---
title: 'Biostatistician II at Karius'
canonical: 'https://feeny.ai/job/biostatistician-ii-karius-redwood-city-ca-or-8rv6mh71ptr6'
type: 'job'
last_seen: '2026-09-12'
---

# Biostatistician II at Karius

- **Company:** Karius
- **Location:** Redwood City CA OR, United States
- **Compensation:** $117k–$176k
- **Employment:** full-time
- **Work type:** remote
- **Posted:** 2026-08-19
- **Last confirmed live:** 2026-09-12
- **Apply:** https://jobs.lever.co/kariusdx/f1b19dd4-0b59-4dc8-a61e-4a8ea1a5f344

## Job description

## About Karius

Karius is a life science, venture-backed clinical metagenomics company, focused on elevating patient care through microbial insights. We are committed to advancing diagnostic science and technology to optimize the diagnosis and treatment of infectious diseases. Through the use of genomics and AI, we are driven to improve the diagnostic landscape for infectious diseases. Karius delivers unprecedented diagnostic insight detecting microbial cell-free DNA circulating in the body to assist physicians to make rapid treatment decisions.

Position SummaryThe Biostatistician II supports the design, analyses and interpretation of clinical, observational, translational, and research studies with minimal guidance. This position owns defined statistical deliverables, develops statistical analysis plans, produces documentation for publication and regulatory submissions, and partners with cross-functional stakeholders to ensure analyses are scientifically rigorous, reproducible, and appropriately interpreted.

Why Should You Join Us?Karius aims to conquer infectious diseases through innovations around genomic sequencing and machine learning. The company’s platform is already delivering unprecedented insights into the microbial landscape, providing clinicians with a comprehensive test capable of identifying more than a thousand pathogens directly from blood, and helping industry accelerate the development of therapeutic solutions. The products Karius offers today are some of the most advanced solutions available to physicians who aim to deliver better care to many otherwise ineffectively treated patients. Our tests are the result of some incredible work done by our scientists, statisticians, engineers, and physicians, all driven by the same mission. You, as part of the Karius team, will be able to see how directly your work has a life-changing impact on people, and at scale.

Reports to:   Director, Clinical Statistics & Data Management

Location:  Remote

Primary Responsibilities Independently perform statistical analyses for clinical studies, research initiatives, product development activities, and evidence-generation efforts. Partner with clinical and scientific stakeholders to define study objectives, endpoints, hypotheses, and appropriate statistical methodologies. Develop statistical analysis plans, including sample size and power calculations, analysis populations, statistical methods, and sensitivity analyses. Analyze clinical, observational, laboratory, and real-world datasets using appropriate statistical techniques. Support the design and analysis of prospective and retrospective clinical studies. Support exploratory analysis of Karius’ large archive of commercial and research data as needed. Develop and validate statistical models to evaluate diagnostic performance, clinical outcomes, and other study endpoints. Analyze diagnostic performance measures, including sensitivity, specificity, diagnostic value, agreement measures, and other relevant metrics. Perform analyses involving longitudinal data, survival outcomes, missing data, confounding, subgroup analyses, and other complex data structures, as appropriate. Collaborate with Data Science, Bioinformatics, Clinical Development, Medical Affairs, and Research and Development teams to ensure statistical rigor and appropriate interpretation of results. Review datasets and analysis outputs for accuracy, completeness, consistency, and statistical validity. Independently manage assigned statistical analyses and deliverables. Interpret analytical findings and communicate results clearly to technical and non-technical audiences. Contribute statistical content to study reports, abstracts, manuscripts, posters, presentations, regulatory materials, and other scientific communications. Support responses to statistical questions arising during scientific, clinical, regulatory, or publication review. Develop robust, reusable statistical programs, workflows, and documentation that support reproducible analyses. Maintain appropriate documentation of statistical methodologies, assumptions, analyses, and results. Contribute to continuous improvement of statistical processes, standards, and analytical approaches.

What’s Fun About the Job? Karius is operating at the edge of what is now known to be possible in diagnostics. With that, comes a wave of new and incredible challenges and opportunities. To deliver on that value, you will be tapping into some of the most advanced technologies, architecting and innovating where the current solutions simply don't suffice. You will get to see how much your work really matters.

Travel: Travel required up to 15% for team events.

Physical Requirements Subject to extended periods of sitting and/or standing, vision to monitor and moderate noise levels. Work is generally performed in an office, lab or clinical environment.

Position Requirements Master’s degree in Biostatistics, Statistics, Epidemiology, Applied Statistics, or a related quantitative field required; PhD preferred. 3–5 years of relevant biostatistics experience in biotechnology, diagnostics, pharmaceuticals, healthcare, academia, or a related life sciences environment. Experience designing and analyzing clinical, observational, or translational research studies. Experience developing statistical analysis plans, including study endpoints, sample size and power calculations, analysis populations, and statistical methodologies. Strong knowledge of statistical methods, including regression analysis, categorical data analysis, longitudinal analysis, survival analysis, and methods for addressing missing data and confounding. Proficiency with diagnostic test performance measures, including sensitivity, specificity, diagnostic value, and agreement measures, preferred. Experience analyzing highly multiplexed clinical assays. Proficiency within statistical programming using R and/or SAS required; experience with Python and SQL preferred. Experience working with complex clinical, biological, genomic, or real-world datasets. Strong understanding of data quality, analytical reproducibility, statistical validation, and documentation practices. Experience contributing statistical analyses to clinical study reports, abstracts, manuscripts, presentations, or regulatory submissions. Ability to independently manage statistical analyses and provide statistical guidance to cross-functional partners. Strong analytical, problem-solving, and critical-thinking skills. Excellent written and verbal communication skills, with the ability to communicate complex statistical concepts to both technical and non-technical audiences. Ability to manage multiple priorities and collaborate effectively in a fast-paced, cross-functional environment. Familiarity with regulatory requirements, Good Clinical Practice (GCP), and statistical practices within regulated life sciences environments preferred.

Personal Qualifications Strong analytical, problem-solving, and critical-thinking skills. Demonstrated ability to work independently while recognizing when to seek input or escalate issues. Strong attention to detail with a commitment to accuracy, quality, and scientific rigor. Ability to evaluate analytical problems and recommend thoughtful, data-driven solutions. Strong organizational skills with the ability to manage multiple priorities and deliverables. Excellent written and verbal communication skills, including the ability to explain statistical concepts clearly to technical and non-technical audiences. Collaborative and proactive approach to working with cross-functional partners. Ability to navigate ambiguity and adapt effectively as study or business priorities evolve. Demonstrated accountability and ownership for assigned work. Commitment to continuous learning and improvement of statistical and analytical practices.

Disclaimer The above job description is intended to describe the general nature and level of work being performed by individuals assigned to this position. It is not intended to be an exhaustive list of all duties, responsibilities, and skills required. Responsibilities and duties may change or be adjusted to meet the needs of the company, and additional duties may be assigned as necessary. The job description is subject to change at any time at the discretion of Karius.

At Karius, we value a diverse and inclusive workplace and provide equal employment opportunities for all applicants and employees and are committed to honor and invest in the full diversity of people, in our hiring, recruiting and development of employees across the Company.  All qualified applicants for employment are encouraged to apply and will be considered without regard to an individual’s race, color, sex, gender identity and gender expression (including transgender individuals who are transitioning, have transitioned, or are perceived to be transitioning to the gender with which they identify), religion, age, national origin or ancestry, citizenship, physical or mental disability, medical condition, family care status, marital status, domestic partner status, sexual orientation, genetic information, military or veteran status, or any other basis protected by federal, state or local laws. If you are unable to submit your application due to a disability, please contact us at recruiting@kariusdx.com and we will accommodate qualified individuals with disabilities.

## About Karius

## Company Overview
- **One-liner**: Karius is a clinical metagenomics company that uses microbial cell-free DNA and AI to diagnose infectious diseases from a single blood test, helping clinicians make faster treatment decisions.
- **Entity Type**: Private (Series C)
- **Headquarters**: Redwood City, California, United States
- **Founded**: 2014
- **Founders**: Based on intellectual property developed at Stanford University (specific founders not widely disclosed; Alec Ford is CEO)

## Core Business
- **Primary Industry**: Biotechnology Research / Clinical Diagnostics
- **Target Customers**: B2B — 600+ leading hospitals and transplant centers across the US
- **Mission**: To create a world where every patient gets a clear and timely diagnosis, and where infectious disease is no longer a major threat to human health [kariusdx.com](https://kariusdx.com/about-us)

## Products & Services
- **Karius Test (Karius Spectrum)**: A clinical metagenomics test that detects microbial cell-free DNA circulating in the blood, identifying over 1,000 pathogens (bacteria, viruses, fungi, parasites) with a single blood draw. Used for immunocompromised patients, sepsis, and complex infections.
- **Karius Cloud**: Software platform for test ordering, reporting, and data integration (assists clinical workflow).

## Market Standing
- **Valuation/Market Cap**: Not publicly disclosed
- **Key Metric (Funding)**: **$354M total funding** — Series C (May 2024): $100M led by Khosla Ventures and 5AM Ventures; prior rounds include Series B, Seed, and Debt Financing from DCVC and Oxford Finance [linkedin.com](https://linkedin.com/company/kariusinc)
- **Annual Revenue**: ~$19.5M (estimated) [linkedin.com](https://linkedin.com/company/kariusinc)
- **Notable Investors/Partners**: Khosla Ventures, 5AM Ventures, DCVC, Oxford Finance LLC — plus partnerships with 600+ hospitals and transplant centers
- **Growth Signals**: 100,000+ patient samples tested; 1.5% YoY headcount growth; 200% increase in job postings quarterly; active expansion of clinical sales roles; CAP-accredited, CLIA-certified, and ISO 15189-accredited lab

## Competitive Advantages
- **Unique Moat**: Proprietary metagenomics platform using cell-free DNA from a simple blood draw — replaces invasive tissue biopsies and broad-spectrum empiric treatment; backed by Stanford IP and validated in clinical practice
- **AI-Driven**: Uses genomics and artificial intelligence for pathogen detection at unprecedented breadth and speed
- **Accreditations**: CLIA-certified, CAP-accredited, and ISO 15189-accredited high-complexity lab — a significant regulatory barrier for competitors
- **Already in Use**: Deployed at 600+ leading US hospitals, demonstrating clinical adoption and trust

## Strategic Focus
- **Clinical Expansion**: Scaling sales organization (multiple Clinical Sales Manager roles open) to deepen hospital penetration and reach new geographies (East Coast, Midwest)
- **Product Development**: Advancing the Karius Spectrum test to cover more pathogens and reduce turnaround time
- **AI & Data Science**: Continued investment in computational biology and machine learning for pathogen identification and microbiome analysis
- **Patient Impact**: Focus on reducing time-to-diagnosis for critically ill patients (sepsis, immunocompromised)

## Why Work Here
- **Culture**: Described as high-integrity, roll-up-your-sleeves, and patient-first. Emphasis on humility, flexibility, respect, and teamwork. Employees report a 3.4/5 rating (77 reviews) — Work-Life 3.8, Compensation 3.9, Culture 3.4, Career 3.3 [linkedin.com](https://linkedin.com/company/kariusinc)
- **Remote/Hybrid**: Hybrid office in Redwood City, CA, with **remote options available for many roles** (USA-wide). The culture values flexibility, outcomes over hours, and work-life balance.
- **Benefits**: 100% company-paid premiums for employees; flexible time off (vacation, sick, mental wellness days); 12 paid holidays; generous paid maternity and paternity leave; 401(k); FSA; mobile phone & internet allowance; access to life coaches and therapists.
- **Career Development**: Access to professional coaches for all levels; twice-yearly development check-ins; learning opportunities from wearing multiple hats in a start-up; mentorship of STEM students.
- **Mission-Driven**: Direct impact on patient lives — "you will help save lives" is a core recruiting message. Employee-led community service (Second Harvest food packaging, St. Jude walks, beach cleanups, STEM mentoring).
- **Engineering & Science**: Strong research culture (computational biology, data science, genomics); opportunity to work at intersection of AI, DNA sequencing, and clinical medicine.

## Sources
1. [Karius About Us](https://kariusdx.com/about-us)
2. [Karius Careers Page](https://kariusdx.com/about-us/careers)
3. [Karius LinkedIn Company Profile](https://linkedin.com/company/kariusinc)
4. [Karius Job Listings (Lever)](https://jobs.lever.co/kariusdx)
5. [Karius Leadership Team](https://kariusdx.com/about-us/our-team)

## Other roles at Karius

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- [Quality Assurance Associate](https://feeny.ai/job/quality-assurance-associate-karius-redwood-city-nr5e1ceg09hv) — Redwood City, CA
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- [Clinical Sales Manager (Eastern Region)](https://feeny.ai/job/clinical-sales-manager-eastern-region-karius-eastern-region-srrf3wz36g4h) — Eastern Region
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