---
title: 'Executive Director, Supply Chain & External Manufacturing at Prime Medicine'
canonical: 'https://feeny.ai/job/executive-director-supply-chain-external-manufacturing-prime-medicine-cambridge-d1vtwfvkgbxn'
type: 'job'
last_seen: '2026-11-05'
---

# Executive Director, Supply Chain & External Manufacturing at Prime Medicine

- **Company:** Prime Medicine
- **Location:** Cambridge, MA
- **Compensation:** $295k–$312k
- **Posted:** 2026-11-02
- **Last confirmed live:** 2026-11-05
- **Apply:** https://job-boards.greenhouse.io/primemedicine/jobs/6240470004

## Job description

Company Overview:

Prime Medicine is a leading biotechnology company dedicated to creating and delivering the next generation of gene editing therapies to patients. The Company is leveraging its proprietary Prime Editing platform, a versatile, precise and efficient gene editing technology, to develop a new class of differentiated, one-time, potentially curative genetic therapies. Designed to make only the right edit at the right position within a gene while minimizing unwanted DNA modifications, Prime Editors have the potential to repair almost all types of genetic mutations and work in many different tissues, organs and cell types.

Prime Medicine is currently progressing a diversified portfolio of investigational therapeutic programs organized around our core areas of focus: hematology, immunology & oncology, liver and lung. Across each core area, Prime Medicine is focused initially on a set of high value programs, each targeting a disease with well-understood biology and a clearly defined clinical development and regulatory path, and each expected to provide the foundation for expansion into additional opportunities. For more information, please visit [www.primemedicine.com](http://www.primemedicine.com/).

Prime Medicine is a clinical-stage biotechnology company creating the next generation of gene editing therapies. Our Prime Editing platform is versatile, precise, and efficient, with the potential to address more than 90% of known disease-causing genetic mutations. We have three programs in the clinic: an ex vivo cell therapy for an ultra-rare disease advancing toward a Biologics License Application (BLA), and two in vivo liver-targeting LNP Prime Editor programs, with more in development. We are a mission-driven team working in a lean, fast-moving environment.

Position Overview

Reporting directly to the Chief Technology Officer, the Executive Director of Supply Chain and External Manufacturing is a member of the Technology, Development and Operations (TDO) leadership team. You will own Prime Medicine’s end-to-end supply chain, from raw materials through clinical supply and commercialization, with direct accountability for materials management and for supporting internal planning and manufacturing needs. You will manage our external manufacturing partners, lead a highly functional lean team, and serve as the primary partner to Finance for TDO external spend. We are looking for a leader who embraces AI as a core part of how supply chain and external manufacturing run at Prime Medicine, from forecasting and materials visibility to partner performance and cost modeling. This role is for someone who thrives in ambiguity, is energized by building, and pairs strategic thinking with hands-on execution.

Primary Responsibilities

- Partner with the CTO and TDO leadership to define manufacturing and supply chain strategy, including network design, make-vs-buy decisions, and partner selection.
- AI-enabled operations. Lead the use of AI and digital tools across supply chain and external manufacturing, including demand forecasting, materials and inventory visibility, partner performance monitoring, contract and cost modeling, and logistics tracking, as well as keeping the function ahead of new tools as they emerge.
- Materials management. Own materials management across the portfolio, including forecasting, sourcing, purchasing, and inventory of raw materials, critical starting materials, and components, so materials are available on time for each program.
- Planning and supply operations. Support internal planning and the manufacturing needs of each program; deliver labeling, packaging, shipping, and cell therapy logistics on time and in full; and resolve supply risks before they affect timelines.
- External manufacturing and partners. Build and manage a network of CDMOs, CROs, and critical suppliers, including contracts, governance, performance, and qualification of new partners.
- Clinical and commercial readiness. Ensure supply chain documentation and external site readiness support IND and BLA submissions, working with CMC, Regulatory, Quality, Non-clinical Development, Clinical, and program teams.
- Own TDO budget development for external spend, cost projections, and financial reporting in close partnership with functional leaders and Finance.
- Leadership. Lead, coach, and inspire your team of supply chain/external manufacturing professionals and indirect colleagues across TDO; foster a culture of accountability, continuous improvement, and collaborative problem-solving and goal attainment

## Preferred Qualifications

- Bachelor’s degree in a relevant technical discipline; advanced degree (MS, MBA, or PhD) preferred
- 15–20+ years of progressive experience in supply chain, technical operations, external manufacturing, process development, or MSAT within biotech or pharma
- Direct ownership of materials management and clinical supply for clinical-stage programs
- Experience managing CDMOs and CROs, including negotiating MSAs and SOWs
- Experience with cell therapy and/or LNP or nucleic acid programs; experience supporting IND/CTA and BLA/MAA submissions
- Financial acumen, including ownership of operating budgets and multi-year cost projections
- Track record of implementing AI or digital tools that improved forecasting, visibility, or decision-making in supply chain or operations, and of changing how teams work as a result
- Strong change management, project management, and communication skills, with the ability to build trust with partners, Finance, and senior leadership
- Plus: lean, fast-moving biotech; ultra-rare disease or small patient population experience

## Why Prime Medicine

Your work will matter: our programs have the potential to be curative therapies for patients with no other options, and this role directly enables that. You will be part of the TDO leadership team, with direct access to the CTO and interact with other Executive leaders, and you will shape how AI is applied to supply chain and manufacturing at a company where it is a growing priority. You will have ownership from day one in building how Prime Medicine delivers for patients.

Prime Medicine is proud to be an equal opportunity employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, national origin, age, sexual orientation, gender identity, disability, veteran status, or any other classification protected by law.

Location: Cambridge, MA | Reports to: Chief Technology Officer | TDO Leadership Team Member The pay range reflects the full-time base salary range we expect to pay for this role at the time of posting. Base pay will be determined based on several factors including, but not limited to, relevant experience, skills, and education. This role is eligible for an annual short-term incentive award (e.g., bonus) and an annual long-term incentive award (e.g., equity).

Prime Medicine offers a comprehensive Total Rewards package with robust health, financial, and wellness benefits—including medical, dental, vision, life insurance, a 401(k) match, and equity programs—along with generous paid time off, wellness days, and company-wide recharge breaks.

Our commitment to employee well-being reflects our belief that when we care for our people, we strengthen our ability to put patients first and make meaningful impact together.

U.S. Pay Range $295,000—$312,000 USD

Prime Medicine is proud to be an equal opportunity employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, national origin, age, sexual orientation, gender identity, disability, veteran status, or any other classification protected by law.

## About Prime Medicine

## Company Overview
- **One-liner**: Prime Medicine is a biotechnology company using prime editing, a next-generation gene editing technology, to “search and replace” disease-causing genetic mutations and restore normal gene function.
- **Entity Type**: Public (NASDAQ: PRME, IPO October 2022)
- **Headquarters**: Cambridge, Massachusetts, United States
- **Founded**: 2019
- **Founders**: David Liu, PhD (Scientific Founder); Andrew Anzalone, MD, PhD (Co-founder)

## Core Business
- **Primary industry**: Biotechnology / Gene Editing Therapeutics
- **Target customers**: Patients with genetic diseases; partners include pharmaceutical companies (e.g., Bristol Myers Squibb) and foundations (e.g., Cystic Fibrosis Foundation)
- **Mission**: “To bring the promise of gene editing to patients” and ultimately “cure, halt, and prevent genetic diseases, providing lifelong benefit to patients.”

## Products & Services
- **Prime Editing Platform**: A proprietary gene editing technology that acts like a “DNA word processor” to precisely replace faulty DNA sequences without causing double-strand breaks. Designed to address ~90% of known disease-causing mutations.
- **PM359** (Phase 1/2): Ex vivo prime editing therapy for p47phox Chronic Granulomatous Disease (CGD). Received FDA RMAT designation and orphan drug designation.
- **PM577a** (Phase 1/2): In vivo prime editing therapy for H1069Q-mutated Wilson Disease. Clinical trial application cleared in New Zealand.
- **Alpha-1 Antitrypsin Deficiency (AATD)**: Discovery-stage liver program using LNP delivery.
- **Cystic Fibrosis**: Discovery program supported by Cystic Fibrosis Foundation (up to $15M), using PASSIGE™ technology.
- **Ex vivo CAR-T** (collaboration with Bristol Myers Squibb): Strategic license and broad collaboration to develop and commercialize ex vivo T-cell prime editor products.

## Market Standing
- **Valuation/Market Cap**: $777.8 million (as of mid-2026, per LinkedIn data)
- **Key Metric**: Annual revenue $4.6 million; total funding raised ~$1.02 billion (including post-IPO equity)
- **Notable Investors/Partners**: ARCH Venture Partners, F-Prime, Bristol-Myers Squibb (corporate round $55M in 2024), Google Ventures (post-IPO equity $5M in 2025), Cystic Fibrosis Foundation
- **Growth Signals**: 
  - Clinical data for PM359 published in *The New England Journal of Medicine*; RMAT designation from FDA.
  - Headcount of 154 (down 29.4% YoY, likely reflecting strategic refocusing).
  - Active job postings: 7 (as of mid-2026), with recent uptick in quarterly postings (+40%).

## Competitive Advantages
- **Prime Editing differentiation**: Unlike CRISPR, prime editing does not require double-strand DNA breaks, enabling more precise and predictable edits with fewer unwanted modifications.
- **Broad applicability**: Can theoretically correct ~90% of known disease-causing mutations across many organs and cell types.
- **Strong IP and scientific foundation**: Co-invented by David Liu (Broad Institute), a pioneer in gene editing.

## Strategic Focus
- **Advancing lead programs** (PM359 for CGD, PM577a for Wilson Disease) through clinical development and regulatory approvals.
- **Expanding pipeline** in liver, lung, hematology/immunology/oncology via internal research and strategic partnerships (e.g., BMS for CAR-T).
- **Leveraging delivery technologies** (LNP, AAV, ex vivo electroporation) to enable both in vivo and ex vivo applications.

## Why Work Here
- **Mission-driven culture**: Opportunity to shape the future of gene editing and directly impact patients with genetic diseases.
- **Collaborative environment**: Emphasis on diversity of viewpoints, scientific curiosity, and passion for patient outcomes.
- **Location**: Headquarters in Cambridge, MA – a hub for biotech innovation. Presence also in India.
- **Career development**: Roles span research, clinical, technical development, finance, HR, and informatics. Recent job postings include AI & Informatics Engineer, Senior Scientist, and Director of People & Culture.
- **Perks & culture**: Not explicitly detailed, but the company values “dedicated, scientifically curious individuals” and offers the chance to work with a world-class scientific team.

## Sources
1. [primemedicine.com](https://primemedicine.com/)
2. [primemedicine.com/about/](https://primemedicine.com/about/)
3. [primemedicine.com/careers/](https://primemedicine.com/careers/)
4. [primemedicine.com/pipeline/](https://primemedicine.com/pipeline/)
5. [linkedin.com/company/prime-medicine](https://www.linkedin.com/company/prime-medicine)

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