---
title: 'Histotechnologist at Nudge'
canonical: 'https://feeny.ai/job/histotechnologist-nudge-san-francisco-s199c1tjhxwm'
type: 'job'
last_seen: '2026-09-04'
---

# Histotechnologist at Nudge

- **Company:** Nudge
- **Location:** San Francisco, CA
- **Employment:** full-time
- **Work type:** onsite
- **Posted:** 2026-03-20
- **Last confirmed live:** 2026-09-04
- **Apply:** https://jobs.ashbyhq.com/nudge/ec11034f-bf73-43dc-8e06-fbfa615b97ac

## Job description

## About Nudge

At Nudge, our mission is to develop the best technology for interfacing with the brain to improve people's lives. We're starting with an approach that we believe can help the most people the fastest, and also allow us to learn as much about the brain as possible: developing a non-invasive, ultrasound-based device that can stimulate and image the brain at high resolution and depth. This is a vertically integrated effort building cutting-edge hardware, software, and research capabilities to create products that can benefit millions — and eventually billions — of people.

To succeed, we need to assemble world-class teams across everything we do. We hire people who are exceptional at their craft, believe hard things are worth doing, and execute relentlessly — people who expect the highest levels of both rigor and integrity from each other.

## About the role

We’re looking for a Histotechnologist to own and execute histology workflows at Nudge, focused primarily on mouse and rat brain tissue. You’ll be responsible for building the full histology pipeline: perfusion, prosection, embedding, sectioning, staining, and imaging — across both traditional and cutting-edge techniques, to understand the mechanisms of ultrasonic neuromodulation.

As a histotechnologist at Nudge, you will:

- Perform routine and advanced histological processing of rodent brain tissue, including perfusion, prosection, fixation, embedding (paraffin and OCT), and sectioning via microtome, cryostat, and vibratome
- Execute standard histological stains (H&E, special stains) and immunohistochemistry using both manual and automated staining platforms
- Operate and optimize tissue clearing platforms (electrophoretic, solvent-based) for whole-brain and thick-section imaging
- Prepare cleared tissue for light sheet fluorescence microscopy and volumetric 3D imaging
- Operate and maintain automated sectioning and tissue processing systems
- Prepare and process samples for spatial omics platforms, including multiplexed protein imaging and spatial transcriptomics, with both RNA- and protein-based tagging approaches
- Develop, optimize, and document SOPs for histological workflows, ensuring reproducibility and quality
- Collaborate with research scientists to adapt tissue processing and staining strategies to specific experimental questions

## About you

We are looking for histotechnologists with at least 3 years of industry experience. Regardless of career level, you should have:

- Hands-on experience in histotechnology, with significant time spent processing rodent brain tissue
- Proficiency across core histological techniques: microtomy (paraffin, cryo, vibratome), tissue embedding, H&E staining, and immunohistochemistry
- Experience with at least one tissue clearing method and associated imaging modalities (light sheet microscopy)
- Familiarity with automated staining and sectioning platforms
- HT(ASCP) certification or equivalent training; Bachelor’s degree in biology, neuroscience, or a related field preferred
- High integrity and strong professional judgment

## About Nudge

## Company Overview
- **One-liner**: Developing non-invasive ultrasound-based brain interfaces to treat neurological disorders and enhance human cognition.
- **Entity Type**: Private (Series A)
- **Headquarters**: San Francisco, California, USA
- **Founded**: 2024
- **Founders**: Fred Ehrsam (Co-Founder & CEO), Jeremy Barenholtz (Co-Founder, President & CTO), Quintin Frerichs (Co-Founder)

## Core Business
- **Primary industry**: Biotechnology / Neurotechnology (non-invasive neuromodulation)
- **Target customers**: Initially medical patients suffering from addiction, chronic pain, and anxiety; long-term goal is a consumer device for cognitive enhancement (focus, sleep, learning, memory).
- **Mission statement**: "To develop the best technology for interfacing with the brain to improve people's lives." [nudge.com](https://www.nudge.com/blog/about/)

## Products & Services
- **Nudge Device (Helmet)**: A high-channel-count ultrasound phased array packed into a helmet that operates inside an MRI machine. It delivers anatomically precise, personalized focused ultrasound to deep brain regions while using advanced imaging to visualize targets and effects. This is a non-invasive, vertically integrated hardware/software system. [nudge.com](https://www.nudge.com/blog/about/)
- **Future Portable Device**: A miniaturized, home-use version designed to be as simple and ubiquitous as headphones, with built-in imaging capabilities and personalized stimulation. [nudge.com](https://www.nudge.com/blog/about/)

## Market Standing
- **Valuation**: Not disclosed
- **Key Metric**: Total Funding – $100M (Series A, August 2025)
- **Notable Investors/Partners**: Series A led by Thrive Capital and Greenoaks. [linkedin.com](https://www.linkedin.com/company/nudge-corp)
- **Growth Signals**: 
  - Headcount grew from ~14 to 32 employees in the past year (+105.9% YoY). [linkedin.com](https://www.linkedin.com/company/nudge-corp)
  - Active job postings increased 66.7% YoY (20 open roles). [builtin.com](https://builtin.com/company/nudge-nudgecom)
  - First device prototype built in six months, with a significantly improved second iteration already completed. [nudge.com](https://www.nudge.com/blog/about/)
  - Early evidence: single session of ultrasound reduced cravings in opioid use patients, with effects persisting up to 90 days. [nudge.com](https://www.nudge.com/blog/about/)

## Competitive Advantages
- **Non-invasive deep brain access**: Uses focused ultrasound to reach millimeter-size subregions deep in the brain without surgery.
- **MRI compatibility**: The helmet works inside an MRI scanner, enabling real-time structural and functional imaging to verify targeting and effects.
- **Vertically integrated**: Builds custom hardware, software, simulation, and imaging algorithms in-house.
- **Whole-brain approach**: Designed to eventually interface with any brain region, not just superficial areas.

## Strategic Focus
- **Near-term**: Demonstrate safety and efficacy for medical conditions (addiction, chronic pain, anxiety) through clinical studies.
- **Long-term**: Develop a portable, affordable, consumer-grade device for daily cognitive enhancement (focus, sleep, learning, memory).
- **Technology roadmap**: Continue iterating on the MRI-guided helmet while building the foundation for a miniaturized at-home device. [nudge.com](https://www.nudge.com/blog/about/)

## Why Work Here
- **Culture**: Mission-driven, tackling hard scientific and engineering problems at the frontier of brain-computer interfaces.
- **Work policy**: In-office (San Francisco) – employees work from physical offices. [builtin.com](https://builtin.com/company/nudge-nudgecom)
- **Team**: Rapidly growing; currently ~32 people with a heavy technical and research focus (34% technical, 23% research). [linkedin.com](https://www.linkedin.com/company/nudge-corp)
- **Perks**: Opportunity to contribute to a groundbreaking technology that could help billions; ownership over challenging hardware, software, and research problems.
- **Hiring**: 20+ open roles across engineering, research, and operations. Apply via [jobs.ashbyhq.com/nudge](https://jobs.ashbyhq.com/nudge)

## Sources
1. [nudge.com – Company Homepage](https://www.nudge.com/)
2. [nudge.com – Mission, Technology, and Approach](https://www.nudge.com/blog/about/)
3. [builtin.com – Nudge Company Profile](https://builtin.com/company/nudge-nudgecom)
4. [linkedin.com – Nudge Company Page](https://www.linkedin.com/company/nudge-corp)

## Other roles at Nudge

- [Clinical Research Operations Manager](https://feeny.ai/job/clinical-research-operations-manager-nudge-san-francisco-qgn8tw94fw5x) — San Francisco, CA
- [Finance Operations Manager](https://feeny.ai/job/finance-operations-manager-nudge-san-francisco-knfwcfaqp2r9) — San Francisco, CA
- [Mechanical Engineer](https://feeny.ai/job/mechanical-engineer-nudge-san-francisco-trne1m2ymsxz) — San Francisco, CA
- [Session Operator](https://feeny.ai/job/session-operator-nudge-san-francisco-dmra3dsc5d99) — San Francisco, CA
- [Clinical Research Coordinator](https://feeny.ai/job/clinical-research-coordinator-nudge-san-francisco-trtf6074y886) — San Francisco, CA
- [Member of Research Staff, Preclinical](https://feeny.ai/job/member-of-research-staff-preclinical-nudge-san-francisco-dtsdehta9a6g) — San Francisco, CA
- [MR Technologist](https://feeny.ai/job/mr-technologist-nudge-san-francisco-cwr7gd4r6487) — San Francisco, CA
- [MR Physicist](https://feeny.ai/job/mr-physicist-nudge-san-francisco-exzz9faqmvkx) — San Francisco, CA
- [Technical Sourcer](https://feeny.ai/job/technical-sourcer-nudge-san-francisco-07n9yb47x57v) — San Francisco, CA
- [Recruiting Coordinator](https://feeny.ai/job/recruiting-coordinator-nudge-san-francisco-ew6eg81fjsx2) — San Francisco, CA