---
title: 'Executive Director, Clinical Pharmacology at Kardigan'
canonical: 'https://feeny.ai/job/executive-director-clinical-pharmacology-kardigan-princeton-qcc162jet0d8'
type: 'job'
last_seen: '2026-11-07'
---

# Executive Director, Clinical Pharmacology at Kardigan

- **Company:** Kardigan
- **Location:** Princeton, NJ
- **Compensation:** $255k–$332k
- **Posted:** 2026-07-20
- **Last confirmed live:** 2026-11-07
- **Apply:** https://job-boards.greenhouse.io/kardigan/jobs/5364648008

## Job description

## About Us

Kardigan is a heart health company working to make cardiovascular disease preventable, curable and no longer the leading cause of death in the world.

It is Kardigan’s mission to develop multiple targeted treatments in parallel that bring people with cardiovascular diseases to the cures they deserve.

Led by Tassos Gianakakos, Jay Edelberg, M.D., Ph.D., and Bob McDowell, Ph.D., Kardigan’s co-founders have reunited after leading MyoKardia to discover and develop mavacamten, the first cardiac myosin inhibitor, resulting in an acquisition by Bristol Myers Squibb in 2020.

We have a cutting-edge discovery and translational research platform, a pipeline of late-stage candidates, and an industry-leading team that is driven to improve the lives of patients.

At Kardigan, we are motivated by our values which guide how we work, interact, and achieve our goals. Driven by patients and their families, we are deeply committed to improving the lives of patients and prioritizing their needs above all else. We believe in being authentic—leading with truth to bring out the best in others by creating an environment where every person knows they will be fully accepted. With an eagerness to learn, we encourage the highest levels of curiosity and are open to changing our minds. We are committed to winning as a team with urgency, excellence, and intention, and support each other no matter what role we play or where we sit. Lastly, we strive to enable the impossible because patients are counting on us. We are not afraid to take risks to unlock innovation and advance scientific discoveries.

These values are the foundation of our work, empowering us to make a real difference, every day.

## About the Job

Job Title: Executive Director, Clinical Pharmacology

Level: Executive Director

Department: Early Development

Hiring Manager: Vice President, Early Development

Location: Princeton, NJ

Classification: Hybrid – On-site 4 days per week (Mon to Thurs)

Job Overview

Reporting to the Vice President, Early Development, the Executive Director, Clinical Pharmacology will provide enterprise-level strategic and scientific leadership for the Clinical Pharmacology function across Kardigan’s cardiovascular development portfolio. This individual will be responsible for defining, establishing, and driving clinical pharmacology strategies from early through late-stage development, supporting regulatory submissions, and serving as the company’s senior clinical pharmacology leader and strategic representative for FDA and other global health authority interactions. This role will partner cross-functionally with senior leaders to shape portfolio priorities, inform critical development decisions, and ensure successful development and registration strategies.

This is a highly visible executive-level leadership position requiring both strategic vision and hands-on execution within a fast-paced, collaborative biotechnology environment. The Executive Director will play a critical role in building and advancing Kardigan’s internal clinical pharmacology capabilities, establishing scientific standards, and ensuring the function effectively supports the company’s long-term pipeline and organizational objectives.

Essential Duties and Responsibilities

- Provide executive-level strategic leadership, functional direction, and operational ownership of the Clinical Pharmacology function, transitioning activities currently supported by external consultants into a sustainable, internally led capability aligned with Kardigan’s portfolio and growth objectives.
- Define, develop, and execute integrated clinical pharmacology strategies across multiple development programs from early phase through late-stage clinical development and regulatory submission, ensuring alignment with portfolio priorities, development milestones, and regulatory objectives.
- Serve as the senior clinical pharmacology leader and primary strategic representative for FDA and other global health authority interactions, including INDs, End-of-Phase meetings, briefing documents, and future NDA submissions, providing scientific leadership and strategic guidance on complex regulatory matters.
- Lead and provide strategic oversight of clinical pharmacology components of development plans, including dose selection, dose optimization, exposure-response analyses, population pharmacokinetic (PopPK) analyses, PK/PD modeling, food effect studies, drug-drug interaction assessments, QT evaluations, and special population strategies.
- Provide scientific oversight for pharmacometric analyses and collaborate with internal and external experts to ensure high-quality interpretation of clinical pharmacology data and its integration into critical program and portfolio-level decisions.
- Oversee external clinical pharmacology consultants and vendors, ensuring scientific excellence, timely execution, and high-quality deliverables, while developing an effective operating model, resource strategy, and internal capabilities to support evolving business needs.
- Collaborate closely with Clinical Development, Clinical Operations, Translational Medicine, Biometrics, Regulatory Affairs, Medical Writing, CMC, Research, and other cross-functional partners to integrate clinical pharmacology strategy into overall program and development plans, influencing key decisions and driving alignment across functions and leadership teams.
- Provide strategic direction for, author and review clinical pharmacology sections of regulatory documents, including INDs, Investigator’s Brochures, briefing books, clinical study reports, NDA submissions, and responses to health authority questions, ensuring scientific rigor, consistency, and regulatory readiness.
- Present clinical pharmacology strategies, data, and recommendations to senior leadership, governance committees, and external stakeholders, serving as a trusted scientific advisor on development strategy, risk assessment, and critical decision-making.
- Establish and continuously strengthen the Clinical Pharmacology function, including scientific standards, governance processes, resource planning, and the strategic use of internal and external expertise.
- Provide functional leadership, mentorship, and scientific guidance to internal team members and external partners, supporting organizational capability development and future team growth as appropriate.
- Stay current with evolving regulatory guidance, scientific advances, and industry best practices to continuously strengthen Kardigan’s clinical pharmacology capabilities and proactively identify opportunities to improve development efficiency, scientific innovation, and regulatory success.

## Qualifications and Experience

## Minimum Qualifications

- Ph.D. in Clinical Pharmacology, Pharmaceutical Sciences, Pharmacometrics, Pharmacokinetics, or a related scientific discipline.
- Approximately 15+ years of clinical pharmacology experience within the biotechnology and/or pharmaceutical industry, including significant strategic and functional leadership responsibility across multiple clinical development programs.
- Demonstrated experience defining, developing, and leading integrated clinical pharmacology strategies supporting early and late-stage clinical development, including portfolio-level strategic planning and decision-making.
- Demonstrated experience with the design, conduct, and interpretation of clinical pharmacology studies such as drug-drug interaction, food effect, and special populations.
- Expertise in the application of population pharmacokinetics (PopPK), pharmacokinetic/pharmacodynamic (PK/PD) modeling, exposure-response analyses, dose optimization, and model-informed drug development to enable clinical development decisions.
- Proven experience serving as the clinical pharmacology lead for FDA and other global regulatory agency interactions, including the ability to lead complex scientific discussions and influence regulatory strategy.
- Experience leading clinical pharmacology contributions to INDs, regulatory briefing packages, NDA/BLA submissions, and responses to regulatory questions.
- Strong understanding of global regulatory expectations related to clinical pharmacology and quantitative drug development.
- Demonstrated success leading cross-functional initiatives and influencing scientific and development strategy within a matrix organization, including the ability to drive alignment and decision-making at the senior leadership level.
- Demonstrated ability to establish functional strategy, manage external partnerships, and build organizational capabilities in a dynamic development environment.
- Excellent leadership, communication, presentation, and scientific writing skills, with demonstrated executive presence and the ability to communicate complex scientific concepts and strategic recommendations to senior leadership and diverse stakeholders.

## Preferred Qualifications

- Experience supporting cardiovascular or cardiometabolic drug development programs.
- Previous experience playing a leadership role in one or more successful NDA and/or BLA submissions.
- Experience building or expanding clinical pharmacology capabilities within an emerging biotechnology company, including establishing functional infrastructure, operating models, and resource strategies.
- Familiarity with quantitative systems pharmacology approaches.
- Demonstrated ability to balance strategic leadership with hands-on execution in a fast-paced, collaborative environment.
- Strong problem-solving, decision-making, and organizational skills with the ability to manage multiple priorities simultaneously and navigate complex development challenges with sound scientific and business judgment.

## Equal Employment Opportunity

Kardigan is an Equal Opportunity Employer. We are committed to creating a diverse and inclusive workplace and consider all qualified applicants for employment without regard to race, color, religion, sex (including pregnancy, childbirth, breastfeeding, gender identity, gender expression, and sexual orientation), national origin, age, disability, genetic information, veteran status, marital status, citizenship status, or any other characteristic protected by applicable federal, state, or local law. We are committed to providing reasonable accommodations to qualified individuals with disabilities throughout the application and employment process. Exact Compensation may vary based on skills, experience and location.

Pay range $255,000—$332,000 USD

## About Kardigan

## Company Overview
- **One-liner**: Kardigan is a publicly traded biopharmaceutical company developing targeted cardiovascular therapies with the aim of transforming treatment from symptom management toward functional cures.
- **Entity Type**: Public (ticker not available from provided sources; IPO closed as per company announcement)
- **Headquarters**: South San Francisco, California, United States (with additional offices in Princeton, New Jersey and Chicago, Illinois)
- **Founded**: Year not specified in available sources
- **Founders**: Tassos Gianakakos (Co-Founder, CEO & Chair), Dr. Jay Edelberg (Co-Founder & Chief Medical Officer), Dr. Bob McDowell (Co-Founder & Scientific Adviser), Brianne Puglisi (Co-Founder)

## Core Business
- **Primary industry**: Biopharmaceuticals – cardiovascular drug discovery and development
- **Target customers**: B2B / B2G – healthcare providers, hospitals, payers, and patients; the company develops prescription medicines for serious cardiovascular conditions
- **Mission or purpose statement**: “To make cardiovascular disease preventable, curable and no longer the leading cause of death in the world.” ([kardigan.bio](https://www.kardigan.bio/))

## Products & Services
- **Tonlamarsen**: A Phase 2/3 candidate for acute severe hypertension (ASH) and uncontrolled hypertension. Positive Phase 2 data presented as a late-breaker at ACC.26 and simultaneously published in JACC. ([kardigan.bio](https://www.kardigan.bio/))
- **Danicamtiv**: A Phase 3 candidate for genetic dilated cardiomyopathy (DCM), targeting the underlying inherited cardiac muscle disease. ([kardigan.bio](https://www.kardigan.bio/))
- **Calcific Aortic Valve Stenosis (CAVS) Program**: A late-stage clinical program addressing calcium deposition that stiffens the aortic valve. ([kardigan.bio](https://www.kardigan.bio/))
- **Prolaio Subsidiary**: An AI and real‑world data platform integrated into Kardigan to generate insights, inform clinical trial design, and reduce time/cost of drug development. ([kardigan.bio](https://www.kardigan.bio/about-us/))
- **Cardiac Intelligence Platform**: A discovery and translational research engine that uses real‑world patient data, AI, and deep cardiovascular expertise to identify disease drivers and design targeted therapies. ([kardigan.bio](https://www.kardigan.bio/))

## Market Standing
- **Valuation/Market Cap**: Not disclosed in provided sources
- **Key Metric**: Public company (IPO closed); annual revenue not disclosed
- **Notable Investors/Partners**: Not explicitly listed in provided sources; company built on the team’s track record from MyoKardia (acquired by Bristol Myers Squibb for $13.1B in 2020)
- **Growth Signals**:
  - Positive Phase 2 pivotal data for Tonlamarsen in hypertension, presented at ACC.26 and published in JACC
  - Three late‑stage clinical programs (CAVS, ASH, DCM) running in parallel
  - Active job postings across 210+ roles in clinical operations, data science, manufacturing, and corporate strategy, indicating scaling ([job-boards.greenhouse.io/kardigan](http://job-boards.greenhouse.io/kardigan))
  - Integration of Prolaio’s AI platform to accelerate R&D

## Competitive Advantages
- **Leadership expertise**: CEO Tassos Gianakakos previously scaled MyoKardia from startup to a $13.1B acquisition; the team includes veterans from MyoKardia, Sanofi, BMS, and Merck.
- **Parallel pipeline strategy**: Multiple late‑stage programs targeting distinct cardiovascular diseases (valve, hypertension, cardiomyopathy) de‑risks development and creates data synergies.
- **Cardiac Intelligence platform**: Proprietary combination of real‑world data, AI, and deep biological insight to move beyond symptom management toward modifying underlying disease.
- **Focus on functional cures**: Each program aims to alter the course of disease rather than merely treat symptoms, creating potential for breakthrough efficacy.

## Strategic Focus
- **Advance late‑stage clinical trials**: Continue Phase 2/3 studies for Tonlamarsen, Danicamtiv, and CAVS while preparing for potential regulatory submissions.
- **Expand platform capabilities**: Leverage Prolaio’s AI and real‑world evidence to design smarter, faster trials and discover new drug targets.
- **Build commercial infrastructure**: Growing corporate strategy, medical affairs, and manufacturing teams in South San Francisco, Princeton, and Chicago signals preparation for launch.

## Why Work Here
- **Culture**: “Everything we do starts with patients – and it’s powered by people.” Emphasis on collaboration, purpose‑driven work, and achieving the impossible together. Mission‑oriented environment focused on curing cardiovascular disease. ([kardigan.bio](https://www.kardigan.bio/job-openings/))
- **Work model**: Roles are listed for South San Francisco, Princeton, NJ, and Chicago, IL; likely on‑site/hybrid given the lab and clinical development nature. Not purely remote.
- **Benefits**:
  - Competitive salaries and annual bonus program
  - Comprehensive medical, dental, and vision coverage
  - 401(k) plan, life and disability insurance
  - Flexible spending and health savings accounts
  - Commuter benefits, cellphone allowance
  - Paid holidays and time off
  - Employee assistance program ([kardigan.bio](https://www.kardigan.bio/job-openings/))
- **Engineering & data science culture**: Active recruitment for data analytics, AI, and clinical data science roles; Executive Director of Data, AI & Collaboration Services is an open position, reflecting a strong tech‑driven R&D approach.

## Sources
1. [kardigan.bio](https://www.kardigan.bio/) – Company homepage and pipeline descriptions
2. [kardigan.bio/about-us](https://www.kardigan.bio/about-us/) – About Us, mission, and Prolaio integration
3. [kardigan.bio/job-openings](https://www.kardigan.bio/job-openings/) – Careers page with benefits and open roles
4. [kardigan.bio/leadership](https://www.kardigan.bio/leadership/) – Leadership team and co‑founder backgrounds
5. [job-boards.greenhouse.io/kardigan](http://job-boards.greenhouse.io/kardigan) – Detailed job listings (32+ postings)

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