---
title: 'Clinical Trial Coordinator at Obsidian Therapeutics'
canonical: 'https://feeny.ai/job/clinical-trial-coordinator-obsidian-therapeutics-bedford-vvsrfj5z90xd'
type: 'job'
last_seen: '2026-10-24'
---

# Clinical Trial Coordinator at Obsidian Therapeutics

- **Company:** Obsidian Therapeutics
- **Location:** Bedford, MA
- **Compensation:** $81k–$99k
- **Work type:** hybrid
- **Posted:** 2026-10-07
- **Last confirmed live:** 2026-10-24
- **Apply:** https://job-boards.greenhouse.io/obsidiantherapeutics/jobs/6216057004

## Job description

## About Us…

Obsidian Therapeutics is pioneering engineered cell and gene therapies to deliver transformative outcomes for patients. Obsidian’s programs apply our cytoDRiVE® technology in Cell and Gene therapy products to control expression of proteins for enhanced therapeutic efficacy and safety. Obsidian’s lead program is currently in clinical development for the treatment of patients with metastatic melanoma and non-small cell lung cancer.

We’re proud of our diverse talented team and committed to cultivating an environment of inclusion where each person feels a strong sense of belonging and is supported to continuously learn and contribute their best work. Our Research team is based in the heart of Cambridge, MA, and Technical Operations team is based in our purpose built facility in Bedford, MA.   Obsidianites enjoy a highly collaborative culture, competitive salary and benefits, and potential for ownership through stock options.

Our Opportunity...

We are looking for a highly motivated Clinical Trial Coordinator with a strong background in supporting clinical research studies or clinical trial operations. As a key contributor within Clinical Operations, you’ll provide operational support for Obsidian Therapeutics' clinical studies by coordinating clinical trial activities, patient scheduling workflows, vendor interactions, and translational sample management, helping to drive the development of our first clinical stage autologous cell therapy program targeting solid tumors.

This role is responsible for supporting the collection, shipment, tracking, and reconciliation of clinical and translational research samples while ensuring accurate study documentation and communication across internal teams, clinical sites, laboratories, and vendors. The CTC will work closely with Clinical Operations, Clinical Science, Supply Chain & Logistics, Data Management, and external service providers to support study execution and maintain operational coordination of clinical and translational activities.

As a member of our Clinical Operations Team, you will be a vital part of a highly collaborative group working to unlock the promise of precision cell therapy for patients, starting with our lead program amsoki-cel (OBX-115), a novel engineered tumor-infiltrating lymphocyte (TIL) cell therapy that uses our proprietary cytoDRiVE® platform. This is a unique opportunity to be a valuable contributor in a well-funded clinical company with field-leading advisors, best-in-class partners, and an experienced team.

This is a Hybrid role based out of our Bedford, MA location.

You Will...

Core responsibilities

- Support day-to-day operational execution of assigned clinical trials.
- Coordinate study-related activities among clinical sites, vendors, laboratories, and internal stakeholders.
- Assist with study start-up, site activation, protocol amendment implementation, and study closeout activities.
- Maintain study tracking tools, study dashboards, action item logs, and Trial Master File (TMF) documentation.
- Support investigational site communications and distribution of study documents.
- Coordinate investigator meetings, study team meetings, and vendor meetings, including preparation of agendas, minutes, and follow-up action items.
- Support implementation and tracking of protocol changes and operational plans.
- Coordinate patient scheduling activities associated with study procedures, leukapheresis collections, manufacturing timelines, treatment administration, and follow-up visits, as applicable.
- Maintain study scheduling trackers and communicate scheduling updates to relevant stakeholders.
- Support coordination of time-sensitive activities among sites, manufacturing partners, central laboratories, and logistics vendors.
- Escalate scheduling conflicts, delays, or operational risks to the Clinical Operations team.
- Coordinate collection, shipment, receipt, tracking, and reconciliation of study-related biological samples, including tumor tissue, blood, plasma, serum, PBMCs, and other translational samples.
- Maintain sample tracking systems to monitor sample collection status, shipment status, receipt confirmation, and data availability.
- Coordinate sample shipments to central laboratories and specialty testing vendors in accordance with study requirements.
- Ensure required sample documentation is complete and maintained.
- Support management of chain of identity (COI) and chain of custody (COC) documentation, where applicable.
- Assist sites and vendors with resolving sample-related operational issues.
- Track sample inventory and status across studies and communicate updates to study teams.
- Serve as an operational point of contact for central laboratories and study vendors.
- Track laboratory deliverables, sample analyses, and data transfers.
- Monitor vendor timelines and follow up on outstanding deliverables.
- Coordinate laboratory manual updates and support sample collection kit management activities.
- Support vendor onboarding, purchase order tracking, invoice processing, and contract-related administrative activities.
- Assist Clinical Operations with vendor oversight documentation and issue tracking.
- Maintain study trackers related to enrollment, sample management, vendor deliverables, and study milestones.
- Support reconciliation of laboratory and sample-related data.
- Assist with query resolution and documentation of sample-related deviations.
- Maintain study documentation in applicable systems and the Trial Master File.
- Support inspection readiness by ensuring complete and accurate study documentation.

You Bring...

Core Qualifications

- Bachelor’s degree in life sciences, health sciences, or a related discipline preferred.
- 2+ years of experience supporting clinical research studies or clinical trial operations.
- Experience coordinating study activities across multiple stakeholders.
- Experience supporting sample management, laboratory operations, or biospecimen logistics preferred.
- Oncology clinical trial experience preferred.
- Experience working with CROs, central laboratories, or specialty vendors preferred.
- Strong organizational and project coordination skills.
- Ability to manage multiple competing priorities in a fast-paced environment.
- Excellent written and verbal communication skills.
- Strong attention to detail and documentation practices.
- Proficiency with Microsoft Office applications and clinical trial tracking tools.
- Experience coordinating time-sensitive clinical and sample management activities.
- Ability to work effectively across cross-functional teams and external partners.
- Scientifically rigorous in designing and executing experiments and record keeping.
- Excellent planning, coordination, and time management skills
- Excellent oral, written, and visual communication skills. You listen to understand and communicate effectively and persuasively with partners, colleagues, and leadership.
- Ability to build and maintain productive relationships with department management, peers, and other colleagues across the organization
- Collaborative and accountable – recognizes success requires teamwork and interdisciplinary thinking; shares feedback and ideas to facilitate better outcomes
- Self-motivated, with a proven ability to meet objectives, timelines, and high standards managing multiple responsibilities in parallel.
- Flexible - adapts to change in a fast paced, rapidly developing environment
- Curious and humble – seeks and welcomes input/expertise of others, continuous learner
- Tenacious and resilient – is not easily overwhelmed by challenges, delivers on commitments, operates with urgency

Bonus Qualifications

- Experience in oncology, cell therapy, gene therapy, or immunotherapy clinical trials.
- Familiarity with biospecimen handling and shipment processes.
- Understanding of chain of identity (COI) and chain of custody (COC) principles.
- Experience supporting global clinical studies and complex vendor networks.

Obsidian is committed to equitable and transparent pay practices.

The anticipated base salary range for this role is below. The actual base salary offered will be determined based on a combination of factors, including applicable qualifications, level of education, the depth of experience, unique skills, geographic location, internal equity, and/or business needs. The actual base salary offered will be in accordance with federal, state, and/or local wage requirements for the role’s location.

Our competitive compensation package includes an annual incentive bonus as a percentage of actual base salary and long-term incentives in the form of employee stock options, both of which are commensurate with the role’s level. We also offer a generous benefits package which includes comprehensive medical, dental, and vision coverage; company contributions to health savings and retirement accounts; ample paid time off; access to wellness programs; and rich career growth opportunities.

Anticipated Base Salary Range $81,000—$99,000 USD

Obsidian is proud to be an equal opportunity employer, cultivating a welcoming and diverse environment. All applicants will receive consideration for employment without regard to race, color, religion, gender, gender identity or expression, sexual orientation, national origin, genetics, disability, age, veteran status or any other applicable legally protected characteristics.

## About Obsidian Therapeutics

## Company Overview
- **One-liner**: Obsidian Therapeutics is a biotechnology company pioneering engineered tumor‑infiltrating lymphocyte (TIL) therapies for solid tumors using its proprietary cytoDRiVE® platform to regulate protein expression with an FDA‑approved small molecule.
- **Entity Type**: Private (later‑stage; most recent Series C closed April 2024; entered a merger agreement with Galera Therapeutics and a concurrent $350M private placement announced in 2025)
- **Headquarters**: Cambridge, Massachusetts, United States (with a laboratory facility in Bedford, MA)
- **Founded**: 2015
- **Founders**: Not publicly disclosed on the company website; the leadership team includes a CEO, CTO, CMO, CFO, and Chief People Officer.

## Core Business
- **Primary industry**: Biotechnology (cell and gene therapy, oncology)
- **Target customers**: B2B / healthcare – primarily developing therapies for patients with solid tumors; partners with academic centers, clinical sites, and biopharma companies.
- **Mission / purpose statement**: “Pioneering engineered cell and gene therapies to deliver transformative outcomes for patients.” The company emphasizes urgency for patients and a commitment to safer, more effective TIL therapies.

## Products & Services
- **cytoDRiVE® Platform**: A proprietary technology that uses drug‑responsive domains (DRDs) to control the function of therapeutic proteins inside cells using an FDA‑approved small‑molecule ligand. The platform can be applied to membrane‑bound, intracellular, or secreted proteins.
- **OBX‑115 (cytoTIL15)**: Lead clinical‑stage engineered TIL cell therapy that expresses membrane‑bound IL‑15 (mbIL15) to enhance TIL persistence and activity without the need for co‑administered IL‑2. Currently in Phase 1 trials for metastatic melanoma and non‑small cell lung cancer (NSCLC). (ClinicalTrials.gov identifiers: NCT05470283, NCT06060613)
- **Pipeline**: Early‑stage research exploring OBX‑115 in combination with PD‑1 inhibitors, as well as additional undisclosed cytoTIL programs for other solid tumor indications.

## Market Standing
- **Valuation / Market Cap**: Not disclosed (privately held).
- **Key Metric – Total Funding**: $325 M in known equity rounds (Series A: $49.5 M led by Google Ventures, 2017; Series B: $115 M led by The Column Group, 2021; Series C: $160.5 M led by Wellington Management, 2024). Additionally, a $350 M private placement was announced in connection with a merger agreement with Galera Therapeutics (the transaction is ongoing).
- **Notable Investors / Partners**: The Column Group, Wellington Management, Google Ventures (GV), and 14 other investors across rounds.
- **Growth Signals**: Lead program OBX‑115 has completed enrollment in a single‑center melanoma study and is now enrolling in a multi‑center Phase 1 study (Agni‑01) for melanoma and NSCLC. The company acquired Galera Therapeutics and secured significant additional capital via a concurrent private placement, indicating strong investor confidence. Headcount as of mid‑2025 is ~92 employees, with a recent slight decline (-11.7% YoY) typical of a focused R‑stage biotech. Active job postings increased 100% month‑over‑month, suggesting renewed hiring.

## Competitive Advantages
- **cytoDRiVE® Platform**: Provides tunable, on‑demand control of therapeutic proteins using an approved small molecule – a unique differentiator that can improve safety and efficacy in cell therapy.
- **Focus on TIL therapy**: Targets the challenging solid tumor space where conventional TIL therapy is limited by IL‑2 toxicity. OBX‑115 removes the need for high‑dose IL‑2, potentially broadening patient access.
- **Proprietary DRD library**: A growing, internally discovered set of drug‑responsive domains that enable rapid optimization for different cell types and protein classes.
- **Well‑funded and experienced team**: Backed by top‑tier investors and led by executives with deep cell therapy and oncology expertise.

## Strategic Focus
- **Clinical execution**: Advancing OBX‑115 through Phase 1 trials in melanoma and NSCLC, with plans to expand indications and combinations.
- **Platform expansion**: Applying cytoDRiVE® to other cell and gene therapy modalities (e.g., CAR‑T, TCR, gene editing) through partnerships and internal programs.
- **Manufacturing and scaling**: Building internal capabilities in process development, quality control, and supply chain to support commercial‑scale production.
- **Talent growth**: Active hiring across R&D, quality, manufacturing, and IT (8 open positions at time of data pull), with a focus on hybrid roles in Cambridge and Bedford, MA.

## Why Work Here
- **Culture**: The company describes itself as collaborative, curious, and authentic, with a strong sense of urgency to deliver therapies to patients. Emphasis on “no silos or hierarchies” and mutual respect.
- **Work model**: Hybrid (Cambridge, MA and Bedford, MA). Some roles may offer remote flexibility; most job postings specify hybrid.
- **Notable benefits**:
  - Employee stock options, 401(k) with HSA options.
  - Flexible time off (unlimited PTO policy).
  - 6 weeks fully paid bonding leave for new parents, plus fully paid medical maternity leave.
  - Generous health/dental coverage with low out‑of‑pocket costs and an annual HSA contribution.
  - Perks: gym, massage therapy, and meditation reimbursements; company‑sponsored lunches and social events.
  - Professional development: mentorship, training programs, tuition reimbursement, and career matrices for planning growth.
- **Engineering / science culture**: Strong cross‑functional collaboration between research, process development, quality, and clinical teams. The company values diversity and inclusion and reports gender pay equity.

## Sources
1. [obsidiantx.com](https://obsidiantx.com/) – Company overview, platform, pipeline, and career page
2. [obsidiantx.com/about-us](https://obsidiantx.com/about-us/) – About Us, management team, vision
3. [obsidiantx.com/join-our-team](https://obsidiantx.com/join-our-team/) – Culture, benefits, open positions
4. [linkedin.com/company/obsidian-therapeutics](https://www.linkedin.com/company/obsidian-therapeutics) – Employee count, funding, headcount trends, recent departures
5. [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT05470283) – OBX-115 melanoma study
6. [clinicaltrials.gov](https://classic.clinicaltrials.gov/ct2/show/NCT06060613) – OBX-115 Agni-01 study

## Other roles at Obsidian Therapeutics

- [Research Associate (Contractor), Viral Vector Engineering and Production](https://feeny.ai/job/research-associate-contractor-viral-vector-engineering-and-production-obsidian-9ca0m445r120) — Cambridge, MA
- [Research Associate (Contractor), Cell Therapy](https://feeny.ai/job/research-associate-contractor-cell-therapy-obsidian-therapeutics-cambridge-r20zjdh1a4h5) — Cambridge, MA
- [Senior Engineer, MSAT](https://feeny.ai/job/senior-engineer-msat-obsidian-therapeutics-bedford-vjak18zyh2q9) — Bedford, MA
- [Associate Director/Director, CMC Digital Business Partner](https://feeny.ai/job/associate-director-director-cmc-digital-business-partner-obsidian-therapeutics-4cdv9q5wppt8) — Bedford, MA
- [Associate Director, Process Data Analytics](https://feeny.ai/job/associate-director-process-data-analytics-obsidian-therapeutics-bedford-3b2cq0sbv19z) — Bedford, MA
- [Scientist/Senior Scientist, Viral Vector Analytical Development](https://feeny.ai/job/scientist-senior-scientist-viral-vector-analytical-development-obsidian-vq7apj9r469n) — Bedford, MA
- [Associate Director/Director, G&A Digital Business Partner](https://feeny.ai/job/associate-director-director-g-a-digital-business-partner-obsidian-therapeutics-4fz5det3zr6d) — Cambridge, MA
- [General Interest Application - Obsidian Talent Community](https://feeny.ai/job/general-interest-application-obsidian-talent-community-obsidian-therapeutics-r3k8fnqhwtmp) — Cambridge, MA