---
title: 'Head of Biology at Output Biosciences'
canonical: 'https://feeny.ai/job/head-of-biology-output-biosciences-new-york-tjktcbm9rvtd'
type: 'job'
last_seen: '2026-09-09'
---

# Head of Biology at Output Biosciences

- **Company:** Output Biosciences
- **Location:** New York, NY
- **Employment:** full-time
- **Work type:** onsite
- **Posted:** 2026-06-05
- **Last confirmed live:** 2026-09-09
- **Apply:** https://jobs.ashbyhq.com/output/1a24d1b4-762d-4007-b82b-ee46c273bbc5

## Job description

## The Role

Output has built a biological reasoning model that understands biology at the scale and complexity life actually operates. Our model independently learned the principles of molecular interactions, opening up drug treatments that were previously impossible. We're already generating therapies that traditional approaches cannot reach. The hardest problems in both AI and biology are being solved here, and there is room for you to own one.

Output is currently in stealth, operated by a team of repeat founders and biotech veterans with multiple exits in AI x Bio, and backed by top-tier VCs including Y Combinator.

You own the feedback loop between Output's models and the lab. You go deep into specific biological problems, translate what the biology requires into priorities for data and modeling, and manage through CRO partners the experimental cycle that validates model outputs and generates new data.

- You will own the active learning cycle between Output's models and experimental validation: designing experiments, managing CRO partners for synthesis and testing, interpreting results, and feeding them back to improve the models
- You will dive into specific biological problem areas, developing the expertise needed to translate nuanced biological requirements into priorities for data construction, modeling, and evaluation
- You will manage CRO relationships for peptide and molecular synthesis, biological assays, and experimental testing, designing each campaign to generate maximally informative data
- You will collaborate with the engineering team to design and build biology-specific agent skills and workflows, encoding your biological expertise into tools that automate experimental decision-making
- You will work closely with the model and data teams, identifying biological phenomena the models should be sensitive to and ensuring that experimental findings shape what and how the models learn
- You will stay current with biological literature and experimental methods, continuously identifying new biological problems and translating them into opportunities for model development

## About You

- You have a PhD in computational biology, biophysics, structural biology, molecular biology, or a related biological field with 3+ years of post-doctoral or industry research experience
- You have deep understanding of protein biology, protein-ligand interactions, and how sequence and structure relate to biological function
- You have experience designing biological experiments and working with CROs for synthesis and experimental validation
- You have experience working with protein language models or machine learning applied to biological sequences and structures
- You have strong programming skills in Python, with experience building computational pipelines and analysis tools
- You can move between the language of biology and the language of machine learning: you understand what models need from data and what experimental results mean for model development
- You are comfortable going deep into unfamiliar biological problem areas and rapidly developing the expertise needed to guide modeling and experimental decisions

Bonus Points

- You have structural biology expertise, including protein structure analysis and structure-function relationships
- You have experience with active learning or iterative experimental design in a computational biology or drug discovery setting
- You have hands-on wet lab experience
- You have experience across multiple therapeutic modalities, including peptides
- You have experience building tools or writing code that automates biological analysis workflows

## OUR VALUES

❤️ Heart: We foster a culture of ownership. We are assembling a team of individuals who are passionate and take pride in their contributions.

🏆 Excellence: We have an unwavering commitment to excellence and continuously challenge ourselves to reach the highest standards.

🚀 Practicality: We value practicality and results-oriented thinking. We are committed to making a tangible impact on the lives of patients and the broader community.

📣 Honesty: We place a high value on honesty and directness. We firmly believe in addressing issues as they arise, in an open and transparent manner.

🎮 Fun: We believe that life is too short to not have fun. Our goal is to create a workplace that is fun, engaging, rewarding and fulfilling.

## WHAT WE OFFER

- We encourage new and different ideas, creativity and contrarian thinking
- Healthy feedback focused environment to help you strive - leadership will have high expectations, regularly share constructive feedback, support you and help you grow, and welcome receiving feedback and ideas from you
- You own your day-to-day management. What we care about is that we all hit our milestones
- Competitive salary and equity in a growing, well-funded startup
- Excellent medical, dental, and vision coverage

## About Output Biosciences

## Company Overview
- **One-liner**: Output Biosciences is pioneering Biologically-Aware Generative AI to understand complex biological systems and generate breakthrough medicines.
- **Entity Type**: Private (Seed stage, Y Combinator S21 batch)
- **Headquarters**: New York, New York, United States
- **Founded**: 2021
- **Founders**: Mirella Mashiach (Co-Founder) and other repeat founders of AI-driven biotech startups

## Core Business
- **Primary industry/industries**: Biotechnology Research, Generative AI, Drug Discovery
- **Target customers**: B2B (pharmaceutical and biotech companies), Enterprise (research institutions)
- **Mission or purpose statement**: "Teaching Generative AI the Language of Biology" to advance humanity to a new level of health by building Large Biological Models that can generate breakthrough medicines.

## Products & Services
- **Large Biological Models**: A new generative AI architecture designed to handle the extremely long, nonlinear, fragmented, and high-dimensional data of biological systems. These models aim to transform the way diseases are diagnosed, treated, and prevented.
- **Biologically-Aware Generative AI Platform**: A proprietary platform that understands complex biological systems, enabling the generation of novel therapeutic candidates and insights.

## Market Standing
- **Valuation/Market Cap**: Not publicly available (private company)
- **Key Metric**: Total Funding – Seed round (2023) and Pre-Seed round (2021) from Y Combinator and other investors; exact amounts not disclosed.
- **Notable Investors/Partners**: Y Combinator (Summer 2021 batch)
- **Growth Signals**: Headcount grew 50% YoY (from 2 to 4 employees); monthly website traffic grew 56.9% month-over-month and 98.3% year-over-year; 9 active job postings as of mid-2025, indicating aggressive hiring.

## Core Business
- Primary industry/industries: Biotechnology Research, Generative AI, Drug Discovery
- Target customers: B2B (pharmaceutical companies, biotech firms, research institutions)
- Mission or purpose statement: Teaching Generative AI the Language of Biology to understand complex biological systems and generate breakthrough medicines.

## Products & Services
- **Large Biological Models (LBMs)**: A proprietary generative AI architecture that can process the extremely long, nonlinear, fragmented, and high-dimensional data of biological systems. These models are designed to generate breakthrough medicines and transform the way diseases are diagnosed, treated, and prevented. Type: AI/Software platform.

## Market Standing
- **Valuation/Market Cap**: Not publicly available
- **Key Metric**: Total Funding – Pre-Seed round (August 2021) and Seed round (January 2023) from Y Combinator and other investors; exact amounts not disclosed.
- **Notable Investors/Partners**: Y Combinator (Summer 2021 batch)
- **Growth Signals**: Headcount grew 50% YoY (from 2 to 4 employees); monthly website traffic grew 56.9% month-over-month and 98.3% year-over-year; 9 active job postings as of mid-2025, indicating a significant hiring push.

## Competitive Advantages
- **Novel AI Architecture**: Their generative AI is specifically designed for biological data, which is "extremely long, nonlinear, fragmented, and high dimensional" — a fundamental challenge that standard LLMs cannot handle.
- **Founding Team Expertise**: Repeat founders of AI-driven biotech startups, with backgrounds in computational systems biology, nonlinear dynamics, and medicine.
- **Y Combinator Backing**: Part of the prestigious Y Combinator Summer 2021 batch, providing strong validation and network effects.
- **First-Mover in Biologically-Aware AI**: They are pioneering a new category of AI models that are "biologically-aware," a significant differentiator from general-purpose AI models applied to biology.

## Strategic Focus
- **Current priorities**: Building and scaling their core team of researchers and engineers to develop Large Biological Models. They are actively hiring across machine learning, computational biology, and interpretability roles.
- **Direction for growth**: Expanding from research to generating breakthrough medicines, with a focus on pretraining, molecular generation, and model interpretability.

## Why Work Here
- **Culture highlights**: A mission-driven environment focused on making a tangible impact on human health. The company emphasizes "impatience to see how your work improves people's lives."
- **Remote/hybrid/office policy**: Hybrid model with a strong New York HQ presence. Some roles are listed as "New York HQ" with a preference for in-person collaboration, while others (e.g., Machine Learning Engineer, Senior Computational Biologist) are available as remote positions.
- **Notable perks or engineering culture**: A small, tight-knit team (currently 4 employees) with a high degree of ownership and impact. The company is at the forefront of generative AI and biology, offering the chance to work on fundamental research problems. They are actively hiring for 9 roles, including research interns and senior computational biologists, indicating a strong commitment to building a world-class R&D team.

## Strategic Focus
- **Current priorities**: Expanding the core team across machine learning, computational biology, and interpretability. They are focused on pretraining large biological models and developing methods to understand and generate biological sequences.
- **Direction for growth**: Moving from foundational research to generating breakthrough medicines, with a clear pipeline toward therapeutic applications.

## Why Work Here
- **Culture highlights**: Mission-driven, high-impact environment where "impatience to see how your work improves people’s lives" is a core value. The team is small (4 employees) and collaborative, offering significant ownership and visibility.
- **Remote/hybrid/office policy**: Hybrid model with a strong New York HQ presence. Some roles (e.g., Machine Learning Engineer, Senior Computational Biologist) are listed as remote, while others are NYC-based. The company has two offices in New York.
- **Notable perks or engineering culture**: Opportunity to work at the cutting edge of generative AI and biology. The company is expanding its core team and has 9 active job postings, including research intern positions, making it accessible to new graduates as well as experienced professionals. The tech stack includes Python, TensorFlow, and PyTorch.

## Sources
1. [outputbio.com](https://outputbio.com/)
2. [ycombinator.com](https://www.ycombinator.com/companies/output)
3. [linkedin.com](https://www.linkedin.com/company/output-biosciences)
4. [jobs.ashbyhq.com](https://jobs.ashbyhq.com/output)

## Other roles at Output Biosciences

- [Member of the Technical Staff, Pretraining](https://feeny.ai/job/member-of-the-technical-staff-pretraining-output-biosciences-new-york-8m06djybaawf) — New York, NY
- [Member of the Technical Staff, Generative](https://feeny.ai/job/member-of-the-technical-staff-generative-output-biosciences-new-york-d7h39gzbcpqj) — New York, NY
- [Member of the Technical Staff, Biological Data](https://feeny.ai/job/member-of-the-technical-staff-biological-data-output-biosciences-new-york-6z41abthyzrk) — New York, NY
- [Member of the Technical Staff, Cheminformatics](https://feeny.ai/job/member-of-the-technical-staff-cheminformatics-output-biosciences-new-york-d0azrngcqn26) — New York, NY
- [Member of the Technical Staff, Interpretability](https://feeny.ai/job/member-of-the-technical-staff-interpretability-output-biosciences-new-york-vnnp41pj7x8r) — New York, NY
- [Software Engineer, Agents](https://feeny.ai/job/software-engineer-agents-output-biosciences-new-york-bjkfjnfqzp3t) — New York, NY
- [AI Technical Recruiter](https://feeny.ai/job/ai-technical-recruiter-output-biosciences-remote-x12g46g758gq)
- [Head of Discovery](https://feeny.ai/job/head-of-discovery-output-biosciences-new-york-6t1706k1y2nz) — New York, NY