---
title: 'Executive Director, Commercial Law/Commercial Contracts at Tango Therapeutics'
canonical: 'https://feeny.ai/job/executive-director-commercial-law-commercial-contracts-tango-therapeutics-boston-4rgpv55eb66w'
type: 'job'
last_seen: '2026-10-20'
---

# Executive Director, Commercial Law/Commercial Contracts at Tango Therapeutics

- **Company:** Tango Therapeutics
- **Location:** Boston, MA
- **Compensation:** $267k–$401k
- **Posted:** 2026-10-02
- **Last confirmed live:** 2026-10-20
- **Apply:** https://job-boards.greenhouse.io/tangotherapeutics/jobs/8011877003

## Job description

Company Overview

Tango Therapeutics is a biotechnology company dedicated to discovering novel drug targets and delivering the next generation of precision medicine for the treatment of cancer.

Using an approach that starts and ends with patients, Tango leverages the genetic principle of synthetic lethality to discover and develop therapies that take aim at critical targets in cancer.

This includes expanding the universe of precision oncology targets into novel areas such as tumor suppressor gene loss and their contribution to the ability of cancer cells to evade immune cell killing.

The Tango labs and offices are located at 201 Brookline Avenue, in the Fenway area of Boston, Massachusetts.

Summary:

We are seeking a highly skilled, motivated attorney to join our team as Executive Director, Commercial Law/Commercial Contracts. Reporting to the SVP, General Counsel, this role will lead the commercial legal function and serve as a strategic partner to Tango’s growing Medical Affairs, Commercial, Patient Support, Market Access & Reimbursement functions as the Company advances toward its first commercial launch. This role will be responsible for providing hands-on, day-to-day legal advice on a wide range of strategic initiatives, including pre-launch activities, market access activities, patient support programs, and materials review (advertising/promotion and medical/scientific communications) and will lead the negotiation of commercial contracts.

The ideal candidate will bring excellent judgment, executive presence, broad-based expertise, and practical business orientation. This leader will be both a strategic advisor and a hands-on matter owner, able to build scalable processes, partner effectively across the enterprise, and translate complex legal risk into clear, actionable guidance for business leaders and the Executive Leadership Team.

Responsibilities:

- Provide pragmatic and solutions-oriented legal advice to the company’s rapidly growing commercial and medical affairs organizations
- Identify and resolve critical legal and business issues associated with pre-launch activities and launch strategy, including medical (e.g., MSL activities and programs), disease awareness, sales, marketing (brand messaging, activities and campaigns), patient advocacy programs, advisory boards, and other business activities
- Serve as a subject matter expert on U.S. healthcare laws, FDA promotional regulations and industry codes to enable legal and compliant pre-launch, launch and ongoing commercial and medical activities
- With the support of outside counsel as needed, lead the negotiation of business agreements in support of Tango’s anticipated product launches, including those with vendors, healthcare professionals, specialty pharmacies, patient support vendors, payor agreements, and distributors
- Provide ongoing contracting support and lifecycle management, including agreement interpretation and risk analysis, for Tango’s commercial, medical affairs, patient support, and other teams
- As a member of the Legal and Compliance Team, actively contribute to the function by building a positive culture, fostering engagement, sharing best practices and participating in initiatives focused on building departmental and functional knowledge and competencies

Education & Experience

- J.D. from an accredited law school and admitted to practice in at least one U.S. jurisdiction
- A minimum of 10-12 years of commercial law experience at a top-tier law firm and/or in a biotech company’s legal department
- In-house experience at a pharmaceutical/biotech company strongly preferred, experience supporting a company through its first launch ideal
- Ability to interpret legal requirements and deliver pragmatic, business-oriented guidance
- Deep knowledge of FDA promotional regulations, Anti-Kickback Statute, False Claims Act, OIG guidance, and industry codes, and ability to stay current on evolving trends and enforcement priorities
- Experience reviewing promotional and medical materials as a Legal reviewer
- Strong business partnering orientation with ability to balance risk and business goals
- Proven capability to manage multiple priorities and collaborative effectively in a fast-paced, collaborative environment; flexible and able to adapt to new situations as the business requires
- Excellent written and verbal communication skills

We are an equal opportunity employer and value diversity at our company.

We do not discriminate on the basis of race, religion, color, national origin, gender, sexual orientation, age, marital status, veteran status, or disability status. Salary range $267,200—$400,800 USD

## About Tango Therapeutics

## Company Overview
- **One-liner**: Tango Therapeutics is a clinical-stage biotechnology company leveraging the principle of synthetic lethality to discover and develop next-generation precision cancer medicines for genetically defined patient populations.
- **Entity Type**: Public (NASDAQ: TNGX)
- **Headquarters**: Boston, Massachusetts, United States
- **Founded**: 2017
- **Founders**: Not publicly disclosed (launched by Third Rock Ventures)

## Core Business
- **Primary industry/industries**: Biotechnology, Precision Oncology, Drug Discovery & Development
- **Target customers**: B2B (pharma partnerships, clinical trial sites); ultimate customers are cancer patients with specific genetic tumor profiles
- **Mission or purpose statement**: "Discover transformative drugs for people with cancer by leveraging the classic principles of synthetic lethality in innovative ways… building a road map to cures that will transform the lives of patients and their families." [tangotx.com](https://www.tangotx.com/join-us/)

## Products & Services
- **Vopimetostat (PRMT5 inhibitor)**: A clinical-stage, wholly-owned program targeting MTAP-deleted cancers, including pancreatic, lung, and glioblastoma. Currently in Phase 1/2 trials. [tangotx.com](https://www.tangotx.com/pipeline/)
- **TNG456 (PRMT5 inhibitor)**: A next-generation PRMT5 inhibitor for MTAP-deleted cancers, currently in pre-clinical development.
- **Daraxonrasib (RAS inhibitor)**: A combination therapy (with vopimetostat) for MTAPdel/RASmut pancreatic and lung cancers. Recently reported a 92% objective response rate in pancreatic cancer in a Phase 1/2 trial. [tangotx.com](https://www.tangotx.com/)
- **CRISPR-based Target Discovery Engine**: A proprietary platform for identifying novel synthetic lethal targets, enabling a robust pipeline of wholly-owned programs.

## Market Standing
- **Valuation/Market Cap**: ~$1.05 billion (as of mid-2026) [linkedin.com](https://www.linkedin.com/company/tango-therapeutics)
- **Key Metric**: Annual Revenue of ~$62.4 million; Total Funding raised ~$901 million (including post-IPO). [linkedin.com](https://www.linkedin.com/company/tango-therapeutics)
- **Notable Investors/Partners**: Third Rock Ventures (lead Series A), Boxer Capital (lead Series B), BCTG Acquisition Corp (parent). Strategic partners include pharma and biotech companies (collaborations under active exploration). [linkedin.com](https://www.linkedin.com/company/tango-therapeutics)
- **Growth Signals**: Completed a $600 million upsized public offering in June 2026; strong clinical data (92% ORR in pancreatic cancer); pipeline expanding into glioblastoma; headcount growth in job postings (+400% YoY in active roles). [tangotx.com](https://www.tangotx.com/)

## Competitive Advantages
- **Synthetic Lethality Expertise**: A deep, proprietary understanding of CRISPR-based target discovery to identify novel vulnerabilities in cancers with tumor suppressor gene loss, undruggable oncogenes, and immune evasion mechanisms.
- **Genetically Defined Patient Selection**: All programs are designed for well-defined patient populations with clear biomarkers, increasing the probability of clinical success and reducing trial risk.
- **Wholly-Owned Pipeline**: Unlike many biotechs that license out rights, Tango retains full ownership of its lead programs, capturing maximum value.
- **Strong Financial Position**: With over $1B in market cap and a recent $600M offering, the company is well-capitalized to advance its pipeline through pivotal trials.

## Strategic Focus
- **Current priorities**: Advancing vopimetostat and daraxonrasib into Phase 3 trials for pancreatic and lung cancers; expanding the pipeline into glioblastoma; continuing to discover and validate new synthetic lethal targets; building out commercial manufacturing and clinical operations infrastructure.
- **Direction for growth**: Becoming a fully-integrated biotechnology company capable of bringing its own medicines to market, while selectively pursuing strategic collaborations to expand reach.

## Why Work Here
- **Culture highlights**: Emphasizes "urgency + compassion," "courage + leadership," "spirit + resilience," and "embrace individuality and face challenges together." Described as a team of "passionate problem solvers" who are "all in for exciting science and changing lives." [tangotx.com](https://www.tangotx.com/join-us/)
- **Remote/hybrid/office policy**: Primarily on-site at Boston HQ (201 Brookline Ave, Suite 901, Boston, MA). Roles appear to be Boston-based, though some field-based positions (e.g., Medical Science Liaisons) are remote.
- **Notable perks or engineering culture**: High scientific ambition with a clear patient-first mission; strong leadership team with deep oncology experience; active hiring across clinical operations, biostatistics, medical affairs, and legal/compliance; 15+ active job postings with significant YoY growth in roles. [greenhouse.io](http://job-boards.greenhouse.io/tangotherapeutics)
- **Workforce**: ~129 employees, with a mix of research (26%), medical (12%), and operations roles. Notable alumni from Novartis, Vertex, Takeda, and Broad Institute. [linkedin.com](https://www.linkedin.com/company/tango-therapeutics)

## Sources
1. [Tango Therapeutics Official Website](https://www.tangotx.com/)
2. [Tango Therapeutics Careers Page (Greenhouse)](http://job-boards.greenhouse.io/tangotherapeutics)
3. [Tango Therapeutics LinkedIn Profile](https://www.linkedin.com/company/tango-therapeutics)
4. [Tango Therapeutics Pipeline Page](https://www.tangotx.com/pipeline/)
5. [Tango Therapeutics Join Us Page](https://www.tangotx.com/join-us/)

## Other roles at Tango Therapeutics

- [Senior Vice President, Medical Affairs](https://feeny.ai/job/senior-vice-president-medical-affairs-tango-therapeutics-boston-yphb7g2va8xb) — Boston, MA
- [Associate Director, Statistical Programming](https://feeny.ai/job/associate-director-statistical-programming-tango-therapeutics-boston-dkt87pa41pb6) — Boston, MA
- [Associate Director, Operational Excellence](https://feeny.ai/job/associate-director-operational-excellence-tango-therapeutics-boston-at4qdd9qfq1w) — Boston, MA
- [Director, Intellectual Property](https://feeny.ai/job/director-intellectual-property-tango-therapeutics-boston-pesyhn9k10dj) — Boston, MA
- [Senior Clinical Data Manager](https://feeny.ai/job/senior-clinical-data-manager-tango-therapeutics-boston-xk614h7zhf91) — Boston, MA
- [Manager, GMP Quality](https://feeny.ai/job/manager-gmp-quality-tango-therapeutics-boston-70t57986x902) — Boston, MA
- [Executive Director, Commercial Strategy & Execution](https://feeny.ai/job/executive-director-commercial-strategy-execution-tango-therapeutics-boston-y7x7vkeeenkd) — Boston, MA
- [Head of Marketing & Sales](https://feeny.ai/job/head-of-marketing-sales-tango-therapeutics-boston-ex81335qs4hc) — Boston, MA
- [Head of Insights & Analytics](https://feeny.ai/job/head-of-insights-analytics-tango-therapeutics-boston-4f5kkx80kztw) — Boston, MA
- [Senior Vice President, Market Access](https://feeny.ai/job/senior-vice-president-market-access-tango-therapeutics-boston-47tt1fw4qxxq) — Boston, MA