---
title: 'Careers@Tessera at Tessera Therapeutics'
canonical: 'https://feeny.ai/job/careers-tessera-tessera-therapeutics-somerville-massachusetts-ywbgb4ejq6gg'
type: 'job'
last_seen: '2026-09-14'
---

# Careers@Tessera at Tessera Therapeutics

- **Company:** Tessera Therapeutics
- **Location:** Somerville Massachusetts, United States
- **Posted:** 2023-07-18
- **Last confirmed live:** 2026-09-14
- **Apply:** https://job-boards.greenhouse.io/tesseratherapeutics/jobs/4034391007

## Job description

Don't see anything listed that fits your background?  Please use this link to share your profile with us and we will keep you in mind for future roles. Company Summary:

Tessera Therapeutics is pioneering Gene Writing™— a new biotechnology designed to offer scientists and clinicians the ability to write small and large therapeutic messages into the genome, thereby curing diseases at their source. Gene Writing holds the potential to become a new category in genetic medicine, building upon recent breakthroughs in gene therapy and gene editing while eliminating important limitations in their reach, utilization, and efficacy.

More about Tessera Therapeutics:

Tessera is proud to be an Equal Opportunity Employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, age, sex, national origin, disability status, marital status, genetics, protected veteran status, citizenship status, sexual orientation, gender identity or expression, or any other characteristic identified by federal, state, or local laws where we operate. Tessera provides reasonable accommodations to qualified applicants and employees with disabilities. To begin an interactive dialogue with Tessera regarding a reasonable accommodation in connection with the hiring process and/or to perform the essential functions of the position for which the applicant has applied, please contact the recruiter or Accommodations@tesseratx.com

Recruitment & Staffing Agencies:  Tessera Therapeutics does not accept unsolicited resumes from any source other than candidates. The submission of unsolicited resumes by recruitment or staffing agencies to Tessera Therapeutics or its employees is strictly prohibited unless contacted directly by Tessera Therapeutics’ internal Talent Acquisition team. Any resume submitted by an agency in the absence of a signed agreement will automatically become the property of Tessera Therapeutics, and Tessera Therapeutics will not owe any referral or other fees with respect thereto.

## About Tessera Therapeutics

## Company Overview
- **One-liner**: Tessera Therapeutics is a biotechnology company pioneering Gene Writing™, a novel genome engineering approach designed to write therapeutic messages into the genome to cure diseases at their source.
- **Entity Type**: Private (Series B; total funding raised: $773.1M)
- **Headquarters**: Somerville, Massachusetts, United States
- **Founded**: 2020 (incorporated within Flagship Pioneering)
- **Founders**: Spun out of Flagship Pioneering; founding team includes Noubar Afeyan, Geoffrey von Maltzahn, and others associated with Flagship.

## Core Business
- Primary industry/industries: Biotechnology Research, Genetic Medicine
- Target customers: B2B (pharma/biotech partners like Regeneron) and B2G (grants from ARPA-H, Gates Foundation); enterprise focus on developing therapeutic candidates for monogenic diseases, cancer, autoimmune diseases, and infectious diseases (e.g., HIV).
- Mission or purpose statement: “To cure disease by writing in the code of life.”

## Products & Services
- **[Gene Writing™ Platform]**: A proprietary technology designed to make small and large permanent alterations to the human genome using engineered gene writers derived from mobile genetic elements.
- **[Non-viral LNP Delivery Platform]**: A tissue-targeted lipid nanoparticle (LNP) delivery system designed to deliver gene writers to specific tissues (e.g., liver, T cells, hematopoietic stem cells) for in vivo applications.
- **[TSRA-196 (Lead Program)]**: An in vivo gene editing investigational therapy for Alpha-1 Antitrypsin Deficiency (AATD) that has received both FDA Fast Track Designation and Orphan Drug Designation.
- **[Pipeline Programs]**: Preclinical programs in sickle cell disease, in vivo CAR-T applications for oncology/autoimmune diseases, and HIV cure approaches (funded by a Gates Foundation/ARPA-H grant).

## Market Standing
- **Valuation/Market Cap**: Not publicly disclosed (private company)
- **Key Metric**: Total Funding of $773.1M raised across 8 rounds; latest grant (2025-11-08): $41.3M from ARPA-H; latest corporate round (2025-12-01): $150M led by Regeneron.
- **Notable Investors/Partners**: Flagship Pioneering (founder), SoftBank Vision Fund, Alaska Permanent Fund, Regeneron (strategic partner), Bill & Melinda Gates Foundation, ARPA-H.
- **Growth Signals**:
  - Received FDA Fast Track and Orphan Drug Designation for TSRA-196 (first in vivo gene editing program for AATD to reach this milestone).
  - Entered into a major collaboration with Regeneron (2025) to develop gene writing therapies.
  - Expanding into new disease areas (HIV cure, autoimmune, oncology).
  - Preclinical data presented at ASGCT (April/May 2026) for sickle cell disease and in vivo CAR-T.

## Competitive Advantages
- **Proprietary Gene Writing Technology**: A distinct approach to genome engineering that can make both small and large alterations, including writing new genetic sequences into the genome—differentiating it from gene editing (e.g., CRISPR) which only cuts or corrects.
- **Endogenous LNP Delivery**: Early mover in non-viral, tissue-targeted delivery for in vivo genetic medicine, reducing the need for viral vectors.
- **Flagship Pioneering Ecosystem**: Deep connection to Flagship provides access to capital, talent, and innovative R&D infrastructure.
- **Strong IP Moat**: Extensive patent portfolio around Gene Writers and delivery systems.

## Strategic Focus
- **Current Priorities**:
  - Advancing TSRA-196 toward clinical trials (IND clearance recently achieved).
  - Developing next-generation Gene Writers with improved efficiency and specificity.
  - Expanding in vivo delivery capabilities to target T cells (for CAR-T oncology/autoimmune) and hematopoietic stem cells (for sickle cell).
  - Pursuing HIV cure via a grant-supported program.
- **Direction for Growth**: Transition from platform discovery company to a clinical-stage therapeutic developer, building an internal pipeline while partnering strategically (e.g., Regeneron).

## Why Work Here
- **Culture Highlights**: Values are explicitly defined: Collaborative, Rigorous, Agile, Tenacious, Community. Described as an inclusive, purpose-driven culture of change makers.
- **Remote/Hybrid/Office Policy**: Office-based in Somerville, MA (no fully remote positions currently posted); free onsite gym, bike storage, commuter stipend, and free snack bars.
- **Notable Perks**:
  - Unlimited PTO, 12 paid holidays, 7 “gift of time” days off (including company-wide winter and summer breaks).
  - Generous medical/dental/vision plans (employer contributions), 401k employer match, company-paid life and disability.
  - Wellness discounts (gym memberships, equipment, athletic gear), Employee Assistance Program.
  - Employee Resource Groups (ERGs), volunteerism program, open office hours with CEO/CHRO/R&D Leadership.
- **Engineering/Lab Culture**: Heavy R&D focus—49% of employees are in Research; emphasis on cutting-edge genomics, delivery science, and early therapeutic development.
- **Talent Signals**: Recent departures and staffing reductions (-39.8% YoY headcount to 210) suggest a strategic pivot/refocus; current active job postings (4 contracts) indicate cautious hiring aligned with pipeline milestones.
- **Ideal Candidate**: Passionate about genetic medicine, comfortable with high-science/high-risk early-stage biotech, thrives in a collaborative and rigorous wet-lab environment.

## Sources
1. [Tessera Therapeutics Official Website](https://www.tesseratherapeutics.com/)
2. [Tessera Therapeutics Careers Page](https://www.tesseratherapeutics.com/careers)
3. [Tessera Therapeutics Leadership Page](https://www.tesseratherapeutics.com/leadership)
4. [Tessera Therapeutics Focus Areas](https://www.tesseratherapeutics.com/focus-areas)
5. [LinkedIn Company Profile](https://www.linkedin.com/company/tessera-therapeutics)

## Other roles at Tessera Therapeutics

- [Medical Monitor/Senior Medical Monitor, Hematology](https://feeny.ai/job/medical-monitor-senior-medical-monitor-hematology-tessera-therapeutics-qz11gngqmr5j) — Somerville Massachusetts, United States
- [Clinical Operations Manager](https://feeny.ai/job/clinical-operations-manager-tessera-therapeutics-somerville-massachusetts-a8aykvrnedy2) — Somerville Massachusetts, United States
- [Senior Scientist, Computational Biology - Contract](https://feeny.ai/job/senior-scientist-computational-biology-contract-tessera-therapeutics-somerville-rczyk6j2n0wa) — Somerville Massachusetts, United States
- [Vice President, Corporate Transactions](https://feeny.ai/job/vice-president-corporate-transactions-tessera-therapeutics-somerville-2n5a5y5sb5cf) — Somerville Massachusetts, United States
- [Director, Head of Program Management](https://feeny.ai/job/director-head-of-program-management-tessera-therapeutics-somerville-6vefttmqb0kg) — Somerville Massachusetts, United States