---
title: 'Data Architect, Clinical at Prolaio'
canonical: 'https://feeny.ai/job/data-architect-clinical-prolaio-chicago-ba9gg4w2mvgt'
type: 'job'
last_seen: '2026-09-09'
---

# Data Architect, Clinical at Prolaio

- **Company:** Prolaio
- **Location:** Chicago, IL
- **Posted:** 2026-06-08
- **Last confirmed live:** 2026-09-09
- **Apply:** https://job-boards.greenhouse.io/prolaio/jobs/5251451008

## Job description

Who Are We?

Prolaio believes that continuous learning and collaboration can make a significant difference in how heart care is administered. We are creating smarter ways to address heart disease and heart risks by uniting patients, care teams, and researchers on a secure, technology-enabled platform that drives clinical innovation and offers a path towards better patient outcomes.

This is precision cardiology, and we know it’s within reach.

What Will You Do?

The Overview

The Data Architect will shape the backbone of Prolaio’s healthcare data ecosystem, defining and scaling the architectures that power clinical intelligence products, real‑world data pipelines, analytics, data science, clinical operations, quality, and other enterprise use cases in a regulated environment. In this role, you turn complex clinical and operational data into interoperable, trustworthy, and scalable platforms that enable Prolaio to transform continuous, predictive, and shareable heart data into faster therapeutic discovery and better cardiovascular outcomes.

This role is ideal for a self‑starter with deep healthcare data experience who wants to architect modern platforms across structured, semi‑structured, and unstructured data, embedding lifecycle management, standardization, lineage, provenance, compliance, and AI enablement into the foundation of Prolaio’s data ecosystem.

The Specifics

- Define the target-state data architecture and roadmap for Prolaio’s regulated healthcare data platform in support of product, analytics, data science, data services, clinical operations, and quality use cases.
- Architect scalable, secure, and interoperable data platforms that support structured, semi-structured, and unstructured data across clinical, operational, device, and patient-generated sources relevant to Prolaio’s cardiovascular and research mission.
- Lead architecture decisions for storage, compute, orchestration, metadata, APIs, and integration patterns across cloud-native environments and modern data platforms.
- Establish architecture standards and reference patterns that support reliability, performance, extensibility, and validated operation in regulated settings.
- Design and govern conceptual, logical, and physical data models for clinical trials, cardiovascular and physiological data, real-world data, claims, medication, socio-economic, behavioral, and related healthcare datasets.
- Apply healthcare terminologies, ontologies, and common data models where appropriate, including standards such as HL7, FHIR, ICD, SNOMED CT, LOINC, RxNorm, OMOP, and CDISC.
- Lead efforts to standardize and normalize disparate data sources into governed, reusable, analysis-ready datasets suitable for regulated workflows, clinical research, and product development.
- Architect end-to-end data flows and reusable pipelines for ingestion, validation, transformation, enrichment, publishing, retention, archival, and decommissioning across batch, streaming, and hybrid workloads.
- Define and implement data lifecycle management practices that support retention, access control, traceability, reproducibility, lineage, provenance, and auditability in regulated healthcare environments.
- Design data architectures that enable AI, analytics, and machine learning use cases by supporting feature generation, retrieval workflows, governed access, and production deployment needs.

Why Prolaio?

- Impactful Work: You will join in the fight against heart failure (HF) and hypertrophic cardiomyopathy (HCM) with the goal of extending and saving the lives of our patients while also being at the forefront of changing the healthcare industry through technology.
- Innovative Environment: You will be part of an organization doing something that’s never been done before.
- Professional Growth: You will join a growing team and have a substantial impact on our daily and future operations with the opportunity to continuously learn and grow.
- Collaborative Team: You will be part of a team of collaborative, curious, and committed individuals focused on the collective good, inclusiveness, scientific excellence, and advancing digital health for cardiology.

Who You Are?

- Bachelor’s degree in computer science, Data Engineering, Information Systems, Biomedical Informatics, Engineering, or a related field.
- Minimum 10 years of experience in healthcare, life sciences, medtech, digital health, or other patient-data-focused environments, including at least 5 years in clinical data, real-world data, clinical trials data, or other patient-centered data platforms.
- Demonstrated experience architecting healthcare data platforms that support structured, semi-structured, and unstructured data in regulated or validated environments.
- Deep understanding of data from cardiology focused wearables devices, claims, socioeconomic, behavioral, and EHR.
- Deep understanding of healthcare data domains, data modeling, standardization, normalization, and the application of healthcare terminologies and common data models.
- Strong experience working in a cross-functional, matrixed organization and partnering effectively with Product, Engineering, Data Science, Analytics, Clinical Operations, Quality, and Security teams, with the ability to operate as a self-starter in a growth-stage environment.
- Strong familiarity with cloud platforms such as GCP, AWS, or Azure and modern data platforms such as Snowflake, Databricks, BigQuery, Redshift, Synapse, or comparable environments.
- Experience with ETL or ELT, orchestration, and large-scale data processing tools such as dbt, Airflow, Dagster, Spark, Kafka, Fivetran, Informatica, Talend, or similar technologies.
- Strong SQL and Python skills, with familiarity in APIs, event-driven architectures, interoperability frameworks, and clinical data exchange patterns such as HL7 and FHIR
- Familiarity with metadata, lineage, catalog, governance, and AI-enablement tools, including platforms for semantic indexing, vectorization, retrieval, and data lifecycle automation.

## Why You’ll Love Working Here

- Meaningful Compensation: Competitive salary, performance bonus, and equity so you can share in what we build.
- Great Health Coverage: Medical, dental, and vision plans with multiple options and strong company contributions.
- Flexible Spending Perks: HSA, FSA, commuter benefits, and a $1,200 annual Lifestyle Spending Account to support wellness, commuting, family needs, and more.
- Time to Recharge: Generous paid time off, sick leave, and company holidays.
- Family-First Benefits: Paid parental leave, caregiver leave, and support for growing families.
- Security & Peace of Mind: Company-paid life insurance and short- and long-term disability coverage.
- Plan for the Future: 401(k) plan to help you build long-term financial security.
- Care When You Need It: Easy access to telehealth and optional supplemental coverage for life’s unexpected moments.

Starting Salary is at $148,000.00 (Exact Compensation may vary based on skills, experience, and location)

## About Prolaio

## Company Overview
- **One-liner**: Prolaio is a clinical intelligence company that uses a connected platform of near real-time heart data and AI to help patients, clinicians, and researchers manage cardiovascular conditions and accelerate the development of new therapies.
- **Entity Type**: Private (startup; combined with Kardigan in 2025)
- **Headquarters**: Chicago, Illinois, USA
- **Founded**: 2022
- **Founders**: Derek Evans (Co-Founder); other founders not publicly disclosed.

## Core Business
- **Primary industry**: Healthtech / Cardiovascular Clinical Intelligence
- **Target customers**: B2B (healthcare providers, clinical researchers, pharmaceutical companies) and B2C (patients with cardiovascular conditions like heart failure and hypertrophic cardiomyopathy)
- **Mission statement**: "Transform real‑world heart data into faster discovery today and precision care for functional cures tomorrow."

## Products & Services
- **Prolaio Clinical Intelligence Platform**: An integrated platform that collects continuous, high‑density heart data (via a mobile relay device and on‑body sensors) and applies proprietary AI algorithms to generate measures of cardiovascular function. The insights are used to improve clinical decision-making, monitor patients remotely, and support clinical trials for new therapies.  
  *Type*: SaaS + Medical Device (cloud analytics, AI algorithms, data relay hardware)

## Market Standing
- **Valuation / Funding**: Not publicly available.  
- **Key Metrics**:
  - 4M+ hours of on‑body patient data collected
  - 7 FDA‑cleared algorithms
  - 20+ issued patents
  - 40+ proven algorithms
  - 26+ countries served
- **Notable Investors/Partners**: Not disclosed. The company is closely linked to **Kardigan** (a cardiovascular drug development company), with which it merged to form a combined heart health company.
- **Growth Signals**:
  - Named a **Best Places to Work 2026** and **World's Top HealthTech Companies of 2025**.
  - Active hiring (9 open roles as of mid‑2026) across data science, engineering, product, and regulatory.
  - Hybrid work model with flexible on‑site presence in Chicago.

## Competitive Advantages
- **High‑density, real‑world heart data**: Combines continuous on‑body monitoring with AI analytics, offering richer insights than traditional episodic care.
- **Integration with drug development**: Through the merger with Kardigan, Prolaio’s platform directly supports parallel clinical trials for multiple cardiovascular therapies, shortening development timelines.
- **Regulatory maturity**: Seven FDA‑cleared algorithms demonstrate a strong regulatory pathway and clinical validation.
- **Patent portfolio**: 20+ issued patents protect the core technology.

## Strategic Focus
- Advance the clinical intelligence platform to support faster, more efficient cardiovascular drug development.
- Scale the platform to more patients and research sites (already in 26+ countries).
- Leverage the combination with Kardigan to create a vertically integrated heart health company that spans both data analytics and therapeutics.
- Continue to expand AI capabilities (hiring for Director of AI Enablement, Product Manager AI, etc.).

## Why Work Here
- **Culture**: Value‑driven organization emphasizing scientific rigor, patient‑centricity, a growth mindset, collaboration, and relentless determination. Listed as a "Best Places to Work 2026" by Built In.
- **Work model**: Hybrid – flexible on‑site work at Chicago HQ; employees typically spend a mix of remote and on‑site time.
- **Benefits**: Competitive health insurance, generous paid time off, 401k retirement plan, professional development opportunities.
- **Engineering culture**: High emphasis on AI, data science, and cloud infrastructure; open roles include Data Architect Clinical, Director AI Enablement, Lead Software Quality Engineer, Mobile Android Engineer, and Senior Integrations Engineer.
- **Team**: Diverse group of experts in cardiovascular medicine, science, technology, and healthcare (82 total employees as of mid‑2026).

## Sources
1. [Prolaio.com](https://www.prolaio.com/)
2. [Prolaio About Page](https://www.prolaio.com/about)
3. [Prolaio Careers Page](https://www.prolaio.com/careers)
4. [Prolaio Job Board (Greenhouse)](https://job-boards.greenhouse.io/prolaio)
5. [Built In Prolaio Profile](https://builtin.com/company/prolaio)

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