--- title: 'Data Engineer 1, Operational Technology - Operations #4941 at GRAIL' canonical: 'https://feeny.ai/job/data-engineer-1-operational-technology-operations-4941-grail-durham-ptks220z9cmw' type: 'job' last_seen: '2026-09-07' --- # Data Engineer 1, Operational Technology - Operations #4941 at GRAIL - **Company:** GRAIL - **Location:** Durham, NC - **Employment:** full-time - **Work type:** onsite - **Posted:** 2026-08-27 - **Last confirmed live:** 2026-09-07 - **Apply:** https://jobs.lever.co/grailbio/36b40389-6f5d-467f-b4b0-e220ca73e89d ## Job description Our mission is to detect cancer early, when it can be cured. We are working to change the trajectory of cancer mortality and bring stakeholders together to adopt innovative, safe, and effective technologies that can transform cancer care. We are a healthcare company, pioneering new technologies to advance early cancer detection. We have built a multi-disciplinary organization of scientists, engineers, and physicians and we are using the power of next-generation sequencing (NGS), population-scale clinical studies, and state-of-the-art computer science and data science to overcome one of medicine’s greatest challenges. GRAIL is headquartered in the bay area of California, with locations in Washington, D.C., North Carolina, and the United Kingdom. It is supported by leading global investors and pharmaceutical, technology, and healthcare companies. For more information, please visit grail.com As a Data Engineer on the Operational Technology team, you will build and maintain the data pipelines that connect GRAIL's lab instruments, automation systems, and operational platforms to a trusted, well modeled data foundation. You will own well scoped ingestion and transformation pipelines end to end, partnering with systems engineers, lab operations, data scientists, and automation engineers to keep data flowing reliably from the lab floor to the analytics and AI systems that depend on it. This is a hands-on role for an engineer who is ready to take ownership of real data infrastructure and grow quickly in a fast paced, regulated environment. Expect to work alongside a talented and highly motivated team that moves quickly. This role is based on-site in RTP, North Carolina, Monday through Friday. The position participates in an on-call rotation and may occasionally require weekend or holiday support for production incidents, maintenance, or critical deployments. Responsibilities: - Build and maintain data pipelines that ingest and integrate information from laboratory instruments, automation systems, sequencers, operational platforms, APIs, autonomous robotics platforms, databases and file based data sources. - Support downstream analytics, reporting, and AI systems by delivering clean, trustworthy datasets and timely data extracts for troubleshooting, root-cause investigations and platform improvements. - Develop and optimize SQL and transformation logic to cleanse, standardize, and model raw instrument and production data into reliable, well structured datasets. - Build and support datasets and data models used by operational dashboards, analytics, process monitoring, troubleshooting, and governed AI enabled workflows. - Implement orchestration, testing, monitoring and alerting so that data failures, freshness issues, schema changes, and incomplete processing are identified early. - Implement data validation and quality checks to ensure datasets are accurate, complete, and reliable. - Document pipelines, data models, and datasets to support reproducibility and compliance with ISO, CLIA, CAP, NYS, GMP, and FDA requirements. - Continuously improve your technical skills and the team's engineering practices. Required Qualifications: - Degree in Computer Science, Mathematics, Software Engineering, Data Science, Life Sciences, Physics or similar field. - 1+ years of relevant professional, internship, academic, or project experience in data engineering, analytics engineering, software development, or a related field, or equivalent practical experience. - Proficiency in SQL. - Working proficiency with one or more programming languages, such as Python, Rust, C++, or similar. - Basic understanding of ETL or ELT pipelines, relational databases, and structured or semi-structured data. - Strong attention to detail and a commitment to data quality, reliability and accuracy. - Ability to collaborate effectively in teams of technical and non-technical individuals, and comfortable working in a rapidly changing environment with dynamic objectives and fast iteration. - Ability to investigate technical problems methodically, continuously learn and communicate clearly. - A highly analytical mindset and eagerness to solve technical problems. Preferred Qualifications: - Familiarity with data pipeline orchestration and transformation tools such as Airflow, dbt, or comparable technologies. - Familiarity with cloud data platforms, object storage and warehouses such as AWS S3, Redshift, Glue, Snowflake or comparable technologies. - Familiarity integrating AI/agentic tooling into the data engineering SDLC. - Experience with semantic data modeling, data lineage, and automated data quality testing. - Familiarity with statistical methods or basic process analytics. - Exposure to manufacturing, clinical laboratory operations, diagnostics, or biotechnology. - Experience with version control systems such as Git and collaborative development practices. - Basic understanding of APIs, file transfers, networking and system integrations. ## About GRAIL ## Company Overview - **One-liner**: GRAIL develops a multi-cancer early detection blood test (Galleri) that screens for many of the deadliest cancer types before symptoms appear. - **Entity Type**: Public (ticker: GRAL on Nasdaq Global Select Market) - **Headquarters**: Menlo Park, California, USA - **Founded**: Not publicly available from provided sources - **Founders**: Not publicly available from provided sources ## Core Business - Primary industry: Healthcare diagnostics / biotechnology - Target customers: B2B (health systems, employers, insurers) and B2C (individuals aged 50+ with elevated cancer risk) - Mission: "To detect cancer early, when it can be cured." ## Products & Services - **[Galleri® Test]**: A multi-cancer early detection (MCED) blood test that uses next-generation sequencing, machine learning, and a proprietary methylation platform to identify cancer signals and predict the tissue of origin. Available by prescription in the U.S. as a CLIA-certified, CAP-accredited laboratory-developed test (not yet FDA cleared). ## Market Standing - **Valuation/Market Cap**: Not publicly available from provided sources (publicly traded; market cap fluctuates) - **Key Metric**: Over 250,000 Galleri tests commercially delivered as of November 2024; >380,000 participants enrolled across clinical studies; >300 scientific publications and presentations - **Notable Investors/Partners**: Providence, Quest Diagnostics, athenahealth, Samsung, AstraZeneca, BeniComp, Curative Insurance Company - **Growth Signals**: Private placement financing of $325 million (October 2025); first healthcare system (Providence) to offer Galleri; collaboration with Samsung for Asia expansion; REACH study enrolling diverse Medicare populations; long-term data from NHS-Galleri trial and PATHFINDER 2 study showing >7-fold increase in cancer detection when added to standard screenings ## Competitive Advantages - First-of-its-kind multi-cancer early detection test that screens for cancers without recommended screening tests - Proprietary methylation-based platform combined with machine learning and large-scale clinical data - Extensive clinical program with >380,000 participants and >300 publications - CAP-accredited, CLIA-certified lab facilities with >170,000 square feet and capacity for multi-year growth - Strong IP portfolio and regulatory experience ## Strategic Focus - Scaling commercial access through health system partnerships, employer/insurer benefits, and digital ordering platforms - Expanding clinical evidence for diverse populations (REACH study, veterans) - International expansion (e.g., Asia via Samsung collaboration) - Building operational foundation as an independent public company post-Illumina spin-off - Advancing next-generation platform and risk classification tests (e.g., lung cancer study with AstraZeneca) ## Why Work Here - Mission-driven culture focused on solving a high-impact problem (early cancer detection) - Recognized as a 2025 Best Place to Work by Built In and BioSpace; Fortune Change the World list (2023) - Multidisciplinary team spanning biotech, genomics, data science, clinical development, and commercial operations - Benefits include competitive salaries, comprehensive health coverage (medical, dental, vision), and flexible time off - Emphasis on collaboration, agility, courage, and data-driven decision-making - Remote/hybrid policy not specified in provided sources; office locations include Menlo Park, CA ## Sources 1. [grail.com/careers](https://grail.com/careers/) 2. [grail.com](https://grail.com/) 3. [grail.com/about-us](https://grail.com/about-us/) 4. [jobs.lever.co/grailbio](https://jobs.lever.co/grailbio) 5. [investors.grail.com (SEC Filing)](https://investors.grail.com/static-files/6f7d7c6d-1d22-4045-a6b3-bf4893548649) ## Other roles at GRAIL - [GRAIL Galleri Consultant 1 (Fort Lauderdale) #4947](https://feeny.ai/job/grail-galleri-consultant-1-fort-lauderdale-4947-grail-fort-lauderdale-gzq8drbf80gk) — Fort Lauderdale, FL - [Head of Employment Law and Litigation #4939](https://feeny.ai/job/head-of-employment-law-and-litigation-4939-grail-sunnyvale-jz799ffzf11k) — Sunnyvale, CA - [Health System Partnerships Associate Director # 4932 (Eastern U.S.)](https://feeny.ai/job/health-system-partnerships-associate-director-4932-eastern-u-s-grail-united-0jyba15gt6kr) — United States - [Health System Partnerships Associate Director # 4931 (Western U.S.)](https://feeny.ai/job/health-system-partnerships-associate-director-4931-western-u-s-grail-united-k6hahc9fstxg) — United States - [Senior Scientist, Operations Investigation Team (OIT) #4936](https://feeny.ai/job/senior-scientist-operations-investigation-team-oit-4936-grail-durham-zcz4f510fq9y) — Durham, NC - [Senior Corporate Counsel, Compliance (Healthcare) #4927](https://feeny.ai/job/senior-corporate-counsel-compliance-healthcare-4927-grail-sunnyvale-tgkznfat42w8) — Sunnyvale, CA - [Director/ Associate Director, International Regulatory Affairs #4809](https://feeny.ai/job/director-associate-director-international-regulatory-affairs-4809-grail-7xm7ycajd3sr) — Sunnyvale, CA - [Director, Regulatory Affairs - Advertising, Promotional and Labeling #4810](https://feeny.ai/job/director-regulatory-affairs-advertising-promotional-and-labeling-4810-grail-0sy0qr0b6srt) — Sunnyvale, CA - [Vice President, People #4921](https://feeny.ai/job/vice-president-people-4921-grail-sunnyvale-dzh8jcbr40e3) — Sunnyvale, CA - [Billing Operations Analyst (Healthcare Billing) #4556](https://feeny.ai/job/billing-operations-analyst-healthcare-billing-4556-grail-raleigh-qdnzgkyzcggk) — Raleigh, NC / Durham, NC