--- title: 'Clinical Trial Manager (Contract) at 4D Molecular Therapeutics' canonical: 'https://feeny.ai/job/clinical-trial-manager-contract-4d-molecular-therapeutics-emeryville-z7y6de7nnaew' type: 'job' last_seen: '2026-09-13' --- # Clinical Trial Manager (Contract) at 4D Molecular Therapeutics - **Company:** 4D Molecular Therapeutics - **Location:** Emeryville, CA / United States - **Work type:** remote - **Posted:** 2026-09-10 - **Last confirmed live:** 2026-09-13 - **Apply:** https://4dmoleculartherapeutics.com/careers/?gh_jid=4732954005 ## Job description Attention recruitment agencies: All agency inquiries are vetted through 4DMT’s internal Talent Acquisition team. No unsolicited resumes will be accepted. The 4DMT Talent Acquisition team must expressly engage agencies on any requisition. Agencies contacting hiring managers directly will not be tolerated, and doing so may impact your ability to work with 4DMT in the future. 4DMT is a leading late-stage biotechnology company advancing durable and disease-targeted therapeutics with potential to transform treatment paradigms and provide unprecedented benefits to patients. The Company’s lead product candidate 4D-150 is designed to be a backbone therapy forming the foundation of treatment of blinding retinal vascular diseases by providing multi-year sustained delivery of anti-VEGF (aflibercept and anti-VEGF-C) with a single, safe, intravitreal injection, which substantially reduces the treatment burden associated with current bolus injections. The Company’s lead indication for 4D-150 is wet age-related macular degeneration, which is currently in Phase 3 development, and second indication is diabetic macular edema. The Company’s second product candidate is 4D-710, which is the first known genetic medicine to demonstrate successful delivery and expression of the CFTR transgene in the lungs of people with cystic fibrosis after aerosol delivery ## GENERAL SUMMARY: The Clinical Trial Manager will support the Company's clinical trial activities.  This position reports to the Director of Clinical Operations.  This will be responsible for management of the day to day operations of one or more phase 1-3 clinical trials including trial start up, conduct and close out activities. ## MAJOR DUTIES & RESPONSIBILITIES: Trial Management: - Serve as the primary contact for managing protocol execution, including oversight of the CRO, other study service providers, and consultants that are involved in a clinical trial - Lead cross-functional study execution team in support of study deliverables - Support establishment of study milestones and ensure accurate tracking and reporting of study metrics and timelines to leadership - Ensure clinical trials are managed and executed in accordance with ICH GCP, regulations, the protocol, and company-specific SOPs - Assist in preparation and review of clinical trial documentation such as; protocol, informed consent, Investigator Brochure, Clinical Monitoring Plan, Project Plan, Case Report Forms, Statistical Analysis Plan, Clinical Study Reports, and other study level documents - Ensure that the Trial Master File (TMF) is set up and maintained appropriately throughout the trial, including periodic reviews - Participate and coordinate resolution of audit finding and ensures audit-ready condition of clinical trial documentation including central clinical files - Participates in service provider selection process as a part of outsourcing activities - Proactively identifies, with the support and guidance from Senior Clinical Operations staff, and supports development of plans and resolution of project issues and participates in process improvement initiatives as required - Supports assessing operational feasibility, recommending study execution plan and site selection under the Director of Clinical Operations - Responsible for the selection and study specific training of CRO study staff, monitors, investigational sites, and service providers - In conjunction with legal  group,  facilitate  the  development  of  clinical  trial agreements and other relevant documents - Manage clinical trial budgets, providing ongoing financial reporting and projections - Negotiate and finalize site contracts and budgets - Perform and manage data review process on an ongoing basis - Perform site visits including site qualification, initiation, monitoring and close-out visits, as needed - Oversee outsourced monitoring by reviewing, monitoring reports to ensure quality and resolution of site-related issues - Ensures tracking and review of protocol deviations and assesses impact on study data - Develops and manages study budget and maintain within financial goals; Reviews and approves clinical invoices against approved budget - Provides oversight for forecasting of clinical supplies, including study drug and supplies Department Management: - May manage and/or oversee work of junior Clinical Operations staff - May support development and review of Clinical SOPs and other department initiatives - Travel as needed to sites, conferences, industry meetings - Other duties as may be assigned ## QUALIFICATIONS: Education: - B.A./B.S. degree in Science Experience: - 6+ years of clinical research experience within the Biotech or similar industry, with at least 2 years directly supporting a retina clinical trial - Global APAC experience desired Other Qualifications/Skills: (non-technical and technical skills) - Knowledge of GCP, ICH guidelines and regulatory requirements for clinical trial management; Strong clinical study management skills - Understanding of, and experience with, regulatory framework applicable to interactions with HCPs, payers, advocacy and other business partners - Proven clinical operational skills to direct protocol execution to ensure timeline, budget and quality metrics are met - Excellent communication skills to effectively disseminate information to project team and outside parties - Experience reviewing trial plans including developing creative strategies for site monitoring, risk mitigation, trial budgets, site selection, and clinical supplies management - Clinical research knowledge and cross-functional understanding of clinical trial methodology - Excellent organizational, conflict resolution, prioritization and negotiation skills - Proven ability in creative problem-solving and exercising sound judgment - Team oriented and ability to effectively collaborate with study team, cross-functional team members, and external partners - Ability to handle a high volume of highly complex tasks within a given timeline - Ability to develop Therapeutic Areas knowledge and expertise through internal training and external conference attendance - Proficient computer skills, specifically with Microsoft Office Suite that include Word, Excel, PowerPoint, and Outlook - Working knowledge of MS Project for development and update of clinical study timelines Travel: 5% Physical Requirements and Working Conditions: - Physical Activity - Repetitive motions: Making substantial movements (motions) of the wrists, hands, and/or fingers. Fingering: Picking, pinching, typing or otherwise working, primarily with fingers rather than with whole hand or arm as in handling. Talking: Expressing or exchanging ideas by means of the spoken word. - Physical Requirements - Sedentary work: Exerting up to 10 pounds of force occasionally and/or a negligible amount of force frequently or constantly to lift, carry, push, pull or otherwise move objects, including the human body. Sedentary work involves sitting most of the time. Jobs are sedentary if walking and standing are required only occasionally, and all other sedentary criteria are met. - Working Conditions - The worker is not substantially exposed to adverse environmental conditions (as in typical office or administrative work). Hourly compensation range: $72.00 - $82.00 / HOUR Please note, the base salary compensation range and actual salary offered to the final candidate depends on various factors: candidate’s geographical location, relevant work experience, skills, and years of experience. 4DMT provides equal employment opportunities to all employees and applicants for employment without regard to race, color, religion, gender, sexual orientation, national origin, age, disability, genetic information, marital status, status as a covered veteran, and any other category protected under applicable federal, state, provincial and local laws. Equal Opportunity Employer/Protected Veterans/Individuals with Disabilities ## About 4D Molecular Therapeutics ## Company Overview - **One-liner**: 4D Molecular Therapeutics is a late-stage clinical biotechnology company inventing and developing customized genetic medicines using a proprietary vector evolution platform to treat large-market diseases. - **Entity Type**: Public (NASDAQ: FDMT) - **Headquarters**: Emeryville, California, United States - **Founded**: 2013 - **Founders**: David Kirn, MD (Co-Founder, President, and CEO) ## Core Business - **Primary industry**: Biotechnology / Genetic Medicine / Gene Therapy - **Target customers**: B2B (partnerships with other biopharma companies) and B2C (patients with retinal and pulmonary diseases) - **Mission or purpose statement**: "To unlock the full potential of genetic medicines for large market diseases" by harnessing directed evolution to invent customized and enhanced vectors for transformative products. ## Products & Services - **4D-150**: A clinical-stage genetic medicine candidate for retinal vascular diseases (wet age-related macular degeneration and diabetic macular edema). It is designed as a single, routine, low-dose intravitreal injection that provides multi-year sustained delivery of anti-VEGF (aflibercept and anti-VEGF-C). Currently in Phase 3 clinical trials (4FRONT-1 and 4FRONT-2) for wet AMD and Phase 1/2 for DME. - **4D-710**: An investigational genetic medicine candidate for cystic fibrosis lung disease. It uses the A101 vector for aerosol delivery of a corrective CFTR transgene (CFTR∆R) and is designed for patients ineligible for or who have discontinued CFTR modulator therapy. Currently in Phase 1/2. - **4D-175**: A preclinical candidate for geographic atrophy (a form of dry AMD) using the R100 vector to deliver a shortened form of human complement factor H (sCFH) to restore normal complement regulation. - **4D-725**: A preclinical candidate for alpha-1 antitrypsin (A1AT) lung disease using the A101 vector for aerosol delivery. ## Market Standing - **Valuation/Market Cap**: $756.4 million (as of latest data from LinkedIn) - **Key Metric**: Annual Revenue of $85.2 million (as of latest data from LinkedIn) - **Notable Investors/Partners**: The company is publicly traded (IPO in 2020). Key partnerships are sought for pipeline candidates like 4D-175 and 4D-725. - **Growth Signals**: The company is a late-stage biotech with two Phase 3 trials (4FRONT-1 and 4FRONT-2) for its lead candidate 4D-150 in wet AMD, and a Phase 1/2 trial for 4D-710 in cystic fibrosis. The company has a presence in Ecuador, France, and India. LinkedIn followers grew 24.7% year-over-year. ## Competitive Advantages - **Proprietary Vector Platform (Therapeutic Vector Evolution)**: The company uses directed evolution to create customized and proprietary AAV vectors (e.g., R100 for retina, A101 for lung) that are optimized for specific tissues and routes of administration, which is a significant differentiator from standard gene therapy approaches. - **Large-Market Focus**: Unlike many gene therapy companies targeting ultra-rare diseases, 4DMT is focused on large-market indications (wet AMD, DME, cystic fibrosis) with high unmet need, offering a potentially massive commercial opportunity. - **Durable, Single-Dose Therapies**: Their products are designed to provide multi-year efficacy from a single injection, which could dramatically reduce treatment burden for patients compared to current standard-of-care (e.g., frequent eye injections for wet AMD). ## Strategic Focus - **Advancing Late-Stage Pipeline**: The primary focus is executing the Phase 3 programs for 4D-150 in wet AMD and progressing 4D-710 in cystic fibrosis. - **Expanding Indications**: The company is exploring 4D-150 for diabetic macular edema (DME) and seeking partnerships to advance 4D-175 (geographic atrophy) and 4D-725 (A1AT deficiency). - **Platform Expansion**: Continuing to leverage the Therapeutic Vector Evolution platform to develop new genetic medicines for other large-market diseases. ## Why Work Here - **Mission-Driven Culture**: The company is deeply committed to "daring to cure" and unlocking the potential of genetic medicine for patients with devastating diseases. Core values include "Dare to Cure," "Break Boundaries," "Prepare & Execute Relentlessly," and "Beyond Yourself." - **Innovative Science**: Employees work on cutting-edge science at the intersection of gene therapy, vector engineering, and clinical development, tackling some of the biggest challenges in medicine. - **Collaborative Environment**: The company emphasizes teamwork, internal and external collaboration, and a culture that empowers innovation. - **Location & Perks**: Based in Emeryville, CA (San Francisco Bay Area). The company offers a competitive benefits package and a dynamic, collaborative environment. - **Diversity & Inclusion**: 4DMT champions diversity, equity, and inclusion through an employee-led initiative called "4Diversity," which partners with charitable organizations and focuses on social equity. - **Work Authorization**: Candidates must be authorized to work in the U.S. The company does not sponsor new nonimmigrant visa status petitions but welcomes candidates who require transfers or extensions. ## Sources 1. [4dmoleculartherapeutics.com](https://4dmoleculartherapeutics.com/) 2. [4dmoleculartherapeutics.com - About](https://4dmoleculartherapeutics.com/about/) 3. [4dmoleculartherapeutics.com - Careers](https://4dmoleculartherapeutics.com/careers/) 4. [4dmoleculartherapeutics.com - Pipeline](https://4dmoleculartherapeutics.com/pipeline/) 5. 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