---
title: 'Engineer, Downstream Process Development & MSAT at Scholar Rock'
canonical: 'https://feeny.ai/job/engineer-downstream-process-development-msat-scholar-rock-cambridge-geqsvbrgdw82'
type: 'job'
last_seen: '2026-09-07'
---

# Engineer, Downstream Process Development & MSAT at Scholar Rock

- **Company:** Scholar Rock
- **Location:** Cambridge, MA
- **Compensation:** $115k–$140k
- **Employment:** full-time
- **Work type:** hybrid
- **Posted:** 2026-08-31
- **Last confirmed live:** 2026-09-07
- **Apply:** https://jobs.lever.co/scholarrock/9c3df4f7-be61-458a-bf7e-56fcd98f5f48

## Job description

Scholar Rock is a late-stage global biopharmaceutical company focused on developing and commercializing apitegromab for children and adults with spinal muscular atrophy (SMA) and other rare, severe, and debilitating neuromuscular diseases. As a global leader in myostatin biology, a field focused on proteins that regulate muscle mass, the Company is named for the visual resemblance of a scholar rock to protein structures. Our commitment to unlock fundamentally different treatment approaches is powered by broad application of a proprietary platform, which has developed novel monoclonal antibodies to modulate protein growth factors with extraordinary selectivity. Scholar Rock works every day to create new possibilities for patients through its highly innovative anti-myostatin program, including opportunities in additional rare neuromuscular diseases. Learn more at ScholarRock.com and follow @ScholarRock on X and on LinkedIn.

Summary of Position:

The Technical Operations Department at Scholar Rock is seeking a scientifically curious and motivated engineer in the Downstream PD & MSAT group. The successful candidate is expected to be proficient in all aspects of the purification process and be comfortable working with a multifunctional team. Experience in late-stage process development and support of external manufacturing is preferred. The selected candidate will work alongside in-house scientists to advance existing projects through the development lifecycle and transfer to CMOs. Proficiency in AKTA operation, TFF, VRF, JMP for data trending and presentation, and design of experiment skills are key traits that will ensure success in this role.

Position Responsibilities

- Support external manufacturing of clinical and commercial assets
- Own and maintain process monitoring databases (CPV and lot history)
- Support manufacturing campaign readiness review process
- Drive batch production record review processes
- Author and drive Downstream change control implementation
- Work closely with CDMO to support tech transfer and manufacturing activities
- Technical presentation to greater TechOps team
- Support process development experiments to develop, optimize, and characterize purification processes for antibodies.
- Detailed documentation of all experimental studies

Candidate Requirements

- Educational background in Chemical Engineering, Biochemistry, Biotechnology, or related biological Sciences.
- Direct experience working with mAbs is preferred, and MSAT experience is highly desirable
- BS with 6+ years of experience
- MS with 4+ years of experience
- Ph.D. with 0-2 years of experience

Scholar Rock is an Equal Opportunity Employer. We celebrate diversity and are committed to creating an inclusive environment for all employees.

## About Scholar Rock

## Company Overview
- **One-liner**: Scholar Rock is a biopharmaceutical company discovering and developing selective therapies targeting growth factors for serious diseases with high unmet need.
- **Entity Type**: Public (NASDAQ: SRRK)
- **Headquarters**: Cambridge, Massachusetts, United States
- **Founded**: 2012
- **Founders**: Not publicly available

## Core Business
- **Primary industry**: Biotechnology / Biopharmaceuticals
- **Target customers**: Patients suffering from neuromuscular disorders, cancer, fibrotic diseases, and hematologic conditions; healthcare providers and payers
- **Mission**: “Turning scientific discoveries into a pipeline of investigational therapies aimed at diseases where growth factors play a central role.”

## Products & Services
- **Apitegromab (SRK-015)**: A selective anti‑latent myostatin antibody in Phase 3 for spinal muscular atrophy (SMA). BLA resubmission and U.S. launch anticipated in 2026.
- **SRK‑181**: A selective anti‑latent TGFβ1 antibody for locally advanced or metastatic solid tumors (immuno‑oncology).
- **SRK‑373**: A context‑dependent anti‑latent TGFβ1 antibody for multiple fibrotic indications.
- **SRK‑256**: A selective anti‑RGMc/HJV antibody for hematology indications.
- **Proprietary Platform**: Broad technology for generating monoclonal antibodies that selectively target latent forms of growth factors (TGFβ superfamily).

## Market Standing
- **Valuation/Market Cap**: $2.8 B (as of search date, 2026‑09‑06)
- **Key Metric**: Annual revenue $0 (pre‑commercial); IPO in 2018
- **Notable Investors/Partners**: Not publicly available
- **Growth Signals**: Headcount grew 27.4% YoY to 278 employees; workforce across 7 countries; 20,522 LinkedIn followers (+45.9% yearly); first company to show clinical proof‑of‑concept for a muscle‑targeted treatment in SMA.

## Competitive Advantages
- First‑in‑class platform for selectively targeting latent growth factors (TGFβ superfamily), enabling high specificity and reduced off‑target effects.
- Proven clinical proof‑of‑concept in SMA with apitegromab, a novel mechanism.
- Broad pipeline spanning neuromuscular, oncology, fibrosis, and hematology, with multiple programs in Phase 2/3.

## Strategic Focus
- Advance apitegromab toward regulatory submission and commercial launch in SMA.
- Expand pipeline into cardiometabolic disorders and other growth‑factor‑driven diseases.
- Leverage platform to address historically under‑addressed disease areas.

## Why Work Here
- **Culture**: “Passion for science” and “every voice counts” – a collaborative, trust‑based environment focused on changing patients’ lives.
- **Work Policy**: Hybrid (e.g., Senior Director, Business Analytics in Cambridge, MA) and on‑site roles available.
- **Benefits**: Competitive health/dental/vision plans, life/AD&D insurance, short‑ and long‑term disability, paid parental leave, 401(k) match, financial wellness program, professional development, free parking/transit pass, onsite fitness center, weekly community lunches, peer‑to‑peer recognition.
- **Engineering/Science Culture**: Emphasis on innovation, cross‑functional teamwork, and direct impact on serious diseases.

## Sources
1. [scholarrock.com – Company Overview](https://scholarrock.com/our-company/careers/)
2. [scholarrock.com – Investors & Media](https://scholarrock.com/investors-media/)
3. [scholarrock.com – Pipeline](https://scholarrock.com/our-pipeline/)
4. [jobs.lever.co/scholarrock – Open Positions](https://jobs.lever.co/scholarrock)
5. [linkedin.com/company/scholar-rock – Company Profile](https://linkedin.com/company/scholar-rock)

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