---
title: 'Executive Director & Head Clinical Data Management at Annexon Biosciences'
canonical: 'https://feeny.ai/job/executive-director-head-clinical-data-management-annexon-biosciences-san-srwq0ehec0wz'
type: 'job'
last_seen: '2026-09-06'
---

# Executive Director & Head Clinical Data Management at Annexon Biosciences

- **Company:** Annexon Biosciences
- **Location:** San Francisco, CA
- **Posted:** 2026-08-10
- **Last confirmed live:** 2026-09-06
- **Apply:** https://job-boards.greenhouse.io/annexonbioscience/jobs/4722755005

## Job description

Company:

At Annexon Biosciences we are a biopharmaceutical company advancing a late-stage clinical platform of novel therapies for people living with devastating classical complement-mediated neuroinflammatory diseases of the body, brain, and eye. Our novel scientific approach targets upstream C1q to block the classical complement inflammatory cascade before it starts, and its therapeutic candidates are designed to provide meaningful benefits across multiple autoimmune, neurodegenerative and ophthalmic diseases. With proof-of concept data in Guillain-Barré syndrome, Huntington’s disease and geographic atrophy, we are rigorously advancing our mid-to late-stage clinical trials to bring new potential treatments to patients as quickly as possible. At Annexon, you’ll be part of a team committed to making an impact together.

For more information on Annexon and our pipeline, check out our site [Annexon Biosciences](https://annexonbio.com/) & [Annexon Pipeline](https://annexonbio.com/pipeline/). We trade on Nasdaq under the ticker symbol ANNX and are headquartered in Brisbane, CA.

We're seeking exceptional talent from all backgrounds to fuel our growth. At Annexon, we're building a diverse, equitable, and inclusive workplace. We value unique perspectives and unconventional paths. If you're the best candidate for the job, even if you don't perfectly fit the traditional mold, we encourage you to apply. Learn more about our commitment to diversity, equity, inclusion, and our company [culture](https://annexonbio.com/our-culture/)!

Position:

Reporting to the SVP, Biometrics, this leader independently oversees a team of data managers and technology experts responsible for acquisition and quality of all Annexon clinical trial data. A highly empowered, visible and collaborative role, the Executive Director & Head Clinical Data Management partners cross-functionally to advance medicines to our patients.

Responsibilities include:

- Set the vision for Clinical Data Management through building and maintaining a best-in-class organization that functions as a key strategic partner within Annexon
- Provide operational, strategic, and technical direction to data managers and technology SMEs while maintaining ultimate responsibility for all clinical data within Annexon
- Accountable for all Clinical Data Management activities from study startup through study conduct and closeout delivering quality data snapshots, interim database locks and final database locks
- Design and deploy appropriate clinical data management operating models including full outsourcing, hybrid delivery and fully in-house
- Ensure clinical data management strategies that incorporate both current best practices and innovative approaches consistent with GCP and GCDMP
- Design and deploy sponsor oversight for outsourced studies including operating model, oversight planning and execution, vendor governance and interactions, risk management and documentation
- Define, advance and codify procedural framework (operating model, process definitions and associated SOPs/WIs, Clinical Data Management best/expected practices) for the department
- Serve on the Biometrics leadership team to provide guidance on direction and operations of the department
- Provide expert guidance to project teams and executive leadership
- Participate cross-functionally with key partners to advance Annexon products
- Contribute to and participate in the development and maintenance of a positive team-focused company culture

Education, Experience, and Skills:

Required:

- Bachelor’s degree with 12+ years of experience in the pharmaceutical or biotechnology industry in a Clinical Data Management leadership capacity
- Extensive experience with industry clinical data management delivery models and associated sponsor oversight (full outsourcing etc.)
- Experience building and leading high performing teams; and identifying, attracting, developing, and retaining top talent
- Proficiency in Clinical Data Management related technology like EDC, eSource, eCOA, IRT etc.
- Experience leading programs through submission and approval
- Deep understanding of GCP and GCDMP
- Solid understanding of eCRF data acquisition best practices

Preferred:

- Ability to communicate with clarity and influence including explaining complex quantitative issues in simple terms
- Solid understanding of Regulatory (FDA/EMA/ICH) guidance with the ability to interpret and apply in real-time drug development setting
- Solid understanding of regulatory submission and approval process
- Collaborative negotiator with excellent judgment around compromising, standing firm, or finding a new way forward.
- Leadership acumen including emotional intelligence and business awareness. Ability to effectively collaborate and influence throughout multiple levels of the organization.
- Strategic and creative drug-development mindset/approach. Willingness to deviate from the status quo
- Ability to balance appropriate levels of structure/process with efficiency and simplicity
- Awareness of external industry landscape with respect to best practices and emerging topics

Salary Range: $301,500 - $330,000

Location: Annexon Biosciences is located in Brisbane, California. This role operates under a hybrid work arrangement and requires regular onsite collaboration at our office. Candidates should be located within commuting distance and able to work in the office multiple days each week.

Benefits:

- A stimulating and rewarding workplace includes flexible work schedules, remote opportunities and the ability to achieve a work-life balance.
- Shuttle service from BART, CalTrain and the Ferry.
- Annexon offers a competitive base salary and equity participation, employee stock purchase plan, as well as a comprehensive health benefit package that includes medical, dental, vision, 401(k), flexible spending plans, and other benefits.

Annexon Biosciences is an Equal Opportunity Employer, and we prohibit discrimination or harassment of any kind.  We are committed to fostering an environment where ALL people are welcome and supported. We cultivate a culture of inclusion for all employees that respects their individual strengths, views, and experiences. We believe that our differences enable us to be a better team – one that makes better decisions, drives innovation, and delivers better business results. Creativity and innovation flourish in an environment of openness, inclusion, and mutual respect.

## About Annexon Biosciences

## Company Overview
- **One-liner**: Annexon Biosciences is a clinical-stage biopharmaceutical company pioneering the development of C1q inhibitors to stop classical complement-mediated neuroinflammation in autoimmune, neurodegenerative, and ophthalmic diseases.
- **Entity Type**: Public (Nasdaq: ANNX)
- **Headquarters**: Brisbane, California, USA
- **Founded**: 2007
- **Founders**: Dr. Ben Barres (co‑founder, deceased) and Dr. Arnon Rosenthal

## Core Business
- **Industry**: Biopharmaceuticals – complement‑targeted therapeutics
- **Target Customers**: Patients and healthcare providers treating classical complement‑mediated diseases (body, brain, eye); B2B partnerships with clinical sites and payers
- **Mission**: “Deliver game‑changing therapies to patients so that they can live their best lives” [annexonbio.com](https://annexonbio.com/about/)

## Products & Services
Annexon’s pipeline is based on inhibiting C1q, the initiating molecule of the classical complement pathway. Key investigational candidates:
- **ANX005**: A monoclonal antibody targeting C1q for intravenous administration. Lead indication is Guillain‑Barré Syndrome (GBS); completed enrollment in a Phase 3 pivotal program – the first such program in GBS in 40 years – and has Orphan Drug Designation from the EMA [annexonbio.com](https://annexonbio.com/about/)
- **ANX007**: An intravitreal antibody fragment targeting C1q for ophthalmic use. Demonstrated statistically significant, dose‑dependent preservation of visual function in a Phase 2 trial in geographic atrophy (GA) [annexonbio.com](https://annexonbio.com/about/)
- **ANX009**: A subcutaneous formulation of ANX005 designed for chronic autoimmune and neurodegenerative indications. Achieved full target engagement in the blood compartment in a Phase 1 healthy volunteer study [annexonbio.com](https://annexonbio.com/about/)
- **ANX1502**: An oral small‑molecule inhibitor of the classical complement pathway. Achieved target pharmacokinetics in a Phase 1 healthy volunteer study [annexonbio.com](https://annexonbio.com/about/)

## Market Standing
- **Valuation / Market Cap**: Not publicly available from provided sources (public company, market cap fluctuates)
- **Key Metric**: Publicly traded (Nasdaq: ANNX); recent major milestones include Phase 3 completion for ANX005 in GBS and Phase 2 data for ANX007 in GA
- **Notable Investors / Partners**: Leaders on board and scientific advisory board include Stephen Hauser (MD, UCSF), Beth Stevens (PhD, Harvard), David Holtzman (MD, Washington University), and others. The co‑founder Dr. Ben Barres was a highly respected neuroscientist [annexonbio.com](https://annexonbio.com/about/)
- **Growth Signals**: Initial public offering in 2020 funded pipeline expansion; active recruiting for senior clinical and medical affairs roles (Senior Director, Clinical Development; VP, Drug Safety; etc.) suggests advancement toward late‑stage trials and potential commercialization [greenhouse.io](https://job-boards.greenhouse.io/annexonbioscience)

## Competitive Advantages
- **First‑in‑class C1q inhibitor focus**: By targeting the top of the classical complement pathway, Annexon aims to block all downstream damaging components rather than a single downstream effector.
- **Broad pipeline across three therapeutic areas** (autoimmunity, neurodegeneration, ophthalmology) targeting nearly 10 million patients worldwide.
- **Biomarker‑driven, disciplined strategy** to improve probability of technical success and deliver precision medicine [ir.annexonbio.com](https://ir.annexonbio.com/corporate-profile)
- **Strong scientific foundation** built on decades of research by co‑founder Dr. Ben Barres on C1q’s role in synapse loss.

## Strategic Focus
- Completing the first Phase 3 program for GBS in 40 years (ANX005) and preparing for regulatory submissions.
- Advancing ANX007 through pivotal trials for geographic atrophy and exploring glaucoma.
- Developing subcutaneous and oral formulations (ANX009, ANX1502) to expand into chronic, less invasive treatment paradigms.
- Employing precision‑medicine biomarkers to identify patients most likely to benefit from classical complement inhibition.

## Why Work Here
- **Culture**: Described as “show up with your heart and mind … team‑based, follow the science.” Core values include warrior spirit, all‑for‑one teamwork, sound judgment, passion, and a thrive mentality [annexonbio.com/careers](https://annexonbio.com/careers/)
- **Work Environment**: Flexible work schedules, remote opportunities, and a Brisbane, CA office with shuttle service from BART, CalTrain, and the Ferry [annexonbio.com/careers](https://annexonbio.com/careers/)
- **Benefits**: Competitive base salary, equity participation, employee stock purchase plan (ESPP), medical/dental/vision insurance, 401(k), flexible spending plans, and a focus on work‑life balance [annexonbio.com/careers](https://annexonbio.com/careers/)
- **Team**: About 4 open positions as of mid‑2026 (Senior Director Clinical Development, VP Drug Safety, etc.) – a small, driven team where contributions are visible and valued [greenhouse.io](https://job-boards.greenhouse.io/annexonbioscience)

## Sources
1. [annexonbio.com – Home](https://annexonbio.com/)
2. [ir.annexonbio.com – Corporate Profile](https://ir.annexonbio.com/corporate-profile)
3. [annexonbio.com – About (Leadership, History, Mission)](https://annexonbio.com/about/)
4. [annexonbio.com – Careers (Culture, Benefits, Values)](https://annexonbio.com/careers/)
5. [greenhouse.io – Jobs at Annexon Biosciences](https://job-boards.greenhouse.io/annexonbioscience)

## Other roles at Annexon Biosciences

- [Senior Director, Global Scientific Communications](https://feeny.ai/job/senior-director-global-scientific-communications-annexon-biosciences-san-ygq0cdyxzd03) — San Francisco, CA
- [Field Medical Director (MSL) – Ophthalmology (Southeast Region)](https://feeny.ai/job/field-medical-director-msl-ophthalmology-southeast-region-annexon-biosciences-f7eyw4qqefam) — San Francisco, CA
- [Senior Director, Regulatory Affairs](https://feeny.ai/job/senior-director-regulatory-affairs-annexon-biosciences-san-francisco-b2av8f6dqd9f) — San Francisco, CA
- [Senior Director, Medical Writing](https://feeny.ai/job/senior-director-medical-writing-annexon-biosciences-san-francisco-kxv9t4ghnxry) — San Francisco, CA
- [Associate Director, Clinical Trial Management](https://feeny.ai/job/associate-director-clinical-trial-management-annexon-biosciences-san-francisco-h3rh38k6a3ek) — San Francisco, CA
- [Senior Director, Drug Safety and Pharmacovigilance](https://feeny.ai/job/senior-director-drug-safety-and-pharmacovigilance-annexon-biosciences-san-w7jhxhsm0t09) — San Francisco, CA
- [Vice President, Medical Affairs-Neuroscience](https://feeny.ai/job/vice-president-medical-affairs-neuroscience-annexon-biosciences-san-francisco-vec8c090165d) — San Francisco, CA
- [Vice President, Clinical Development-Ophthalmology](https://feeny.ai/job/vice-president-clinical-development-ophthalmology-annexon-biosciences-san-8j8gnj3vpggn) — San Francisco, CA
- [Vice President, Medical Affairs-Ophthalmology](https://feeny.ai/job/vice-president-medical-affairs-ophthalmology-annexon-biosciences-san-francisco-4k8s7zf170d6) — San Francisco, CA
- [Senior Director, Clinical Development](https://feeny.ai/job/senior-director-clinical-development-annexon-biosciences-san-francisco-7swmbmmj4tzf) — San Francisco, CA