---
title: 'Director, HR Business Partner at Replimune'
canonical: 'https://feeny.ai/job/director-hr-business-partner-replimune-milton-park-z5a3s7k1jy7g'
type: 'job'
last_seen: '2026-09-09'
---

# Director, HR Business Partner at Replimune

- **Company:** Replimune
- **Location:** Milton Park
- **Employment:** full-time
- **Work type:** onsite
- **Posted:** 2026-09-08
- **Last confirmed live:** 2026-09-09
- **Apply:** https://jobs.ashbyhq.com/replimune/0f3768eb-c6c4-4043-97b4-7e3b0f210019

## Job description

## Overview

Replimune’s mission is to revolutionize cancer treatment with therapies designed to activate a powerful and durable full-body anti-tumor response, boldly transforming cancer care because patient’s lives depend on it.

At Replimune, we live by our values:

United: We Collaborate for a Common Goal.

Audacious: We Are Bold.

Dedicated: We Give Our Full Commitment.

Candid: We Are Honest With Each Other.

People are at the center of everything we do, and when it comes to our employees, we make it personal. With a deep sense of purpose, a strong and evolving culture, a competitive and forward-looking total rewards program, everyone at Replimune has a unique opportunity to impact on the lives of patients, caregivers and themselves.

Join us, as we reshape the future.

Job Summary:

The Director, HR Business Partner (HRBP) provides HR leadership and expert support to Replimune leaders and employees in our Milton Park, UK site. With the support of the broader HR team, the Director will be responsible for a broad range of human capital matters for this site, from employee relations and performance management to onboarding and development. The HR Business Partner is a resource to employees and managers and liaises with other internal functions when needed to bring solutions to clients. The Director, HRBP is expected to play a key role in developing and implementing HR programs and practices to help grow the business, contribute to the development of leaders and people managers, and drive employee engagement.

The Director, HRBP role requires at least four days per week on-site in Milton Park, UK. Additionally, 10-15% travel required to the Boston area of the United States.

Responsibilities:

- Manages the HR Business Partner day-to-day support and issue resolution for site teams – including but not limited to matters related to HR policies and business processes, employee relations, career development, performance management, learning and skill development, etc., to achieve key business and HR objectives
- Advise functional leaders in solving complex issues in all areas of human capital with a specific emphasis on employee relations, performance management, and talent acquisition to build a sustainable, high-growth organization.
- Maintains the pulse of the people and drives effective employee engagement programs in alignment with our company culture, mission, vision, and values. Supports all efforts around employee engagement, ensuring follow up and action planning from annual employee survey. Motivates and supports employee engagement in a dynamic and high-growth collaborative culture.
- Ensure compliance with all applicable labor laws, policies, and practices to maintain the highest standards of compliance and fairness.
- Manage key HR processes for the UK, such as new hire onboarding and the year-end performance management process (performance assessment and calibration).
- Builds strong partnerships with the HR specialist functions such as Talent Acquisition and Total Rewards to provide HR solutions to business needs and to support the roll out corporate-wide programs that enhance the overall employee experience and support growth and success of overall business strategy
- Works in coordination with the Talent Acquisition team to interview site candidates and facilitate the offer process with the manager as needed
- Works closely with the US team on leaves of absence administration for the UK; identify, research and recommend areas for benefits enhancement to the HR Leadership Team. Lead a benefits orientation session for new UK hires
- Identifies new approaches or process improvements to existing or non-existing business processes, policies, and/or procedures as it relates to the needs of a high-growth organization
- Provides support and guidance to employees when complex and sensitive questions and issues arise.
- Engages in larger HR or cross-functional projects, e.g., around wellness offerings, HR or business process improvements, talent attraction and retention strategies. Acts as an influencer and an integrator

Education:

- Undergraduate degree required, Master’s degree preferred

Required Experience:

- 10+ years of broad Human Resources experience with significant exposure to employee relations, performance management, talent acquisition and other HR disciplines (e.g., training, benefits)
- 3+ years of experience in roles working directly with senior leaders as internal clients in an HR business partner capacity.
- Experience in the Biotech industry or within a lab-environment strongly preferred; familiarity with R&D functions also preferred.
- Ability to effectively influence leaders and other stakeholders in an organization by demonstrating a high level of service, maturity, executive presence, and business acumen.
- Strong operational and business acumen, with the ability to act as a business partner with senior leaders in helping them meet or exceed their strategic objectives and tactical goals; ability and willingness to shift quickly between the strategic and tactical on a daily basis.
- Strong general knowledge of UK employment laws, employee compensation, benefits, payroll, recruiting, performance management and training.
- Embraces the pace and opportunities of a fast-growing organization and has proven ability to handle a broad range of responsibilities; strong project management and prioritization skills to effectively drive multiple projects and initiatives.
- Possesses a high energy level, sense of urgency, ability to work hard and well under pressure and to effectively partner with the rest of the HR team.

## About Replimune

Replimune Group, Inc., headquartered in Woburn, MA, was founded in 2015 with the mission to transform cancer treatment by pioneering the development of a novel portfolio of oncolytic immunotherapies. Replimune’s proprietary RPx platform is based on a potent HSV-1 backbone intended to maximize immunogenic cell death and the induction of a systemic anti-tumor immune response. The RPx platform is designed to have a unique dual local and systemic activity consisting of direct selective virus-mediated killing of the tumor resulting in the release of tumor derived antigens and altering of the tumor microenvironment to ignite a strong and durable systemic response. The RPx product candidates are expected to be synergistic with most established and experimental cancer treatment modalities, leading to the versatility to be developed alone or combined with a variety of other treatment options. For more information, please visit www.replimune.com http://www.replimune.com.

We are an Equal Opportunity Employer.

## About Replimune

## Company Overview
- **One-liner**: Replimune is a clinical-stage biotech company focused on revolutionizing cancer treatment with a new class of oncolytic immunotherapies intended to activate a powerful and durable full-body anti-tumor response.
- **Entity Type**: Public (ticker not explicitly provided in search results, but company is publicly traded)
- **Headquarters**: Framingham, Massachusetts, USA (with additional locations in Woburn, MA and Oxfordshire, UK)
- **Founded**: 2015
- **Founders**: Robert Coffin, Ph.D. (Founder and Chief Scientist)

## Core Business
- **Primary industry**: Biotechnology – oncology, oncolytic immunotherapy
- **Target customers**: B2B (pharmaceutical partners) and ultimately patients through healthcare providers
- **Mission**: To ignite a systemic immune response to cancer and reshape the future of cancer care

## Products & Services
- **RPx Platform**: Proprietary, next-generation HSV-1-based oncolytic immunotherapy platform that powers all pipeline candidates.
- **RP1**: Investigational oncolytic immunotherapy for advanced melanoma (IGNYTE trial, PDUFA date April 10, 2026) and non-melanoma skin cancers; also being studied as monotherapy in organ transplant patients with skin cancer (ARTACUS trial).
- **RP2**: Investigational oncolytic immunotherapy for metastatic uveal melanoma (Phase 2/3 RP2-202 trial) and hepatocellular carcinoma (Phase 2 in combination with atezolizumab/bevacizumab).

## Market Standing
- **Valuation/Market Cap**: Not publicly available in provided sources
- **Key Metric**: Clinical-stage; no approved products yet. Key regulatory milestone: FDA action date for RP1 in advanced melanoma on April 10, 2026.
- **Notable Partners**: Bristol-Myers Squibb (supply of nivolumab), Roche (supply of atezolizumab and bevacizumab) – Replimune retains full commercial rights.
- **Growth Signals**: Completed enrollment in IGNYTE trial; confirmatory IGNYTE-3 trial underway; own 63,000 sq ft U.S. manufacturing facility in Woburn, MA enabling global commercial supply; broad pipeline across multiple solid tumor indications.

## Competitive Advantages
- **Strong IP position**: Wholly-owned, unencumbered RPx platform with broad patent protection.
- **In-house manufacturing**: Dedicated U.S. facility for commercial-scale production, reducing reliance on contract manufacturers.
- **First-mover potential**: Poised to be one of the first oncolytic immunotherapies to reach the market if RP1 gains FDA approval.
- **Full rights retained**: All partnership agreements allow Replimune to keep full commercial rights to its therapies.

## Strategic Focus
- Advancing RP1 toward FDA approval in advanced melanoma (April 2026 PDUFA date)
- Expanding pipeline into additional indications (uveal melanoma, hepatocellular carcinoma, non-melanoma skin cancers)
- Building out commercial infrastructure and manufacturing capabilities
- Exploring combination therapies with checkpoint inhibitors (nivolumab, atezolizumab)

## Why Work Here
- **Culture**: Cross-functional, collaborative, values-driven environment. Employee survey results show 92% proud to work at Replimune, 88% feel they make a positive difference, 78% would recommend the company.
- **Flexibility**: Hybrid and remote work options available depending on role; home office and mobile phone stipend provided.
- **Compensation**: New hire equity grants, generous annual bonus plans, retirement plans with substantial company match (100% vested from day one).
- **Benefits**: Medical, dental, and vision insurance 100% paid by the company.
- **Locations**: U.S. (Woburn, MA and Framingham, MA) and UK (Oxfordshire) – opportunities to work across both sites.

## Sources
1. [Replimune Homepage](https://www.replimune.com/)
2. [Replimune Careers](https://www.replimune.com/careers)
3. [Replimune About Us](https://www.replimune.com/about-us)
4. [Replimune Team](https://www.replimune.com/team)
5. [Replimune Pipeline](https://www.replimune.com/pipeline)

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