---
title: 'Director/Senior Director, AI/ML for Drug Discovery at Septerna'
canonical: 'https://feeny.ai/job/director-senior-director-ai-ml-for-drug-discovery-septerna-south-san-francisco-h3g812gjhpds'
type: 'job'
last_seen: '2026-10-16'
---

# Director/Senior Director, AI/ML for Drug Discovery at Septerna

- **Company:** Septerna
- **Location:** South San Francisco, CA
- **Posted:** 2026-10-15
- **Last confirmed live:** 2026-10-16
- **Apply:** https://job-boards.greenhouse.io/septerna/jobs/5454752008

## Job description

Septerna is a biotechnology company based in South San Francisco, CA on a mission to develop life-changing medicines for patients with the vision to become the industry-leading G protein-coupled receptor (GPCR)-focused drug discovery company. The company’s Native Complex Platform™ recapitulates GPCRs with their native structure, function, and dynamics outside of the cellular context. This approach enables novel access to modern structural and screening technologies used in industrial-scale drug discovery for the entire class of GPCRs. Septerna has an emerging pipeline of GPCR-targeted small molecule programs, many in the Endocrinology space, with potential for growth to target many GPCRs that have been undruggable and unexploited to date.

We are excited to expand our multidisciplinary team of individuals focused on creating revolutionary medicines to address the unmet needs of patients. At Septerna we strive to embrace diversity of thought, expertise, and background through collaboration. To join our ambitious team, be prepared to bring your real self to work every day; grow and learn from a talented team of drug hunters, scientists, and business professionals; and contribute your passion, creativity, and energy to accomplish our mission. We share a fearless pursuit of ground-breaking innovations and cultivate an environment where our employees succeed by learning from each other and working as a team.

We are committed to the development of meaningful therapeutics for patients with indications of high unmet need. This is a tremendous opportunity to work with talented individuals on the frontlines of therapeutic discovery and development. You will directly help move therapies through preclinical research, positioning them for success in the clinic. The successful candidate will add their passion, unique talents, and expertise to a dynamic team motivated to discover new disease-modifying therapeutics for patients in a fast-paced environment.

For more information see: [www.septerna.com](http://www.septerna.com).

The Role:

Septerna is seeking an experienced scientific leader with expertise in AI/ML to lead our Data Science function. The successful candidate will implement advanced machine learning and statistical approaches to leverage Septerna’s proprietary GPCR structural and assay data in advancing our small-molecule drug discovery programs.

This is a visionary, hands-on leadership role that requires a strong understanding of our internal data assets, modern drug discovery practices, and advanced computational methods. This leader will create and execute a strategy for fully leveraging Septerna’s proprietary data, while collaborating closely with Computational Chemistry, Structural Biology, and other cross-functional research teams to accelerate hypothesis generation and advance scientific discovery.

The ideal candidate brings technical depth in machine learning, practical expertise in statistics, a strong scientific foundation in drug discovery, and the leadership capability to build a high-impact function in a fast-moving environment.

## Key Responsibilities

- Lead Septerna’s Data Science team, providing technical direction, developing team capabilities, and integrating and prioritizing projects, with a primary focus on machine-learning applications.
- Develop and execute a roadmap for implementing state-of-the-art AI/ML approaches that use Septerna’s GPCR structural data to discover and refine novel chemical matter.
- Identify productive emerging technologies; lead their integration into Septerna’s computational stack through internal development, strategic partnerships, or a combination of both.
- Oversee and extend analysis pipelines, including DNA-encoded library (DEL), high-throughput screening (HTS), and assay-data workflows, and identify opportunities to advance Data Science as part of the broader Platform development team.
- Advance and support ML-QSAR models leveraging internal and external assay and ADMET data to impact the efficiency of DMTA cycles and as a basis for generative chemistry workflows.
- Refine data-engineering and cloud-infrastructure requirements while establishing best practices for data curation and model validation.

Required Qualifications

- PhD in computational biology, computational chemistry, or a degree in computer science, applied mathematics or statistics that was focused on modeling biological systems.
- Minimum of 10+ years of relevant industry experience including application of machine learning to diverse scientific problems.
- Demonstrated leadership in machine learning for drug discovery, with a track record of building and applying predictive models to real-world, noisy, and multimodal scientific datasets.
- Experience applying co-folding or hybrid models to enable productive ligand pose prediction ideally on membrane proteins and flexible protein classes.
- Previous work transfer learning or fine-tuning foundation models and using appropriate metrics to demonstrate model performance improvements and characterize applicability domain.
- Experience leading teams and serving as the senior technical lead of cross functional initiatives with track record of applying technical insight and scientific judgement to guide research strategy.

Technical and Platform Requirements

- Expertise in scientific machine-learning and drug discovery dependencies such as PyTorch, scikit-learn, numpy, pandas, pyarrow, and RDKit.
- Deep knowledge of modern machine-learning and statistical methods, including gradient boosting decision trees (XGBoost, LGBM), graph neural networks (GNN/D-MPNN), transformers, generative modeling, active learning, and Bayesian optimization.
- Extensive experience with cloud and distributed computing environments, including AWS, GCP, or Azure, as well as building and maintaining containerized machine-learning workflows.
- A strong track record in MLOps and in partnering with software and platform engineering teams to define fit-for-purpose infrastructure for scientific applications.

## Preferred Qualifications

- Experience with molecular property prediction, generative chemistry, graph neural networks, protein–ligand modeling, sequence modeling, or physics-informed machine learning.
- Hands on structure-based drug discovery and experience collaborating closely with Computational Chemistry teams.
- Publications, patents, or open-source contributions in relevant scientific or machine-learning domains.

The anticipated salary range for candidates who will work in South San Francisco, CA is $240,000 - $300,000. Individual pay may vary based on additional factors, including, and without limitation, job-related skills, experience, work location and relevant education or training. Septerna's compensation package also includes benefits, stock options, and annual target bonus for full-time positions.

We are an Equal Opportunity employer and will consider all qualified applicants for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, protected veteran status, or disability status.

Note to Employment Agencies: Please do not forward any agency resumes. The company will not be responsible for any fees related to resumes that are unsolicited.

Note to Employment Agencies: Please do not forward any agency resumes. The company will not be responsible for any fees related to resumes that are unsolicited.  We are an Equal Opportunity employer and will consider all qualified applicants for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, protected veteran status, or disability status.  Septerna participates in the E-Verify program.  California Consumer Privacy Act Privacy Notice For Job Applicants.  If you are a California resident, click [here](https://septerna.com/california-consumer-privacy-act-privacy-notice-for-job-applicants/) for our CCPA Notice.

## About Septerna

## Company Overview
- **One-liner**: Septerna is a clinical-stage biotechnology company pioneering oral small molecule therapies targeting G protein-coupled receptors (GPCRs) using its proprietary Native Complex Platform®.
- **Entity Type**: Public (NYSE: SEPN)
- **Headquarters**: South San Francisco, California, United States
- **Founded**: 2020
- **Founders**: Jeffrey Finer, MD, PhD (CEO and Co-Founder); scientific founders include Robert Lefkowitz, MD (Nobel laureate), Arthur Christopoulos, PhD, and Patrick Sexton, PhD, DSc.

## Core Business
- **Primary industry**: Biotechnology – GPCR-targeted drug discovery and development.
- **Target customers**: Patients with unmet medical needs in endocrinology, immunology & inflammation, and metabolic diseases; potential pharmaceutical partners for co-development or licensing.
- **Mission**: To unlock the full potential of GPCR drug targets and develop the next generation of impactful new medicines for patients across therapeutic areas.

## Products & Services
- **Native Complex Platform®**: A proprietary technology that enables the isolation, purification, and reconstitution of functional GPCRs in their native lipid bilayer outside of cells. This platform allows structure-based drug design at industrial scale, targeting previously undruggable GPCRs and opening novel binding pockets.
- **SEP-479**: An oral small molecule PTH1R agonist in Phase 1 clinical development for hypoparathyroidism. Initiated Phase 1 trial in Australia in first half of 2026; topline data expected around end of 2026 or early 2027.
- **SEP-786**: A first-generation oral PTH1R agonist that was discontinued in February 2025 due to UGT1A1 inhibition leading to unconjugated bilirubin elevations.
- **Additional Pipeline**: Programs in immunology & inflammation, metabolic diseases (e.g., GPCR targets for metabolic disorders), and discovery-stage programs across neurology, women’s health, cardiovascular, and respiratory diseases.

## Market Standing
- **Valuation/Market Cap**: $826.4 million (as of mid-2026, per LinkedIn).
- **Key Metric**: Annual revenue not publicly available (pre-revenue, clinical-stage). Total funding: IPO in October 2024 raised approximately $215 million (including overallotment). Cash, cash equivalents, and marketable securities as of December 31, 2025 were not disclosed in the available 10-K summary.
- **Notable Investors/Partners**: Board includes seasoned biotech leaders such as Shalini Sharp, Keith M. Gottesdiener, MD, and Jeffrey Tong, PhD. Lead investors from the IPO and prior private rounds include Third Rock Ventures (co-led Series A) and other top-tier healthcare investors.
- **Growth Signals**: Headcount grew 40.9% year-over-year to 105 employees as of mid-2026; IPO in 2024; advancement of SEP-479 into Phase 1; active hiring across drug discovery, clinical development, regulatory, and technical accounting.

## Competitive Advantages
- **Native Complex Platform®** is the first industrial-scale method to isolate functional GPCRs outside living cells, enabling structure-based drug design for the ~75% of GPCRs that remain undrugged.
- World-class GPCR expertise: scientific founders include Nobel laureate Robert Lefkowitz and leaders in GPCR biology and pharmacology.
- Focus on oral small molecules for peptide GPCR targets offers patient convenience and dosing flexibility over injectable biologics.
- Deep pipeline targeting validated pathways with clear clinical precedent (e.g., PTH1R for hypoparathyroidism).

## Strategic Focus
- Advance SEP-479 through Phase 1 and into Phase 2 proof-of-concept trials.
- Expand pipeline within core therapeutic areas (endocrinology, immunology/inflammation, metabolic diseases).
- Continue platform innovation to unlock additional GPCR targets.
- Explore value-creating strategic partnerships to leverage the platform for new indications or geographies.

## Why Work Here
- **Culture**: Values-driven organization emphasizing “Kick-ass science rooted in daily innovation,” collaboration, patient urgency, and results-oriented tenacity. A strong commitment to diversity, open-mindedness, and transparent communication.
- **Work Environment**: Likely on-site / hybrid in South San Francisco (biotech standard). The company is in growth mode, offering opportunities to shape early-stage programs and work alongside renowned GPCR experts.
- **Benefits**: Comprehensive benefits package including health coverage, retirement plans, and perks designed to support employee well-being. Specific details not publicly detailed but noted as “meaningful benefits and perks” (careers page).
- **Engineering/Science Culture**: Drug hunters, GPCR experts, drug developers, and company builders collaborate in a data-driven, rigorous scientific environment. Active hiring in analytical development, regulatory affairs, clinical development, and pharmaceutical development.

## Sources
1. [septerna.com](https://www.septerna.com/)
2. [septerna.com/about](https://www.septerna.com/about/)
3. [septerna.com/careers](https://www.septerna.com/careers/)
4. [SEC 10-K (2025 Annual Report)](https://www.sec.gov/Archives/edgar/data/1984086/000119312526197525/d17403dars.pdf)
5. [LinkedIn Company Page](https://www.linkedin.com/company/septernainc)

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