---
title: 'Director, Tax at Definium Therapeutics'
canonical: 'https://feeny.ai/job/director-tax-definium-therapeutics-remote-3p6021vsf7fs'
type: 'job'
last_seen: '2026-11-10'
---

# Director, Tax at Definium Therapeutics

- **Company:** Definium Therapeutics
- **Location:** Remote
- **Compensation:** $200k–$290k
- **Work type:** remote
- **Posted:** 2026-11-06
- **Last confirmed live:** 2026-11-10
- **Apply:** https://job-boards.greenhouse.io/definiumtherapeutics/jobs/6250673004

## Job description

Definium Therapeutics is a late-stage clinical biopharmaceutical company and our mission is to forge a new era of psychiatry by applying scientific rigor to psychedelics, with the goal of developing accessible treatments that unlock healing at scale.

Our lead product candidate, lysergide tartrate (our proprietary orally disintegrating tablet form of lysergide (LSD) D-tartrate), represents a highly differentiated, potential best-in-class opportunity for patients suffering from generalized anxiety, major depressive disorder, and posttraumatic stress disorder. Our early stage pipeline includes DT402, the R-enantiomer of MDMA and is under development to target the core symptoms of autism spectrum disorder (ASD), specifically addressing social communication challenges.

Guided by the recognition that patients deserve more than better, Definium is relentlessly advancing a new generation of therapeutics intended to address the underlying causes of psychiatric and neurological disorders. By turning evidence into impact, Definium aims to change the trajectory of today’s mental health care crisis and enable a healthier future. Headquartered in New York, Definium Therapeutics trades on Nasdaq under the symbol DFTX.

Together we are moving psychiatry forward—beyond better, into a boundless future. Join us!

In this role, you will develop and execute Definium's tax strategy as we transition from a development-stage to a commercial-stage company. As our primary internal tax resource and trusted advisor to Finance leadership, you will oversee tax accounting and planning, coordinate compliance through external advisors, and build the infrastructure to support commercial operations. The ideal candidate pairs strong technical expertise with a practical, business-oriented approach and is comfortable leading strategy and executing hands-on.

Responsibilities:

- Lead Definium's tax strategy and planning, including the tax impact of financings, equity compensation, corporate structure changes, and strategic transactions
- Own ASC 740 tax accounting, including quarterly and annual provisions, deferred tax assets, valuation allowances, and uncertain tax positions, in support of SEC reporting and audits
- Oversee federal, state, local, and international compliance performed by external providers, and coordinate responses to tax authority inquiries
- Lead tax readiness for commercialization, including state and local, sales and use, franchise, and nexus considerations for a growing field-based and commercial workforce
- Manage tax attributes and credits, including Section 382 analyses, NOL preservation, and federal and state R&D credit studies
- Support business development, licensing, and collaboration transactions, plus transfer pricing and legal entity planning as needed
- Serve as principal liaison to external tax advisors, managing workstreams, budgets, and deliverables, and challenging recommendations as needed
- Partner with Accounting, FP&A, Treasury, Legal, Payroll, HR, Commercial, and Executive Leadership, and build scalable tax processes, policies, and documentation

Qualifications:

- Minimum bachelor's degree in accounting, Finance, Tax, or a related field required; Master's in Taxation (MST) or advanced tax credential preferred
- CPA certification required
- Minimum 10 years of progressive tax experience required
- Strong knowledge of ASC 740 and U.S. corporate taxation required
- Experience supporting public company reporting and managing external tax service providers required
- Strong project management, organizational, and communication skills, with the ability to balance strategy and hands-on execution
- Up to 10% travel will be required based upon business needs

Preferred:

- Big Four or national public accounting experience
- Biotech, pharmaceutical, life sciences, or healthcare industry experience
- Experience supporting organizations transitioning from development-stage to commercial operations.
- Experience with Section 382, NOL planning, R&D credits, multi-state taxation, equity compensation, and capital markets transactions

Individual compensation within the range is determined based on factors such as relevant skills, experience, qualifications, scope of the role, and other legitimate business considerations.  In addition to base salary, this role may be eligible for bonus and equity opportunities. We also offer a comprehensive benefits package including health insurance, 401(k) with company match, flexible time off and additional wellness benefits and perks.  Learn more about our benefits on our Careers page.

The anticipated base salary range for this position is: $200,000—$290,000 USD

## About Definium Therapeutics

## Company Overview
- **One-liner**: Definium Therapeutics is a clinical-stage biopharmaceutical company applying scientific rigor to psychedelic medicine to develop accessible treatments for psychiatric disorders.
- **Entity Type**: Public (NASDAQ: DFTX)
- **Headquarters**: Not specified in available sources; the company operates as a remote-first organization.
- **Founded**: 2019 (originally as MindMed)
- **Founders**: Not publicly available in provided sources.

## Core Business
- **Primary Industry**: Biotechnology / Psychiatric drug development (psychedelic medicine)
- **Target Customers**: Patients with major depressive disorder (MDD), generalized anxiety disorder (GAD), posttraumatic stress disorder (PTSD), and autism spectrum disorder (ASD); also healthcare providers and payers.
- **Mission/Purpose**: “Unlock healing at scale” by harnessing the full therapeutic potential of psychedelic medicine through precise, evidence-based science.

## Products & Services
- **DT120 ODT (Lysergide/LSD D-Tartrate Oral Disintegrating Tablet)**: Investigational drug for GAD, MDD, and PTSD. Currently in four Phase 3 trials (Voyage, Panorama, Emerge, Ascend) and a fifth planned for PTSD. FDA Breakthrough Therapy Designation for GAD. No adjunctive psychotherapy required.
- **DT402 (R(-)-MDMA)**: R-enantiomer of MDMA selected for serotonergic properties with a potentially superior tolerability profile. In Phase 2a study for social communication challenges in autism spectrum disorder.

## Market Standing
- **Valuation/Market Cap**: Not publicly available (publicly listed on NASDAQ as DFTX as of 2026, but recent market cap not provided in search results).
- **Key Metric**: Pre-revenue clinical-stage company; total funding history not disclosed in available sources.
- **Notable Investors/Partners**: Not disclosed in provided sources.
- **Growth Signals**:
  - Five Phase 3 trials ongoing or planned for DT120 ODT.
  - FDA Breakthrough Therapy Designation for DT120 in GAD.
  - Phase 2a trial initiated for DT402 in ASD.
  - Full results from Phase 2b GAD trial published in JAMA (2025).
  - Strong intellectual property with issued patents covering formulation, manufacturing, and treatment.

## Competitive Advantages
- **Proprietary Formulations**: Pharmaceutically optimized ODT for LSD (DT120) and novel R-enantiomer of MDMA (DT402) with potential improved tolerability.
- **Scientific Rigor**: Standalone drug studies without psychotherapy, enabling clearer efficacy and safety data.
- **Regulatory Momentum**: FDA Breakthrough Therapy Designation and multiple IND clearances.
- **Experienced Management Team**: Proven track record in developing and commercializing CNS therapies.
- **Comprehensive IP Strategy**: Patents covering drug formulations, methods of manufacture, and treatment use.

## Strategic Focus
- **Late-Stage Pipeline Advancement**: Completing Phase 3 trials for GAD and MDD, initiating PTSD trial.
- **Pipeline Expansion**: Advancing DT402 for ASD and exploring additional neuropsychiatric indications.
- **Commercial Readiness**: Building infrastructure (hiring VP of Sales, Senior Director of Field VEOR, etc.) to support potential future launch.
- **Data Generation**: Generating high-quality evidence to support regulatory submissions and differentiation.

## Why Work Here
- **Remote-First Culture**: “You can live anywhere in the country you’re employed in” (remote-first workforce).
- **Comprehensive Benefits**: 100% paid medical, dental, vision for employees and dependents; FSA/HSA; life and disability insurance.
- **Wellness & Time Off**: Annual wellness allowance, flexible PTO, company-wide shutdowns for rest.
- **Family Support**: Paid parental leave for birthing and non-birthing parents, 2-week return-to-work transition.
- **Financial Wellness**: Competitive compensation, 401(k) with employer match, employee equity (new hire grants and refreshes), Employee Stock Purchase Plan (ESPP) with discount.
- **Mission-Driven Work**: Opportunity to contribute to groundbreaking treatments in psychedelic psychiatry with a science-driven, collaborative team.

## Sources
1. [definiumtx.com](https://definiumtx.com/) – Company overview and pipeline details
2. [definiumtx.com](https://definiumtx.com/story/) – Company history, leadership, and strategic milestones
3. [definiumtx.com](https://definiumtx.com/careers/) – Careers page with benefits and remote-first policy
4. [definiumtx.com](https://definiumtx.com/research-development/) – Research and development pipeline details
5. [linkedin.com](https://www.linkedin.com/company/definiumtherapeutics) – LinkedIn company page

## Other roles at Definium Therapeutics

- [Director, Market Research, Competitive Intelligence & Forecasting](https://feeny.ai/job/director-market-research-competitive-intelligence-forecasting-definium-5rs3dqpfqnkw)
- [Director, Medical Marketing](https://feeny.ai/job/director-medical-marketing-definium-therapeutics-remote-mc5tpawqn5hb)
- [Regional Director, Site Engagement & Access](https://feeny.ai/job/regional-director-site-engagement-access-definium-therapeutics-remote-svpfzm9r0a9n)
- [Director, Medical Information](https://feeny.ai/job/director-medical-information-definium-therapeutics-remote-scwvv7cx6eas)
- [Senior Clinical Trial Manager](https://feeny.ai/job/senior-clinical-trial-manager-definium-therapeutics-remote-wvrjhsw19grb)
- [Associate Director, Brand Counsel](https://feeny.ai/job/associate-director-brand-counsel-definium-therapeutics-remote-drzwb505czfs)
- [Director, Field Operations](https://feeny.ai/job/director-field-operations-definium-therapeutics-remote-03sqbsdm57aa)
- [Manager, Data & Analytics](https://feeny.ai/job/manager-data-analytics-definium-therapeutics-remote-1myd7q4ncfyq)
- [Sr. Director, Sales Training](https://feeny.ai/job/sr-director-sales-training-definium-therapeutics-remote-4e05xqacax1x)
- [Associate Director, Statistical Programming](https://feeny.ai/job/associate-director-statistical-programming-definium-therapeutics-remote-32hes91t3fd9)