--- title: 'Director, IT Business Partner, R&D at 4D Molecular Therapeutics' canonical: 'https://feeny.ai/job/director-it-business-partner-r-d-4d-molecular-therapeutics-emeryville-e54sw1t7qbqz' type: 'job' last_seen: '2026-11-01' --- # Director, IT Business Partner, R&D at 4D Molecular Therapeutics - **Company:** 4D Molecular Therapeutics - **Location:** Emeryville, CA - **Work type:** hybrid - **Posted:** 2026-10-21 - **Last confirmed live:** 2026-11-01 - **Apply:** https://4dmoleculartherapeutics.com/careers/?gh_jid=4745740005 ## Job description Attention recruitment agencies: All agency inquiries are vetted through 4DMT’s internal Talent Acquisition team. No unsolicited resumes will be accepted. The 4DMT Talent Acquisition team must expressly engage agencies on any requisition. Agencies contacting hiring managers directly will not be tolerated, and doing so may impact your ability to work with 4DMT in the future. 4DMT is a leading late-stage biotechnology company advancing durable and disease-targeted therapeutics with potential to transform treatment paradigms and provide unprecedented benefits to patients. The Company’s lead product candidate 4D-150 is designed to be a backbone therapy forming the foundation of treatment of blinding retinal vascular diseases by providing multi-year sustained delivery of anti-VEGF (aflibercept and anti-VEGF-C) with a single, safe, intravitreal injection, which substantially reduces the treatment burden associated with current bolus injections. The Company’s lead indication for 4D-150 is wet age-related macular degeneration, which is currently in Phase 3 development, and second indication is diabetic macular edema. The Company’s second product candidate is 4D-710, which is the first known genetic medicine to demonstrate successful delivery and expression of the CFTR transgene in the lungs of people with cystic fibrosis after aerosol delivery ## GENERAL SUMMARY 4D Molecular Therapeutics (4DMT) is a late-stage clinical gene therapy company advancing a potentially transformative pipeline toward its first Biologics License Application (BLA) & commercial launch. Reporting to the Sr. Director, IT Business Partner, R&D, the Director serves as a broad deputy across R&D & helps translate the integrated R&D technology strategy into delivery across clinical, regulatory, safety, laboratory, scientific informatics, manufacturing, supply, quality & facility systems, data & integrations required for pivotal development, BLA submission, inspection readiness & launch. This role partners across PreClinical R&D, Technical Operations (including Supply Management), Clinical Science & Operations, Data Sciences & Biostatistics, Quality, Regulatory Affairs, Pharmacovigilance, Program Management, Facilities & Medical Affairs. The Director supports the objectives of the Sr. Director by managing assigned platforms, initiatives & workstreams; coordinating vendors, contractors & project teams; & connecting functional needs to the integrated R&D roadmap across the research-to-commercial lifecycle. Success will be measured by stakeholder satisfaction; delivery of assigned roadmap commitments on schedule & within budget; inspection, submission, manufacturing, supply & launch readiness; availability, adoption & validated-state performance of assigned platforms; effective risk, vendor & financial management; & measurable business value from compliant data, analytics, automation & AI. ## MAJOR DUTIES & RESPONSIBILITIES: - Serve as a broad deputy to the Sr. Director, IT Business Partner, R&D, helping execute the integrated R&D technology strategy & representing R&D IT in assigned forums, initiatives & escalations. - Serve as IT business partner & system owner for assigned R&D platforms, accountable for roadmap execution, implementation, integrations, validated-state maintenance, service performance, security, data integrity, adoption & lifecycle planning within the strategy, architecture, investment priorities & governance established by the Sr. Director. - Lead vendors, contractors & cross-functional project teams for assigned initiatives, setting clear deliverables, coordinating resources, resolving delivery issues & escalating material risks or decisions to the Sr. Director. - Partner with R&D, TechOps, Quality & Facilities leaders, IT Council members, Security, Finance & Procurement to manage demand intake, develop business cases, recommend priorities, plan resources, oversee delivery, track benefits & prepare portfolio reporting. - Contribute to the R&D systems & data architecture & roadmap aligned to Phase 3, BLA, PDUFA, inspection, technology transfer, external manufacturing, commercial-readiness & operational-resilience objectives, translating approved direction into executable plans. - Represent IT for assigned systems & workstreams in GxP inspections, regulatory audits & internal quality reviews, ensuring system ownership, validation evidence, access controls, audit trails, vendor oversight & data integrity documentation are ready & defensible. - Lead assigned BLA submission-readiness workstreams, partnering with Regulatory Affairs to ensure relevant submission publishing & archival platforms, including Peer & Veeva RIM, are validated, optimized & inspection-ready ahead of the rolling BLA submission. - Manage assigned technology & data initiatives supporting 4DMT’s transition to a commercial organization across Regulatory Affairs, Pharmacovigilance, Medical Affairs, TechOps, Supply Management, Quality & Facilities, aligned to topline data, BLA, technology transfer, PDUFA & launch milestones. - Manage assigned safety technology capabilities for the transition from clinical to post-marketing safety operations, including Argus, signal detection, case intake / AE adjudication & social media safety monitoring. - Manage assigned laboratory systems & scientific informatics capabilities, including ELN, LIMS, scientific data platforms, instrument software, chromatography & analytical systems, imaging, NGS, sample & inventory management, & instrument connectivity, partnering with scientists, lab leaders & IT infrastructure to protect availability, cybersecurity, data integrity & chain of custody. - Support execution of the TechOps & Supply Management technology roadmap through assigned manufacturing, materials, inventory, planning, supplier, cold-chain, serialization, warehouse, logistics, external partner & product traceability initiatives integrated with enterprise, quality, laboratory & financial platforms. - Support execution of the Quality technology roadmap through assigned quality & document management, training, deviations, CAPA, change control, complaints, supplier quality, audits & inspection-management initiatives. - Partner with Facilities & Engineering on assigned technology supporting building management, environmental monitoring, maintenance management (CMMS), calibration, metrology, asset management, physical access, alarms & critical facility operations. - Help implement the unified R&D data strategy across clinical, scientific, manufacturing & quality data, including data governance, metadata, master data, FAIR principles, retention, archival & reuse for analytics & AI-enabled decision support. - Partner with the AI Governance Council & Quality to implement responsible, validated & auditable use of AI in assigned regulated GxP, laboratory & manufacturing workflows, applying the approved risk-scaled framework with model validation, human review & traceability. - Manage assigned R&D technology vendors & managed service providers, including contracts, budgets, forecasts, service levels, performance metrics, escalation, validation obligations, security, data protection, business continuity, exit planning & periodic risk reviews. - Apply 4DMT’s Computer System Validation, Computer Software Assurance & SDLC procedures using a risk-based, fit-for-purpose approach, ensuring controls for backup & recovery, role-based security, user provisioning, audit trails, data transfer & archival meet 21 CFR Part 11, Annex 11 & applicable 4DMT procedures for assigned platforms. - Provide assigned technology support for Medical Affairs field & launch-readiness capabilities, including medical content management & Medical, Legal & Regulatory review through Veeva PromoMats, until ownership transitions to the Sr. Director, Commercial IT Business Partner. - Maintain operational excellence & drive continuous improvement for assigned services, staying current on clinical technology, laboratory informatics, manufacturing, supply chain, quality, data management, AI & life sciences best practices. ## QUALIFICATIONS: Education: - BS/BA required, with a technical, scientific, engineering, information systems or computer science major preferred - MS/MA preferred - Veeva Vault Platform Administrator or relevant laboratory informatics, quality, supply chain or project-management certification a plus Experience: - 13+ years of progressive experience in IT, digital, clinical technology, laboratory informatics or manufacturing/quality technology roles in biotechnology, pharmaceutical or another regulated life sciences environment, including 8+ years leading R&D applications, business partnerships & GxP technology operations. - 3+ years leading vendors, contractors, technical contributors & cross-functional project teams across multiple R&D functions. - Experience supporting R&D systems & data through at least one Phase 3 clinical trial, one regulatory inspection, multiple regulatory submissions & a technology transfer or other major regulated operational milestone. - Deep experience applying risk-based system assurance, SDLC, change control, access management, supplier oversight, cybersecurity & data-integrity practices, with working knowledge of 21 CFR Part 11, EU Annex 11, ICH E6(R3), GAMP 5, cGMP, ALCOA+ & relevant data standards such as IDMP. Key Qualifications/Skills: - Deep understanding of Research/PreClinical, Clinical, Regulatory Affairs, Pharmacovigilance, TechOps, Supply Management, Quality & Facilities business processes across the research-to-commercial lifecycle. - Strong working knowledge of regulated R&D platforms, including CTMS, EDC, eTMF, eCOA/ePRO, IRT, statistical computing, RIM, safety, ELN, LIMS, scientific data, ERP, planning, warehouse, quality management, document & learning management, CMMS, calibration, environmental & building management systems. Experience with Veeva Vault, SAS, Spotfire, Argus, PeerAI, Sapio, Benchling, ACE, ComplianceWire, NetSuite, Blue Mountain, M365 Copilot or comparable platforms is preferred. - Proven ability to identify, evaluate & deploy AI solutions with business, IT, Quality, Security & AI governance stakeholders to maximize value & compliant use in regulated workflows. - Strong knowledge of enterprise & scientific data architecture, instrument connectivity, IT operations, cybersecurity, portfolio & project management, continuous improvement & organizational change management. - Strong senior-stakeholder partnership, influence & communication skills, including the ability to translate between business & technology audiences, make clear recommendations & operate effectively with senior scientific, clinical & operations leaders. - Contributes to a positive culture & thrives within a high-growth, fast-paced, small but growing company. - Accountable, responsive, self-driven & able to operate independently within established strategy, governance & decision rights, with timely escalation of material risks, tradeoffs & decisions. Physical Requirements and Working Conditions: - Physical Activity - Repetitive motions: Making substantial movements (motions) of the wrists, hands, and/or fingers. Fingering: Picking, pinching, typing or otherwise working, primarily with fingers rather than with whole hand or arm as in handling. Talking: Expressing or exchanging ideas by means of the spoken word. - Physical Requirements - Sedentary work: Exerting up to 10 pounds of force occasionally and/or a negligible amount of force frequently or constantly to lift, carry, push, pull or otherwise move objects, including the human body. Sedentary work involves sitting most of the time. Jobs are sedentary if walking and standing are required only occasionally, and all other sedentary criteria are met. - Working Conditions - The worker is not substantially exposed to adverse environmental conditions (as in typical office or administrative work). Base salary compensation range: $208,000 - $242,000 Please note, the base salary compensation range and actual salary offered to the final candidate depends on various factors: candidate’s geographical location, relevant work experience, skills, and years of experience. 4DMT provides equal employment opportunities to all employees and applicants for employment without regard to race, color, religion, gender, sexual orientation, national origin, age, disability, genetic information, marital status, status as a covered veteran, and any other category protected under applicable federal, state, provincial and local laws. Equal Opportunity Employer/Protected Veterans/Individuals with Disabilities ## About 4D Molecular Therapeutics ## Company Overview - **One-liner**: 4D Molecular Therapeutics is a late-stage clinical biotechnology company inventing and developing customized genetic medicines using a proprietary vector evolution platform to treat large-market diseases. - **Entity Type**: Public (NASDAQ: FDMT) - **Headquarters**: Emeryville, California, United States - **Founded**: 2013 - **Founders**: David Kirn, MD (Co-Founder, President, and CEO) ## Core Business - **Primary industry**: Biotechnology / Genetic Medicine / Gene Therapy - **Target customers**: B2B (partnerships with other biopharma companies) and B2C (patients with retinal and pulmonary diseases) - **Mission or purpose statement**: "To unlock the full potential of genetic medicines for large market diseases" by harnessing directed evolution to invent customized and enhanced vectors for transformative products. ## Products & Services - **4D-150**: A clinical-stage genetic medicine candidate for retinal vascular diseases (wet age-related macular degeneration and diabetic macular edema). It is designed as a single, routine, low-dose intravitreal injection that provides multi-year sustained delivery of anti-VEGF (aflibercept and anti-VEGF-C). Currently in Phase 3 clinical trials (4FRONT-1 and 4FRONT-2) for wet AMD and Phase 1/2 for DME. - **4D-710**: An investigational genetic medicine candidate for cystic fibrosis lung disease. It uses the A101 vector for aerosol delivery of a corrective CFTR transgene (CFTR∆R) and is designed for patients ineligible for or who have discontinued CFTR modulator therapy. Currently in Phase 1/2. - **4D-175**: A preclinical candidate for geographic atrophy (a form of dry AMD) using the R100 vector to deliver a shortened form of human complement factor H (sCFH) to restore normal complement regulation. - **4D-725**: A preclinical candidate for alpha-1 antitrypsin (A1AT) lung disease using the A101 vector for aerosol delivery. ## Market Standing - **Valuation/Market Cap**: $756.4 million (as of latest data from LinkedIn) - **Key Metric**: Annual Revenue of $85.2 million (as of latest data from LinkedIn) - **Notable Investors/Partners**: The company is publicly traded (IPO in 2020). Key partnerships are sought for pipeline candidates like 4D-175 and 4D-725. - **Growth Signals**: The company is a late-stage biotech with two Phase 3 trials (4FRONT-1 and 4FRONT-2) for its lead candidate 4D-150 in wet AMD, and a Phase 1/2 trial for 4D-710 in cystic fibrosis. The company has a presence in Ecuador, France, and India. LinkedIn followers grew 24.7% year-over-year. ## Competitive Advantages - **Proprietary Vector Platform (Therapeutic Vector Evolution)**: The company uses directed evolution to create customized and proprietary AAV vectors (e.g., R100 for retina, A101 for lung) that are optimized for specific tissues and routes of administration, which is a significant differentiator from standard gene therapy approaches. - **Large-Market Focus**: Unlike many gene therapy companies targeting ultra-rare diseases, 4DMT is focused on large-market indications (wet AMD, DME, cystic fibrosis) with high unmet need, offering a potentially massive commercial opportunity. - **Durable, Single-Dose Therapies**: Their products are designed to provide multi-year efficacy from a single injection, which could dramatically reduce treatment burden for patients compared to current standard-of-care (e.g., frequent eye injections for wet AMD). ## Strategic Focus - **Advancing Late-Stage Pipeline**: The primary focus is executing the Phase 3 programs for 4D-150 in wet AMD and progressing 4D-710 in cystic fibrosis. - **Expanding Indications**: The company is exploring 4D-150 for diabetic macular edema (DME) and seeking partnerships to advance 4D-175 (geographic atrophy) and 4D-725 (A1AT deficiency). - **Platform Expansion**: Continuing to leverage the Therapeutic Vector Evolution platform to develop new genetic medicines for other large-market diseases. ## Why Work Here - **Mission-Driven Culture**: The company is deeply committed to "daring to cure" and unlocking the potential of genetic medicine for patients with devastating diseases. Core values include "Dare to Cure," "Break Boundaries," "Prepare & Execute Relentlessly," and "Beyond Yourself." - **Innovative Science**: Employees work on cutting-edge science at the intersection of gene therapy, vector engineering, and clinical development, tackling some of the biggest challenges in medicine. - **Collaborative Environment**: The company emphasizes teamwork, internal and external collaboration, and a culture that empowers innovation. - **Location & Perks**: Based in Emeryville, CA (San Francisco Bay Area). The company offers a competitive benefits package and a dynamic, collaborative environment. - **Diversity & Inclusion**: 4DMT champions diversity, equity, and inclusion through an employee-led initiative called "4Diversity," which partners with charitable organizations and focuses on social equity. - **Work Authorization**: Candidates must be authorized to work in the U.S. The company does not sponsor new nonimmigrant visa status petitions but welcomes candidates who require transfers or extensions. ## Sources 1. [4dmoleculartherapeutics.com](https://4dmoleculartherapeutics.com/) 2. [4dmoleculartherapeutics.com - About](https://4dmoleculartherapeutics.com/about/) 3. [4dmoleculartherapeutics.com - Careers](https://4dmoleculartherapeutics.com/careers/) 4. [4dmoleculartherapeutics.com - Pipeline](https://4dmoleculartherapeutics.com/pipeline/) 5. 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