---
title: 'Executive Director, Clinical Development at Tango Therapeutics'
canonical: 'https://feeny.ai/job/executive-director-clinical-development-tango-therapeutics-boston-xhzk5j65r72k'
type: 'job'
last_seen: '2026-09-08'
---

# Executive Director, Clinical Development at Tango Therapeutics

- **Company:** Tango Therapeutics
- **Location:** Boston, MA
- **Compensation:** $315k–$473k
- **Posted:** 2026-08-17
- **Last confirmed live:** 2026-09-08
- **Apply:** https://job-boards.greenhouse.io/tangotherapeutics/jobs/7855068003

## Job description

Company Overview

Tango Therapeutics is a biotechnology company dedicated to discovering novel drug targets and delivering the next generation of precision medicine for the treatment of cancer.

Using an approach that starts and ends with patients, Tango leverages the genetic principle of synthetic lethality to discover and develop therapies that take aim at critical targets in cancer.

This includes expanding the universe of precision oncology targets into novel areas such as tumor suppressor gene loss and their contribution to the ability of cancer cells to evade immune cell killing.

The Tango labs and offices are located at 201 Brookline Avenue, in the Fenway area of Boston, Massachusetts.

Summary

Tango Therapeutics is seeking a visionary and strategic oncology leader to serve as Executive Director, Clinical Development. Reporting directly to the President of Research & Development, this highly visible executive will lead the clinical development strategy for an early-stage program.

As a senior clinical and scientific leader, you will partner with Translational Medicine, Biometrics, Clinical Pharmacology, Regulatory, Medical Affairs, and Executive Leadership driving cross-functional alignment, prioritization, and operational excellence. You will serve as an external facing ambassador for Tango, representing the company within the scientific and medical communities.

This role offers the opportunity to shape enterprise-wide clinical development strategy, build high-performing development capabilities, and play a pivotal role in advancing transformational therapies for patients with cancer.

Your Role:

As Executive Director, Clinical Development, you will provide strategic leadership for the development of TNG456. Working closely with cross-functional leaders, you will together be responsible execution of clinical studies and enable informed portfolio decisions. You will represent Tango within the external oncology community to advance innovative therapies for patients with cancer. You will manage, mentor and develop Medical Directors supporting TNG456.

- Provide strategic leadership for clinical development, including protocol design, regulatory strategy, and cross-functional execution
- Lead, mentor, and develop physicians, fostering a culture of scientific excellence, integrity and collaboration
- Oversee the preparation of key regulatory documents, including INDs, CTAs, protocols, and briefing packages
- Partner with Project Management and cross-functional leaders to drive governance, operational excellence, and program execution
- Guide clinical trial execution through investigator engagement, patient recruitment strategies, and quality oversight
- Build and maintain strong relationships with key opinion leaders, investigators, and external collaborators
- Represent Tango at scientific meetings, advisory boards, and other external engagements
- Support scientific communications, including publications, abstracts, and presentations

What You Bring:

- MD with board certification or eligibility in Medical Oncology or Hematology/Oncology
- 11+ years of oncology clinical development experience in biotech or pharma, spanning early- and late-stage development
- Expertise designing and executing oncology clinical trials involving targeted therapies
- Experience building and leading high-performing clinical development teams
- Deep knowledge of ICH-GCP, FDA, and global regulatory requirements
- Strategic, collaborative leader with excellent communication and cross-functional leadership skills
- Exceptional communication, collaboration, and cross-functional leadership skills, with the ability to influence across diverse scientific and operational teams
- Resourceful, adaptable, and execution-focused with a passion for advancing innovative cancer therapies

We are an equal opportunity employer and value diversity at our company. We do not discriminate on the basis of race, religion, color, national origin, gender, sexual orientation, age, marital status, veteran status, or disability status.

Salary range $315,200—$472,800 USD

## About Tango Therapeutics

## Company Overview
- **One-liner**: Tango Therapeutics is a clinical-stage biotechnology company leveraging the principle of synthetic lethality to discover and develop next-generation precision cancer medicines for genetically defined patient populations.
- **Entity Type**: Public (NASDAQ: TNGX)
- **Headquarters**: Boston, Massachusetts, United States
- **Founded**: 2017
- **Founders**: Not publicly disclosed (launched by Third Rock Ventures)

## Core Business
- **Primary industry/industries**: Biotechnology, Precision Oncology, Drug Discovery & Development
- **Target customers**: B2B (pharma partnerships, clinical trial sites); ultimate customers are cancer patients with specific genetic tumor profiles
- **Mission or purpose statement**: "Discover transformative drugs for people with cancer by leveraging the classic principles of synthetic lethality in innovative ways… building a road map to cures that will transform the lives of patients and their families." [tangotx.com](https://www.tangotx.com/join-us/)

## Products & Services
- **Vopimetostat (PRMT5 inhibitor)**: A clinical-stage, wholly-owned program targeting MTAP-deleted cancers, including pancreatic, lung, and glioblastoma. Currently in Phase 1/2 trials. [tangotx.com](https://www.tangotx.com/pipeline/)
- **TNG456 (PRMT5 inhibitor)**: A next-generation PRMT5 inhibitor for MTAP-deleted cancers, currently in pre-clinical development.
- **Daraxonrasib (RAS inhibitor)**: A combination therapy (with vopimetostat) for MTAPdel/RASmut pancreatic and lung cancers. Recently reported a 92% objective response rate in pancreatic cancer in a Phase 1/2 trial. [tangotx.com](https://www.tangotx.com/)
- **CRISPR-based Target Discovery Engine**: A proprietary platform for identifying novel synthetic lethal targets, enabling a robust pipeline of wholly-owned programs.

## Market Standing
- **Valuation/Market Cap**: ~$1.05 billion (as of mid-2026) [linkedin.com](https://www.linkedin.com/company/tango-therapeutics)
- **Key Metric**: Annual Revenue of ~$62.4 million; Total Funding raised ~$901 million (including post-IPO). [linkedin.com](https://www.linkedin.com/company/tango-therapeutics)
- **Notable Investors/Partners**: Third Rock Ventures (lead Series A), Boxer Capital (lead Series B), BCTG Acquisition Corp (parent). Strategic partners include pharma and biotech companies (collaborations under active exploration). [linkedin.com](https://www.linkedin.com/company/tango-therapeutics)
- **Growth Signals**: Completed a $600 million upsized public offering in June 2026; strong clinical data (92% ORR in pancreatic cancer); pipeline expanding into glioblastoma; headcount growth in job postings (+400% YoY in active roles). [tangotx.com](https://www.tangotx.com/)

## Competitive Advantages
- **Synthetic Lethality Expertise**: A deep, proprietary understanding of CRISPR-based target discovery to identify novel vulnerabilities in cancers with tumor suppressor gene loss, undruggable oncogenes, and immune evasion mechanisms.
- **Genetically Defined Patient Selection**: All programs are designed for well-defined patient populations with clear biomarkers, increasing the probability of clinical success and reducing trial risk.
- **Wholly-Owned Pipeline**: Unlike many biotechs that license out rights, Tango retains full ownership of its lead programs, capturing maximum value.
- **Strong Financial Position**: With over $1B in market cap and a recent $600M offering, the company is well-capitalized to advance its pipeline through pivotal trials.

## Strategic Focus
- **Current priorities**: Advancing vopimetostat and daraxonrasib into Phase 3 trials for pancreatic and lung cancers; expanding the pipeline into glioblastoma; continuing to discover and validate new synthetic lethal targets; building out commercial manufacturing and clinical operations infrastructure.
- **Direction for growth**: Becoming a fully-integrated biotechnology company capable of bringing its own medicines to market, while selectively pursuing strategic collaborations to expand reach.

## Why Work Here
- **Culture highlights**: Emphasizes "urgency + compassion," "courage + leadership," "spirit + resilience," and "embrace individuality and face challenges together." Described as a team of "passionate problem solvers" who are "all in for exciting science and changing lives." [tangotx.com](https://www.tangotx.com/join-us/)
- **Remote/hybrid/office policy**: Primarily on-site at Boston HQ (201 Brookline Ave, Suite 901, Boston, MA). Roles appear to be Boston-based, though some field-based positions (e.g., Medical Science Liaisons) are remote.
- **Notable perks or engineering culture**: High scientific ambition with a clear patient-first mission; strong leadership team with deep oncology experience; active hiring across clinical operations, biostatistics, medical affairs, and legal/compliance; 15+ active job postings with significant YoY growth in roles. [greenhouse.io](http://job-boards.greenhouse.io/tangotherapeutics)
- **Workforce**: ~129 employees, with a mix of research (26%), medical (12%), and operations roles. Notable alumni from Novartis, Vertex, Takeda, and Broad Institute. [linkedin.com](https://www.linkedin.com/company/tango-therapeutics)

## Sources
1. [Tango Therapeutics Official Website](https://www.tangotx.com/)
2. [Tango Therapeutics Careers Page (Greenhouse)](http://job-boards.greenhouse.io/tangotherapeutics)
3. [Tango Therapeutics LinkedIn Profile](https://www.linkedin.com/company/tango-therapeutics)
4. [Tango Therapeutics Pipeline Page](https://www.tangotx.com/pipeline/)
5. [Tango Therapeutics Join Us Page](https://www.tangotx.com/join-us/)

## Other roles at Tango Therapeutics

- [Vice President, Marketing & Sales](https://feeny.ai/job/vice-president-marketing-sales-tango-therapeutics-boston-ex81335qs4hc) — Boston, MA
- [Executive Director, Insights & Analytics](https://feeny.ai/job/executive-director-insights-analytics-tango-therapeutics-boston-4f5kkx80kztw) — Boston, MA
- [Senior Vice President, Market Access](https://feeny.ai/job/senior-vice-president-market-access-tango-therapeutics-boston-47tt1fw4qxxq) — Boston, MA
- [Senior Manager, Clinical Informatics](https://feeny.ai/job/senior-manager-clinical-informatics-tango-therapeutics-boston-g3pk44zmymam) — Boston, MA
- [Executive Director, FP&A](https://feeny.ai/job/executive-director-fp-a-tango-therapeutics-boston-kph81hnp4jvk) — Boston, MA
- [Manager, Total Rewards](https://feeny.ai/job/manager-total-rewards-tango-therapeutics-boston-fywb3xy2sabn) — Boston, MA
- [Associate Director, Pharmacovigilance Scientist](https://feeny.ai/job/associate-director-pharmacovigilance-scientist-tango-therapeutics-boston-5cgk3mmdsprr) — Boston, MA
- [Associate Medical Director, Pharmacovigilance](https://feeny.ai/job/associate-medical-director-pharmacovigilance-tango-therapeutics-boston-4kcjnjy0vpys) — Boston, MA
- [Clinical Trials Manager](https://feeny.ai/job/clinical-trials-manager-tango-therapeutics-boston-7yaaz94j244a) — Boston, MA
- [Senior Director, Clinical Sciences](https://feeny.ai/job/senior-director-clinical-sciences-tango-therapeutics-boston-j8hypf1vqq14) — Boston, MA