---
title: 'Associate Scientist, Upstream Process Development at LOTTE BIOLOGICS USA, LLC'
canonical: 'https://feeny.ai/job/associate-scientist-upstream-process-development-lotte-biologics-usa-llc-3vdre3a96ps4'
type: 'job'
last_seen: '2026-09-09'
---

# Associate Scientist, Upstream Process Development at LOTTE BIOLOGICS USA, LLC

- **Company:** LOTTE BIOLOGICS USA, LLC
- **Location:** Syracuse, NY
- **Compensation:** $60k–$88k
- **Posted:** 2026-08-11
- **Last confirmed live:** 2026-09-09
- **Apply:** https://job-boards.greenhouse.io/lottebiologicsusallc/jobs/5381998008

## Job description

We are LOTTE BIOLOGICS! Delivering Therapies That Enable a Healthier World.

A new company, built on 80 years of tradition. We embody our core values of being Inspired by Science, Embracing Diversity, Fostering Talent, and Connecting Lives. Our mission is to be the most trusted partner in the industry, with high standards of quality and continuous innovation, to reliably deliver benefits for patients worldwide.

Position Summary

The primary role of the Associate Scientist, Upstream Process Development is to execute laboratory experiments in the development, optimization, characterization, and scale-up of biologics upstream cell culture processes from laboratory to manufacturing scale using knowledge of cell culture, cell banking, medium preparation, bioreactor production, and primary recovery. This role is a combination of laboratory- and office-based work. This role will execute and document laboratory studies in laboratory notebooks. Additionally, this role will support documentation review, protocols, technical reports, change controls, and CMC regulatory submissions under supervision. The Associate Scientist is expected to follow detailed GLP/GMP procedures and safety requirements and will work in a team environment and will interact with other functional departments. Additionally, this position is a team-based position that may require work on evenings, weekends, and holidays.

Duties & Responsibilities

- Leverage an understanding of the drug substance upstream cell culture process to support execution and data analysis of scale-down/scale-up studies for media development and optimization, upstream process development, process characterization, and process validation
- Support development of the upstream inoculum expansion and cell culture process control strategy through identification of critical process parameters and process attributes
- Support process technical transfers from laboratory-scale or pilot-scale to manufacturing-scale
- Support process optimization, process robustness initiatives, process troubleshooting, process yield improvements, and process-related investigations at manufacturing-scale through conducting scale-down studies
- Document execution and results of experimental plans in laboratory notebooks, perform data verification, and author and review SOPs and upstream cell culture documentation to capture experimental designs and results via protocols and other associated scientific technical documents for process development, process characterization, as well as validation protocols with supervision
- Support continuous process improvements and advance technology for implementation in laboratory and manufacturing operations
- Support CMC review and verification of regulatory filings (IND, IND amendment, BLA, MAA, PAS, etc.), with interactions with global Health Authorities for inspections
- Cell culture expansion and handling utilizing sterile technique in plates, T-flasks, and shaker flasks
- Support routine operation, cleaning, and maintenance of laboratory equipment, including small-scale and pilot-scale bioreactors, autoclaves, centrifuges, scales, and balances
- Preparation of media, buffers, and reagents
- Analyze samples on HPLCs and other analytical instrumentation such as metabolite and cell viability analyzers, and Raman spectroscopy
- Work with other team members and on cross-functional technical teams

Education & Experience

- Bachelor's degree in Biology, Chemistry, Biochemical Engineering, Chemical Engineering, or a related scientific field, or equivalent combination of education and relevant industry experience.
- Relevant experience in biologics upstream process development, manufacturing and/or manufacturing technology is required.
- Candidates should possess:
- A B.Sc. or B.Eng. with 3-5 years of relevant experience, or
- An M.Sc. or M.Eng. with 0-2 years of relevant experience
- Experience with mammalian cell culture processes, aseptic technique, and bioreactor operations is preferred.
- Experience working in a GLP/GMP-regulated environment and supporting technical documentation is preferred.
- Experience with experimental design, statistical analysis, and process development data interpretation is preferred.

Knowledge, Skills, Abilities

- General scientific knowledge and laboratory skills; knowledge of upstream mammalian cell culture and bioreactors is preferred
- Experience with experimental design, statistical design and data analysis is preferred
- Strong problem-solving skills, with the ability to apply risk-based critical thinking in a technical environment

- Effective written and verbal communication skills, including the ability to prepare and present scientific and technical information.

- Ability to complete assignments accurately, compliantly, and within established timelines.

- Ability to work effectively both independently and as part of a cross-functional team.

- Strong attention to detail and commitment to quality and safety standards.

Physical Demands

- Frequent repetitive motions may be required, including pipetting, lifting, bending, twisting, squatting, crouching, kneeling, reaching, and climbing step stools.
- Occasional unassisted lifting of up to 50 pounds may be required.
- Repetitive use of the arms, hands, and wrists, including grasping and fine motor movements, is required.
- Office-based responsibilities associated with the role may require extended periods of sitting and computer use.

Work Environment

- This position is primarily laboratory-based and performed in an indoor environment.
- Appropriate personal protective equipment (PPE) must be worn when working in laboratory areas.
- The role may involve exposure to biohazardous materials, including live cell cultures, as well as hazardous chemicals such as methotrexate, acids, and caustics. Handling of powdered materials and high-temperature liquids or solids may also be required.
- The position requires working both collaboratively with cross-functional teams and independently.
- Occasional shift work, including evenings, weekends, and holidays, may be required to support project and operational needs.
- This role is performed in a dynamic, fast-paced, collaborative, and innovative environment.

Travel

Less than 5% travel required for this role.

Target Bonus

8%

Work Location:

East Syracuse, NY New York Pay Range $60,000—$88,000 USD

We are an Equal Employment Opportunity (“EEO”) Employer.

We believe that women, people of color, veterans and LGBTQ communities must participate in the work we do, so we strongly encourage applications from people with these identities or who are members of underrepresented communities!  If this is the work that you want to do, in a culture of inclusion and excellence with the goal of making our world to be a healthier place, then please apply today!

## About LOTTE BIOLOGICS USA, LLC

## Company Overview
- **One-liner**: LOTTE BIOLOGICS is a global Contract Development and Manufacturing Organization (CDMO) focused on end-to-end biopharmaceutical antibody production, dedicated to becoming the most trusted partner in the industry.
- **Entity Type**: Private (Subsidiary of LOTTE Group, a large South Korean conglomerate)
- **Headquarters**: Seoul, South Korea (Parent entity); Syracuse, NY, USA (Primary US operational campus)
- **Founded**: 2022
- **Founders**: Established as a subsidiary of LOTTE Group

## Core Business
- **Primary industry/industries**: Biopharmaceutical Contract Development and Manufacturing (CDMO); Biotechnology
- **Target customers**: Pharmaceutical and biotechnology companies (B2B, Enterprise) needing outsourced development and cGMP manufacturing of biologic drug substances, including antibodies and antibody-drug conjugates (ADCs).
- **Mission or purpose statement**: Dedicated to improving the lives of patients worldwide as a leading global CDMO. The company aims to deliver therapies that enable a healthier world.

## Products & Services
- **Contract Development Organization (CDO)**: Development service capabilities across the product life cycle, including product launches, scale-down process verification, and technology transfers.
- **Contract Manufacturing Organization (CMO)**: cGMP manufacturing services for the clinical and commercial supply of biological Drug Substance. The Syracuse Bio Campus has 40,000 liters of manufacturing capacity with 8x 5,000L stainless steel bioreactors.
- **Analytical Testing Services**: Quality control testing including analytical tech transfer, in-process testing, finished product testing, and stability testing. The site is equipped with HPLC, UPLC, mass spectrometers, PCR systems, and automated ELISA systems.
- **ADC Service**: Conjugation of Antibody-Drug Conjugates (ADCs), combining the specificity of monoclonal antibodies with the potency of small-molecule drugs using stable linkers.
- **Drug Substance Storage**: On-site cell bank facility and cryogenic storage of drug substance with capacity for 5,460 x 10L bottles in a dedicated cryogenic storage building.

## Market Standing
- **Valuation/Market Cap**: Not publicly available (private subsidiary of LOTTE Group)
- **Key Metric**: Major capital investment underway with a 360,000L bio campus under construction in Songdo, Incheon, South Korea (operations beginning 2027), complementing the 40,000L Syracuse campus. The parent LOTTE Group is one of the largest conglomerates in Korea with operations in 30+ countries.
- **Notable Investors/Partners**: LOTTE Group (parent company with businesses in petro/fine chemicals, food, retail, hotels, construction, and IT). Regulatory compliance track record includes 62+ approvals by health authorities worldwide including FDA, EMA, PMDA, and MFDS.
- **Growth Signals**: Rapid expansion with a "two-track strategy of acquiring and building." The Songdo Bio Campus will add 120,000L of capacity at its first facility with plans for a total of 360,000L. The company describes itself as having a "start-up spirit" combined with the backing of a major global conglomerate.

## Competitive Advantages
- **End-to-end capabilities**: Offers full lifecycle support from development through clinical and commercial production, including unique ADC conjugation services.
- **Conglomerate backing**: As part of LOTTE Group (established 1948, operating in 30+ countries), the company has deep financial resources, global supply chain access, and long-term strategic stability.
- **Proven regulatory track record**: With 62+ global health authority approvals, the company demonstrates mature quality systems and regulatory expertise.
- **Dual-campus strategy**: Operations in both the US (Syracuse, NY) and South Korea (Songdo, Incheon) provide geographic diversification and access to two major biotech markets.
- **State-of-the-art facilities**: Syracuse campus features 8 x 5,000L stainless steel bioreactors, 3 inoculation suites, 2 purification suites, and advanced analytical equipment for concurrent manufacturing of multiple products.

## Strategic Focus
- **Capacity expansion**: Major focus on constructing the Songdo Bio Campus in South Korea to add significant manufacturing capacity (up to 360,000L total).
- **Technology investment**: Emphasis on sustainable clean energy, automation, artificial intelligence, and quality systems to meet global manufacturing standards.
- **Talent development**: Commitment to fostering talent and offering secure, fulfilling career paths as the company scales.
- **Quality leadership**: Priority on maintaining the highest standards of quality and regulatory compliance to serve as a trusted partner for clients.
- **Patient-centric approach**: Focus on improving patient outcomes and making a positive impact on global quality of life.

## Why Work Here
- **Start-up spirit with big-company backing**: The company describes itself as having a "start-up spirit" and "passion for quality manufacturing," combined with the resources and stability of being part of the LOTTE Group, a major global conglomerate.
- **Growth opportunities**: With a new 360,000L bio campus under construction and rapid expansion, there are significant career growth opportunities for professionals joining at this early stage.
- **Mission-driven work**: Employees contribute directly to delivering therapies that enable a healthier world, with a focus on improving patient outcomes globally.
- **Work environment**: The company emphasizes "Enriching the lives of its diverse workforce and their families" through a secure work environment where individual rights are respected. Core values include being inspired by science, embracing diversity, fostering talent, and connecting lives.
- **Location**: Syracuse, NY campus at 6000 Thompson Rd, East Syracuse, NY 13057. The facility includes robust manufacturing support services onsite including MS&T, procurement, quality assurance, engineering, and enabling functions like HR and finance.
- **Benefits**: The company offers a "highly competitive and comprehensive benefits package" [greenhouse.io](https://job-boards.greenhouse.io/lottebiologicsusallc).
- **Current opportunities**: Active hiring in Syracuse, NY for roles including Principal Scientist (ADC Bioconjugation), Sr. Scientist (Analytical Sciences & Technology), Facilities Engineer, Plant Engineer, Senior Project Engineer, Senior Engineer (ADC Manufacturing), Sr. Project Manager (PMO), Senior Specialist (Computer System Validation), and Associate Director (HR Operations) [greenhouse.io](https://job-boards.greenhouse.io/lottebiologicsusallc).

## Sources
1. [LOTTE BIOLOGICS - Company About Page](https://www.lottebiologics.com/en/aboutus/company)
2. [LOTTE BIOLOGICS - Syracuse Bio Campus Page](https://www.lottebiologics.com/en/aboutus/syracuse)
3. [LOTTE BIOLOGICS - Main Website](https://www.lottebiologics.com/en)
4. [Greenhouse Careers Page - LOTTE BIOLOGICS USA, LLC](https://job-boards.greenhouse.io/lottebiologicsusallc)

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