---
title: 'Director, Program Management at Immunome, Inc.'
canonical: 'https://feeny.ai/job/director-program-management-immunome-inc-bothell-washington-n20n226vpr8t'
type: 'job'
last_seen: '2026-09-12'
---

# Director, Program Management at Immunome, Inc.

- **Company:** Immunome, Inc.
- **Location:** Bothell Washington, United States
- **Compensation:** $215k–$242k
- **Posted:** 2026-09-09
- **Last confirmed live:** 2026-09-12
- **Apply:** https://job-boards.greenhouse.io/immunomeinc/jobs/5418612008

## Job description

Company Overview

Immunome is a clinical-stage targeted oncology company committed to developing first-in-class and best-in-class targeted cancer therapies. We are advancing an innovative portfolio of therapeutics, supported by a leadership team with deep experience in the design, development, and commercialization of cutting-edge therapies, including antibody-drug conjugates. Our pipeline includes varegacestat, an investigational gamma secretase inhibitor for which an NDA has been accepted by the U.S. FDA; IM-1021, a clinical-stage ROR1 ADC; IM-1617, a clinical-stage solid tumor ADC; and IM-3050, a clinical-stage FAP-targeted radioligand therapy. We are also advancing a broad portfolio of early-stage ADCs pursuing undisclosed solid tumor targets.

Position Overview

The Director, Program Management is a hands-on program manager responsible for driving cross-functional planning and execution across two assets at different stages of development. First, this role will serve as the program manager for our first ADC program as it transitions from early to late-stage development, building the integrated development plan, operating cadence, and governance infrastructure required to carry the asset forward. Second, this role will support an early-stage asset within our radiopharmaceutical portfolio, serving as both the program manager and the CMC project manager from candidate selection through IND-enabling activities and early clinical evaluation.

This is a broad role that spans the development lifecycle and calls for a program manager who can drive stage-gate readiness for a maturing program while establishing the plans and processes that set an emerging one up for success. Reporting to the Senior Vice President of Project and Program Management, the successful candidate will partner closely with Research, Nonclinical, CMC, Clinical Development, Clinical Operations, Regulatory Affairs, Quality, and external partners to translate program strategy into actionable plans, align teams to the critical path, and provide decision-ready reporting to governance forums and senior leadership. This position will also contribute to evolving the program management operating model, tools, and templates to support a growing pipeline.

## Responsibilities

ADC Program Management – Early to Late-Stage Transition

- Serve as the program manager for our first ADC asset, owning the integrated development plan across clinical, nonclinical, CMC, and regulatory workstreams.
- Drive the operational transition from early to late-stage development, evolving team structure, planning rigor, and governance cadence to meet late-stage requirements.
- Build and maintain the integrated program timeline and critical path; proactively identify sequencing conflicts, resourcing constraints, and long-lead items.
- Drive preparation for key stage-gates, health authority interactions, and governance decision points, ensuring materials and recommendations are decision-ready.

Radiopharmaceutical Program Management – Early Stage

- Serve as the program manager for an early-stage radiopharmaceutical asset, supporting the cross-functional team from candidate selection through IND-enabling activities and early clinical evaluation.
- Develop the integrated early development plan spanning discovery deliverables, nonclinical studies, CMC, regulatory strategy, and first-in-human readiness.
- Coordinate workstreams into a single critical path and drive candidate selection and IND stage-gate readiness.
- Anticipate and plan for the operational and supply considerations specific to radiopharmaceutical development.

CMC Project Management

- Represent CMC on the core product development team, serving as the point of accountability for CMC deliverables, timelines, and risks.
- Develop and drive integrated CMC timelines to meet the needs of the product development team, coordinating activities across CMC functions.
- Serve as the primary liaison to contract manufacturing organizations and other external partners, managing scope, deliverables, and schedule adherence.
- Direct the CMC budgeting process for the program and manage project spend to target.

Cross-Functional Team Coordination

- Coordinate cross-functional teams spanning research, nonclinical, CMC, clinical development, clinical operations, regulatory affairs, quality assurance, and external partners.
- Facilitate core team and sub-team meetings; drive agendas, capture decisions and actions, and hold the team accountable to commitments.
- Foster a collaborative, transparent, and high-accountability team environment across both programs.

Stakeholder Engagement and Reporting

- Serve as the primary point of contact for internal and external stakeholders on program status, ensuring transparent communication of progress, risks, and mitigation plans.
- Prepare and present program updates, performance metrics, and outcomes to senior leadership and portfolio review forums.
- Direct the preparation of program dashboards, timelines, and executive presentations.

Risk and Issue Management

- Proactively identify program risks across technical, operational, supply, and regulatory dimensions.
- Develop, own, and drive mitigation and contingency strategies throughout the program lifecycle.
- Maintain and actively manage the program risk register; escalate with clear options and recommendations.

Budget and Resource Management

- Partner with Finance and functional leaders to develop and manage program budgets and forecasts; track spend versus plan and support prioritization decisions.
- Support program resourcing and capacity planning across functions; flag constraints early and propose options to protect the critical path.
- Secure and allocate resources to ensure efficient use across both programs.

Documentation and Compliance

- Ensure all program documentation is complete, accurate, and compliant with regulatory requirements.
- Maintain detailed records of program activities, including progress reports, meeting minutes, program decisions, and action items.
- Ensure programs adhere to industry standards, GxP expectations, and regulatory guidelines.

Program Management Operating Model

- Develop and implement metrics to evaluate program performance and use data-driven insights to recommend strategic adjustments.
- Contribute to the development and adoption of program management best practices, templates, dashboards, and tools across the portfolio.
- Support additional projects and initiatives within the project management organization as the company continues to grow.

## Qualifications

- Bachelor’s degree required in a technical or scientific field such as chemistry, chemical engineering, pharmaceutical sciences, biology, or a related life sciences discipline; advanced degree (PhD, MS, PharmD, MBA) preferred.
- Formal project management training or certification (e.g., PMP) highly desirable.
- 8 to 10 years of project and program management experience within the biotechnology or pharmaceutical industry preferred, including both drug development program management and CMC project management experience.

Knowledge and Skills

- Demonstrated success managing programs across multiple stages of development, including experience supporting the transition from early to late-stage.
- Direct, hands-on CMC project management experience, including ownership of manufacturing timelines and external manufacturing partnerships.
- Proven track record driving cross-functional core teams and managing complex, interdependent programs in a matrixed environment.
- Strong working knowledge of drug development functions and their key interdependencies, along with familiarity with FDA and EMA requirements and industry standards.
- Excellent cross-functional communication skills, with the ability to influence and build relationships at all levels of the organization.
- Demonstrated ability to manage multiple priorities in a fast-paced environment, with strong problem-solving and decision-making abilities.
- Proficiency in project management tools and software (e.g., Smartsheet, MS Project, Asana) and high proficiency in MS Office Suite (Word, Excel, PowerPoint).

## Preferred Experience

- Experience with antibody drug conjugates, radiopharmaceuticals, or other targeted oncology modalities.
- Oncology development experience and exposure to both large molecule and small molecule programs.
- Experience supporting regulatory submissions and health authority interactions (e.g., IND, CTA, briefing packages).
- Experience in a small to mid-size biotech environment where building process and infrastructure is part of the role.

Washington State Pay Range $214,962—$242,116 USD

E/E/O

Immunome, Inc. is an equal opportunity employer. We celebrate diversity and are committed to creating an inclusive environment for all employees.

E-Verify

Immunome, Inc. is a participant in E-Verify. Please review the following notices: [E-Verify Participation Poster](https://immunome.box.com/s/bopxukipfidxjscs4bjxt75f90bvpppk) | https://immunome.box.com/s/r51g9subw1wqni9xkutbl6up635sjr8e | https://immunome.box.com/s/r3ekbimwh988my9vzl76tnlbg60zvh9u.

## About Immunome, Inc.

## Company Overview
- **One-liner**: Immunome is a clinical-stage oncology company developing first-in-class and best-in-class targeted cancer therapies, with a primary focus on antibody-drug conjugates (ADCs).
- **Entity Type**: Public (Nasdaq: IMNM)
- **Headquarters**: Bothell, Washington, United States
- **Founded**: The company was formed through a merger of Morphimmune and Immunome in October 2023.
- **Founders**: The company is led by Clay Siegall, Ph.D. (Chairman, CEO, and President), who co-founded Seagen. The original Immunome entity was founded earlier, but the current company structure dates to the 2023 merger.

## Core Business
- Primary industry/industries: Biotechnology, Oncology, Drug Discovery & Development
- Target customers: Patients with cancer, healthcare providers, and clinical trial sites. The company is a B2B/B2C entity in the healthcare and life sciences space.
- Mission or purpose statement: "Our mission is to improve outcomes for cancer patients by advancing and expanding a portfolio of first-in-class and best-in-class therapeutic candidates." [immunome.com](https://immunome.com/)

## Products & Services
- **Varegacestat (formerly AL102)**: A late-clinical stage gamma secretase inhibitor for the treatment of desmoid tumors. The company submitted a New Drug Application (NDA) to the U.S. FDA in April 2026. [investors.immunome.com](https://investors.immunome.com/)
- **IM-1021**: A ROR1-targeted antibody-drug conjugate (ADC) currently in a Phase 1 trial.
- **IM-3050**: A FAP-targeted radioligand which received IND clearance in Q1 2025.
- **Preclinical ADC Pipeline (IM-1617, IM-1340, IM-1335)**: ADCs pursuing undisclosed targets with expression in multiple solid tumors. IM-1617 had its first patient dosed in a Phase 1 trial in June 2026. [investors.immunome.com](https://investors.immunome.com/)

## Market Standing
- **Valuation/Market Cap**: Not publicly available in the search results. As a public company, this fluctuates. (Check recent filings for current data).
- **Key Metric**: The company is pre-revenue (clinical-stage) and has raised significant capital. Since the 2023 merger, CEO Clay Siegall has raised $355 million in equity financings. [immunome.com](https://immunome.com/about/)
- **Notable Investors/Partners**: The company is publicly traded. Key leadership previously worked at Seagen (acquired by Pfizer for $43 billion).
- **Growth Signals**: The company is rapidly advancing its pipeline. Key milestones include the NDA submission for varegacestat, first patient dosed for IM-1617, and positive Phase 3 data presented at ASCO 2026. The company currently lists 32 open positions on its careers page, indicating strong hiring momentum. [job-boards.greenhouse.io](http://job-boards.greenhouse.io/immunomeinc)

## Competitive Advantages
- **World-Class Leadership**: The executive team, led by Seagen co-founder Clay Siegall, has deep experience in designing, developing, and commercializing blockbuster ADCs (ADCETRIS, PADCEV, TIVDAK, TUKYSA). [immunome.com](https://immunome.com/about/)
- **Proprietary ADC Platform**: A systematic, data-driven process for optimizing antibodies, linkers, and payloads to create differentiated ADCs. [immunome.com](https://immunome.com/)
- **Near-Term Catalyst**: The NDA submission for varegacestat provides a potential near-term commercial opportunity.
- **Strong Financial Backing**: Raised $355M in equity since the merger, providing a solid runway for pipeline advancement.

## Strategic Focus
- **Advancing the Pipeline**: The primary focus is on executing clinical trials for varegacestat (Phase 3), IM-1021 (Phase 1), and IM-3050 (Phase 1), and advancing preclinical ADCs into the clinic.
- **Regulatory Filing**: Successfully navigating the FDA NDA submission and potential approval for varegacestat.
- **Discovery & Expansion**: Using their ADC discovery platform to generate new candidates and identify and acquire targeted oncology assets to expand the portfolio. [immunome.com](https://immunome.com/about/)

## Why Work Here
- **Mission-Driven**: The work directly impacts the lives of cancer patients, with a stated goal of developing transformative therapies. [immunome.com](https://immunome.com/about/)
- **High-Impact Team**: Opportunity to work with "some of the brightest and most experienced minds in ADC development," including leaders who have brought multiple drugs to market. [immunome.com](https://immunome.com/careers/)
- **Growth Stage**: With 32 open roles, the company is in a rapid growth phase, offering significant career advancement opportunities. [job-boards.greenhouse.io](http://job-boards.greenhouse.io/immunomeinc)
- **Comprehensive Benefits**: Includes 100% company-paid medical premiums for employees, a 401(k) with employer match, paid parental leave, and a week-long winter break. [immunome.com](https://immunome.com/careers/)
- **Location & Culture**: Based in Bothell, WA. The company describes a culture of "innovative, collaborative environment where employees are empowered to do their best work." [immunome.com](https://immunome.com/careers/)

## Sources
1. [Immunome Official Website](https://immunome.com/)
2. [Immunome About Page](https://immunome.com/about/)
3. [Immunome Investor Relations](https://investors.immunome.com/)
4. [Immunome Careers Page](https://immunome.com/careers/)
5. [Immunome Jobs on Greenhouse](http://job-boards.greenhouse.io/immunomeinc)

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