---
title: 'Business System Engineer – Enterprise Applications at Rezolute'
canonical: 'https://feeny.ai/job/business-system-engineer-enterprise-applications-rezolute-redwood-city-9pw1asb8npz9'
type: 'job'
last_seen: '2026-09-11'
---

# Business System Engineer – Enterprise Applications at Rezolute

- **Company:** Rezolute
- **Location:** Redwood City, CA
- **Employment:** full-time
- **Work type:** onsite
- **Posted:** 2026-08-04
- **Last confirmed live:** 2026-09-11
- **Apply:** https://jobs.lever.co/rezolutebio/778cfb4b-3b78-429b-abf9-ceb14e91e61c

## Job description

Rezolute is a late-stage rare disease biopharmaceutical company focused on developing transformative therapies for patients living with severe metabolic and endocrine disorders. Our lead investigational therapy, RZ358 (ersodetug), is a fully human monoclonal antibody in late-stage clinical development for the treatment of congenital and acquired forms of hyperinsulinism (HI). Rezolute’s mission is to bring hope and meaningful solutions to patients and families affected by rare diseases through scientific innovation, collaboration, and integrity.

The Business Systems Engineer - Enterprise Applications position is a hands-on technical contributor responsible for executing and supporting the implementation, integration, and optimization of enterprise and business systems across the organization.

This role bridges business stakeholders, vendors, and IT, ensuring systems are deployed effectively, align with operational needs, and adhere to compliance and validation standards. The Business Systems Engineer - Enterprise Applications works directly with technical environments and configurations—not just project coordination—to help bring systems online efficiently and correctly.

This individual collaborates closely with the Director of Quality Assurance- Computer Systems to ensure implementation activities align with validation requirements and reports to the Associate Director of IT, who oversees enterprise architecture, strategic planning, and IT roadmap execution.

The ideal candidate has experience in the biotech or pharmaceutical industry, particularly in organizations moving from clinical to commercial phases, and understands how to deliver systems that meet both business and compliance expectations.

Key Responsibilities:

- Take a hands-on role in configuring, implementing, and supporting enterprise and business systems across departments.
- Work with business stakeholders to capture requirements and translate them into technical and system configurations.
- Lead cross-functional and IS/IT-centric projects, ensuring alignment between business stakeholders, vendors, and internal IT resources.
- Collaborate with IT staff and external vendors to deploy, integrate, and optimize systems that support operational growth.
- Partner with the CSV team to ensure implementation tasks align with validation processes, providing technical assistance (e.g., system setup, environment readiness, data preparation, and issue resolution).
- Support and troubleshoot system integrations, user access issues, and environment dependencies within AWS and Azure ecosystems.
- Participate in data migration and environment setup activities during system deployment.
- Maintain detailed documentation of system configurations, workflows, and change controls.
- Identify and escalate project risks, blockers, or dependencies to the Associate Director of IT.
- Provide post-implementation support and assist in transitioning systems to steady-state ownership.

Qualifications:

- Bachelor’s degree in Information Technology, Computer Science, or a related discipline (or equivalent experience).
- Minimum of 5  years of experience implementing or supporting enterprise and business systems in biotech or pharmaceutical organizations.
- Hands-on experience with platforms such as Veeva Vault, ERP systems (e.g., NetSuite, SAP, or Oracle), and cloud environments (AWS and Azure).
- Familiarity with GxP, SOX, and data integrity principles.
- Understanding of both clinical-phase and commercial-phase biotech operations.
- Strong troubleshooting, analytical, and documentation skills.
- Ability to manage multiple priorities and adapt to evolving business needs.
- Excellent communication skills and ability to work cross-functionally across IT, QA/CSV, and business teams.

Core Competencies

Hands-On Executor: Comfortable configuring, testing, and deploying systems directly.

Collaborative Partner: Works effectively with IT, CSV, and business stakeholders to drive compliant implementations.

Analytical Problem-Solver: Identifies technical challenges and implements scalable solutions.

Detail-Oriented: Maintains precision in documentation and configuration management.

Clear Communicator: Provides concise updates and transparent reporting to leadership.

Adaptable: Operates effectively in a fast-paced, evolving biotech environment.

Rezolute (RZLT) currently anticipates the base salary for the Business Systems Engineer - Enterprise Applications role could range from $120,000 to $160,000 and will depend, in part, on the successful candidate’s geographical location and their qualifications for the role, including education and experience. This position will also be eligible for an annual performance bonus in accordance with the terms of the applicable plan (depending, in part, on company and individual performance and at the Company’s discretion on an individual basis). The compensation described above is subject to change and could be higher or lower than the range described based on current market survey data and the qualifications, education, experience and geographical location of the selected candidate. Rezolute offers competitive compensation, stock options and a rich benefits package.

Qualifying employees are eligible to participate in benefit programs such as: Health Insurance (Medical / Dental / Vision) Disability, Life & Long-Term Care Insurance Holiday Pay Tracking Free Vacation Program 401(k) Plan Match Educational Assistance Benefit Fitness Center Reimbursement We are an Equal Opportunity Employer and do not discriminate against applicants due to race, ethnicity, gender, veteran status, or on the basis of disability or any other federal, state or local protected class.

## About Rezolute

## Company Overview
- **One-liner**: Rezolute is a late-stage rare disease biotechnology company developing ersodetug, a monoclonal antibody therapy for hypoglycemia caused by congenital and tumor hyperinsulinism.
- **Entity Type**: Public (Nasdaq: RZLT)
- **Headquarters**: Redwood City, California, United States (with an additional office in Louisville)
- **Founded**: Not publicly available (IPO 2012)
- **Founders**: Not publicly available

## Core Business
- **Primary industry**: Biotechnology – rare disease therapeutics
- **Target customers**: B2B – healthcare providers, patients, and payers; focuses on addressing severe unmet medical needs in hyperinsulinism
- **Mission/purpose**: Significantly improve outcomes for individuals with hypoglycemia caused by hyperinsulinism ([rezolutebio.com – About](https://rezolutebio.com/job-openings/))

## Products & Services
- **Ersodetug (lead candidate)**: An intravenously administered human monoclonal antibody that allosterically binds to the insulin receptor, down‑modulating insulin action to restore normal glucose levels. Being developed for two indications:
  - **Congenital Hyperinsulinism (sunRIZE Phase 3 study)** – completed enrollment (May 2025) with 62 participants; topline results expected December 2025.
  - **Tumor Hyperinsulinism (upLIFT Phase 3 study)** – initiated mid‑2025; FDA agreed to a single‑arm open‑label design; topline results expected second half 2026.
  - Designations: Orphan Drug (US/EU), Rare Pediatric Disease, Breakthrough Therapy (US), PRIME (EU), ILAP (UK) ([ir.rezolutebio.com – 10-K](https://ir.rezolutebio.com/sec-filings/content/0001104659-25-090848/0001104659-25-090848.pdf))

## Market Standing
- **Valuation/Market Cap**: $317.7 million (as of recent data, per LinkedIn) ([linkedin.com](https://linkedin.com/company/rezolute))
- **Key Metric (Public)**: Annual revenue of $14.1 million (likely from grants or collaboration revenue; no product revenue yet) ([linkedin.com](https://linkedin.com/company/rezolute))
- **Notable Investors/Partners**: Not publicly available – company is publicly traded and does not disclose a lead investor list. Key partners include clinical trial sites and regulatory agencies (FDA, EMA).
- **Growth Signals**:
  - Headcount: 50 employees (+2.9% YoY) ([linkedin.com](https://linkedin.com/company/rezolute))
  - Phase 3 sunRIZE study fully enrolled; topline data pending December 2025.
  - Phase 3 upLIFT study enrolling with streamlined design; data expected second half 2026.
  - FDA granted Breakthrough Therapy Designation for tumor HI in May 2025.
  - Multiple regulatory designations accelerating development pathway.

## Competitive Advantages
- **Unique mechanism**: Ersodetug acts downstream from beta cells at the insulin receptor, allowing it to potentially treat all forms of hyperinsulinism (genetic or acquired) regardless of underlying cause.
- **Dosing convenience**: Half‑life >2 weeks enables monthly intravenous administration.
- **Regulatory momentum**: Orphan Drug, Rare Pediatric Disease, Breakthrough Therapy, PRIME, and ILAP designations provide expedited review, potential priority review voucher, and closer FDA/EMA collaboration.
- **Pivotal data catalysts**: Two Phase 3 studies read out within ~12‑18 months, creating clear value inflection points.

## Strategic Focus
- Execute the two ongoing Phase 3 trials (sunRIZE in congenital HI, upLIFT in tumor HI).
- Assuming positive topline data from sunRIZE, submit a Biologics License Application (BLA) to the FDA for ersodetug in mid‑2026.
- Continue to build commercial and medical affairs infrastructure (recent job postings indicate hires in Commercial Operations, Marketing, Payer Strategy, and Supply Chain) ([rezolutebio.com – Job Openings](https://rezolutebio.com/job-openings/)).

## Why Work Here
- **Mission‑driven**: Employees work on therapies for ultra‑rare, life‑threatening conditions with high unmet medical need.
- **Benefits**: Comprehensive health/dental/vision insurance, competitive salaries, annual bonus, 401(k) with company match, tuition assistance, on‑site meals, flexible spending accounts ([rezolutebio.com – Benefits](https://rezolutebio.com/job-openings/)).
- **Work environment**: Hybrid/office policy not explicitly stated; roles are based in Redwood City (HQ) and Louisville. Recent openings include remote-friendly functions? Not confirmed.
- **Growth opportunity**: Small company (~50 people) entering late‑stage development and pre‑commercial build‑out – employees can have broad impact and career advancement.
- **Engineering culture**: For biotech, the focus is on clinical operations, regulatory, and commercial roles rather than traditional engineering. IT positions (Business System Engineer) exist.

## Sources
1. [linkedin.com – Rezolute company page](https://linkedin.com/company/rezolute)
2. [rezolutebio.com – Job Openings & Benefits](https://rezolutebio.com/job-openings/)
3. [ir.rezolutebio.com – SEC 10-K Filing (September 2025)](https://ir.rezolutebio.com/sec-filings/content/0001104659-25-090848/0001104659-25-090848.pdf)
4. [rezolutebio.com – Leadership page](https://rezolutebio.com/leadership/)

## Other roles at Rezolute

- [Sr. Medical Science Liaison](https://feeny.ai/job/sr-medical-science-liaison-rezolute-remote-p0q0xz8s2neg)
- [Senior Manager, External Supplier Operations](https://feeny.ai/job/senior-manager-external-supplier-operations-rezolute-redwood-city-pqxs0q5vsnyp) — Redwood City, CA
- [Director of Medical Affairs Operations](https://feeny.ai/job/director-of-medical-affairs-operations-rezolute-redwood-city-ck5kj9c3wbfs) — Redwood City, CA
- [Sr Director, Regulatory Affairs](https://feeny.ai/job/sr-director-regulatory-affairs-rezolute-redwood-city-wqvf8n5fvptf) — Redwood City, CA
- [Head of Global Product Supply](https://feeny.ai/job/head-of-global-product-supply-rezolute-redwood-city-9yv4d2b9fg0s) — Redwood City, CA
- [Director Program Manager, Product Launch (Rare Disease)](https://feeny.ai/job/director-program-manager-product-launch-rare-disease-rezolute-redwood-city-vn56yjrm5v16) — Redwood City, CA
- [Sr. Director, Commercial Supply Chain](https://feeny.ai/job/sr-director-commercial-supply-chain-rezolute-redwood-city-e3ss6gz4cayw) — Redwood City, CA
- [Marketing Operations Director (Tumor HI Program)](https://feeny.ai/job/marketing-operations-director-tumor-hi-program-rezolute-redwood-city-n2vdgj2z6tjs) — Redwood City, CA