--- title: 'Director, Drug Safety at Nurix' canonical: 'https://feeny.ai/job/director-drug-safety-nurix-brisbane-6cvez55232p3' type: 'job' last_seen: '2026-10-29' --- # Director, Drug Safety at Nurix - **Company:** Nurix - **Location:** Brisbane, CA - **Posted:** 2026-09-27 - **Last confirmed live:** 2026-10-29 - **Apply:** https://job-boards.greenhouse.io/nurix/jobs/8849321002 ## Job description Director, Drug Safety Join Nurix’s pharmacovigilance team to help ensure patient safety across our clinical pipeline of targeted protein degradation therapies. As Director, Drug Safety, you’ll lead aggregate safety analysis, benefit–risk assessments, and safety strategy for assigned programs — shaping how we evaluate risk and bring new medicines safely to patients. It’s a chance to influence critical safety decisions at the intersection of clinical medicine, data, and drug development. The Opportunity Medical Safety Leadership - Serve as the medical safety lead for assigned products, providing clinical and pharmacovigilance expertise to safety strategy and activities - Lead aggregate safety data analysis for signal detection, signal evaluation, and risk characterization - Conduct medical review and interpretation of safety data, contributing to benefit–risk assessments - Monitor emerging safety signals and proactively address potential safety risks through appropriate internal and external communication Regulatory and Safety Documentation - Oversee medical review of Individual Case Safety Reports (ICSRs) - Author and review regulatory safety documents, including Development Safety Update Reports (DSURs) and safety sections of INDs and regulatory briefing books - Contribute to safety responses to regulatory authorities and participate in regulatory interactions - Provide clinical leadership during inspections and audits related to safety and risk management Clinical Development Support - Provide clinical input into safety aspects of clinical trial protocols, informed consent forms, and investigator brochures - Collaborate with clinical development, regulatory affairs, medical affairs, and other stakeholders to ensure a consistent global safety strategy Governance and Cross-Functional Collaboration - Serve on safety governance committees, supporting strategic decision-making for risk mitigation and benefit–risk evaluation ## What You’ll Bring - Advanced clinical or scientific degree, such as MD, DO, PharmD, or equivalent relevant training and experience - Clinical experience preferred - 5–10 years of experience in pharmacovigilance/drug safety within the pharmaceutical or biotechnology industry - Experience supporting early clinical development and small biotechnology companies - Demonstrated expertise in aggregate safety analysis and benefit–risk evaluation - Strong knowledge of global pharmacovigilance regulations and guidance (ICH, FDA, EMA, MHRA) - Experience interacting with global health authorities on safety matters - Familiarity with signal detection and safety surveillance tools and databases - Strong communication, collaboration, and cross-functional leadership skills - Ability to interpret complex clinical and safety data and translate insights into regulatory and business strategy - Ability to work effectively and collaboratively in a fast-paced, growing organization across functional boundaries Salary Range:  Non-MD $247,300 - $280,400 |  MD  $295,000 - $317,100 The posted range applies to roles based in the San Francisco Bay Area and reflects local market conditions. Where an offer lands within that range depends on the candidate’s relevant experience, technical expertise, and how their background aligns with the role’s requirements. Location:          Onsite – Brisbane, CA Fit with Nurix Culture and Values - Strong team orientation; highly collaborative - Solutions and results-oriented focus - Hands-on approach; resourceful and open to diverse points of view ## About Nurix Therapeutics Nurix Therapeutics is a clinical stage biopharmaceutical company focused on the discovery, development, and commercialization of targeted protein degradation medicines, the next frontier in innovative drug design aimed at improving treatment options for patients with cancer and inflammatory diseases. Powered by a fully AI-integrated discovery engine capable of tackling any protein class, and coupled with unparalleled ligase expertise, Nurix’s dedicated team has built a formidable advantage in translating the science of targeted protein degradation into clinical advancements. Nurix aims to establish degrader-based treatments at the forefront of patient care, writing medicine’s next chapter with a new script to outmatch disease. ## About Nurix ## Company Overview - **One-liner**: Nurix Therapeutics is a clinical-stage biopharmaceutical company pioneering targeted protein degradation medicines to outmatch disease by harnessing the cell’s natural protein disposal system. - **Entity Type**: Public (NASDAQ: NRIX) - **Headquarters**: San Francisco, California, USA - **Founded**: 2009 - **Founders**: Not publicly listed as individual founders; the company was spun out from research at UC Berkeley and UC San Francisco. ## Core Business - **Primary industry**: Biopharmaceuticals / Targeted Protein Degradation - **Target customers**: B2B (pharma partners) and B2C (patients via clinical trials and eventual commercial therapies); enterprise-level partnerships with major pharma. - **Mission or purpose statement**: "Writing medicine’s next chapter using targeted protein degradation as a new script to outmatch disease." [nurixtx.com](https://www.nurixtx.com/) ## Products & Services - **Bexobrutideg (NX-5948)**: A potential best-in-class BTK degrader in Phase 1b/2 clinical trials for relapsed/refractory CLL/SLL and chronic spontaneous urticaria. Co-developed and co-commercialized with Roche under a global collaboration announced June 2026. [nurixtx.com](https://www.nurixtx.com/) - **NX-2127**: A BTK degrader in clinical development for B-cell malignancies. - **CBL-B Inhibitor (NX-1607)**: An E3 ligase inhibitor designed to activate T cells for immuno-oncology, in Phase 1 clinical trials. - **IRAK4 Degrader**: A partnered program with Gilead in Phase 1 for inflammatory diseases. - **STAT6 Degrader**: A partnered program with Sanofi in IND-enabling studies. - **DEL-AI Discovery Engine**: A proprietary, fully AI-integrated platform combining DNA-encoded libraries (DEL), automated chemistry, and machine learning to design and optimize targeted protein degraders and degrader-antibody conjugates (DACs). ## Market Standing - **Valuation/Market Cap**: Not publicly available in the provided search results; as a public company (NRIX), market cap fluctuates daily. Check financial platforms for the latest figure. - **Key Metric**: Annual Revenue (public) — Not publicly available in the provided search results; as a clinical-stage biotech, revenue is typically minimal or pre-revenue. Total funding raised prior to IPO is not detailed in the provided results. - **Notable Investors/Partners**: Roche (global co-development and co-commercialization collaboration for bexobrutideg, announced June 2026), Gilead (partnered IRAK4 degrader program), Sanofi (partnered STAT6 degrader program). - **Growth Signals**: Announced a landmark global collaboration with Roche in June 2026 to co-develop and co-commercialize bexobrutideg across malignant hematology, immunology, and neurology. Presented positive Phase 1a/b data for bexobrutideg in CLL/SLL and chronic spontaneous urticaria in 2026. Multiple partnered and wholly owned pipeline programs advancing through clinical and preclinical stages. ## Competitive Advantages - **Proprietary DEL-AI Discovery Engine**: A fully AI-integrated platform combining DNA-encoded libraries, automated chemistry, and machine learning to design degraders against any protein class, providing a significant speed and innovation advantage. [nurixtx.com](https://www.nurixtx.com/) - **Unparalleled Ligase Expertise**: Deep understanding of E3 ligase biochemistry and biology, a critical and complex component of the protein degradation mechanism, giving them a unique moat. - **Multi-Modal Pipeline**: Developing both small molecule degraders and Degrader-Antibody Conjugates (DACs), expanding the therapeutic reach and creating multiple shots on goal. - **Strong Partnership Network**: Collaborations with top-tier pharma (Roche, Gilead, Sanofi) validate their platform and provide non-dilutive funding and shared risk. ## Strategic Focus - **Clinical Advancement**: Driving lead asset bexobrutideg through pivotal trials in CLL/SLL and expanding into immunology (chronic spontaneous urticaria) and neurology. - **Platform Expansion**: Leveraging the DEL-AI engine to develop Degrader-Antibody Conjugates (DACs) for enhanced cell specificity and safety. - **Pipeline Breadth**: Advancing a multi-modal pipeline across oncology, immunology, and neurology, both wholly owned and through strategic partnerships. - **Partnership Leverage**: Deepening collaborations with Roche, Gilead, and Sanofi to co-develop and co-commercialize programs, reducing risk and accelerating timelines. ## Why Work Here - **Culture**: Mission-focused, values-based, and spirited culture emphasizing "breakthrough innovation," "leadership," "accountability," and "zealousness." Employees are encouraged to "think big and act bold." [nurixtx.com](https://www.nurixtx.com/work-at-nurix/) - **Work with Industry Leaders**: The team includes scientific innovators who built the protein degradation field, seasoned executives with biotech scaling expertise, and leading clinicians. [nurixtx.com](https://www.nurixtx.com/work-at-nurix/) - **Growth & Impact**: Employees can "wear many hats" and gain broad exposure in a lean, virtual drug developer environment. The company emphasizes career growth and opportunity-rich experiences. - **Work Policy**: Onsite in Brisbane, CA (San Francisco Bay Area) for most roles, as indicated by job postings. [nurixtx.com](https://www.nurixtx.com/explore-jobs/) - **Benefits**: Comprehensive health and welfare plans, enhanced parental leave, wellness reimbursement, 401(k) employer match, and a highly collaborative culture. [nurixtx.com](https://www.nurixtx.com/work-at-nurix/) - **Engineering/Science Culture**: Described as "mission-focused, values-based, and spirited," with a focus on "intellectual and technical ingenuity" and "intelligent risk-taking." The company is a "virtual drug developer" with a lean internal infrastructure, relying on SaaS and cloud platforms. [nurixtx.com](https://www.nurixtx.com/explore-jobs/) ## Sources 1. [nurixtx.com](https://www.nurixtx.com/) 2. [nurixtx.com](https://www.nurixtx.com/work-at-nurix/) 3. [nurixtx.com](https://www.nurixtx.com/explore-jobs/) 4. [nurixtx.com](https://www.nurixtx.com/our-story/) ## Other roles at Nurix - [Director, Quality Assurance](https://feeny.ai/job/director-quality-assurance-nurix-brisbane-3g1nz641gtdv) — Brisbane, CA - [Senior/Principal Scientist, Medicinal Chemistry](https://feeny.ai/job/senior-principal-scientist-medicinal-chemistry-nurix-brisbane-sk240f67bwms) — Brisbane, CA - [Scientist I, Bioanalytical](https://feeny.ai/job/scientist-i-bioanalytical-nurix-brisbane-tns4szvd5c07) — Brisbane, CA - [Senior Research Associate, Preclinical Pharmacology](https://feeny.ai/job/senior-research-associate-preclinical-pharmacology-nurix-brisbane-whtmqmhser7g) — Brisbane, CA - [Senior Scientist, Medicinal Chemistry](https://feeny.ai/job/senior-scientist-medicinal-chemistry-nurix-the-woodlands-y4nmgjxktsm5) — The Woodlands, TX - [Scientist I, Medicinal Chemistry](https://feeny.ai/job/scientist-i-medicinal-chemistry-nurix-the-woodlands-bxgy2c1m60vz) — The Woodlands, TX - [Senior Director, Head of Pharmacovigilance Operations](https://feeny.ai/job/senior-director-head-of-pharmacovigilance-operations-nurix-brisbane-qvx5sf5gc0cv) — Brisbane, CA - [Senior Manager / Associate Director, Regulatory Affairs CMC (Small Molecules)](https://feeny.ai/job/senior-manager-associate-director-regulatory-affairs-cmc-small-molecules-nurix-pp3fh8jc68k1) — Brisbane, CA - [Administrative Assistant, Clinical Development (Contract)](https://feeny.ai/job/administrative-assistant-clinical-development-contract-nurix-brisbane-6rnsp2fj2vte) — Brisbane, CA - [Administrative Assistant, CMC (Contract)](https://feeny.ai/job/administrative-assistant-cmc-contract-nurix-brisbane-cgkssyzb35sq) — Brisbane, CA