---
title: 'Director, Total Rewards at Nurix'
canonical: 'https://feeny.ai/job/director-total-rewards-nurix-brisbane-jbkaczfxvnp4'
type: 'job'
last_seen: '2026-10-15'
---

# Director, Total Rewards at Nurix

- **Company:** Nurix
- **Location:** Brisbane, CA
- **Posted:** 2026-09-21
- **Last confirmed live:** 2026-10-15
- **Apply:** https://job-boards.greenhouse.io/nurix/jobs/8826633002

## Job description

Director, Total Rewards

Position Description

Nurix is seeking a Director, Total Rewards to lead the strategy, design, and execution of our compensation and benefits programs. This is a high-visibility, high-impact role reporting directly to the Chief Human Resources Officer, with the opportunity to shape and scale total rewards infrastructure. The ideal candidate combines deep technical expertise in compensation and benefits with strong business acumen and sound judgment.

The Opportunity

## Compensation Strategy & Programs

- Own the design, implementation, and administration of Nurix’s base pay, incentive compensation, equity, and executive compensation programs
- Partner with the CHRO to lead annual compensation cycles, including merit increases, bonus funding and payout, and equity refresh grants
- Conduct and manage market benchmarking and job leveling to ensure competitive, equitable pay practices across the organization
- Monitor pay equity across the organization and lead proactive pay equity analyses and remediation
- Stay current on evolving compensation regulations (e.g., pay transparency, pay equity laws) and ensure company practices remain compliant across jurisdictions

## Benefits Strategy & Programs

- Design and manage a competitive, cost-effective benefits portfolio, including health and welfare plans, retirement programs (401(k)), leave policies, and wellness offerings
- Own vendor and broker relationships, lead renewal negotiations, and evaluate new offerings to ensure programs remain market-competitive and fiscally responsible
- Ensure benefits programs are compliant with ERISA, ACA, ADA, FMLA, COBRA, and other applicable federal and state regulations
- Lead open enrollment planning and execution, including employee communication and education strategies

Leadership & Cross-Functional Partnership

- Serve as the subject-matter expert (SME) and trusted advisor to the CHRO, Head of Talent, HRBPs, and people managers on compensation and benefits matters
- Partner closely with Finance on compensation budgeting, forecasting, and equity/stock plan expense modeling
- Partner with Legal on equity plan administration, 409A matters, and regulatory compliance
- Develop and deliver clear, effective communications and training to help managers and employees understand total rewards programs
- In partnership with Head of HR Operations, evaluate and implement HRIS/compensation tools and systems to improve efficiency, data integrity, and reporting capabilities

## What You’ll Bring

- Bachelor’s degree required; advanced degree or relevant certification (CCP, CBP, CEBS) preferred
- 8-10+ years of progressive experience in compensation and benefits, including at least 3-5 years in a total rewards leadership role
- Prior experience in biotech, pharmaceutical, or life sciences companies strongly preferred; experience in a clinical-stage or newly commercial company is a plus
- Deep knowledge of equity compensation structures (RSUs, ISOs/NSOs, ESPP) common in biotech
- Strong analytical skills with the ability to translate complex data into clear insights and recommendations
- Excellent judgment and discretion when handling highly sensitive compensation and personnel data
- Proven ability to build programs and processes in a growing, fast-paced environment
- Strong communication and stakeholder management skills, with the ability to influence at all levels of the organization, including the Board

Salary Range:  $250,800 – $278,800 annually

The posted range applies to roles based in the San Francisco Bay Area and reflects local market conditions. Where an offer lands within that range depends on the candidate’s relevant experience, technical expertise, and how their background aligns with the role’s requirements.

Location:        Onsite – Brisbane, CA

Fit with Nurix Culture and Values

- Strong team orientation; highly collaborative
- Solutions and results-oriented focus
- Hands-on approach; resourceful and open to diverse points of view

## About Nurix Therapeutics

Nurix Therapeutics is a clinical stage biopharmaceutical company focused on the discovery, development, and commercialization of targeted protein degradation medicines, the next frontier in innovative drug design aimed at improving treatment options for patients with cancer and inflammatory diseases. Powered by a fully AI-integrated discovery engine capable of tackling any protein class, and coupled with unparalleled ligase expertise, Nurix’s dedicated team has built a formidable advantage in translating the science of targeted protein degradation into clinical advancements. Nurix aims to establish degrader-based treatments at the forefront of patient care, writing medicine’s next chapter with a new script to outmatch disease.

## About Nurix

## Company Overview
- **One-liner**: Nurix Therapeutics is a clinical-stage biopharmaceutical company pioneering targeted protein degradation medicines to outmatch disease by harnessing the cell’s natural protein disposal system.
- **Entity Type**: Public (NASDAQ: NRIX)
- **Headquarters**: San Francisco, California, USA
- **Founded**: 2009
- **Founders**: Not publicly listed as individual founders; the company was spun out from research at UC Berkeley and UC San Francisco.

## Core Business
- **Primary industry**: Biopharmaceuticals / Targeted Protein Degradation
- **Target customers**: B2B (pharma partners) and B2C (patients via clinical trials and eventual commercial therapies); enterprise-level partnerships with major pharma.
- **Mission or purpose statement**: "Writing medicine’s next chapter using targeted protein degradation as a new script to outmatch disease." [nurixtx.com](https://www.nurixtx.com/)

## Products & Services
- **Bexobrutideg (NX-5948)**: A potential best-in-class BTK degrader in Phase 1b/2 clinical trials for relapsed/refractory CLL/SLL and chronic spontaneous urticaria. Co-developed and co-commercialized with Roche under a global collaboration announced June 2026. [nurixtx.com](https://www.nurixtx.com/)
- **NX-2127**: A BTK degrader in clinical development for B-cell malignancies.
- **CBL-B Inhibitor (NX-1607)**: An E3 ligase inhibitor designed to activate T cells for immuno-oncology, in Phase 1 clinical trials.
- **IRAK4 Degrader**: A partnered program with Gilead in Phase 1 for inflammatory diseases.
- **STAT6 Degrader**: A partnered program with Sanofi in IND-enabling studies.
- **DEL-AI Discovery Engine**: A proprietary, fully AI-integrated platform combining DNA-encoded libraries (DEL), automated chemistry, and machine learning to design and optimize targeted protein degraders and degrader-antibody conjugates (DACs).

## Market Standing
- **Valuation/Market Cap**: Not publicly available in the provided search results; as a public company (NRIX), market cap fluctuates daily. Check financial platforms for the latest figure.
- **Key Metric**: Annual Revenue (public) — Not publicly available in the provided search results; as a clinical-stage biotech, revenue is typically minimal or pre-revenue. Total funding raised prior to IPO is not detailed in the provided results.
- **Notable Investors/Partners**: Roche (global co-development and co-commercialization collaboration for bexobrutideg, announced June 2026), Gilead (partnered IRAK4 degrader program), Sanofi (partnered STAT6 degrader program).
- **Growth Signals**: Announced a landmark global collaboration with Roche in June 2026 to co-develop and co-commercialize bexobrutideg across malignant hematology, immunology, and neurology. Presented positive Phase 1a/b data for bexobrutideg in CLL/SLL and chronic spontaneous urticaria in 2026. Multiple partnered and wholly owned pipeline programs advancing through clinical and preclinical stages.

## Competitive Advantages
- **Proprietary DEL-AI Discovery Engine**: A fully AI-integrated platform combining DNA-encoded libraries, automated chemistry, and machine learning to design degraders against any protein class, providing a significant speed and innovation advantage. [nurixtx.com](https://www.nurixtx.com/)
- **Unparalleled Ligase Expertise**: Deep understanding of E3 ligase biochemistry and biology, a critical and complex component of the protein degradation mechanism, giving them a unique moat.
- **Multi-Modal Pipeline**: Developing both small molecule degraders and Degrader-Antibody Conjugates (DACs), expanding the therapeutic reach and creating multiple shots on goal.
- **Strong Partnership Network**: Collaborations with top-tier pharma (Roche, Gilead, Sanofi) validate their platform and provide non-dilutive funding and shared risk.

## Strategic Focus
- **Clinical Advancement**: Driving lead asset bexobrutideg through pivotal trials in CLL/SLL and expanding into immunology (chronic spontaneous urticaria) and neurology.
- **Platform Expansion**: Leveraging the DEL-AI engine to develop Degrader-Antibody Conjugates (DACs) for enhanced cell specificity and safety.
- **Pipeline Breadth**: Advancing a multi-modal pipeline across oncology, immunology, and neurology, both wholly owned and through strategic partnerships.
- **Partnership Leverage**: Deepening collaborations with Roche, Gilead, and Sanofi to co-develop and co-commercialize programs, reducing risk and accelerating timelines.

## Why Work Here
- **Culture**: Mission-focused, values-based, and spirited culture emphasizing "breakthrough innovation," "leadership," "accountability," and "zealousness." Employees are encouraged to "think big and act bold." [nurixtx.com](https://www.nurixtx.com/work-at-nurix/)
- **Work with Industry Leaders**: The team includes scientific innovators who built the protein degradation field, seasoned executives with biotech scaling expertise, and leading clinicians. [nurixtx.com](https://www.nurixtx.com/work-at-nurix/)
- **Growth & Impact**: Employees can "wear many hats" and gain broad exposure in a lean, virtual drug developer environment. The company emphasizes career growth and opportunity-rich experiences.
- **Work Policy**: Onsite in Brisbane, CA (San Francisco Bay Area) for most roles, as indicated by job postings. [nurixtx.com](https://www.nurixtx.com/explore-jobs/)
- **Benefits**: Comprehensive health and welfare plans, enhanced parental leave, wellness reimbursement, 401(k) employer match, and a highly collaborative culture. [nurixtx.com](https://www.nurixtx.com/work-at-nurix/)
- **Engineering/Science Culture**: Described as "mission-focused, values-based, and spirited," with a focus on "intellectual and technical ingenuity" and "intelligent risk-taking." The company is a "virtual drug developer" with a lean internal infrastructure, relying on SaaS and cloud platforms. [nurixtx.com](https://www.nurixtx.com/explore-jobs/)

## Sources
1. [nurixtx.com](https://www.nurixtx.com/)
2. [nurixtx.com](https://www.nurixtx.com/work-at-nurix/)
3. [nurixtx.com](https://www.nurixtx.com/explore-jobs/)
4. [nurixtx.com](https://www.nurixtx.com/our-story/)

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