---
title: 'Director, Medical Affairs - Immunology at Nurix'
canonical: 'https://feeny.ai/job/director-medical-affairs-immunology-nurix-brisbane-california-8q3w67dea5xq'
type: 'job'
last_seen: '2026-09-09'
---

# Director, Medical Affairs - Immunology at Nurix

- **Company:** Nurix
- **Location:** Brisbane California, United States
- **Posted:** 2026-09-07
- **Last confirmed live:** 2026-09-09
- **Apply:** https://job-boards.greenhouse.io/nurix/jobs/8785543002

## Job description

Director, Medical Affairs – Immunology

Nurix Therapeutics is a clinical stage biopharmaceutical company focused on the discovery, development, and commercialization of targeted protein degradation medicines, the next frontier in innovative drug design aimed at improving treatment options for patients with cancer and inflammatory diseases. Powered by a fully AI-integrated discovery engine capable of tackling any protein class, and coupled with unparalleled ligase expertise, Nurix’s dedicated team has built a formidable advantage in translating the science of targeted protein degradation into clinical advancements. Nurix aims to establish degrader-based treatments at the forefront of patient care, writing medicine’s next chapter with a new script to outmatch disease.

Position Overview:

Nurix Therapeutics is seeking a Director, Medical Affairs – Immunology to lead medical strategy and execution for the company's Phase 2 immunology and inflammation (I&I) assets, with initial focus on bexobrutideg (NX-5948), an oral BTK degrader advancing into Phase 2 development in chronic spontaneous urticaria (CSU) and Multiple Sclerosis (MS) as part of Nurix's global collaboration with Roche. This role owns the tactical medical affairs plan for the CSU and MS Phase 2 programs end-to-end — from advisory input and KOL engagement through investigator relationships, field medical guidance, and evidence generation planning — and will expand scope as additional I&I assets advance through Phase 2.

Reporting to the Head of Medical Affairs, I&I, this leader will operate as the day-to-day scientific and strategic lead for the CSU and MS indications, translating emerging clinical and mechanism-of-action data into credible medical narratives for allergists, immunologists, dermatologists, neurologists and academic investigators. The role partners closely with Hematology, Clinical Development, Clinical Operations, HEOR, Regulatory, Legal, Compliance, and Nurix's co-development partner Roche to ensure medical activities are aligned with the development plan and conducted compliantly.

Key Responsibilities:

- Own and execute the Medical Affairs tactical plan for bexobrutideg in CSU and MS, including medical messaging, advisory boards, congress strategy, publication planning, and scientific engagement priorities, in partnership with the Head of Medical Affairs, I&I.
- Translate Phase 1/2 clinical and translational data (e.g., BTK degradation, FcεRI-driven biology) into clear, credible medical narratives for external and internal audiences.
- Provide Medical guidance to the Field Medical team supporting the Immunology Pipeline including education priorities, scientific training, and KOL engagement objectives.
- Build relationships with select key opinion leaders, allergists, immunologists, dermatologists, neurologists and academic investigators relevant to CSU, MS and the broader I&I portfolio.
- Support investigator identification, site engagement, and treatment-center collaboration to inform Phase 2 trial site selection and enrollment planning.
- Lead or co-lead advisory boards, investigator meetings, and congress activities (e.g., AAAAI) to gather external input and inform development and evidence generation priorities.
- Partner with Hematology, HEOR and Clinical Development on evidence generation planning to address stakeholder and future payer needs as the pipeline programs mature.
- Collaborate with External medical affairs counterparts to ensure aligned scientific messaging and engagement strategy under the co-development agreement.
- Partner with Regulatory, Legal, and Compliance to ensure all medical affairs activities are conducted within regulatory and compliance guardrails.
- Monitor the CSU, MS and broader I&I competitive and scientific landscape, translating insights into medical strategy recommendations.
- Contribute to the build-out of Medical Affairs infrastructure (SOPs, MLR processes, medical information) as the I&I function scales.

Qualifications:

- MD, PharmD, PhD, or DO required.
- 8+ years of biopharmaceutical Medical Affairs and/or Field Medical experience, with direct experience supporting clinical development of Phase 2 (or Phase 1b/2) assets.
- Demonstrated experience in translating scientific data and HCP feedback into effective medical communication strategy.
- Experience in immunology, allergy/immunology, dermatology, or related inflammatory/autoimmune disease areas required; strong preference for a combination of neuroscience and immunology expertise consistent with the Nurix portfolio.
- Demonstrated experience engaging neurologists, allergists, immunologists, dermatologists, and academic investigators to support trial enrollment, disease-state education, and scientific adoption.
- Experience partnering with Clinical Development, HEOR, Regulatory, Legal, and Compliance to align medical strategy with development priorities.
- Experience operating within a co-development or partnered program (large pharma collaboration) strongly preferred.
- Experience in a growth-stage or pre-launch biotechnology setting preferred.
- Excellent leadership, communication, and cross-functional collaboration skills, with the ability to operate both strategically and hands-on in a fast-moving, build-out environment.

Fit with Nurix Culture and Values

- Strong team orientation; highly collaborative
- Solutions and results-oriented focus
- Hands-on approach; resourceful and open to diverse points of view

Salary Range:   MD $283,000 - $316,500   NonMD $254,000 -285,000

Location:         Brisbane, CA - Onsite

## About Nurix

## Company Overview
- **One-liner**: Nurix Therapeutics is a clinical-stage biopharmaceutical company pioneering targeted protein degradation medicines to outmatch disease by harnessing the cell’s natural protein disposal system.
- **Entity Type**: Public (NASDAQ: NRIX)
- **Headquarters**: San Francisco, California, USA
- **Founded**: 2009
- **Founders**: Not publicly listed as individual founders; the company was spun out from research at UC Berkeley and UC San Francisco.

## Core Business
- **Primary industry**: Biopharmaceuticals / Targeted Protein Degradation
- **Target customers**: B2B (pharma partners) and B2C (patients via clinical trials and eventual commercial therapies); enterprise-level partnerships with major pharma.
- **Mission or purpose statement**: "Writing medicine’s next chapter using targeted protein degradation as a new script to outmatch disease." [nurixtx.com](https://www.nurixtx.com/)

## Products & Services
- **Bexobrutideg (NX-5948)**: A potential best-in-class BTK degrader in Phase 1b/2 clinical trials for relapsed/refractory CLL/SLL and chronic spontaneous urticaria. Co-developed and co-commercialized with Roche under a global collaboration announced June 2026. [nurixtx.com](https://www.nurixtx.com/)
- **NX-2127**: A BTK degrader in clinical development for B-cell malignancies.
- **CBL-B Inhibitor (NX-1607)**: An E3 ligase inhibitor designed to activate T cells for immuno-oncology, in Phase 1 clinical trials.
- **IRAK4 Degrader**: A partnered program with Gilead in Phase 1 for inflammatory diseases.
- **STAT6 Degrader**: A partnered program with Sanofi in IND-enabling studies.
- **DEL-AI Discovery Engine**: A proprietary, fully AI-integrated platform combining DNA-encoded libraries (DEL), automated chemistry, and machine learning to design and optimize targeted protein degraders and degrader-antibody conjugates (DACs).

## Market Standing
- **Valuation/Market Cap**: Not publicly available in the provided search results; as a public company (NRIX), market cap fluctuates daily. Check financial platforms for the latest figure.
- **Key Metric**: Annual Revenue (public) — Not publicly available in the provided search results; as a clinical-stage biotech, revenue is typically minimal or pre-revenue. Total funding raised prior to IPO is not detailed in the provided results.
- **Notable Investors/Partners**: Roche (global co-development and co-commercialization collaboration for bexobrutideg, announced June 2026), Gilead (partnered IRAK4 degrader program), Sanofi (partnered STAT6 degrader program).
- **Growth Signals**: Announced a landmark global collaboration with Roche in June 2026 to co-develop and co-commercialize bexobrutideg across malignant hematology, immunology, and neurology. Presented positive Phase 1a/b data for bexobrutideg in CLL/SLL and chronic spontaneous urticaria in 2026. Multiple partnered and wholly owned pipeline programs advancing through clinical and preclinical stages.

## Competitive Advantages
- **Proprietary DEL-AI Discovery Engine**: A fully AI-integrated platform combining DNA-encoded libraries, automated chemistry, and machine learning to design degraders against any protein class, providing a significant speed and innovation advantage. [nurixtx.com](https://www.nurixtx.com/)
- **Unparalleled Ligase Expertise**: Deep understanding of E3 ligase biochemistry and biology, a critical and complex component of the protein degradation mechanism, giving them a unique moat.
- **Multi-Modal Pipeline**: Developing both small molecule degraders and Degrader-Antibody Conjugates (DACs), expanding the therapeutic reach and creating multiple shots on goal.
- **Strong Partnership Network**: Collaborations with top-tier pharma (Roche, Gilead, Sanofi) validate their platform and provide non-dilutive funding and shared risk.

## Strategic Focus
- **Clinical Advancement**: Driving lead asset bexobrutideg through pivotal trials in CLL/SLL and expanding into immunology (chronic spontaneous urticaria) and neurology.
- **Platform Expansion**: Leveraging the DEL-AI engine to develop Degrader-Antibody Conjugates (DACs) for enhanced cell specificity and safety.
- **Pipeline Breadth**: Advancing a multi-modal pipeline across oncology, immunology, and neurology, both wholly owned and through strategic partnerships.
- **Partnership Leverage**: Deepening collaborations with Roche, Gilead, and Sanofi to co-develop and co-commercialize programs, reducing risk and accelerating timelines.

## Why Work Here
- **Culture**: Mission-focused, values-based, and spirited culture emphasizing "breakthrough innovation," "leadership," "accountability," and "zealousness." Employees are encouraged to "think big and act bold." [nurixtx.com](https://www.nurixtx.com/work-at-nurix/)
- **Work with Industry Leaders**: The team includes scientific innovators who built the protein degradation field, seasoned executives with biotech scaling expertise, and leading clinicians. [nurixtx.com](https://www.nurixtx.com/work-at-nurix/)
- **Growth & Impact**: Employees can "wear many hats" and gain broad exposure in a lean, virtual drug developer environment. The company emphasizes career growth and opportunity-rich experiences.
- **Work Policy**: Onsite in Brisbane, CA (San Francisco Bay Area) for most roles, as indicated by job postings. [nurixtx.com](https://www.nurixtx.com/explore-jobs/)
- **Benefits**: Comprehensive health and welfare plans, enhanced parental leave, wellness reimbursement, 401(k) employer match, and a highly collaborative culture. [nurixtx.com](https://www.nurixtx.com/work-at-nurix/)
- **Engineering/Science Culture**: Described as "mission-focused, values-based, and spirited," with a focus on "intellectual and technical ingenuity" and "intelligent risk-taking." The company is a "virtual drug developer" with a lean internal infrastructure, relying on SaaS and cloud platforms. [nurixtx.com](https://www.nurixtx.com/explore-jobs/)

## Sources
1. [nurixtx.com](https://www.nurixtx.com/)
2. [nurixtx.com](https://www.nurixtx.com/work-at-nurix/)
3. [nurixtx.com](https://www.nurixtx.com/explore-jobs/)
4. [nurixtx.com](https://www.nurixtx.com/our-story/)

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