--- title: 'Director / Senior Director, DMPK at Formation Bio' canonical: 'https://feeny.ai/job/director-senior-director-dmpk-formation-bio-boston-10bqxqx8sfs2' type: 'job' last_seen: '2026-11-07' --- # Director / Senior Director, DMPK at Formation Bio - **Company:** Formation Bio - **Location:** Boston, MA / New York, NY - **Posted:** 2026-11-02 - **Last confirmed live:** 2026-11-07 - **Apply:** https://job-boards.greenhouse.io/formationbio/jobs/8325520 ## Job description ## About Formation Bio Formation Bio is a tech and AI driven pharma company differentiated by radically more efficient drug development. Advancements in AI and drug discovery are creating more candidate drugs than the industry can progress because of the high cost and time of clinical trials. Recognizing that this development bottleneck may ultimately limit the number of new medicines that can reach patients, Formation Bio, founded in 2016 as TrialSpark Inc., has built technology platforms, processes, and capabilities to accelerate all aspects of drug development and clinical trials. Formation Bio partners, acquires, or in-licenses drugs from pharma companies, research organizations, and biotechs to develop programs past clinical proof of concept and beyond, ultimately helping to bring new medicines to patients. The company is backed by investors across pharma and tech, including a16z, Sequoia, Sanofi, Thrive Capital, John Doerr, Spark Capital, SV Angel Growth, and others. You can read more at the following links: - [Our Vision for AI in Pharma](https://www.formation.bio/blog/our-vision-for-ai-in-pharma) - [Our Current Drug Portfolio](https://www.formation.bio/licensing-and-pipeline) - [Our Technology & Platform](https://www.formation.bio/technology) At Formation Bio, our values are the driving force behind our mission to revolutionize the pharma industry. Every team and individual at the company shares these same values, and every team and individual plays a key part in our mission to bring new treatments to patients faster and more efficiently. ## About the Position Formation Bio is seeking an experienced Director of Drug Metabolism and Pharmacokinetics (DMPK) to provide scientific and strategic leadership across our growing portfolio of development-stage therapeutics. This role will have two important areas of responsibility. First, the Director will serve as a DMPK expert in the evaluation and diligence of potential in-licensing and acquisition opportunities, rapidly assessing the quality of available data, identifying key risks and uncertainties, and developing a clear view of an asset’s pharmacokinetic, translational, and clinical potential. Second, the Director will provide DMPK leadership for programs in our advanced preclinical and clinical pipeline, integrating nonclinical and clinical data to support development strategy, dose selection, clinical pharmacology, and regulatory decision-making. The ideal candidate combines deep technical expertise in DMPK with excellent drug-development judgment. They are equally comfortable digging into source data during a fast-moving diligence process, developing a quantitative understanding of an asset’s PK and exposure-response relationships, and representing DMPK on a multidisciplinary development team. This is a highly cross-functional role with the opportunity to influence both which medicines Formation Bio brings into its portfolio and how we develop them. ## Responsibilities - Serve as the DMPK subject-matter expert for scientific diligence of potential in-licensing, acquisition, and partnership opportunities across a range of therapeutic areas and stages of development. - Rapidly evaluate nonclinical and clinical PK (in collaboration with Clinical Pharmacology), ADME, metabolism, transporter, bioavailability, PK/PD, and exposure-response datasets to assess an asset’s strengths, liabilities, and development potential. - Critically assess the quality and completeness of available data, identify important gaps or inconsistencies, and distinguish issues that represent material development risks from those that can be readily addressed. - Evaluate human PK characteristics, dose and exposure projections, therapeutic margins, DDI potential, organ impairment considerations, formulation and absorption issues, and other factors that may affect an asset’s clinical profile. - Integrate DMPK findings with pharmacology, toxicology, clinical, CMC, and regulatory information to develop a holistic assessment of an asset. - Develop clear, decision-oriented recommendations for cross-functional diligence teams and senior leadership, including articulation of key risks, uncertainties, potential mitigations, and value-creating opportunities. - Define priority experiments, analyses, or data requests needed to resolve critical questions during diligence and transition promising assets into the Formation Bio portfolio. - Preclinical & Clinical Development - Provide DMPK leadership for advanced preclinical and clinical-stage programs, serving as the DMPK representative on cross-functional development teams. - Develop fit-for-purpose DMPK strategies from late preclinical development through IND/CTA, early clinical development, and subsequent stages of development. - Integrate in vitro ADME, animal PK, toxicokinetics, clinical PK, pharmacology, biomarker, and safety data to develop a quantitative understanding of exposure and response. - Lead human PK prediction and nonclinical-to-clinical PK/PD translation to inform FiH dose selection, and partner with Clinical Pharmacology and Pharmacometrics to support clinical dose escalation and dose optimization - Partner with Clinical Pharmacology to Identify and investigate unexpected or suboptimal clinical PK and develop hypotheses, analyses, and studies to inform program decisions. - Partner with Clinical Pharmacology to provide strategic oversight for metabolism, transporter and DDI assessments, metabolite characterization, MIST strategy, mass-balance studies, organ impairment assessments, food-effect studies, and other relevant clinical pharmacology activities. - Partner closely with Clinical Pharmacology, Pharmacometrics, Clinical Development, Toxicology, CMC, and other functions to optimize development plans. - Contribute to regulatory strategy and author or critically review relevant sections of INDs, CTAs, briefing documents, and other regulatory submissions. - Provide scientific oversight of CROs, consultants, and other external partners conducting DMPK and related studies. - Scientific & Programmatic Leadership - Bring an informed perspective to DMPK questions, ensuring that the depth and timing of work are appropriate to the maturity, risk, and value of each program. - Develop integrated views of DMPK and translational risk that enable rapid, high-quality portfolio decisions. - Establish and evolve fit-for-purpose DMPK capabilities, external partnerships, analytical approaches, and best practices as Formation Bio’s portfolio grows. - Communicate complex scientific findings clearly and concisely to multidisciplinary teams and senior leadership. ## About You - PhD in pharmaceutical sciences, pharmacokinetics, pharmacology, chemistry, biochemistry, or a related discipline, with typically 8+ years of relevant biotechnology or pharmaceutical industry experience, or an equivalent combination of education and experience. - Deep expertise in DMPK with substantial experience supporting development-stage small-molecule programs. - Demonstrated experience integrating nonclinical and clinical PK data to guide drug-development decisions. - Strong understanding of ADME, clearance mechanisms, drug metabolism, transporters, absorption and bioavailability, protein binding, tissue distribution, and drug-drug interactions. - Experience with human PK prediction, PK/PD and exposure-response analysis, and clinical translation. - Experience supporting IND-enabling development and clinical-stage programs; direct experience supporting first-in-human and subsequent clinical studies strongly preferred. - Strong working knowledge of regulatory expectations for DMPK and clinical pharmacology during drug development. - Experience evaluating complex datasets and making recommendations when information is incomplete, inconsistent, or evolving. - Demonstrated ability to work effectively with external CROs, consultants, and partners. - Excellent written and verbal communication skills, including the ability to synthesize complex technical information into clear conclusions for non-specialist and senior audiences. Total Compensation Range: $245,500 - $388,500; includes Director and Senior Director ranges Compensation Individual compensation is determined by several factors, including role scope, geographic location, and skills & experience. Your offer will reflect where you fall within the range based on these considerations. In addition to base salary, we offer equity, comprehensive benefits, and generous perks. If the posted range doesn't match your expectations, we still encourage you to apply! Where We Hire Formation Bio is prioritizing hiring in key hubs, primarily the New York City and Boston metro areas, with a hybrid model requiring 3 days per week in office. Applicants from the Research Triangle (NC) and San Francisco Bay Area may also be considered. Please apply only if you reside in these locations or are willing to relocate. Equal Opportunity Formation Bio is committed to building a diverse and inclusive team. We are an equal opportunity employer and welcome candidates from all backgrounds. All qualified applicants will receive consideration for employment without regard to race, color, creed, religion, national origin, ancestry, sex (including pregnancy, childbirth, breastfeeding, and related medical conditions), gender identity or expression, sexual orientation, age, disability, genetic information, marital status, military or veteran status, or any other characteristic protected by federal, state, or local law. We've seen a rise in recruiting impersonation scams across the industry, where fake profiles pose as recruiters aiming to trick candidates into sharing personal and financial information through illegitimate interviews and job offers. All legitimate recruiting communications from Formation Bio will come from a @formation.bio email address. If you receive outreach from someone claiming to work at Formation Bio through any other domain or channel, please disregard it and do not share any personal information. ## About Formation Bio ## Company Overview - **One-liner**: Formation Bio is an AI-native, tech-driven pharmaceutical company that acquires and develops clinical-stage drug candidates faster and more efficiently using its proprietary technology platform. - **Entity Type**: Private (Series D) - **Headquarters**: New York, New York, USA - **Founded**: Year not publicly specified; founded by Ben Liu and Linhao Zhang - **Founders**: Ben Liu (CEO & Co-Founder) and Linhao Zhang (Co-Founder) ## Core Business - **Primary industry**: Pharmaceuticals / Drug Development / AI in Biotech - **Target customers**: B2B; partners include pharmaceutical companies, universities, and biotech firms that have clinical-stage assets; end customers are patients awaiting new treatments. - **Mission or purpose statement**: "To bring new treatments to patients faster and more efficiently." ## Products & Services - **AI-Native Drug Development Platform**: A proprietary, tech-driven platform that integrates patient intelligence, data surveillance, and a universal data layer to power hyper-efficient clinical development across the drug lifecycle. - **Drug Asset Acquisition & Development**: Formation Bio acquires promising clinical-stage drug candidates from pharma, universities, and biotech, then develops them in-house using flexible financing pathways and bespoke exit strategies. - **Clinical Operations**: In-house management of trials including patient recruitment, site management, and study monitoring. ## Market Standing - **Valuation/Market Cap**: Not publicly disclosed (private company) - **Total Funding**: Not publicly disclosed in search results; investors include Sequoia Capital, a16z (Andreessen Horowitz), Thrive Capital, Section 32, Sam Altman, Michael Moritz, John Doerr, and others. - **Notable Investors/Partners**: Sequoia Capital, a16z, Thrive Capital, Section 32, Sam Altman, Michael Moritz, John Doerr; advisors include former Pfizer CSO Mikael Dolsten, former Allergan R&D head Lawrence Olanoff, and Microsoft EVP of CoreAI Jay Parikh. - **Growth Signals**: The team and advisors have collectively worked on 45+ approved drugs; the company is actively hiring across multiple functions (engineering, data science, clinical operations, business development) in four key hubs; has attracted top-tier tech and pharma talent. ## Competitive Advantages - **AI-Native Model**: Unlike traditional pharma, Formation Bio is built from first principles with AI and data-driven iteration at its core, creating feedback loops that accelerate decision-making. - **In-House Execution**: Runs trials in-house (patient recruitment, site management, monitoring) rather than outsourcing, enabling tighter control and faster cycles. - **Cross-Industry Talent**: Bridges the best of tech and pharma, combining software engineering, data science, and AI with deep drug development expertise. - **Flexible Deal Structures**: Offers varied financing and exit pathways for drug programs, making it a preferred partner for asset holders. ## Strategic Focus - **Radical Efficiency**: Ruthless process improvement across the drug development lifecycle without sacrificing quality or safety. - **Platform Scaling**: Building a scalable, tech-driven pharma company that can handle multiple drug programs simultaneously. - **Therapeutic Breadth**: Focusing on critical unmet patient needs across a variety of therapeutic areas. ## Why Work Here - **Mission-Driven**: "The world’s hardest problems deserve the world’s best people" — employees work on transforming how medicines are created, with tangible patient impact. - **Hybrid Culture**: Teams are hybrid based in four hubs: New York City, Boston, San Francisco Bay Area, and North Carolina’s Research Triangle. - **Comprehensive Benefits**: Health, vision, dental insurance; 401k; pre-tax commuter benefits; short and long-term disability; life insurance. - **Parental Leave**: 16 weeks paid for birthing parents, 12 weeks for non-birthing parents. - **Flexible PTO**: Trust-based time off policy. - **Professional Development**: Fireside chats with industry experts, conference passes, certification courses, internal mobility, manager training, leadership coaching. - **Community**: Quarterly company gatherings, bi-annual company-wide retreat, Employee Resource Groups. - **Engineering Culture**: AI-native, data-driven, first-principles thinking — a place for people who "chase excellence" and want to solve hard problems. ## Sources 1. [formation.bio](https://www.formation.bio/) 2. [formation.bio/about-us](https://www.formation.bio/about-us) 3. [formation.bio/careers](https://www.formation.bio/careers) 4. [formation.bio/our-model](https://www.formation.bio/our-model) 5. 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