--- title: 'In vivo Research Associate, Oncology at Pattern Biosciences' canonical: 'https://feeny.ai/job/in-vivo-research-associate-oncology-pattern-biosciences-south-san-francisco-vt7a9t7s29tp' type: 'job' last_seen: '2026-11-08' --- # In vivo Research Associate, Oncology at Pattern Biosciences - **Company:** Pattern Biosciences - **Location:** South San Francisco, CA - **Employment:** full-time - **Work type:** onsite - **Posted:** 2025-10-24 - **Last confirmed live:** 2026-11-08 - **Apply:** https://jobs.lever.co/pantheon-bio/e9a7ac6d-ebe0-4a19-8b57-57f168e75220 ## Job description You will perform in vivo studies of our AAV-based cancer therapeutic candidates to advance our oncology pipeline and technology platform. You will contribute to the design of the preclinical studies and their execution, ensuring high level of scientific rigor and compliance with relevant regulations. This is an ideal position for a candidate with a strong background in vivo experiments who thrives in a team-oriented, cross-disciplinary, and collaborative environment. Primary Responsibilities - Plan and execute in vivo studies in collaboration with discovery and data scientists - Perform various in vivo procedures in mice: dosing via IV, IP and SC, blood sampling, and complex surgeries to establish orthotopic tumor models via abdominal surgery - Conduct routine animal health monitoring and recording and monitor tumor volume by in vivo imaging or caliper measurement - Perform necropsy, biological sample processing, tissue dissociation and cell sorting via MACS or FACS, and downstream analysis - Conduct mammalian cell culture and QC for in vivo experiments - Generate, document and analyze in vivo study data in accordance with study protocols, SOPs, and regulatory guidelines - Interface with external laboratories and partners Required Skills & Qualifications - MSc in life sciences. - At least 3 years of hands-on experience working with murine oncology models in an academic or industry setting. - Strong hands-on experience with complex rodent procedures, such as thoracic or abdominal surgery, suturing and wound closure, and tail vein dosing - Experience in necropsy, tissue handling and processing, tumor cell and splenocyte isolation, and flow cytometry - Detail-oriented with strong organizational and record-keeping skills - Excellent communication skills and ability to collaborate effectively in a cross-functional team. - Experience working in a GLP or regulatory-compliant environment is a plus. At Pattern Bio, we design biological circuits at the intersection of synthetic biology and AI for cell-specific targeting of cancer tissue. By integrating data-driven design into every step—from DNA constructs to AAV-based delivery systems—we are building precise, rationally engineered, curative therapies. Our cohesive and driven team in South San Francisco is dedicated to curing cancer and saving lives. ## About Pattern Biosciences ## Company Overview - **One-liner**: Pattern Biosciences builds DNA computers that run molecular programs inside human cells to treat cancer and other diseases with unprecedented precision. - **Entity Type**: Private (Privately Held; Pre-Seed Stage) - **Headquarters**: South San Francisco, California, United States (with additional presence in Switzerland) - **Founded**: 2018 (based on earliest grant funding records) - **Founders**: Yaakov (Kobi) Benenson (CEO) and Bartolomeo Angelici (VP Discovery Research) ## Core Business - **Primary Industry**: Biotechnology Research (Synthetic Biology / DNA Computing for Therapeutics) - **Target Customers**: B2B/B2C – developing therapies aimed at oncology and other hard-to-treat diseases; potential partners include pharmaceutical and biotech companies. - **Mission Statement**: “Reprogram disease for health” (from careers page) / “We build DNA computers to cure disease.” ## Products & Services - **DNA Computer Platform (Therapeutic Candidates)**: A proprietary biomolecular computing technology that uses transcription factors, microRNAs, promoters, and enhancers as inputs. The platform senses multiple molecular cues at the single‑cell level, computes a molecular program, and activates a potent therapeutic effector when a disease‑specific pattern is identified. This enables therapies that can target previously undruggable drivers of disease. ## Market Standing - **Valuation / Market Cap**: Not publicly available - **Key Metric**: Total known funding – Pre‑Seed round (September 2023, 1 investor) plus early grants: ~USD 81,868 (2019) and EUR 50,000 (2018). Additional pre‑seed amount not disclosed. - **Notable Investors**: Not named in public sources. - **Growth Signals**: - Headcount of 18 employees (+26.7% YoY growth). - Active job postings for In Vivo Scientist, Biomarker Scientist, and Finance & Business Operations Lead. - Growing LinkedIn presence (+21.5% yearly follower growth to 4,356). - Described as building a “world‑class team” to translate two decades of DNA computing research into the clinic. ## Competitive Advantages - **Proprietary DNA Computing Platform**: The only company systematically engineering multi‑input molecular computation at the single‑cell level using bottom‑up, data‑driven design. - **Targets Undruggable Drivers**: Leverages intracellular molecules (e.g., transcription factors, microRNAs) that are key disease drivers but largely inaccessible to conventional small molecules or biologics. - **Rational Engineering Approach**: Uses a build‑design‑test cycle with sophisticated *in vitro* and *in vivo* models, enabling faster iteration and higher probability of success than traditional drug discovery. ## Strategic Focus - **Current Priorities**: Advancing early‑stage pipeline of cancer therapies; validating and iterating therapeutic candidates in clinically‑relevant models; expanding the R&D team (especially in vivo pharmacology, biomarker science, and data engineering). - **Direction for Growth**: Transition from platform development toward IND‑enabling studies and eventual clinical trials, with an emphasis on curative therapies for diseases where the one‑drug‑one‑target paradigm has failed. ## Why Work Here - **Culture**: Small, tight‑knit team (18 people) with a shared mission to “cure disease” using cutting‑edge synthetic biology. Emphasis on rational, data‑driven engineering and collaborative science. - **Work Model**: Fully in‑person at the South San Francisco headquarters. No remote or hybrid options mentioned. - **Notable Perks / Engineering Culture**: Opportunity to work at the forefront of DNA computing and synthetic biology; direct impact on therapeutic design from bench to clinic; access to state‑of‑the‑art lab facilities and sophisticated model systems. The company values iterative debugging – failure modes are quickly identified and corrected. - **Open Roles (as of mid‑2025)**: In Vivo Scientist, Oncology; Biomarker Scientist, Immuno‑oncology; Finance & Business Operations Lead. ## Sources 1. [patternbio.com](https://www.patternbio.com/) – Company overview and technology description 2. [patternbio.com/careers](https://patternbio.com/careers) – Careers page with headquarters, mission, and team philosophy 3. [patternbio.com/home-copy](https://www.patternbio.com/home-copy) – Founders list and detailed platform explanation 4. [linkedin.com/company/pattern-biosciences](https://linkedin.com/company/pattern-biosciences) – Employee count, growth, funding history, job postings, and company details ## Other roles at Pattern Biosciences - [In vivo Scientist, Oncology](https://feeny.ai/job/in-vivo-scientist-oncology-pattern-biosciences-south-san-francisco-aafan0a641cs) — South San Francisco, CA - [Corporate Counsel](https://feeny.ai/job/corporate-counsel-pattern-biosciences-south-san-francisco-cykshnnbanyh) — South San Francisco, CA - [Strategic Finance Lead](https://feeny.ai/job/strategic-finance-lead-pattern-biosciences-south-san-francisco-n9x7mg1a101x) — South San Francisco, CA