---
title: 'Computational Biologist at Valius Sciences'
canonical: 'https://feeny.ai/job/computational-biologist-valius-sciences-san-francisco-9hh0dj4aa8eq'
type: 'job'
last_seen: '2026-09-09'
---

# Computational Biologist at Valius Sciences

- **Company:** Valius Sciences
- **Location:** San Francisco, CA
- **Compensation:** $125k–$185k
- **Employment:** full-time
- **Work type:** onsite
- **Posted:** 2026-04-28
- **Last confirmed live:** 2026-09-09
- **Apply:** https://jobs.ashbyhq.com/valiussciences/507f147a-35f2-4c49-a3c0-a7d97706dc58

## Job description

Valius overview

At Valius, we believe that the future of cancer care will be defined by “maximalist” diagnostics: deep, comprehensive assessments of DNA, RNA, and protein designed to give patients and their care teams the best possible understanding of how their tumor works and what its vulnerabilities are.

We’re building the diagnostics and bioinformatics company to power this future, starting by applying this approach to patients with challenging cancers. In our first year, we worked with over 75 of these patients and, in many cases, identified plausible therapeutic targets which had not been discovered previously. This coming year, we’re on track to scale our patient volume significantly, all while bringing new diagnostic modalities (e.g., single-cell transcriptomics) and analytical approaches into clinical care for the very first time.

We’ve just raised a $13.5M seed round, led by 8VC and Basis Set Ventures, and are looking for people passionate about changing cancer care to join our growing team.

Computational biologist role

We're hiring a computational biologist to analyze our patients’ omics data. This role sits at the intersection of cutting-edge science and real-world clinical impact: you'll apply state-of-the-art omics techniques to complex patient datasets to deliver rigorous, actionable insights.

You'll have significant ownership from day one, including direct exposure to, and regular meetings with, the founding team. As we grow, you’ll have the potential to develop into a broader scientific leadership role.

This role will be expected to work out of our beautiful San Francisco office four days a week.

## What you’ll do

- Analyze multi-modal omics data. Apply cutting-edge techniques, including scRNAseq, spatial transcriptomics, and long-read sequencing, to derive meaningful insights from complex patient datasets.
- Deliver patient-facing results. Translate computational findings into clear, rigorous outputs that directly inform treatment decisions for patients and their care teams.
- Develop and maintain analytical pipelines. Build robust, reproducible workflows that scale with our growing patient programs.
- Partner with the scientific and clinical teams. Collaborate closely with colleagues across disciplines to ensure analyses are well-designed, well-interpreted, and actionable.
- Stay at the frontier. Continuously evaluate and incorporate emerging methods in omics and computational biology to keep Valius's science best-in-class.
- Contribute across the company as needed. In a small team, you may pitch in on cross-functional initiatives as we scale.

## What you’ll bring

- Deep fluency in omics analysis, including experience with techniques such as scRNAseq, spatial transcriptomics, or long-read sequencing
- Strong programming skills in Python and/or R, with experience building reproducible analytical workflows (i.e., Snakemake, Nextflow, Git)
- Proven ability to move quickly and deliver rigorous results in parallel
- Clear communicator who can translate complex findings for both scientific and non-scientific audiences
- High agency and ownership mindset with the ability to see analyses through to actionable conclusions
- Excited to work in a fast-paced startup environment where flexibility and initiative are valued
- Commitment to our patient-focused mission
- Interest in working for a small, early-stage startup

Other nice to haves

- Experience in oncology or translational research
- Familiarity with cloud-based computing environments and large-scale data infrastructure
- Interest in growing into a scientific leadership role as the company scales

## What we’ll bring

- Competitive salary and equity compensation
- Generous refresh grants
- Comprehensive benefits (health, dental, vision, 401(k))
- Genuine investment in your professional development

Fun, mission-driven team culture

## About Valius Sciences

## Company Overview
- **One-liner**: Valius Sciences provides maximalist molecular diagnostic testing for cancer patients, mapping tumors across DNA, RNA, and protein layers to identify actionable therapeutic targets.
- **Entity Type**: Private (Seed/Series A – conflicting reports)
- **Headquarters**: San Francisco, United States
- **Founded**: 2025
- **Founders**: Edward Larkin, Claire Oldfield (COO), Sarah Hesse (Head of Translational Science)

## Core Business
- Primary industry/industries: Cancer diagnostics, precision oncology, molecular testing
- Target customers: B2C (cancer patients, especially those with rare, aggressive, or treatment-resistant cancers) and B2B (oncologists and care teams)
- Mission or purpose statement: To give every cancer patient — particularly those facing rare, aggressive, or treatment-resistant disease — access to the most comprehensive molecular understanding of their tumor and available treatments.

## Products & Services
- **Valius Maximalist Diagnostics Platform**: A comprehensive testing battery that includes whole genome sequencing, whole transcriptome (RNA) sequencing, single-cell RNA sequencing, spatial transcriptomics, high-plex protein staining (IHC), and ultra-sensitive ctDNA monitoring. The service identifies mutations, copy number changes, gene expression, pathway activation, tumor heterogeneity, immune microenvironment, resistance mechanisms, and actionable surface targets. Results are delivered with ongoing scientific partnership and an AI-powered, queryable data platform.

## Market Standing
- **Valuation/Market Cap**: Not disclosed
- **Key Metric**: Total funding — conflicting reports: $10M (Seed, per DefineVC and Tracxn) or $13.5M (per company blog). [definevc.com](https://www.definevc.com/insights/putting-the-patient-at-the-center-of-cancer-science-with-valius-sciences) / [valiussciences.com](https://www.valiussciences.com/) (blog post)
- **Notable Investors/Partners**: 8VC, Basis Set Ventures (seed round)
- **Growth Signals**: Raised funding in early 2026; has worked with patients across 25+ cancer types; early cases identified new drug targets not found by prior diagnostics; hiring across key roles (Computational Biologist, Translational Scientist, Software Engineer, Operations Lead).

## Competitive Advantages
- **Maximalist, multi-omics approach**: Covers DNA, RNA, and protein comprehensively rather than limited panel testing; leaves no stone unturned.
- **Ongoing scientific partnership**: Unlike standard PDF-report diagnostics, Valius provides dedicated scientists who meet regularly with patients and physicians, and data remains accessible and queryable forever via AI.
- **Patient-centric model**: Direct-pay service (pricing $50k–$150k with discounts); focuses on biologically plausible targets regardless of cancer type; supports clinical trial matching, single-patient INDs, and recurrence monitoring.
- **Top-tier team**: Founders combine operational discipline, commercial rigor, and deep scientific credibility.

## Strategic Focus
- Scale the platform to reach more patients with rare, aggressive, or recurrent cancers.
- Continue refining the AI-powered data platform for real-time querying and analysis.
- Expand partnerships with oncologists and treatment centers to integrate Valius findings into care pathways.

## Why Work Here
- **Mission-driven**: Direct, immediate impact on cancer patients’ treatment options.
- **Interdisciplinary culture**: Hires computational biologists, scientists, engineers, and clinicians who span disciplines and don’t fit neatly into boxes.
- **Cutting-edge tech**: Work with whole genome, single-cell, spatial, and proteomic data at scale.
- **Autonomy & ownership**: Small, focused team with front-line patient interaction.
- **Location**: San Francisco (likely office-first; remote/hybrid policy not explicitly stated). “Outlier” culture emphasized.
- **Open roles**: Computational Biologist, Translational Scientist, Software Engineer, Operations Lead (as of 2026).

## Sources
1. [Valius Sciences Website](https://www.valiussciences.com/)
2. [Valius Sciences Careers Page](https://www.valiussciences.com/careers)
3. [DefineVC Investment Blog](https://www.definevc.com/insights/putting-the-patient-at-the-center-of-cancer-science-with-valius-sciences)
4. [Tracxn Company Profile](https://tracxn.com/d/companies/valius/__spxuU3YvDbNRZwJnIIruRczc89b40XA-xktgbWeCXkI)
5. [Ashby Careers Portal](https://jobs.ashbyhq.com/valiussciences)

## Other roles at Valius Sciences

- [Director of Translational Science](https://feeny.ai/job/director-of-translational-science-valius-sciences-san-francisco-svfhd275hh5n) — San Francisco, CA
- [Clinical Translational Scientist](https://feeny.ai/job/clinical-translational-scientist-valius-sciences-san-francisco-rch03b5c4vrz) — San Francisco, CA
- [Head/VP of Engineering](https://feeny.ai/job/head-vp-of-engineering-valius-sciences-san-francisco-0nf568e2qf06) — San Francisco, CA
- [Computational Biologist](https://feeny.ai/job/computational-biologist-boltz-london-ywq0h6gna1qr) — London, United Kingdom
- [Computational Biologist](https://feeny.ai/job/computational-biologist-freenome-remote-989vnftsd0w5)
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- [Computational Biologist](https://feeny.ai/job/computational-biologist-neptune-bio-new-york-78e9np0pt8ae) — New York, NY