--- title: 'In vivo Scientist, Oncology at Pattern Biosciences' canonical: 'https://feeny.ai/job/in-vivo-scientist-oncology-pattern-biosciences-south-san-francisco-aafan0a641cs' type: 'job' last_seen: '2026-11-08' --- # In vivo Scientist, Oncology at Pattern Biosciences - **Company:** Pattern Biosciences - **Location:** South San Francisco, CA - **Employment:** full-time - **Work type:** onsite - **Posted:** 2026-11-05 - **Last confirmed live:** 2026-11-08 - **Apply:** https://jobs.lever.co/pantheon-bio/5f756489-fd22-4ad3-bb28-20f84b7ad692 ## Job description ## About Pattern Biosciences At Pantheon Bio, we build DNA computers that run molecular programs in cells to treat cancer and other diseases. Using multi-input molecular-level computation in individual cells, our approach leads to curative therapies where the conventional one drug-one target paradigm has failed to deliver effective treatments. We are building a world-class team at our headquarters in South San Francisco to translate two decades of scientific progress in DNA computing and synthetic biology into the clinic. ## About the role You will design and execute in vivo mouse studies of AAV-based cancer therapeutic candidates to advance our oncology pipeline and technology platform. You will contribute to preclinical study design and lead their execution, ensuring high levels of scientific rigor and compliance with relevant regulations. This is an ideal position for a candidate with a strong background in immuno-oncology and in vivo pharmacology who thrives in a team-oriented, cross-disciplinary collaborative environment. ## Key responsibilities - Design and execute in vivo studies in various preclinical tumor models to evaluate the mechanism of action, efficacy and safety of therapeutic candidates - Perform in vivo procedures, such as orthotopic tumor implantation, IV and IP injections, blood sampling, in vivo imaging, and animal welfare monitoring - Perform necropsy, tissue collection and processing for IHC or histopathology, tissue dissociation and cell sorting via MACS/FACS for downstream tumor cell-based or immune cell-based assays - Conduct immune cell profiling using multicolor flow cytometry, and cytokine/chemokine analysis using ELISA and Luminex - Generate, document, analyze and interpret experimental data to support critical decisions on the lead candidates - Manage external laboratories and partners ## Who you are - PhD in Life Sciences with specialization in oncology or immunology - At least 3 years of hands-on experience working with murine tumor models in an industry and/or academic setting - Demonstrated independent ability to design, execute and interpret experimental data - Demonstrated experience in in vivo procedures, such as rodent surgery and IV dosing - Experience with tissue handling and processing, cell sorting, multi-color flow cytometry and cytokine profiling, experience with IHC and ISH is a plus - Proficiency in mammalian cell and tissue culture - Detail-oriented, with strong organizational and record-keeping skills - Excellent communication skills and ability to collaborate effectively in a cross-functional team - Experience working in a GLP or regulatory-compliant environment is a plus To apply, please submit a cover letter and a detailed CV to careers@pantheonbio.com ## About Pattern Biosciences ## Company Overview - **One-liner**: Pattern Biosciences builds DNA computers that run molecular programs inside human cells to treat cancer and other diseases with unprecedented precision. - **Entity Type**: Private (Privately Held; Pre-Seed Stage) - **Headquarters**: South San Francisco, California, United States (with additional presence in Switzerland) - **Founded**: 2018 (based on earliest grant funding records) - **Founders**: Yaakov (Kobi) Benenson (CEO) and Bartolomeo Angelici (VP Discovery Research) ## Core Business - **Primary Industry**: Biotechnology Research (Synthetic Biology / DNA Computing for Therapeutics) - **Target Customers**: B2B/B2C – developing therapies aimed at oncology and other hard-to-treat diseases; potential partners include pharmaceutical and biotech companies. - **Mission Statement**: “Reprogram disease for health” (from careers page) / “We build DNA computers to cure disease.” ## Products & Services - **DNA Computer Platform (Therapeutic Candidates)**: A proprietary biomolecular computing technology that uses transcription factors, microRNAs, promoters, and enhancers as inputs. The platform senses multiple molecular cues at the single‑cell level, computes a molecular program, and activates a potent therapeutic effector when a disease‑specific pattern is identified. This enables therapies that can target previously undruggable drivers of disease. ## Market Standing - **Valuation / Market Cap**: Not publicly available - **Key Metric**: Total known funding – Pre‑Seed round (September 2023, 1 investor) plus early grants: ~USD 81,868 (2019) and EUR 50,000 (2018). Additional pre‑seed amount not disclosed. - **Notable Investors**: Not named in public sources. - **Growth Signals**: - Headcount of 18 employees (+26.7% YoY growth). - Active job postings for In Vivo Scientist, Biomarker Scientist, and Finance & Business Operations Lead. - Growing LinkedIn presence (+21.5% yearly follower growth to 4,356). - Described as building a “world‑class team” to translate two decades of DNA computing research into the clinic. ## Competitive Advantages - **Proprietary DNA Computing Platform**: The only company systematically engineering multi‑input molecular computation at the single‑cell level using bottom‑up, data‑driven design. - **Targets Undruggable Drivers**: Leverages intracellular molecules (e.g., transcription factors, microRNAs) that are key disease drivers but largely inaccessible to conventional small molecules or biologics. - **Rational Engineering Approach**: Uses a build‑design‑test cycle with sophisticated *in vitro* and *in vivo* models, enabling faster iteration and higher probability of success than traditional drug discovery. ## Strategic Focus - **Current Priorities**: Advancing early‑stage pipeline of cancer therapies; validating and iterating therapeutic candidates in clinically‑relevant models; expanding the R&D team (especially in vivo pharmacology, biomarker science, and data engineering). - **Direction for Growth**: Transition from platform development toward IND‑enabling studies and eventual clinical trials, with an emphasis on curative therapies for diseases where the one‑drug‑one‑target paradigm has failed. ## Why Work Here - **Culture**: Small, tight‑knit team (18 people) with a shared mission to “cure disease” using cutting‑edge synthetic biology. Emphasis on rational, data‑driven engineering and collaborative science. - **Work Model**: Fully in‑person at the South San Francisco headquarters. No remote or hybrid options mentioned. - **Notable Perks / Engineering Culture**: Opportunity to work at the forefront of DNA computing and synthetic biology; direct impact on therapeutic design from bench to clinic; access to state‑of‑the‑art lab facilities and sophisticated model systems. The company values iterative debugging – failure modes are quickly identified and corrected. - **Open Roles (as of mid‑2025)**: In Vivo Scientist, Oncology; Biomarker Scientist, Immuno‑oncology; Finance & Business Operations Lead. ## Sources 1. [patternbio.com](https://www.patternbio.com/) – Company overview and technology description 2. [patternbio.com/careers](https://patternbio.com/careers) – Careers page with headquarters, mission, and team philosophy 3. [patternbio.com/home-copy](https://www.patternbio.com/home-copy) – Founders list and detailed platform explanation 4. [linkedin.com/company/pattern-biosciences](https://linkedin.com/company/pattern-biosciences) – Employee count, growth, funding history, job postings, and company details ## Other roles at Pattern Biosciences - [Corporate Counsel](https://feeny.ai/job/corporate-counsel-pattern-biosciences-south-san-francisco-cykshnnbanyh) — South San Francisco, CA - [Strategic Finance Lead](https://feeny.ai/job/strategic-finance-lead-pattern-biosciences-south-san-francisco-n9x7mg1a101x) — South San Francisco, CA - [In vivo Research Associate, Oncology](https://feeny.ai/job/in-vivo-research-associate-oncology-pattern-biosciences-south-san-francisco-vt7a9t7s29tp) — South San Francisco, CA