---
title: 'Executive Director, FP&A at Tango Therapeutics'
canonical: 'https://feeny.ai/job/executive-director-fp-a-tango-therapeutics-boston-kph81hnp4jvk'
type: 'job'
last_seen: '2026-09-08'
---

# Executive Director, FP&A at Tango Therapeutics

- **Company:** Tango Therapeutics
- **Location:** Boston, MA
- **Compensation:** $251k–$377k
- **Posted:** 2026-08-28
- **Last confirmed live:** 2026-09-08
- **Apply:** https://job-boards.greenhouse.io/tangotherapeutics/jobs/7980710003

## Job description

Company Overview

Tango Therapeutics is a biotechnology company dedicated to discovering novel drug targets and delivering the next generation of precision medicine for the treatment of cancer.

Using an approach that starts and ends with patients, Tango leverages the genetic principle of synthetic lethality to discover and develop therapies that take aim at critical targets in cancer.

This includes expanding the universe of precision oncology targets into novel areas such as tumor suppressor gene loss and their contribution to the ability of cancer cells to evade immune cell killing.

The Tango labs and offices are located at 201 Brookline Avenue, in the Fenway area of Boston, Massachusetts.

Summary

Tango Therapeutics is seeking an experienced and strategic finance leader to serve as Executive Director, FP&A. Reporting directly to the SVP, Finance, this highly visible role will drive enterprise-wide financial planning & analysis strategy and execution, partnering closely with the executive team and Global Program Teams as Tango's pipeline and organization continue to scale.

This role offers the opportunity to build and lead a growing FP&A function, sharpen the rigor of the company's budgeting, forecasting, and long-range planning processes, and play a pivotal role in supporting Tango's evolving development organization through its next stage of growth.

Your Role:

As Executive Director, FP&A, you will lead enterprise-wide FP&A strategy and execution in partnership with the SVP, Finance. You will serve as a member of the Global Program Teams, ensuring alignment across functions on strategy execution and resourcing, and will partner closely with Clinical Operations to sharpen clinical trial forecasting as the development organization grows. You will lead and develop the FP&A function, initially overseeing a team of two, building scalable FP&A capabilities and processes to support a growing, increasingly complex organization.

- Drive enterprise-wide FP&A strategy and execution in close partnership with the SVP, Finance
- Lead the Annual Operating Plan (AOP), quarterly reforecasts, and Long-Range Plan (LRP), adding depth, discipline, and rigor to the budgeting and planning process
- Partner with Clinical Operations to sharpen clinical trial forecasting and support increasingly complex, late-stage development budgets
- Serve as the Finance representative on Global Program Team(s) (GPTs), ensuring cross-functional alignment on execution of strategy and appropriate resourcing
- Assess the financial impact of strategic changes, drive scenario planning, and deliver insights and analyses that support decision-making across the leadership team
- Lead cash runway and burn-rate analysis to inform capital planning and support strategic decision-making by the executive team and Board
- Develop and support materials for the Board of Directors and executive leadership on financial performance, forecasts, and key business drivers
- Convert R&D and clinical program assumptions into financial and headcount forecasts across the pipeline, in partnership with Clinical and Program Management
- Provide financial modeling and analytical support for business development, licensing, and other corporate development opportunities as they arise
- Partner with Accounting on the monthly/quarterly close process and budget-to-actual variance analysis to ensure accurate, timely financial reporting
- Build and refine scalable FP&A processes, systems, and tools to support a growing and increasingly complex organization
- Provide early-stage commercial finance support and analysis, bridging near-term needs ahead of a dedicated commercial finance function
- Lead, mentor, and develop the FP&A team optimizing resource planning and building a high-performing function that can scale with the organization
- Partner with cross-functional leaders across R&D, Clinical, Commercial, and Corporate functions to deliver timely, accurate, and actionable financial insights

What You Bring:

- Bachelor’s degree in Finance, Accounting, or a related field required; MBA and/or CPA preferred
- 15+ years of progressive Finance and FP&A experience, including significant leadership experience within the biotechnology or pharmaceutical industry
- Demonstrated experience with late-stage clinical trial budgeting and forecasting; pre-commercial finance experience is desirable
- Proven track record leading Annual Operating Plan, reforecast, and Long-Range Plan processes
- Experience with FP&A planning systems and ERP/procurement tools (e.g., Adaptive Insights, NetSuite) and building scalable financial processes to support organizational growth
- Experience leading, mentoring, and developing a team of finance professionals
- Strong business partnering skills, with experience supporting cross-functional teams such as Global Program Teams, Clinical Operations, and Commercial
- Demonstrated experience partnering with and presenting financial insights, forecasts, scenarios, and recommendations to executive leadership and board members
- Experience with cash flow and runway modeling in a clinical-stage biotech or pharmaceutical environment
- Solid understanding of the drug development lifecycle, from early research through clinical development and toward commercialization
- Excellent analytical, scenario-planning, and communication skills, with the ability to translate complex financial data into actionable insights for executive leadership
- Resourceful, adaptable, and execution-oriented, with the ability to operate effectively in a fast-paced, evolving organization

#LI-Hybrid

We are an equal opportunity employer and value diversity at our company. We do not discriminate on the basis of race, religion, color, national origin, gender, sexual orientation, age, marital status, veteran status, or disability status.

Salary range $251,200—$376,800 USD

## About Tango Therapeutics

## Company Overview
- **One-liner**: Tango Therapeutics is a clinical-stage biotechnology company leveraging the principle of synthetic lethality to discover and develop next-generation precision cancer medicines for genetically defined patient populations.
- **Entity Type**: Public (NASDAQ: TNGX)
- **Headquarters**: Boston, Massachusetts, United States
- **Founded**: 2017
- **Founders**: Not publicly disclosed (launched by Third Rock Ventures)

## Core Business
- **Primary industry/industries**: Biotechnology, Precision Oncology, Drug Discovery & Development
- **Target customers**: B2B (pharma partnerships, clinical trial sites); ultimate customers are cancer patients with specific genetic tumor profiles
- **Mission or purpose statement**: "Discover transformative drugs for people with cancer by leveraging the classic principles of synthetic lethality in innovative ways… building a road map to cures that will transform the lives of patients and their families." [tangotx.com](https://www.tangotx.com/join-us/)

## Products & Services
- **Vopimetostat (PRMT5 inhibitor)**: A clinical-stage, wholly-owned program targeting MTAP-deleted cancers, including pancreatic, lung, and glioblastoma. Currently in Phase 1/2 trials. [tangotx.com](https://www.tangotx.com/pipeline/)
- **TNG456 (PRMT5 inhibitor)**: A next-generation PRMT5 inhibitor for MTAP-deleted cancers, currently in pre-clinical development.
- **Daraxonrasib (RAS inhibitor)**: A combination therapy (with vopimetostat) for MTAPdel/RASmut pancreatic and lung cancers. Recently reported a 92% objective response rate in pancreatic cancer in a Phase 1/2 trial. [tangotx.com](https://www.tangotx.com/)
- **CRISPR-based Target Discovery Engine**: A proprietary platform for identifying novel synthetic lethal targets, enabling a robust pipeline of wholly-owned programs.

## Market Standing
- **Valuation/Market Cap**: ~$1.05 billion (as of mid-2026) [linkedin.com](https://www.linkedin.com/company/tango-therapeutics)
- **Key Metric**: Annual Revenue of ~$62.4 million; Total Funding raised ~$901 million (including post-IPO). [linkedin.com](https://www.linkedin.com/company/tango-therapeutics)
- **Notable Investors/Partners**: Third Rock Ventures (lead Series A), Boxer Capital (lead Series B), BCTG Acquisition Corp (parent). Strategic partners include pharma and biotech companies (collaborations under active exploration). [linkedin.com](https://www.linkedin.com/company/tango-therapeutics)
- **Growth Signals**: Completed a $600 million upsized public offering in June 2026; strong clinical data (92% ORR in pancreatic cancer); pipeline expanding into glioblastoma; headcount growth in job postings (+400% YoY in active roles). [tangotx.com](https://www.tangotx.com/)

## Competitive Advantages
- **Synthetic Lethality Expertise**: A deep, proprietary understanding of CRISPR-based target discovery to identify novel vulnerabilities in cancers with tumor suppressor gene loss, undruggable oncogenes, and immune evasion mechanisms.
- **Genetically Defined Patient Selection**: All programs are designed for well-defined patient populations with clear biomarkers, increasing the probability of clinical success and reducing trial risk.
- **Wholly-Owned Pipeline**: Unlike many biotechs that license out rights, Tango retains full ownership of its lead programs, capturing maximum value.
- **Strong Financial Position**: With over $1B in market cap and a recent $600M offering, the company is well-capitalized to advance its pipeline through pivotal trials.

## Strategic Focus
- **Current priorities**: Advancing vopimetostat and daraxonrasib into Phase 3 trials for pancreatic and lung cancers; expanding the pipeline into glioblastoma; continuing to discover and validate new synthetic lethal targets; building out commercial manufacturing and clinical operations infrastructure.
- **Direction for growth**: Becoming a fully-integrated biotechnology company capable of bringing its own medicines to market, while selectively pursuing strategic collaborations to expand reach.

## Why Work Here
- **Culture highlights**: Emphasizes "urgency + compassion," "courage + leadership," "spirit + resilience," and "embrace individuality and face challenges together." Described as a team of "passionate problem solvers" who are "all in for exciting science and changing lives." [tangotx.com](https://www.tangotx.com/join-us/)
- **Remote/hybrid/office policy**: Primarily on-site at Boston HQ (201 Brookline Ave, Suite 901, Boston, MA). Roles appear to be Boston-based, though some field-based positions (e.g., Medical Science Liaisons) are remote.
- **Notable perks or engineering culture**: High scientific ambition with a clear patient-first mission; strong leadership team with deep oncology experience; active hiring across clinical operations, biostatistics, medical affairs, and legal/compliance; 15+ active job postings with significant YoY growth in roles. [greenhouse.io](http://job-boards.greenhouse.io/tangotherapeutics)
- **Workforce**: ~129 employees, with a mix of research (26%), medical (12%), and operations roles. Notable alumni from Novartis, Vertex, Takeda, and Broad Institute. [linkedin.com](https://www.linkedin.com/company/tango-therapeutics)

## Sources
1. [Tango Therapeutics Official Website](https://www.tangotx.com/)
2. [Tango Therapeutics Careers Page (Greenhouse)](http://job-boards.greenhouse.io/tangotherapeutics)
3. [Tango Therapeutics LinkedIn Profile](https://www.linkedin.com/company/tango-therapeutics)
4. [Tango Therapeutics Pipeline Page](https://www.tangotx.com/pipeline/)
5. [Tango Therapeutics Join Us Page](https://www.tangotx.com/join-us/)

## Other roles at Tango Therapeutics

- [Vice President, Marketing & Sales](https://feeny.ai/job/vice-president-marketing-sales-tango-therapeutics-boston-ex81335qs4hc) — Boston, MA
- [Executive Director, Insights & Analytics](https://feeny.ai/job/executive-director-insights-analytics-tango-therapeutics-boston-4f5kkx80kztw) — Boston, MA
- [Senior Vice President, Market Access](https://feeny.ai/job/senior-vice-president-market-access-tango-therapeutics-boston-47tt1fw4qxxq) — Boston, MA
- [Senior Manager, Clinical Informatics](https://feeny.ai/job/senior-manager-clinical-informatics-tango-therapeutics-boston-g3pk44zmymam) — Boston, MA
- [Manager, Total Rewards](https://feeny.ai/job/manager-total-rewards-tango-therapeutics-boston-fywb3xy2sabn) — Boston, MA
- [Associate Director, Pharmacovigilance Scientist](https://feeny.ai/job/associate-director-pharmacovigilance-scientist-tango-therapeutics-boston-5cgk3mmdsprr) — Boston, MA
- [Associate Medical Director, Pharmacovigilance](https://feeny.ai/job/associate-medical-director-pharmacovigilance-tango-therapeutics-boston-4kcjnjy0vpys) — Boston, MA
- [Executive Director, Clinical Development](https://feeny.ai/job/executive-director-clinical-development-tango-therapeutics-boston-xhzk5j65r72k) — Boston, MA
- [Clinical Trials Manager](https://feeny.ai/job/clinical-trials-manager-tango-therapeutics-boston-7yaaz94j244a) — Boston, MA
- [Senior Director, Clinical Sciences](https://feeny.ai/job/senior-director-clinical-sciences-tango-therapeutics-boston-j8hypf1vqq14) — Boston, MA