---
title: 'Director, Process Chemistry at Praxis Precision Medicines, Inc.'
canonical: 'https://feeny.ai/job/director-process-chemistry-praxis-precision-medicines-inc-united-states-wd43azpwxys8'
type: 'job'
last_seen: '2026-09-13'
---

# Director, Process Chemistry at Praxis Precision Medicines, Inc. 

- **Company:** Praxis Precision Medicines, Inc. 
- **Location:** United States
- **Compensation:** $210k–$230k
- **Work type:** remote
- **Posted:** 2026-03-10
- **Last confirmed live:** 2026-09-13
- **Apply:** https://job-boards.greenhouse.io/praxisprecisionmedicines/jobs/5140290008

## Job description

Location:  This position may be performed remotely, but requires the flexibility and willingness to travel as needed.

The Opportunity

As Director of Process Chemistry, you will take the lead on drug substance activities for one or more projects within Praxis’ portfolio of small molecule programs to drive forward both clinical and commercial readiness.  You’ll design products & processes that support clinical phase testing and then mature those processes through development to Commercial supply.  Working intimately within the CMC and project teams under Agile management you’ll identify requirements and constraints of our product to define a workplan that will lead to the successful manufacturing and creation of a data package to support commercial regulatory submissions.

This role is ideal for someone who thrives in a fast-moving, collaborative environment, where science meets ownership. You’ll help define product requirements, anticipate challenges, and co-create practical, creative solutions that accelerate progress for patients in urgent need.

Primary Responsibilities

- Leads the Process Chemistry Research and Development for one or more projects from early to late phase within Praxis.
- Designs both early phase and late-phase/commercial drug substance process and then leads their demonstration from lab to pilot plant.
- Provides chemistry and technical leadership throughout the lifecycle
- Participates/leads activities to identify final API forms for pharmaceutical development.
- Working closely with formulations, analytical, operations, engineering and quality, expectation to be integrated into the overall CMC team responsible for delivery of clinical and commercial drug substance to Praxis programs.
- Identify, collaborate and lead external CRO, and CDMO organization(s) to achieve deliverables.
- Analyze external experimental data to drive synthetic experimental plans at CROs and CDMO.
- Authoring or co-authoring of regulatory submissions.
- Define manufacturing strategy and execution, including GMP requirements and issue resolution.
- Assessment and application of new trends and concerns in process development, quality and manufacturing to Praxis’ products.
- Manage quarterly budgeting of drug substance relevant activities.
- Contributor to inventions that add value to Praxis and its patients while strengthening our intellectual property position.

## Qualifications and Key Success Factors

- Advanced degree or commensurate experience equivalent in Chemistry, Pharmaceutical Sciences, Engineering or related discipline.
- Minimum of 12 years of industry experience in CMC specifically for small molecule drug substance.
- A scientific track record or working knowledge in continuous processing, biocatalysis, catalysis, and/or high throughput experimentation desirable.
- Strong knowledge of US and EU cGMP requirements and best practices relating to drug substances and drug products.
- Strong knowledge of CMC development across all phases of drug development from initial regulatory filings through registration, validation and launch.
- Experience in working with third-party CRO / CMO partners and associated service providers to develop and manufacturing pharmaceutical products.
- Experience with salt/crystalline form selection preferred.
- Experience with oligonucleotide chemistry is a plus
- Demonstrates a high level of intellectual curiosity, innovation and creative problem solving with an entrepreneurial spirit; can thrive in an agile environment.
- Excellent interpersonal and communication skills, with the ability to develop important relationships that include trust and encourage diversity in all its forms.
- Highly organized and detail-oriented with a passion to deliver quality results.

Annualized Base Salary $210,000—$230,000 USD

## Compensation & Benefits

At Praxis, we believe that taking care of our people (and their people) is important, so we provide a world class benefits package to help you thrive.  This includes 99% of the premium paid for medical, dental and vision plans.  We also provide company-paid life insurance, AD&D, disability benefits, and voluntary plans to personalize your coverage. Thinking about the future?  We match dollar-for-dollar up to 6% on eligible 401(k) contributions and sweeten the deal with long-term stock incentives and ESPP.  We provide a discretionary quarterly bonus, an extremely flexible wellness benefit, generous PTO, paid holidays and company-wide shutdowns.  Not to mention, you'll also be joining a phenomenal crew of colleagues who are smart, engaged and inspiring.  We aim high, collaborate hard, and produce results.  Let’s achieve the impossible together!

Company Overview

Praxis Precision Medicines is a clinical-stage biopharmaceutical company translating genetic insights into the development of therapies for central nervous system disorders characterized by neuronal imbalance.  At Praxis we share a common vision of reshaping the human condition into a more freeing and fulfilled existence by developing high impact medicines for patients and families affected by and living with complex brain disorders.  Our core Values of Trust, Ownership, Curiosity and Results are foundational to every aspect of our business and are exemplified by each and every one of our team members.

Diversity, Equity & Inclusion Guided by our core values, at Praxis Precision Medicines, Inc. we continue to DARE FOR MORE® to advance, promote, and champion diversity, equity, and inclusion by encouraging individuals to bring their authentic selves and perspectives to work each day. We are an equal opportunity employer and committed to providing opportunities to all qualified applicants without regard to race, religious creed, color, gender identity or expression, age, national origin, sexual orientation, disability, genetics, military service and veteran status, or any other characteristic protected by federal, state, or local laws.

Attention: Job Scam Alert Praxis has recently become aware of fraudulent job recruitment postings from individuals claiming to represent Praxis. These postings seek financial information in connection with fraudulent opportunities for employment. If you suspect any fraudulent activity or misrepresentation in connection with a Praxis job opportunity, please report it to careers@praxismedicines.com.

Praxis does not accept unsolicited submissions from recruitment agencies for open positions. We ask all recruitment agencies to refrain from contacting any Praxis employee regarding any position. All unsolicited resumes submitted by recruitment agencies to any Praxis employee in any form or method will be deemed to be the property of Praxis, and Praxis explicitly reserves the right to hire those candidate(s) without any financial obligation to the recruitment agency.

## About Praxis Precision Medicines, Inc. 

## Company Overview
- **One-liner**: Praxis Precision Medicines is a fully integrated, clinical-stage biopharmaceutical company developing precision therapies for central nervous system (CNS) disorders characterized by neuronal excitation-inhibition imbalance.
- **Entity Type**: Public (NASDAQ: PRAX)
- **Headquarters**: Boston, Massachusetts, United States
- **Founded**: 2015
- **Founders**: Dr. Steven Petrou (Co-Founder and President of R&D)

## Core Business
- **Primary Industry**: Biotechnology (CNS / Neuroscience)
- **Target Customers**: Patients with rare and prevalent neurological disorders (e.g., essential tremor, developmental and epileptic encephalopathies, focal epilepsy); healthcare providers; payers.
- **Mission / Purpose**: To translate genetic insights into the development of life-altering therapies for CNS disorders more effectively and efficiently.

## Products & Services
Praxis operates two proprietary platforms and a pipeline of late-stage and early-stage programs:
- **Cerebrum™ (Small Molecule Platform)**: Orally available precision therapies targeting ion channels and neuronal circuits. Key assets include:
    - **Ulixacaltamide**: A T-type calcium channel inhibitor for essential tremor (ET). NDA submission to the FDA expected by mid-February 2026. Breakthrough Therapy Designation.
    - **Relutrigine**: For SCN2A- and SCN8A-developmental and epileptic encephalopathies (DEEs). NDA submission expected by mid-February 2026. Breakthrough Therapy Designation. Also in Phase 3 for broad DEEs.
    - **Vormatrigine**: A sodium-channel modulator for focal onset seizures (FOS). In Phase 3 trials (POWER1, POWER2).
- **Solidus™ (Antisense Oligonucleotide Platform)**: For genetically defined CNS disorders. Key asset:
    - **Elsunersen**: An ASO designed to reduce SCN2A gene expression for early-seizure-onset SCN2A-DEE. In Phase 3 (EMBRAVE3). Orphan Drug Designation.
- **Early-Stage Pipeline**: Preclinical candidates (PRAX-020, PRAX-080, PRAX-090, PRAX-100) targeting other genetic epilepsies and neurodevelopmental disorders.

## Market Standing
- **Market Cap**: ~$156.0 million (as of mid-2026 data) [linkedin.com]
- **Key Metric (Revenue/Funding)**: Annual revenue reported at ~$8.6M (pre-commercial stage). Pro forma cash, cash equivalents, and marketable securities stand at **$1.5 billion** following a public offering in January 2026 that raised ~$621 million [ir.praxismedicines.com].
- **Notable Investors/Partners**: Ionis Pharmaceuticals, Inc. (collaboration on elsunersen); RogCon, Inc. (license agreement).
- **Growth Signals**:
    - Rapidly scaling headcount: 166 employees (+49.7% year-over-year) [linkedin.com].
    - Transformation to a commercial-stage company: Preparing for two NDA submissions by mid-February 2026.
    - Combined peak revenue estimates for its four late-stage assets expected to exceed **$20 billion** [ir.praxismedicines.com].
    - Active hiring: 31 open positions in mid-2026 (up 933% year-over-year) [linkedin.com].

## Competitive Advantages
- **Precision Neuroscience Moat**: Deep understanding of shared biological targets and circuits in the brain derived from genetic epilepsies.
- **Proprietary Dual Platforms**: Leveraging both small molecule (Cerebrum) and ASO (Solidus) modalities to address a wide range of CNS disorders.
- **Breakthrough Therapy Designations**: Both lead assets (ulixacaltamide, relutrigine) have FDA Breakthrough Therapy Designation, accelerating development and review.
- **Strong Cash Position**: $1.5 billion pro forma cash provides a long runway through multiple potential product launches and pipeline expansion.
- **Late-Stage Pipeline**: Four late-stage product candidates approaching potential commercial launch, de-risking the company substantially.

## Strategic Focus
- **Commercial Launch Readiness**: Building out commercial infrastructure, sales force, and patient support programs in parallel with regulatory submissions.
- **Pipeline Expansion**: Declaring multiple new drug candidates from both Cerebrum and Solidus platforms in 2026.
- **Lifecycle Management**: Exploring indication expansion for existing assets (e.g., relutrigine in broad DEEs via the EMERALD study; vormatrigine for monotherapy FOS).
- **Global Reach**: Operating in 5 countries (US, Australia, India, Colombia, Brazil) with a growing workforce.

## Why Work Here
- **Mission-Driven Work**: Opportunity to deliver transformative therapies to patients with severe, underserved CNS disorders.
- **Growth Trajectory**: The company is at a pivotal inflection point, transitioning from a clinical-stage to a commercial-stage organization — offering dynamic career growth.
- **Remote-First Culture**: The vast majority of open positions across all departments (Clinical, Medical, Commercial, Finance, Legal, etc.) are listed as **"United States - Remote"** [greenhouse.io]. This includes roles like Director, Commercial Compliance; Senior Clinical Trial Manager; and Director, Field Reimbursement.
- **Global Talent**: Engineering and technical roles are open internationally (e.g., Software Engineer in Brazil) [greenhouse.io].
- **Strong Leadership**: Recent appointments of experienced pharmaceutical executives (Jeffrey B. Kinder, Stuart Arbuckle) and internal promotions (Megan Sniecinski to COO).
- **Compensation**: Employee reviews indicate a strong **Compensation rating of 4.0/5.0**, though overall culture and career ratings are lower (2.8 and 2.7 respectively on LinkedIn) [linkedin.com].
- **Workforce Demographics**: A high proportion of Director-level roles are open (20% of workforce), alongside specialists and senior IC roles, suggesting significant opportunities for leadership-level hires.

## Sources
1. [greenhouse.io](http://job-boards.greenhouse.io/praxisprecisionmedicines) - Jobs at Praxis Precision Medicines, Inc.
2. [ir.praxismedicines.com](https://ir.praxismedicines.com/news-releases/news-release-details/praxis-precision-medicines-enters-its-next-chapter-following) - Press Release: Business Outlook and Priorities for 2026
3. [linkedin.com](https://www.linkedin.com/company/praxis-precision-medicines-inc) - LinkedIn Company Profile
4. [stockanalysis.com](https://stockanalysis.com/stocks/prax/company/) - Company Profile & Key Executives

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