--- title: 'Director, Biostatistics at Bicara Therapeutics' canonical: 'https://feeny.ai/job/director-biostatistics-bicara-therapeutics-boston-8acrty1k88h7' type: 'job' last_seen: '2026-09-13' --- # Director, Biostatistics at Bicara Therapeutics - **Company:** Bicara Therapeutics - **Location:** Boston, MA - **Employment:** full-time - **Work type:** hybrid - **Posted:** 2026-08-24 - **Last confirmed live:** 2026-09-13 - **Apply:** https://jobs.ashbyhq.com/bicara-therapeutics/249400b4-a96e-4c76-9ab1-e5993c32e766 ## Job description Position Overview Bicara Therapeutics is seeking an experienced Director of Biostatistics to lead statistical activities supporting our oncology clinical programs. This individual will provide both strategic direction and hands-on expertise, shaping study design, data analysis, and evidence generation across the development. In this highly visible role within a growing biotech organization, the Director will collaborate closely with internal teams and external partners to deliver high-quality, data-driven insights that advance our oncology pipeline. The ideal candidate thrives in a dynamic, fast-paced environment and is eager to contribute both technically and strategically to program success. This role is based in our Boston office and follows a hybrid schedule, with three in-office days each week. ## Responsibilities - Serve as the lead statistician for assigned oncology programs and studies. - Partner cross-functionally with Clinical, Regulatory, Medical, Statistical Programming, and Data Management teams to define and execute statistical strategies aligned with development objectives. - Provide statistical input to clinical protocols, SAPs, CRFs, and data management plans; oversee execution of analyses and reporting deliverables. - Perform or oversee statistical analyses using SAS and/or R, ensuring scientific rigor and reproducibility. - Manage and oversee deliverables from CROs and external vendors, providing statistical review, feedback, and quality control. - Contribute to the design and implementation of innovative statistical methodologies to enhance the efficiency and interpretability of oncology studies. - Promote statistical literacy across cross-functional teams, helping colleagues understand key concepts and data-driven insights. - Support the development of publications, abstracts, and presentations through data interpretation and statistical input. ## Qualifications - Master’s degree or PhD in Biostatistics, Statistics, or a related quantitative field. - 10+ years of industry experience, including 5+ years in oncology clinical development. - Demonstrated hands-on experience in designing and analyzing oncology trials (e.g., dose escalation, expansion cohorts, or registrational studies). - Strong and proficient programming skills in SAS and/or R; working knowledge of CDISC standards (ADaM, SDTM). - Strong problem-solving, communication, and organizational skills. - Ability to work independently in a fast-paced environment. - Experience managing CROs and collaborating in a cross-functional matrix team. - Prior experience supporting regulatory submissions and interactions is preferred. Company Overview Bicara Therapeutics is a clinical-stage biotech company pioneering bifunctional antibodies for targeted tumor modulation. Founded in 2020, we've built a global team of over 100 employees headquartered in Boston, with a clear focus on advancing our lead asset, ficerafusp alfa, or FICERA - a potentially first-in-class bifunctional EGFR-directed antibody combined with a TGF-β ligand trap. Our innovative approach combines tumor-targeting with tumor modulation, where one arm localizes to the tumor while the other serves as a modulator, designed to deliver superior efficacy, improved safety, and enhanced durability directly at the tumor site. FICERA specifically addresses a key challenge in solid tumor treatment by enabling immune cell penetration into tumors, reducing fibrosis and immunosuppression while reversing TGF-β-driven resistance mechanisms - ultimately designed to drive the deep, durable responses that may translate into better outcomes and survival for patients. For more information, please visit [www.bicara.com](http://www.bicara.com). Here at Bicara, we believe in building diverse teams and cultivating a culture where all voices are included. We encourage people from all backgrounds to apply. Bicara Therapeutics is an equal opportunity employer and will not discriminate against any employee or applicant on the basis of age, color, disability, gender, national origin, race, religion, sexual orientation, veteran status, or any classification protected by federal, state, or local law. ## About Bicara Therapeutics ## Company Overview - **One-liner**: Bicara Therapeutics is a clinical-stage biotechnology company developing first-in-class bifunctional antibodies that combine tumor-targeting with tumor microenvironment modulation, with a lead asset in head and neck squamous cell carcinoma. - **Entity Type**: Public (NASDAQ: BCAX) - **Headquarters**: Boston, Massachusetts, USA - **Founded**: 2020 - **Founders**: Not publicly listed ## Core Business - **Industry**: Biotechnology – oncology drug development - **Target Customers**: B2B (pharma partnerships, licensing) and ultimately cancer patients and healthcare providers - **Mission**: "Dedicated to improving the lives of people living with cancer through the development of innovative targeted therapies… bringing hope and control back into their lives." [bicara.com](https://www.bicara.com/) ## Products & Services - **[Ficerafusp alfa (BCA101)](https://www.bicara.com/)**: First-in-class, dual-action bifunctional antibody targeting EGFR and containing a TGF-β ligand trap. Currently in Phase 1/1b clinical development for HPV-negative head and neck squamous cell carcinoma and other solid tumors. Mechanism designed to deliver an immunomodulatory payload directly to the tumor microenvironment, reduce fibrosis/immunosuppression, and enable immune cell penetration. (Biologic, clinical-stage therapeutic) ## Market Standing - **Valuation/Market Cap**: ~$1.3 billion (as of mid-2026) [linkedin.com](https://www.linkedin.com/company/bicara-therapeutics) - **Key Metric**: Total funding raised $825M (includes Series C $165M led by The Rise Fund and TPG, $362M from 2024 IPO, and a $150M post-IPO equity round in February 2026) [linkedin.com](https://www.linkedin.com/company/bicara-therapeutics) - **Notable Investors/Partners**: The Rise Fund, TPG, Biocon (seed round). Additional institutional investors from IPO and follow-on offerings. - **Growth Signals**: IPO completed September 2024; headcount grew 78.1% year-over-year (95 employees, though LinkedIn notes a slight monthly decline of -0.9%); operates across 8 countries including the UK, Italy, Germany, India, and Spain; 11 active job postings as of mid-2026. [linkedin.com](https://www.linkedin.com/company/bicara-therapeutics) ## Competitive Advantages - **First-in-class bifunctional approach**: By combining an EGFR-targeting antibody with a TGF-β trap, BCA101 directly addresses a key solid-tumor resistance mechanism (TGF-β-driven immunosuppression and fibrosis) while localizing therapy to the tumor. - **Potential for superior efficacy and safety**: Designed to deliver synergistic therapeutic impact at the tumor site, aiming for deep, durable responses with reduced systemic toxicity. - **Experienced leadership**: Team with deep oncology drug development backgrounds and relationships with top cancer centers. [bicara.com/about](https://www.bicara.com/about/) ## Strategic Focus - **Priority**: Advancing ficerafusp alfa through clinical development toward potential regulatory approvals, initially in HPV-negative head and neck squamous cell carcinoma. - **Pipeline expansion**: Leveraging the bifunctional antibody platform (BCA101 and follow-on programs) to address multiple solid tumor types. - **Commercial readiness**: Hiring senior roles in medical affairs, quality, regulatory, and commercial operations signals preparation for launch. [bicara.com/careers](https://www.bicara.com/careers/) ## Why Work Here - **Culture & Mission**: A patient-first, mission-driven environment focused on developing meaningful new therapies for cancer. Company describes itself as "dynamic" with a shared passion for advancing science. [bicara.com](https://www.bicara.com/) - **Diversity & Inclusion**: Explicitly states commitment to building diverse teams and encourages applicants from all backgrounds. [bicara.com/careers](https://www.bicara.com/careers/) - **Growth Trajectory**: Fast-growing public company (78% headcount growth YoY) with a strong balance sheet, offering career progression opportunities. - **Work Environment**: Headquarters in Boston with a global presence. Specific remote/hybrid policy not publicly detailed, but the company employs staff across 8 countries. Glassdoor rating of 4.0/5 on LinkedIn based on limited reviews. [linkedin.com](https://www.linkedin.com/company/bicara-therapeutics) - **Engagement**: Active hiring across multiple senior-level roles in medical affairs, regulatory, quality, IT, and clinical operations, indicating a ramp-up toward commercialization. [bicara.com/careers](https://www.bicara.com/careers/) ## Sources 1. [bicara.com](https://www.bicara.com/) – Company home page, product, mission 2. [bicara.com/about](https://www.bicara.com/about/) – Leadership team, technology description 3. [bicara.com/careers](https://www.bicara.com/careers/) – Open positions, culture, diversity statement 4. [linkedin.com/company/bicara-therapeutics](https://www.linkedin.com/company/bicara-therapeutics) – Headcount, financials, stock info, employee reviews, talent sources 5. [massbio.org/members/bicara-therapeutics](https://www.massbio.org/members/bicara-therapeutics/) – Membership description, pipeline summary ## Other roles at Bicara Therapeutics - [Senior Manager, GxP Audit Program Lead](https://feeny.ai/job/senior-manager-gxp-audit-program-lead-bicara-therapeutics-boston-z2743dyfw8v5) — Boston, MA - [Director, Marketing Operations](https://feeny.ai/job/director-marketing-operations-bicara-therapeutics-boston-308n8g5t9f73) — Boston, MA - [Senior Medical Science Liaison - West (CA, WA)](https://feeny.ai/job/senior-medical-science-liaison-west-ca-wa-bicara-therapeutics-united-states-tv5xs4prg9y2) — United States - [Associate Director, Financial Planning & Analysis (Development Finance Business Partner)](https://feeny.ai/job/associate-director-financial-planning-analysis-development-finance-business-nt8nz0xbxns1) — Boston, MA - [Senior Manager, Accounting and SEC Reporting](https://feeny.ai/job/senior-manager-accounting-and-sec-reporting-bicara-therapeutics-boston-hngf1v66tht9) — Boston, MA - [Associate Director, Global Scientific Communications](https://feeny.ai/job/associate-director-global-scientific-communications-bicara-therapeutics-boston-b20sj17zmqbw) — Boston, MA - [Sr. Quality Specialist, GxP Document Control](https://feeny.ai/job/sr-quality-specialist-gxp-document-control-bicara-therapeutics-boston-pmtejzsn39sj) — Boston, MA - [Senior Clinical Trial Manager](https://feeny.ai/job/senior-clinical-trial-manager-bicara-therapeutics-boston-07s96d5xygx4) — Boston, MA - [Associate Director, Project Management (Clinical Operations)](https://feeny.ai/job/associate-director-project-management-clinical-operations-bicara-therapeutics-jc50anna3jrm) — United States - [Senior Director, Regulatory Affairs](https://feeny.ai/job/senior-director-regulatory-affairs-bicara-therapeutics-boston-t7b77r839mdy) — Boston, MA