--- title: 'Head of Global Medical Affairs at Praxis Precision Medicines, Inc.' canonical: 'https://feeny.ai/job/head-of-global-medical-affairs-praxis-precision-medicines-inc-united-states-6trj5srg82zg' type: 'job' last_seen: '2026-09-13' --- # Head of Global Medical Affairs at Praxis Precision Medicines, Inc. - **Company:** Praxis Precision Medicines, Inc. - **Location:** United States - **Compensation:** $310k–$360k - **Work type:** remote - **Posted:** 2025-12-31 - **Last confirmed live:** 2026-09-13 - **Apply:** https://job-boards.greenhouse.io/praxisprecisionmedicines/jobs/5045860008 ## Job description Location:  This position may be performed remotely, but requires the flexibility and willingness to travel as needed. The Opportunity Praxis is hiring a dedicated and experienced leader to serve as Head of Global Medical Affairs.  You'll be responsible for building and leading the team with the goal of enhancing the development and commercialization of our neuroscience pipeline.  As a key contributor you will work closely with a cross-functional group that includes counterparts in Research & Development and Commercial to implement and ensure an all-encompassing strategy. This is an outstanding opportunity to serve as a driving force in building medical affairs excellence at Praxis.  The role will actively participate in strategic planning, ongoing and new development projects, existing and future corporate alliances, and partnering discussions. It is an ideal opportunity for a hands-on builder who brings both scientific rigor and strategic judgment—someone energized by creating Medical Affairs excellence from the ground up and translating complex science into real impact for patients. Primary Responsibilities - Build out and lead the medical affairs function to support commercial launches of new products into the marketplace. - Lead, manage and develop a best-in-class, high-performance medical affairs team and related support functions. - Identify, define and implement process and operating procedures for this group which are consistent with general guidance already in place for the development organization. - Develop and manage a Medical Science Liaison team and a Medical Information team. - Develop and implement Medical Communication and Disease State Awareness strategies. - Develop and execute life cycle management plans. - Partner with KOLs to gather information on current focused therapeutic area issues and questions. - Lead the development of product publication plans, key opinion leader engagement plans, medical education plans, advisory boards, medical symposia, congress activities and compassionate use/post-trial access programs. - Collaborate with the Clinical Development and Commercial teams with the development of education material for providers and patients that is medically accurate and appropriate. - Possess an understanding of government and industry guidelines, regulations, laws, etc., for appropriate scientific/medical exchange and communication with customers. - Provide direction and input to deliver integrated evidence to support successful reimbursement and market-access strategies. - Work closely with members of the senior management team, to develop the overall strategic direction for Praxis; evaluate alternative strategies, identify competitive issues, capitalize on core strengths, and develop and implement operating plans to achieve objectives for profitable growth. - Help represent Praxis in the context of conferences, presentations, industry, and investment groups. ## Qualifications and Key Success Factors - Advanced Scientific or Clinical degree is required (MD, PhD or PharmD) with a demonstrated passion for neuroscience. - Minimum of 15 years of applicable experience within a medical affairs leadership role in the pharmaceutical industry, including global experience. - Demonstrate an ability to build, lead and develop a team of highly performing and motivated medical affairs individuals. - A visionary business leader with a track-record of inspiring, influencing, and supporting direct and cross functional teams. - Prior experience thriving in a small/entrepreneurial setting is preferred. - Highly developed written and verbal communication skills, including ability to effectively articulate highly technical/complex scientific data and concepts to audiences with various levels of scientific and technical knowledge. - Excellent understanding of healthcare and a curiosity for business opportunities. - Customer-focused: Keep patients, payers and physicians front and center in their daily work and collaborate to solve critical scientific and business challenges. - Ability to lead by example, attract and develop talent, build interdependent partnerships and create a culture of collaboration and teamwork that fosters open communication, constructive conflict resolution and organizational flexibility. - Extensive experience in launch and commercialization of specialty drugs and direct interaction with the FDA and international regulatory agencies is highly desirable. - The physical and mental requirements of our roles include but are not limited to regular use of a computer, devices or other office equipment, clear communication, and occasional movement.  You'll need comfort with screen work, basic hand coordination, and focus.  Reasonable accommodations may be made to enable individuals with disabilities to perform these functions. Annualized Base Salary $310,000—$360,000 USD ## Compensation & Benefits At Praxis, we believe that taking care of our people (and their people) is important, so we provide a world class benefits package to help you thrive.  This includes 99% of the premium paid for medical, dental and vision plans.  We also provide company-paid life insurance, AD&D, disability benefits, and voluntary plans to personalize your coverage. Thinking about the future?  We match dollar-for-dollar up to 6% on eligible 401(k) contributions and sweeten the deal with long-term stock incentives and ESPP.  We provide a discretionary quarterly bonus, an extremely flexible wellness benefit, generous PTO, paid holidays and company-wide shutdowns.  Not to mention, you'll also be joining a phenomenal crew of colleagues who are smart, engaged and inspiring.  We aim high, collaborate hard, and produce results.  Let’s achieve the impossible together! Company Overview Praxis Precision Medicines is a clinical-stage biopharmaceutical company translating genetic insights into the development of therapies for central nervous system disorders characterized by neuronal imbalance.  At Praxis we share a common vision of reshaping the human condition into a more freeing and fulfilled existence by developing high impact medicines for patients and families affected by and living with complex brain disorders.  Our core Values of Trust, Ownership, Curiosity and Results are foundational to every aspect of our business and are exemplified by each and every one of our team members. Diversity, Equity & Inclusion Guided by our core values, at Praxis Precision Medicines, Inc. we continue to DARE FOR MORE® to advance, promote, and champion diversity, equity, and inclusion by encouraging individuals to bring their authentic selves and perspectives to work each day. We are an equal opportunity employer and committed to providing opportunities to all qualified applicants without regard to race, religious creed, color, gender identity or expression, age, national origin, sexual orientation, disability, genetics, military service and veteran status, or any other characteristic protected by federal, state, or local laws. Attention: Job Scam Alert Praxis has recently become aware of fraudulent job recruitment postings from individuals claiming to represent Praxis. These postings seek financial information in connection with fraudulent opportunities for employment. If you suspect any fraudulent activity or misrepresentation in connection with a Praxis job opportunity, please report it to careers@praxismedicines.com. Praxis does not accept unsolicited submissions from recruitment agencies for open positions. We ask all recruitment agencies to refrain from contacting any Praxis employee regarding any position. All unsolicited resumes submitted by recruitment agencies to any Praxis employee in any form or method will be deemed to be the property of Praxis, and Praxis explicitly reserves the right to hire those candidate(s) without any financial obligation to the recruitment agency. ## About Praxis Precision Medicines, Inc. ## Company Overview - **One-liner**: Praxis Precision Medicines is a fully integrated, clinical-stage biopharmaceutical company developing precision therapies for central nervous system (CNS) disorders characterized by neuronal excitation-inhibition imbalance. - **Entity Type**: Public (NASDAQ: PRAX) - **Headquarters**: Boston, Massachusetts, United States - **Founded**: 2015 - **Founders**: Dr. Steven Petrou (Co-Founder and President of R&D) ## Core Business - **Primary Industry**: Biotechnology (CNS / Neuroscience) - **Target Customers**: Patients with rare and prevalent neurological disorders (e.g., essential tremor, developmental and epileptic encephalopathies, focal epilepsy); healthcare providers; payers. - **Mission / Purpose**: To translate genetic insights into the development of life-altering therapies for CNS disorders more effectively and efficiently. ## Products & Services Praxis operates two proprietary platforms and a pipeline of late-stage and early-stage programs: - **Cerebrum™ (Small Molecule Platform)**: Orally available precision therapies targeting ion channels and neuronal circuits. Key assets include: - **Ulixacaltamide**: A T-type calcium channel inhibitor for essential tremor (ET). NDA submission to the FDA expected by mid-February 2026. Breakthrough Therapy Designation. - **Relutrigine**: For SCN2A- and SCN8A-developmental and epileptic encephalopathies (DEEs). NDA submission expected by mid-February 2026. Breakthrough Therapy Designation. Also in Phase 3 for broad DEEs. - **Vormatrigine**: A sodium-channel modulator for focal onset seizures (FOS). In Phase 3 trials (POWER1, POWER2). - **Solidus™ (Antisense Oligonucleotide Platform)**: For genetically defined CNS disorders. Key asset: - **Elsunersen**: An ASO designed to reduce SCN2A gene expression for early-seizure-onset SCN2A-DEE. In Phase 3 (EMBRAVE3). Orphan Drug Designation. - **Early-Stage Pipeline**: Preclinical candidates (PRAX-020, PRAX-080, PRAX-090, PRAX-100) targeting other genetic epilepsies and neurodevelopmental disorders. ## Market Standing - **Market Cap**: ~$156.0 million (as of mid-2026 data) [linkedin.com] - **Key Metric (Revenue/Funding)**: Annual revenue reported at ~$8.6M (pre-commercial stage). Pro forma cash, cash equivalents, and marketable securities stand at **$1.5 billion** following a public offering in January 2026 that raised ~$621 million [ir.praxismedicines.com]. - **Notable Investors/Partners**: Ionis Pharmaceuticals, Inc. (collaboration on elsunersen); RogCon, Inc. (license agreement). - **Growth Signals**: - Rapidly scaling headcount: 166 employees (+49.7% year-over-year) [linkedin.com]. - Transformation to a commercial-stage company: Preparing for two NDA submissions by mid-February 2026. - Combined peak revenue estimates for its four late-stage assets expected to exceed **$20 billion** [ir.praxismedicines.com]. - Active hiring: 31 open positions in mid-2026 (up 933% year-over-year) [linkedin.com]. ## Competitive Advantages - **Precision Neuroscience Moat**: Deep understanding of shared biological targets and circuits in the brain derived from genetic epilepsies. - **Proprietary Dual Platforms**: Leveraging both small molecule (Cerebrum) and ASO (Solidus) modalities to address a wide range of CNS disorders. - **Breakthrough Therapy Designations**: Both lead assets (ulixacaltamide, relutrigine) have FDA Breakthrough Therapy Designation, accelerating development and review. - **Strong Cash Position**: $1.5 billion pro forma cash provides a long runway through multiple potential product launches and pipeline expansion. - **Late-Stage Pipeline**: Four late-stage product candidates approaching potential commercial launch, de-risking the company substantially. ## Strategic Focus - **Commercial Launch Readiness**: Building out commercial infrastructure, sales force, and patient support programs in parallel with regulatory submissions. - **Pipeline Expansion**: Declaring multiple new drug candidates from both Cerebrum and Solidus platforms in 2026. - **Lifecycle Management**: Exploring indication expansion for existing assets (e.g., relutrigine in broad DEEs via the EMERALD study; vormatrigine for monotherapy FOS). - **Global Reach**: Operating in 5 countries (US, Australia, India, Colombia, Brazil) with a growing workforce. ## Why Work Here - **Mission-Driven Work**: Opportunity to deliver transformative therapies to patients with severe, underserved CNS disorders. - **Growth Trajectory**: The company is at a pivotal inflection point, transitioning from a clinical-stage to a commercial-stage organization — offering dynamic career growth. - **Remote-First Culture**: The vast majority of open positions across all departments (Clinical, Medical, Commercial, Finance, Legal, etc.) are listed as **"United States - Remote"** [greenhouse.io]. This includes roles like Director, Commercial Compliance; Senior Clinical Trial Manager; and Director, Field Reimbursement. - **Global Talent**: Engineering and technical roles are open internationally (e.g., Software Engineer in Brazil) [greenhouse.io]. - **Strong Leadership**: Recent appointments of experienced pharmaceutical executives (Jeffrey B. Kinder, Stuart Arbuckle) and internal promotions (Megan Sniecinski to COO). - **Compensation**: Employee reviews indicate a strong **Compensation rating of 4.0/5.0**, though overall culture and career ratings are lower (2.8 and 2.7 respectively on LinkedIn) [linkedin.com]. - **Workforce Demographics**: A high proportion of Director-level roles are open (20% of workforce), alongside specialists and senior IC roles, suggesting significant opportunities for leadership-level hires. ## Sources 1. [greenhouse.io](http://job-boards.greenhouse.io/praxisprecisionmedicines) - Jobs at Praxis Precision Medicines, Inc. 2. [ir.praxismedicines.com](https://ir.praxismedicines.com/news-releases/news-release-details/praxis-precision-medicines-enters-its-next-chapter-following) - Press Release: Business Outlook and Priorities for 2026 3. [linkedin.com](https://www.linkedin.com/company/praxis-precision-medicines-inc) - LinkedIn Company Profile 4. [stockanalysis.com](https://stockanalysis.com/stocks/prax/company/) - Company Profile & Key Executives ## Other roles at Praxis Precision Medicines, Inc. - [Corporate Counsel - US](https://feeny.ai/job/corporate-counsel-us-praxis-precision-medicines-inc-united-states-3pawyte701ph) — United States - [Associate Director, Regulatory Affairs, AD Promo](https://feeny.ai/job/associate-director-regulatory-affairs-ad-promo-praxis-precision-medicines-inc-knjtsbdgq5rn) — United States - [Medical Information Specialist](https://feeny.ai/job/medical-information-specialist-praxis-precision-medicines-inc-united-states-p7f0w7ye8d61) — United States - [Clinical Medical Monitor](https://feeny.ai/job/clinical-medical-monitor-praxis-precision-medicines-inc-united-states-aycaavkze79q) — United States - [Manager, Analytical Sciences - Commercial](https://feeny.ai/job/manager-analytical-sciences-commercial-praxis-precision-medicines-inc-united-fj5ctas3k0w2) — United States - [Director, Medical Science Liaisons](https://feeny.ai/job/director-medical-science-liaisons-praxis-precision-medicines-inc-united-states-bhakzbah9dvw) — United States - [Associate Director, Regulatory CMC](https://feeny.ai/job/associate-director-regulatory-cmc-praxis-precision-medicines-inc-united-states-e2y1dazam5bd) — United States - [Computer Systems Validation Engineer](https://feeny.ai/job/computer-systems-validation-engineer-praxis-precision-medicines-inc-united-84kqsazb917h) — United States - [Clinical Development Leader, Lifecycle Management](https://feeny.ai/job/clinical-development-leader-lifecycle-management-praxis-precision-medicines-inc-hvv6gtsjkytp) — United States - [Clinical Development Leader, Epilepsies](https://feeny.ai/job/clinical-development-leader-epilepsies-praxis-precision-medicines-inc-united-ywq6h858ygqj) — United States