---
title: 'Director, Demand/Supply Planning at Kardigan'
canonical: 'https://feeny.ai/job/director-demand-supply-planning-kardigan-south-san-francisco-jcz16k67hq5r'
type: 'job'
last_seen: '2026-09-12'
---

# Director, Demand/Supply Planning at Kardigan

- **Company:** Kardigan
- **Location:** South San Francisco, CA
- **Compensation:** $203k–$264k
- **Posted:** 2026-09-04
- **Last confirmed live:** 2026-09-12
- **Apply:** https://job-boards.greenhouse.io/kardigan/jobs/5415602008

## Job description

## About Us

Kardigan is a heart health company working to make cardiovascular disease preventable, curable and no longer the leading cause of death in the world.

It is Kardigan’s mission to develop multiple targeted treatments in parallel that bring people with cardiovascular diseases to the cures they deserve.

Led by Tassos Gianakakos, Jay Edelberg, M.D., Ph.D., and Bob McDowell, Ph.D., Kardigan’s co-founders have reunited after leading MyoKardia to discover and develop mavacamten, the first cardiac myosin inhibitor, resulting in an acquisition by Bristol Myers Squibb in 2020.

We have a cutting-edge discovery and translational research platform, a pipeline of late-stage candidates, and an industry-leading team that is driven to improve the lives of patients.

At Kardigan, we are motivated by our values which guide how we work, interact, and achieve our goals. Driven by patients and their families, we are deeply committed to improving the lives of patients and prioritizing their needs above all else. We believe in being authentic—leading with truth to bring out the best in others by creating an environment where every person knows they will be fully accepted. With an eagerness to learn, we encourage the highest levels of curiosity and are open to changing our minds. We are committed to winning as a team with urgency, excellence, and intention, and support each other no matter what role we play or where we sit. Lastly, we strive to enable the impossible because patients are counting on us. We are not afraid to take risks to unlock innovation and advance scientific discoveries.

These values are the foundation of our work, empowering us to make a real difference, every day.

Reporting to the Senior Director, Head of Planning, the Director, Demand & Supply Planning will lead execution of integrated demand, supply, inventory, and planning processes across Kardigan’s outsourced manufacturing and clinical supply network.

You will work closely with teams across Technical Operations, CMC, Clinical Operations, Quality, Regulatory Affairs, Finance, Procurement, Program Management, External Manufacturing, Clinical Supply Chain, and external partners. This role is a great fit for someone who enjoys bringing structure to ambiguity, connecting strategy to execution, and using data to help teams make smart decisions in a fast-moving clinical development environment.

## What You’ll Do

- Build demand plans that translate clinical enrollment assumptions, protocol requirements, regional plans, and future launch expectations into practical forecasts.
- Create integrated supply plans across drug substance, drug product, packaging, labeling, testing, release, distribution, and clinical supply activities.
- Help ensure patients and clinical sites have the supply they need by balancing service, continuity, shelf life, and inventory investment.
- Track inventory health, supply plan performance, forecast accuracy, capacity constraints, and emerging risks before they become issues.
- Partner with External Manufacturing and Technical Operations to align CDMO execution activities with approved demand and supply plans.
- Lead scenario planning for demand changes, manufacturing delays, batch outcomes, inventory needs, capacity availability, and launch readiness.
- Turn complex planning data into clear recommendations, dashboards, and decision points for cross-functional planning and governance forums.
- Improve how planning gets done by strengthening templates, assumptions, reporting cadences, data quality, and planning tools.

## What You’ll Bring

- 10+ years for Director level in supply chain planning, demand planning, supply planning, clinical supply, manufacturing planning, or related operations roles.
- Experience in biotechnology, pharmaceutical, medical device, or another regulated life sciences environment.
- Strong understanding of clinical-stage supply chains, outsourced manufacturing networks, CDMO/CMO coordination, and planning across drug substance, drug product, packaging, labeling, testing, release, and distribution.
- Ability to build forecasts, supply plans, inventory scenarios, planning dashboards, and data-driven recommendations that support cross-functional decisions.
- Clear communicator who can influence without direct authority and partner effectively with technical, operational, financial, clinical, and executive stakeholders.
- Bachelor’s degree in Supply Chain, Operations Management, Engineering, Life Sciences, Business, or a related discipline required; advanced degree, MBA, or APICS/ASCM certification preferred.

## Preferred Experience

- Experience in a clinical-stage, pre-commercial, launch-stage, or rapidly scaling biotech/pharma organization.
- Experience supporting S&OP, Integrated Business Planning, long-range planning, or supply governance processes.
- Experience with ERP, planning, inventory visibility, IRT, dashboarding, or analytics tools.
- Comfort operating in a fast-paced, matrixed environment where priorities evolve and processes are still being built.

Exact Compensation may vary based on skills, experience and location.

Pay range $203,000—$264,000 USD

## About Kardigan

## Company Overview
- **One-liner**: Kardigan is a publicly traded biopharmaceutical company developing targeted cardiovascular therapies with the aim of transforming treatment from symptom management toward functional cures.
- **Entity Type**: Public (ticker not available from provided sources; IPO closed as per company announcement)
- **Headquarters**: South San Francisco, California, United States (with additional offices in Princeton, New Jersey and Chicago, Illinois)
- **Founded**: Year not specified in available sources
- **Founders**: Tassos Gianakakos (Co-Founder, CEO & Chair), Dr. Jay Edelberg (Co-Founder & Chief Medical Officer), Dr. Bob McDowell (Co-Founder & Scientific Adviser), Brianne Puglisi (Co-Founder)

## Core Business
- **Primary industry**: Biopharmaceuticals – cardiovascular drug discovery and development
- **Target customers**: B2B / B2G – healthcare providers, hospitals, payers, and patients; the company develops prescription medicines for serious cardiovascular conditions
- **Mission or purpose statement**: “To make cardiovascular disease preventable, curable and no longer the leading cause of death in the world.” ([kardigan.bio](https://www.kardigan.bio/))

## Products & Services
- **Tonlamarsen**: A Phase 2/3 candidate for acute severe hypertension (ASH) and uncontrolled hypertension. Positive Phase 2 data presented as a late-breaker at ACC.26 and simultaneously published in JACC. ([kardigan.bio](https://www.kardigan.bio/))
- **Danicamtiv**: A Phase 3 candidate for genetic dilated cardiomyopathy (DCM), targeting the underlying inherited cardiac muscle disease. ([kardigan.bio](https://www.kardigan.bio/))
- **Calcific Aortic Valve Stenosis (CAVS) Program**: A late-stage clinical program addressing calcium deposition that stiffens the aortic valve. ([kardigan.bio](https://www.kardigan.bio/))
- **Prolaio Subsidiary**: An AI and real‑world data platform integrated into Kardigan to generate insights, inform clinical trial design, and reduce time/cost of drug development. ([kardigan.bio](https://www.kardigan.bio/about-us/))
- **Cardiac Intelligence Platform**: A discovery and translational research engine that uses real‑world patient data, AI, and deep cardiovascular expertise to identify disease drivers and design targeted therapies. ([kardigan.bio](https://www.kardigan.bio/))

## Market Standing
- **Valuation/Market Cap**: Not disclosed in provided sources
- **Key Metric**: Public company (IPO closed); annual revenue not disclosed
- **Notable Investors/Partners**: Not explicitly listed in provided sources; company built on the team’s track record from MyoKardia (acquired by Bristol Myers Squibb for $13.1B in 2020)
- **Growth Signals**:
  - Positive Phase 2 pivotal data for Tonlamarsen in hypertension, presented at ACC.26 and published in JACC
  - Three late‑stage clinical programs (CAVS, ASH, DCM) running in parallel
  - Active job postings across 210+ roles in clinical operations, data science, manufacturing, and corporate strategy, indicating scaling ([job-boards.greenhouse.io/kardigan](http://job-boards.greenhouse.io/kardigan))
  - Integration of Prolaio’s AI platform to accelerate R&D

## Competitive Advantages
- **Leadership expertise**: CEO Tassos Gianakakos previously scaled MyoKardia from startup to a $13.1B acquisition; the team includes veterans from MyoKardia, Sanofi, BMS, and Merck.
- **Parallel pipeline strategy**: Multiple late‑stage programs targeting distinct cardiovascular diseases (valve, hypertension, cardiomyopathy) de‑risks development and creates data synergies.
- **Cardiac Intelligence platform**: Proprietary combination of real‑world data, AI, and deep biological insight to move beyond symptom management toward modifying underlying disease.
- **Focus on functional cures**: Each program aims to alter the course of disease rather than merely treat symptoms, creating potential for breakthrough efficacy.

## Strategic Focus
- **Advance late‑stage clinical trials**: Continue Phase 2/3 studies for Tonlamarsen, Danicamtiv, and CAVS while preparing for potential regulatory submissions.
- **Expand platform capabilities**: Leverage Prolaio’s AI and real‑world evidence to design smarter, faster trials and discover new drug targets.
- **Build commercial infrastructure**: Growing corporate strategy, medical affairs, and manufacturing teams in South San Francisco, Princeton, and Chicago signals preparation for launch.

## Why Work Here
- **Culture**: “Everything we do starts with patients – and it’s powered by people.” Emphasis on collaboration, purpose‑driven work, and achieving the impossible together. Mission‑oriented environment focused on curing cardiovascular disease. ([kardigan.bio](https://www.kardigan.bio/job-openings/))
- **Work model**: Roles are listed for South San Francisco, Princeton, NJ, and Chicago, IL; likely on‑site/hybrid given the lab and clinical development nature. Not purely remote.
- **Benefits**:
  - Competitive salaries and annual bonus program
  - Comprehensive medical, dental, and vision coverage
  - 401(k) plan, life and disability insurance
  - Flexible spending and health savings accounts
  - Commuter benefits, cellphone allowance
  - Paid holidays and time off
  - Employee assistance program ([kardigan.bio](https://www.kardigan.bio/job-openings/))
- **Engineering & data science culture**: Active recruitment for data analytics, AI, and clinical data science roles; Executive Director of Data, AI & Collaboration Services is an open position, reflecting a strong tech‑driven R&D approach.

## Sources
1. [kardigan.bio](https://www.kardigan.bio/) – Company homepage and pipeline descriptions
2. [kardigan.bio/about-us](https://www.kardigan.bio/about-us/) – About Us, mission, and Prolaio integration
3. [kardigan.bio/job-openings](https://www.kardigan.bio/job-openings/) – Careers page with benefits and open roles
4. [kardigan.bio/leadership](https://www.kardigan.bio/leadership/) – Leadership team and co‑founder backgrounds
5. [job-boards.greenhouse.io/kardigan](http://job-boards.greenhouse.io/kardigan) – Detailed job listings (32+ postings)

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