--- title: 'Director, Nonclinical Toxicology Operations at Nurix' canonical: 'https://feeny.ai/job/director-nonclinical-toxicology-operations-nurix-brisbane-california-a7ynjr847xvh' type: 'job' last_seen: '2026-09-17' --- # Director, Nonclinical Toxicology Operations at Nurix - **Company:** Nurix - **Location:** Brisbane California, United States - **Posted:** 2026-09-08 - **Last confirmed live:** 2026-09-17 - **Apply:** https://job-boards.greenhouse.io/nurix/jobs/8785509002 ## Job description Director, Nonclinical Toxicology Operations Nurix Therapetics is a clinical stage biopharmaceutical company focused on the discovery, development, and commercialization of targeted protein degradation medicines, the next frontier in innovative drug design aimed at improving treatment options for patients with cancer and inflammatory diseases. Powered by a fully AI-integrated discovery engine capable of tackling any protein class, and coupled with unparalleled ligase expertise, Nurix’s dedicated team has built a formidable advantage in translating the science of targeted protein degradation into clinical advancements. Nurix aims to establish degrader-based treatments at the forefront of patient care, writing medicine’s next chapter with a new script to outmatch disease. Position Summary: Nurix Therapeutics is seeking a Director of Preclinical Safety and Toxicology Operations to drive planning and execution of nonclinical safety and toxicology activities within our Research and Early Development division. The role will be responsible for operations activities including owning timelines, budgets, contracts, and cross-functional coordination for a portfolio of targeted protein degradation programs.  The ideal candidate will be adept at partnering closely with subject matter experts, preclinical Project Leads, clinical Asset Team Leaders, and the SVP of Preclinical Toxicology who will provide oversight and scientific direction. The role has two complementary halves. The first is operational support to the nonclinical Safety and Toxicology function — helping study directors and toxicology leads scope and design studies, selecting and managing CROs, negotiating and administering contracts, and keeping study execution on schedule and on budget. The second is program-level project management for drug discovery projects as they transition from late lead optimization through IND filing, integrating chemistry, DMPK, pharmacology, safety, CMC, and regulatory timelines into a single credible plan. You will thrive here if you are highly organized, scientifically fluent, comfortable holding teams and stakeholders to a schedule, and energized by turning complex, interdependent work into clear milestones and decisions. Key Responsibilities: Toxicology study support and vendor management - Partner with Toxicology Leads and Study Directors to scope, design, and schedule GLP and non-GLP in vivo and in vitro safety studies, including exploratory tox, DRF, GLP repeat-dose toxicology, safety pharmacology, and genetic toxicology. - Identify, qualify, and manage CROs and specialty vendors; coordinate bid solicitation, bid defense, and vendor selection in partnership with Toxicology, Procurement, and Legal. - Own the contract lifecycle: draft and route work orders, MSAs, change orders, and amendments; track scope changes against budget; reconcile invoices and support accruals and forecasting. - Build and maintain integrated study timelines; monitor study milestones, sample logistics, bioanalytical turnaround, and report delivery, escalating slippage early with options rather than surprises. - Coordinate protocol and report review cycles, ensuring documents move efficiently through internal review, QA, and sign-off. - Track deliverables required for regulatory submissions, including study reports, certificates of analysis, and test article documentation. - Demonstrated ability to ensure safety issues are communicated rapidly and with appropriate escalation to the drug safety/project team, leadership and relevant agencies. Program management, late lead optimization to IND - Serve as project manager for assigned discovery and development programs from late lead optimization through candidate selection, IND-enabling studies, and IND filing. - Develop and maintain integrated program plans, critical paths, and resource views spanning medicinal chemistry, analytical chemistry, computational chemistry, DMPK, pharmacology, toxicology, CMC, and regulatory. - Run project team meetings: set agendas, capture actions and decision rationale in meeting minutes, and follow through to closure. - Maintain program dashboards, milestone trackers, and risk registers; surface risks with mitigation and contingency plans. - Prepare materials and pre-reads for portfolio reviews, governance meetings, and leadership updates; ensure a single, consistent version of program status. - Coordinate scenario and what-if planning to support go/no-go decisions, candidate selection, and IND timing. Cross-functional leadership and process - Act as a connective hub across functions and sites, resolving interface issues before they become timeline issues. - Contribute to continuous improvement of project management practices, templates, and tools within the group. Qualifications: Education - Required: M.S. or Ph.D. in a life sciences discipline (toxicology, pharmacology, biology, chemistry, pharmaceutical sciences, or related). - Preferred: formal project management credential such as PMP. ## Experience - Typically, 10+ years of relevant biotech or pharmaceutical experience, including demonstrable project management ownership of multidisciplinary programs. - Track record managing CROs and external vendors, including contracting, budget tracking, and performance management. - Direct experience supporting and coordinating IND-enabling activities - Working knowledge of small molecule drug discovery and development, nonclinical safety assessment, and GLP requirements, with scientific fluency sufficient to plan, question, and integrate the work. - Experience in targeted protein degradation, oncology, or immunology is an advantage. ## Skills and attributes - Proficiency with project management tools and methods, including integrated timelines, critical path analysis, and resource planning (e.g., MS Project, Smartsheet, Planisware, or equivalent). Familiarity with AI tools a plus. - Exceptional organizational skills and attention to detail, with the judgment to know what matters and what does not. - Clear, concise written and verbal communication; able to present status and risk to senior leadership without embellishment. - Ability to influence and drive accountability without direct authority across a group of senior, highly experienced scientists. - Comfort with ambiguity and shifting priorities in a fast-moving discovery environment. Reporting and Location - Reporting to SVP of Nonclinical Toxicology, Based at Nurix Therapeutics, Brisbane, CA, with on-site presence expected to support close partnership with laboratory and program teams. Fit with Nurix Culture and Values - Strong team orientation; highly collaborative - Solutions and results-oriented focus - Hands-on approach; resourceful and open to diverse points of view Salary Range:   $220,700 - $252,667 Location:         Brisbane, CA - Onsite ## About Nurix ## Company Overview - **One-liner**: Nurix Therapeutics is a clinical-stage biopharmaceutical company pioneering targeted protein degradation medicines to outmatch disease by harnessing the cell’s natural protein disposal system. - **Entity Type**: Public (NASDAQ: NRIX) - **Headquarters**: San Francisco, California, USA - **Founded**: 2009 - **Founders**: Not publicly listed as individual founders; the company was spun out from research at UC Berkeley and UC San Francisco. ## Core Business - **Primary industry**: Biopharmaceuticals / Targeted Protein Degradation - **Target customers**: B2B (pharma partners) and B2C (patients via clinical trials and eventual commercial therapies); enterprise-level partnerships with major pharma. - **Mission or purpose statement**: "Writing medicine’s next chapter using targeted protein degradation as a new script to outmatch disease." [nurixtx.com](https://www.nurixtx.com/) ## Products & Services - **Bexobrutideg (NX-5948)**: A potential best-in-class BTK degrader in Phase 1b/2 clinical trials for relapsed/refractory CLL/SLL and chronic spontaneous urticaria. Co-developed and co-commercialized with Roche under a global collaboration announced June 2026. [nurixtx.com](https://www.nurixtx.com/) - **NX-2127**: A BTK degrader in clinical development for B-cell malignancies. - **CBL-B Inhibitor (NX-1607)**: An E3 ligase inhibitor designed to activate T cells for immuno-oncology, in Phase 1 clinical trials. - **IRAK4 Degrader**: A partnered program with Gilead in Phase 1 for inflammatory diseases. - **STAT6 Degrader**: A partnered program with Sanofi in IND-enabling studies. - **DEL-AI Discovery Engine**: A proprietary, fully AI-integrated platform combining DNA-encoded libraries (DEL), automated chemistry, and machine learning to design and optimize targeted protein degraders and degrader-antibody conjugates (DACs). ## Market Standing - **Valuation/Market Cap**: Not publicly available in the provided search results; as a public company (NRIX), market cap fluctuates daily. Check financial platforms for the latest figure. - **Key Metric**: Annual Revenue (public) — Not publicly available in the provided search results; as a clinical-stage biotech, revenue is typically minimal or pre-revenue. Total funding raised prior to IPO is not detailed in the provided results. - **Notable Investors/Partners**: Roche (global co-development and co-commercialization collaboration for bexobrutideg, announced June 2026), Gilead (partnered IRAK4 degrader program), Sanofi (partnered STAT6 degrader program). - **Growth Signals**: Announced a landmark global collaboration with Roche in June 2026 to co-develop and co-commercialize bexobrutideg across malignant hematology, immunology, and neurology. Presented positive Phase 1a/b data for bexobrutideg in CLL/SLL and chronic spontaneous urticaria in 2026. Multiple partnered and wholly owned pipeline programs advancing through clinical and preclinical stages. ## Competitive Advantages - **Proprietary DEL-AI Discovery Engine**: A fully AI-integrated platform combining DNA-encoded libraries, automated chemistry, and machine learning to design degraders against any protein class, providing a significant speed and innovation advantage. [nurixtx.com](https://www.nurixtx.com/) - **Unparalleled Ligase Expertise**: Deep understanding of E3 ligase biochemistry and biology, a critical and complex component of the protein degradation mechanism, giving them a unique moat. - **Multi-Modal Pipeline**: Developing both small molecule degraders and Degrader-Antibody Conjugates (DACs), expanding the therapeutic reach and creating multiple shots on goal. - **Strong Partnership Network**: Collaborations with top-tier pharma (Roche, Gilead, Sanofi) validate their platform and provide non-dilutive funding and shared risk. ## Strategic Focus - **Clinical Advancement**: Driving lead asset bexobrutideg through pivotal trials in CLL/SLL and expanding into immunology (chronic spontaneous urticaria) and neurology. - **Platform Expansion**: Leveraging the DEL-AI engine to develop Degrader-Antibody Conjugates (DACs) for enhanced cell specificity and safety. - **Pipeline Breadth**: Advancing a multi-modal pipeline across oncology, immunology, and neurology, both wholly owned and through strategic partnerships. - **Partnership Leverage**: Deepening collaborations with Roche, Gilead, and Sanofi to co-develop and co-commercialize programs, reducing risk and accelerating timelines. ## Why Work Here - **Culture**: Mission-focused, values-based, and spirited culture emphasizing "breakthrough innovation," "leadership," "accountability," and "zealousness." Employees are encouraged to "think big and act bold." [nurixtx.com](https://www.nurixtx.com/work-at-nurix/) - **Work with Industry Leaders**: The team includes scientific innovators who built the protein degradation field, seasoned executives with biotech scaling expertise, and leading clinicians. [nurixtx.com](https://www.nurixtx.com/work-at-nurix/) - **Growth & Impact**: Employees can "wear many hats" and gain broad exposure in a lean, virtual drug developer environment. The company emphasizes career growth and opportunity-rich experiences. - **Work Policy**: Onsite in Brisbane, CA (San Francisco Bay Area) for most roles, as indicated by job postings. [nurixtx.com](https://www.nurixtx.com/explore-jobs/) - **Benefits**: Comprehensive health and welfare plans, enhanced parental leave, wellness reimbursement, 401(k) employer match, and a highly collaborative culture. [nurixtx.com](https://www.nurixtx.com/work-at-nurix/) - **Engineering/Science Culture**: Described as "mission-focused, values-based, and spirited," with a focus on "intellectual and technical ingenuity" and "intelligent risk-taking." The company is a "virtual drug developer" with a lean internal infrastructure, relying on SaaS and cloud platforms. [nurixtx.com](https://www.nurixtx.com/explore-jobs/) ## Sources 1. [nurixtx.com](https://www.nurixtx.com/) 2. [nurixtx.com](https://www.nurixtx.com/work-at-nurix/) 3. [nurixtx.com](https://www.nurixtx.com/explore-jobs/) 4. 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