---
title: 'Director, Clinical Business Operations at Maze Therapeutics'
canonical: 'https://feeny.ai/job/director-clinical-business-operations-maze-therapeutics-south-san-francisco-asppwh94sg0p'
type: 'job'
last_seen: '2026-09-13'
---

# Director, Clinical Business Operations at Maze Therapeutics

- **Company:** Maze Therapeutics
- **Location:** South San Francisco, CA
- **Posted:** 2026-08-04
- **Last confirmed live:** 2026-09-13
- **Apply:** http://www.mazetx.com/careers/?gh_jid=8659939002

## Job description

The Position

At Maze Therapeutics, we believe precision medicine has the power to transform the lives of patients with both common and rare diseases. As Director, Clinical Business Operations, you will serve as a strategic business partner to the Head of Clinical Operations and the Clinical Development organization. Working closely with Finance and cross-functional stakeholders, you will provide direction for the financial planning, budgeting, contracting, and operational business processes that support efficient and predictable clinical trial execution.

In partnership with the Head of Clinical Operations, Oversight Directors, Study Leads, and Clinical Development functional leaders, you will oversee study and program budgets, financial forecasting, vendor financial management, and clinical business operations across the development portfolio. You will help build scalable processes, establish budgeting standards, and provide the financial insights needed to support informed business decisions while maintaining sound fiscal stewardship.

This role requires a highly collaborative professional who enjoys solving complex operational challenges and working across Clinical Operations, Safety, Biometrics, Finance, Procurement, Legal, and external partners to support operational effectiveness and organizational success.

The Impact You’ll Have

- Clinical Business Operations Leadership
- Serve as a strategic business partner to the Head of Clinical Operations, providing financial and operational guidance to the Clinical Development organization.
- Develop scalable business processes, governance models, and operational standards that improve forecasting accuracy, budget visibility, and operational quality and decision-making.
- Oversee Clinical Development's preferred vendor program by evaluating emerging vendors, establishing strategic partnerships, and maintaining a strong network of qualified providers that support current and future development programs.
- Establish standardized budgeting methodologies, templates, assumptions, and financial tools aligned with industry benchmarks and organizational needs.
- Develop dashboards and KPIs that provide visibility into budget performance, vendor spend, forecasting accuracy, contracting timelines, and operational efficiency.
- Budget Strategy & Financial Management:
- Oversee development of study budgets from protocol planning through study closeout, ensuring budgets appropriately reflect study objectives and operational requirements.
- Partner with Clinical Study Leads and Oversight Directors and Clinical Development Functional Leads to develop realistic financial forecasts and proactively manage study financial risks.
- Collaborate closely with Finance to support monthly accruals and forecasting, quarterly financial updates, annual operating plans, and long-range portfolio planning.
- Monitor study financial performance, identify budget variances, and develop mitigation strategies to maintain financial objectives.
- Prepare executive-level financial analyses, dashboards, and budget reporting to support portfolio and corporate decision-making.
- Ensure vendors maintain accurate change logs and communicate budget impacts in a timely and transparent manner where applicable.
- Contract & Budget Negotiations
- Facilitate negotiations for CRO, vendor, and clinical site budgets, balancing market competitiveness, operational requirements, study timelines, and organizational financial objectives.
- Partner with Legal to support negotiation and execution of Master Service Agreements (MSAs), work orders, study budgets, site budgets, change orders, and other clinical service agreements.
- Develop negotiation strategies, templates, and playbooks that establish organizational standards and improve consistency across studies.
- Serve as the Clinical Operations subject matter expert for financial negotiations, providing strategic guidance to Study Leads, Oversight Directors, and senior leadership.
- Maintain awareness of industry pricing trends and fair market value benchmarks to support competitive and fiscally responsible negotiations.
- Serve as the senior operational escalation point for CRO, vendor, and critical site performance issues
- Vendor Financial Management
- Develop and oversee financial governance for CROs, vendors, and central laboratories, ensuring budget adherence, accurate forecasting, and contractual compliance for Clinical Development vendors.
- Build collaborative relationships with strategic vendors that promote financial transparency, accountability, and high-quality execution.
- Partner with vendors to proactively identify financial risks and develop mitigation strategies before they impact study execution.
- Establish vendor performance metrics related to financial delivery, forecasting accuracy, invoice quality, and budget management.
- Support invoice review, financial reconciliation, and budget tracking throughout the lifecycle of each study.

Leadership Competencies

As a Director, we also expect our leaders to demonstrate the following Leadership Competencies:

- Communication and Influence
- Builds communication channels across Maze for sharing information
- Influences Senior Management decisions through persuasive arguments
- Respectfully addresses differing opinions leading to support of decision
- Teamwork and Collaboration
- Champions partnerships and connections across Maze
- Proactively addresses issues that could result in breakdown of team relationships
- Spotlights team and individual contributions in public forums
- Execution and Results
- Addresses gaps and leverages strengths to get best results
- Maintains a steadying presence and clarifies priorities during change
- Anticipates and removes barriers that put functional/corporate goals at risk
- Develop Others and Self
- Removes barriers to staff development and empowers them to make their own decisions
- Stays current on industry trends and keeps direct-reports prepared and responsive

## What We’re Looking For

You might be the right fit for this role if you have:

- Bachelor's degree in Business, Finance, Life Sciences, Healthcare Administration, or a related field.
- 10–12+ years of experience in Clinical Business Operations, Clinical Finance, Strategic Sourcing, Clinical Operations, or related business roles within biotechnology, pharmaceutical, or CRO organizations.
- Extensive experience developing and managing global clinical trial budgets across all phases of clinical development.
- Demonstrated success negotiating CRO, vendor, and investigator site budgets, including Master Service Agreements, work orders, study budgets, site budgets, and change orders.
- Strong understanding of clinical development, outsourcing models, fair market value methodologies, vendor contracting, and financial planning processes.
- Experience partnering closely with Finance on monthly accruals and forecasting, annual budgeting, long-range planning, and financial governance.
- Strong financial acumen with demonstrated ability to analyze complex financial data and translate insights into strategic business recommendations.
- Experience establishing scalable business processes, templates, governance models, and operational standards within a growing organization.
- Exceptional negotiation, project management, organizational, and problem-solving skills.
- Outstanding communication and interpersonal skills with the ability to influence cross-functional teams, external partners, and executive leadership.
- Ability to thrive in a fast-paced, evolving biotech environment while managing multiple priorities with a strong sense of urgency.
- Willing to occasionally travel to support vendor relationship needs.

## About Maze Therapeutics

Maze Therapeutics is a clinical-stage biopharmaceutical company harnessing human genetics to develop precision medicines for patients with kidney and metabolic diseases. Our clinical pipeline is anchored by two small molecule programs: MZE829, an APOL1 inhibitor for patients with APOL1‑mediated kidney disease, and MZE782, which targets genetic drivers of disease in phenylketonuria (PKU) and chronic kidney disease. We are also advancing a preclinical pipeline through our Compass platform, which links human genetic variants to the biological pathways that drive disease.

Our People

Maze is comprised of a team of passionate and creative professionals committed to discovering and delivering transformative medicines to patients suffering from both rare and common genetic diseases. We are fostering a culture that encourages vision, initiative and the development of talent. Our supportive work environment inspires creative thinking and freedom of expression, resulting in a stimulating atmosphere where people enjoy coming to work. While we have a passion for advanced science and pride ourselves on excellence in execution, ultimately, everything we do is about patients.

Our Core Values

Further Together – Our path is paved with challenges, but with resilience and a team-first mentality, we’ll achieve our mission.

Impact Obsessed – We embrace the bold, take calculated risks, and learn from our mistakes to improve the lives of others.

Stand True – Our integrity is foundational; it guides us no matter the obstacle.

The expected annual salary range for employees located in the San Francisco Bay Area is $222,000 - $271,000. Additionally, this position is eligible for an annual performance bonus.

Maze performs position-based compensation benchmarking to industry market data to ensure we pay competitive wages. Determination of starting salary will depend upon a variety of job-related factors, which may include professional experience, skills, and job location. The expected salary range for this role may be modified in the future.

Maze offers a robust benefits package to our eligible employees including competitive medical, dental, and vision insurance, mental health offerings, equity incentive plan, 401(k) program with employer match and a generous holiday and PTO policy.

#LI-Hybrid

## About Maze Therapeutics

## Company Overview
- **One-liner**: Maze Therapeutics is a clinical-stage biopharmaceutical company developing small molecule precision medicines for common diseases, primarily kidney disease, by leveraging human genetics and its proprietary Compass platform.
- **Entity Type**: Public (NASDAQ: MAZE)
- **Headquarters**: South San Francisco, California, United States
- **Founded**: 2018
- **Founders**: Not publicly listed as individual founders; the company was established by a team of geneticists and industry veterans.

## Core Business
- **Primary industry/industries**: Biotechnology / Biopharmaceuticals (Precision Medicine)
- **Target customers**: B2B (partners and investors), B2C (patients with APOL1-mediated kidney disease, chronic kidney disease, and phenylketonuria)
- **Mission or purpose statement**: "Harnessing the power of genetics to transform the lives of patients" by translating genetic insights into effective precision medicines.

## Products & Services
- **MZE829 (Lead Program)**: An oral, small molecule, dual-mechanism APOL1 inhibitor for the treatment of APOL1-mediated kidney disease (AMKD). Recently reported positive topline Phase 2 HORIZON trial data.
- **MZE782 (SLC6A19 Inhibitor)**: A precision medicine in development for chronic kidney disease (CKD) and phenylketonuria (PKU), currently in clinical trials.
- **Maze Compass™ Platform**: A proprietary platform that leverages variant functionalization to link genetic variants to disease pathways, enabling the discovery and design of precision medicines.
- **Other Pipeline Programs**: Several additional programs in drug discovery targeting renal, cardiovascular, and metabolic diseases.

## Market Standing
- **Valuation/Market Cap**: Approximately **$1.48 Billion** (as of mid-2026, per CB Insights market cap data).
- **Key Metric**: **Total Raised** (including IPO): **$496 Million**. The company also announced a **$150 Million registered offering** in 2026.
- **Notable Investors/Partners**: Key investors include **Third Rock Ventures**, **Gilead Sciences**, **Genentech**, **Denali Therapeutics**, and **Calico Life Sciences** (as top talent sources and likely institutional backers). The company went public via a PIPE/IPO structure.
- **Growth Signals**: 
    - Positive topline data from the Phase 2 HORIZON trial of MZE829 (announced March 2026).
    - Three clinical-stage programs and several discovery-stage programs.
    - Active job postings increased by **120% year-over-year**.
    - Headcount of approximately 150 employees (based on LinkedIn data showing ~150 total employees).

## Competitive Advantages
- **Proprietary Compass Platform**: A unique, data-driven platform that functionally validates genetic variants, giving Maze a differentiated ability to identify and target disease-causing pathways that are often overlooked.
- **Focus on Common Diseases**: Unlike many precision medicine companies that focus on rare diseases, Maze targets large, unmet medical needs (e.g., chronic kidney disease), which represents a massive market opportunity.
- **Strong Genetic Foundation**: The company’s entire strategy is built on robust human genetic evidence, reducing the risk of late-stage clinical failures and increasing the probability of success.
- **Experienced Leadership Team**: The team includes veterans from leading biotech and pharma companies (Gilead, Genentech, Amgen), providing deep industry expertise in drug development and commercialization.

## Strategic Focus
- **Advance Lead Programs**: Primary focus is on progressing MZE829 through Phase 2/3 trials for APOL1-mediated kidney disease and advancing MZE782 for CKD and PKU.
- **Expand Pipeline**: Leveraging the Compass platform to identify and develop additional precision medicines for renal, cardiovascular, and metabolic diseases.
- **Clinical Data Generation**: Delivering key clinical readouts to support regulatory filings and potential partnerships.
- **Commercial Preparation**: Building the infrastructure and team (e.g., Senior Director, Talent Acquisition; Senior Director, Pharmaceutical Development) to prepare for potential late-stage success and launch.

## Why Work Here
- **Mission-Driven Culture**: The company is deeply committed to "harnessing the power of genetics to transform the lives of patients," with core values of "Impact Obsessed," "Stand True" (integrity), and "Further Together" (teamwork and resilience).
- **Supportive Work Environment**: Maze promotes a culture that encourages "vision, initiative, and the development of talent," with a "stimulating atmosphere where people enjoy coming to work."
- **Comprehensive Benefits**: Offers "comprehensive and competitive health, financial, paid time off and many other benefits designed to promote the health and financial well-being of employees and their families."
- **Equal Opportunity Employer**: Committed to diversity and non-discrimination.
- **Growth Trajectory**: As a public clinical-stage company with positive clinical data and a 120% increase in job postings year-over-year, there are significant opportunities for career growth and impact.
- **Location**: Based in South San Francisco (a major biotech hub), though specific remote/hybrid policy is not publicly detailed.

## Sources
1. [mazetx.com](https://mazetx.com/)
2. [mazetx.com](https://mazetx.com/about-us/)
3. [mazetx.com](https://mazetx.com/careers/)
4. [cbinsights.com](https://www.cbinsights.com/company/maze-therapeutics)
5. [linkedin.com](https://www.linkedin.com/company/mazetx)

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