
- **Mission**: To build a future where DNA becomes the source code for medicines that can be tailored across diseases and scaled for global impact.

## Products & Services
- **Modified DNA Platform**: A proprietary technology that chemically modifies DNA to minimize innate immunogenicity during delivery into cells. Once inside the nucleus, the Modified DNA reverts to unmodified DNA, enabling transcription into therapeutic RNA and proteins. This platform combines the best features of mRNA and gene therapy while mitigating their limitations (durability, redosability, cell-specific expression).
- **mRNA Co-factors**: Delivered alongside Modified DNA, these transiently express proteins that enhance nuclear entry and gene expression.
- **AI-Enabled Design-Build-Test-Learn Cycle**: Integrates AI to optimize DNA and mRNA co-factor sequences and lipid nanoparticle (LNP) formulations by learning from massive datasets.
- **Therapeutic Pipeline**: Initial drug discovery programs focused on rare diseases and immune programming.

## Market Standing
- **Valuation/Market Cap**: Not disclosed (private, Flagship Pioneering portfolio company)
- **Key Metric**: Total Funding — Not publicly disclosed (launched with Flagship Pioneering backing; no specific funding round announced)
- **Notable Investors/Partners**: Flagship Pioneering (originator and primary backer); Board includes Noubar Afeyan (Flagship CEO), John Maraganore (founding CEO of Alnylam), Andrew Allen (CEO of Tessera Therapeutics), and others.
- **Growth Signals**: Public launch in April 2026 with significant press coverage; presenting data at ASGCT 2026; actively hiring across multiple R&D functions (Protein Engineering, LNP Process & Development, Immunology, Bioanalytics, Molecular Biology).

## Competitive Advantages
- **Novel Platform Technology**: Serif is the first company to establish Modified DNA as a therapeutic modality, creating a new category of genetic medicine that combines the durability of gene therapy with the redosability and programmability of mRNA.
- **Flagship Pioneering Backing**: Originated and funded by Flagship, a top-tier biotech venture creation firm with a track record of building category-defining companies (Moderna, Tessera, etc.).
- **Integrated Capability Stack**: Combines nucleic acid chemistry, synthetic biology, delivery science (LNPs), and AI/ML for optimization — a full-stack approach to genetic medicine.
- **Strong IP & Scientific Team**: Leadership includes veterans from Flagship, Alnylam, and Tessera, with deep expertise in nucleic acid discovery, development, and delivery.

## Strategic Focus
- **Initial Therapeutic Areas**: Rare diseases and immune programming, where Modified DNA’s durability, redosability, and cell-specific expression offer clear advantages.
- **Platform Expansion**: Building scalable manufacturing processes and AI-driven design cycles to enable broad therapeutic application across diseases.
- **Talent Acquisition**: Actively hiring across R&D functions to build out the platform and pipeline.

## Why Work Here
- **Pioneering Science**: Opportunity to work on a first-in-class technology that could redefine genetic medicine — comparable to the early days of mRNA therapeutics.
- **Flagship Ecosystem**: Access to the resources, network, and expertise of Flagship Pioneering, one of the most successful biotech incubators.
- **Culture**: Described as a team of scientists, engineers, and company builders united by a mission to create a new foundational biotechnology. Emphasis on collaboration and innovation.
- **Location**: Cambridge, MA — a global hub for biotech and life sciences.
- **Growth Stage**: Early-stage (just launched in April 2026), offering significant impact and career growth potential for early hires.
- **Work Policy**: Not explicitly stated, but typical for early-stage biotech in Cambridge — likely on-site or hybrid.

## Sources
1. [serifbiomedicines.com](https://serifbiomedicines.com)
2. [serifbiomedicines.com/team](https://serifbiomedicines.com/team)
3. [serifbiomedicines.com/science](https://serifbiomedicines.com/science)
4. [flagshippioneering.com](https://www.flagshippioneering.com/companies/serif-biomedicines)
5. [job-boards.greenhouse.io/serif](https://job-boards.greenhouse.io/serif/jobs/8511741002)

## Other roles at Serif Biomedicines, Inc.

- [Senior Scientist, LNP Formulations](https://feeny.ai/job/senior-scientist-lnp-formulations-serif-biomedicines-inc-cambridge-e6as2tmxztgp) — Cambridge, MA
- [Scientist, In Vivo Pharmacology](https://feeny.ai/job/scientist-in-vivo-pharmacology-serif-biomedicines-inc-cambridge-ss8e62xdrcqp) — Cambridge, MA
- [Senior Scientist, Analytical Development and Quality Control](https://feeny.ai/job/senior-scientist-analytical-development-and-quality-control-serif-biomedicines-1ewhtadm3tmg) — Cambridge, MA
- [Laboratory Operations Associate](https://feeny.ai/job/laboratory-operations-associate-serif-biomedicines-inc-cambridge-stbt1pbzxjn6) — Cambridge, MA
- [Associate Scientist, Bioanalytical Assays](https://feeny.ai/job/associate-scientist-bioanalytical-assays-flagship-pioneering-inc-cambridge-4e8va9zqgs4p) — Cambridge, MA