---
title: 'Associate Scientist/Senior Associate Scientist, In Vivo Pharmacology – Study Coordinator at Manifold Bio'
canonical: 'https://feeny.ai/job/associate-scientist-senior-associate-scientist-in-vivo-pharmacology-study-3ptd3fq79378'
type: 'job'
last_seen: '2026-10-18'
---

# Associate Scientist/Senior Associate Scientist, In Vivo Pharmacology – Study Coordinator at Manifold Bio

- **Company:** Manifold Bio
- **Location:** Boston, MA
- **Posted:** 2026-09-14
- **Last confirmed live:** 2026-10-18
- **Apply:** https://job-boards.greenhouse.io/manifoldbio/jobs/5238016007

## Job description

Manifold Bio is a platform biotechnology company pioneering AI-guided protein design and massively multiplexed in vivo screening to unlock tissue-targeted medicines and organism-scale models of living systems. Using proprietary molecular barcoding technology, we screen hundreds of thousands of protein designs simultaneously in living systems, producing in vivo-validated datasets at a scale no one else can match. The datasets power our computational models, which leads to better drug designs, creating a flywheel that gets stronger with every campaign. Our team of protein engineers, biologists, and computational scientists works across this full stack to pursue programs both internally and with leading pharma companies.

Position

We are seeking an experienced and highly organized In Vivo Study Coordinator to own the end-to-end planning, coordination, and execution of our preclinical in vivo pharmacology programs. This is a senior, hands-on role at the intersection of scientific rigor and operational excellence — you will be the single point of accountability for study lifecycle management across multiple parallel programs, from initial study design through execution, collection, and delivery.

The ideal candidate brings deep in vivo pharmacology expertise, strong cross-functional coordination instincts, and the ability to operate independently in a fast-moving, early-stage environment. You are as comfortable building a detailed study timeline as you are troubleshooting a dosing day in real time — and you know when to push back on unrealistic timelines and when to find creative solutions.

## Key Responsibilities

- Work closely with pharmacology team members to oversee and execute assays assessing the pharmacological activity, biodistribution, and efficacy of test articles in research and preclinical studies, supporting development of therapies across the pipeline.
- Manage tissue analysis and oversee the transfer and storage of samples from rodent and large animal studies performed at external contract vivarium facilities.
- Perform test article dosing via various administration routes, including systemic administration (I.V., I.P.).
- Perform rodent perfusion and tissue collection.
- Independently analyze and interpret data, with careful documentation of experiments and presentation of results within the company.
- Perform various molecular and biochemical assays on tissue samples from preclinical studies across a range of drug development programs, including quantitative and qualitative target analysis.

Required Qualifications

- Bachelor's or Master's degree in Biology, Pharmacology, Biomedical Science, or related field
- 5+ years of hands-on in vivo pharmacology experience in a biotech, pharma, or CRO environment
- Demonstrated experience as a study director, study coordinator, or study lead — owning studies end-to-end with accountability for timelines and deliverables
- Deep proficiency with in vivo techniques: IV, SC, IP, and PO dosing; submandibular and cardiac bleeds; necropsy; tissue collection and processing across a broad panel
- Experience coordinating multiple concurrent studies across different programs and timelines
- Strong organizational skills and attention to detail — you do not let things slip
- Excellent cross-functional communication — comfortable working with scientists, RAs, vivarium staff, and leadership simultaneously
- Self-motivated and capable of operating independently with minimal supervision
- A genuine passion for science and for building something impactful

## Preferred Qualifications

- Experience with humanized or disease mouse models
- Familiarity with NHP study coordination and CRO management
- Familiarity with histology, tissue sectioning, and confocal imaging workflows
- Experience with Benchling or similar LIMS platforms
- Exposure to protein therapeutics and other modalities
- Experience writing detailed study plans, SOPs, and IACUC protocol amendments
- Comfortable with data analysis tools including GraphPad Prism and Microsoft Office

Base Salary Range: $106,000 - $123,000

This reflects the typical offer range for this role, based on experience, role scope, and internal equity. Final compensation decisions are made using a consistent leveling framework and consider the candidate’s experience, interview performance, and expected impact.

This role is eligible for:

- Annual performance-based target bonus
- Stock options
- Comprehensive medical, dental, and vision coverage
- 401(k) plan
- Flexible paid time off and holidays
- Perks including on-site gym, onsite lunch, and commuter support

Our compensation ranges are reviewed annually to ensure alignment with market trends and internal equity.

If you’re excited to build a platform that combines DNA and protein multiplexing technologies, please reach out to careers@manifold.bio. We value different experiences and ways of thinking and believe the most talented teams are built by bringing together people of diverse cultures, genders, and backgrounds.

## About Manifold Bio

## Company Overview
- **One-liner**: Manifold Bio is a platform therapeutics company building the first AI-guided direct-to-vivo discovery platform to design tissue-targeted biologics.
- **Entity Type**: Private (Series A)
- **Headquarters**: Boston, Massachusetts, United States
- **Founded**: 2019
- **Founders**: Gleb Kuznetsov (CEO), Pierce Ogden (CTO), Shane Lofgren (Head of Business Development)

## Core Business
- **Primary industries**: Biotechnology, Drug Discovery, Artificial Intelligence for Protein Design
- **Target customers**: B2B – large pharmaceutical companies (via partnerships and collaborations) and internal pipeline for novel therapeutics
- **Mission or purpose statement**: “Tissue-targeted medicines, designed in vivo” – building a predictive model of living systems to enable rational design of biologics that precisely reach intended tissues.

## Products & Services
- **mDesign Engine**: Integrated platform combining AI-guided protein design with massively multiplexed in vivo screening to measure pharmacokinetics, biodistribution, and target engagement directly in living systems.
- **mCodes**: Multiplexed protein barcodes decoded via NGS, enabling high-throughput tracking of millions of protein variants in a single experiment.
- **mShuttle Portfolio**: Modular library of brain shuttles engineered and optimized in vivo to deliver payloads across the blood-brain barrier with high specificity and exposure.
- **mBER**: Open-sourced AI model for designing epitope-specific antibodies, validated in million-scale experiments. (SaaS/model, not a product per se)
- **Internal Pipeline**: Tissue-targeted biologic candidates for Alzheimer’s disease, Parkinson’s disease, rare CNS diseases, and cardiometabolic disease.

## Market Standing
- **Valuation/Market Cap**: Not publicly disclosed
- **Total Funding**: $78.18M (CBInsights) / $61.4M (Apollo.io) – conflicting reports; latest available data shows multiple rounds including a $15M Series A in April 2024.
- **Notable Investors/Partners**: Playground Global, Fifty Years, Amazon Web Services, and a strategic collaboration with Roche announced in November 2025.
- **Growth Signals**: Headcount grew 58.1% YoY to 54 employees; published a joint study with NVIDIA validating million-scale AI-driven protein binder design; active job postings up 100% monthly.

## Competitive Advantages
- **Direct-to-vivo platform**: Unlike most AI-driven drug discovery companies that rely on in vitro data, Manifold tests protein designs directly in living systems, capturing physiologically relevant properties like PK, biodistribution, and toxicity.
- **Massively multiplexed experimentation**: Proprietary molecular tracking (mCodes) enables simultaneous testing of millions of protein variants against hundreds of targets, closing the loop between generative AI design and experimental validation at scale.
- **High-profile collaborations**: The Roche partnership and NVIDIA validation provide external credibility and access to industry-leading resources.

## Strategic Focus
- **Expanding tissue-specific delivery**: Starting with brain (CNS) through mShuttle, then moving to peripheral tissues (adipose, cardiometabolic).
- **Building the “virtual organism”**: Integrating high-throughput in vivo data to train a predictive model of how biomolecules behave in the body, enabling fully rational design.
- **Deepening pharma partnerships**: Leveraging platform capabilities to co-develop next-generation biologics with partners like Roche.
- **Open-sourcing AI models**: Releasing mBER and other tools to attract talent, drive adoption, and set industry standards.

## Why Work Here
- **Culture**: Flat, science-driven organization where ML engineers, computational biologists, and wet-lab scientists collaborate closely. Emphasis on “hybrid computational/wet lab science” and library-guided design.
- **Growth trajectory**: 58% employee growth YoY, active hiring across AI/ML, protein engineering, biology, and operations – signals rapid scaling.
- **Work environment**: Boston-based (Seaport area), likely office-first with some flexibility; job postings don’t mention remote but roles are Boston-listed.
- **Notable perks**: Opportunity to work at the frontier of AI + biology, access to cutting-edge wet lab infrastructure, and direct impact on pipeline decisions from early discovery through IND-enabling studies.

## Sources
1. [manifold.bio](https://www.manifold.bio/) (Company website)
2. [linkedin.com](https://www.linkedin.com/company/manifold-bio) (LinkedIn company page)
3. [cbinsights.com](https://www.cbinsights.com/company/manifold-bio) (CBInsights profile)
4. [boards.greenhouse.io](http://job-boards.greenhouse.io/manifoldbio) (Careers page)
5. [manifold.bio/news](https://www.manifold.bio/news) (News – Roche collaboration, NVIDIA study)
6. [apollo.io](https://www.apollo.io/companies/Manifold-Bio) (Apollo.io revenue/funding data)

## Other roles at Manifold Bio

- [(Contract) Research Technician, Pre-clinical Pharmacology](https://feeny.ai/job/contract-research-technician-pre-clinical-pharmacology-manifold-bio-boston-w1sedywb9a2k) — Boston, MA
- [Computational Scientist, Assay Development](https://feeny.ai/job/computational-scientist-assay-development-manifold-bio-boston-4qvj0atdygfs) — Boston, MA
- [Product Manager, AI Platform & Partnerships](https://feeny.ai/job/product-manager-ai-platform-partnerships-manifold-bio-boston-pghg83twvq9t) — Boston, MA / San Francisco, CA
- [AI/ML Research Engineer](https://feeny.ai/job/ai-ml-research-engineer-manifold-bio-boston-ma-or-san-francisco-0qe65tmrvvjb) — Boston MA OR San Francisco, CA
- [Scientist, cDNA Display](https://feeny.ai/job/scientist-cdna-display-manifold-bio-boston-k20s594tsp1s) — Boston, MA
- [Director, Oligo Team Lead](https://feeny.ai/job/director-oligo-team-lead-manifold-bio-boston-fx7psa85j698) — Boston, MA