--- title: 'In Vivo Technical Specialist at Nosis Bio' canonical: 'https://feeny.ai/job/in-vivo-technical-specialist-nosis-bio-alameda-5krynm64qyg2' type: 'job' last_seen: '2026-11-06' --- # In Vivo Technical Specialist at Nosis Bio - **Company:** Nosis Bio - **Location:** Alameda, CA - **Employment:** full-time - **Work type:** onsite - **Posted:** 2026-10-09 - **Last confirmed live:** 2026-11-06 - **Apply:** https://jobs.ashbyhq.com/nosisbio/e6f423b7-997f-40ef-8c14-dc6dce0bbf1a ## Job description About Nosis Bio: Nosis Bio is a well-funded biotech startup exclusively focused on cell-specific delivery of RNA therapeutics. We are an all-scientist team of biologists, chemists, and machine learning experts who believe targeted extrahepatic delivery is the key to making RNA therapies the standard of care for a wide range of chronic diseases. We combine deep expertise in receptor biology, generative AI, and high-throughput in vivo data generation to accelerate the development of RNA therapeutics for new tissues. We are addressing a major unmet need across the industry and actively partner with pharmaceutical companies, research institutions, and biotech companies. About the Role: We are seeking a Technical Specialist / Research Associate to conduct in-vivo experiments to evaluate the pharmacokinetic (PK), pharmacodynamic (PD), and efficacious properties of therapeutic candidates. The successful candidate will have hands-on experience with in-vivo animal studies and will work closely with multidisciplinary teams to support various drug discovery projects. This is an on-site, in person position. ## Responsibilities - Perform in-vivo PK/PD and efficacy studies in animal models, including intravenous (IV) and subcutaneous dose administration, blood sampling, tissue collection, and necropsy. - Adopt new techniques and develop disease models for in house use. - Ensure proper animal handling and dosing techniques, following established protocols and ethical guidelines. - Collect, organize, and document experimental data accurately and maintain laboratory records in compliance with company protocols and regulatory standards. - Stock/maintain consumables and reagents necessary for experiments. - Collaborate with cross-functional teams, including biology, chemistry, and translational science, to support project goals and timelines. What we’re looking for: - Ability to work on site in our lab spaces located in the California Bay Area – Research park at Marina Village (Alameda, CA) - Motivated and proactive with strong problem-solving skills. - Team-oriented and open to collaboration across scientific disciplines. - Title and track is dependent on academic and professional experience – we recruit diverse backgrounds including those with academic, non-profit, and industry experiences! - General Requirement: AS or BS degree with 3+ years in vivo experience (industry or academia) and 1+ years experience in an industry (or similar) environment ## About Nosis Bio ## Company Overview - **One-liner**: Nosis Bio is a biotechnology company developing receptor-targeted RNA medicines using an AI-native platform to enable cell-specific gene silencing for the treatment of chronic diseases. - **Entity Type**: Private (Series stage not publicly disclosed) - **Headquarters**: Berkeley, California, United States - **Founded**: Not publicly disclosed - **Founders**: Jim Martineau (CEO & Co-founder), Seth Myers (CTO & Co-founder), Chad Miller (Head of Research Platform & Co-founder) ## Core Business - **Primary industry/industries**: Biotechnology, RNA Therapeutics, Drug Delivery, AI-Powered Drug Design - **Target customers**: B2B (pharmaceutical partners for co-development and licensing) and B2C (patients via internal pipeline of therapeutics) - **Mission or purpose statement**: To end chronic disease by changing the cost and risk curve of new therapeutic development. ## Products & Services - **Connexa™ Platform**: An AI-native, physics-aware deep learning platform that designs RNA therapeutics capable of targeting any cell type. It co-selects and co-optimizes delivery ligands with specific RNA payloads to unlock therapeutic access for conditions of the heart, lungs, kidneys, muscle, small intestine, blood cells, and brain. - **Internal Pipeline (Fibrosis)**: Nosis Bio nominated its first development candidate in fibrosis in July 2025, advancing its cell-targeted gene silencing platform into IND-enabling studies. ## Market Standing - **Valuation**: Not disclosed - **Key Metric**: Total funding amount not publicly disclosed; revenue not applicable (pre-commercial biotech) - **Notable Investors/Partners**: Johnson & Johnson (strategic collaboration and license agreement, expanded in March 2026 for Neurology), Daiichi Sankyo (collaboration announced March 2025) - **Growth Signals**: 46.2% year-over-year headcount growth (13 employees as of mid-2026); opened a new 16,000-square-foot facility in Alameda, CA; nominated first development candidate; secured major pharma partnerships with J&J and Daiichi Sankyo; active job postings (3 open roles as of July 2026). ## Competitive Advantages - **Cell-specific delivery**: The company’s core differentiator is solving the "largest unmet need in RNA therapeutic development" — delivering RNA medicines to cells beyond the liver. This unlocks an entirely new class of treatable diseases. - **Physics-aware AI**: Unlike many AI drug discovery companies that rely purely on pattern recognition, Nosis uses physics-informed machine learning (e.g., Deep Kernel Inversion) to scale accurate molecular interaction predictions, reducing the risk of overpromising. - **Full-stack platform**: The Connexa platform integrates delivery vehicle design, payload selection, and high-throughput biochemistry in-house, allowing rapid, de-risked in vivo development. ## Strategic Focus - **Neurology and beyond**: The expanded J&J collaboration (March 2026) signals a major push into central nervous system (CNS) indications, a notoriously difficult area for drug delivery. - **Internal pipeline advancement**: With a development candidate nominated in fibrosis, the company is transitioning from a pure platform play to a pipeline-stage biotech, moving toward IND-enabling studies. - **Partnership-driven growth**: Nosis is leveraging pharma collaborations to validate its platform while simultaneously advancing its own therapeutic programs, balancing near-term revenue with long-term value creation. ## Why Work Here - **Culture**: The company emphasizes a culture of "empathy and respect," "first principles thinking," and "failing fast, failing often, and learning." They value patient-centric outcomes and hold themselves to the highest standards of scientific rigor. - **Team**: Highly collaborative with a flat structure; the team includes brilliant scientists and engineers across computational, biochemistry, and translational disciplines. As of mid-2026, the team is small (~13 people) but growing rapidly (+46% YoY), offering significant impact and ownership. - **Work Environment**: Based in a brand-new, 16,000-square-foot facility in Alameda, CA, equipped for in-house high-throughput biochemistry. The company is on-site (Alameda/Berkeley area), with a focus on wet-lab and computational science collaboration. - **Notable Perks**: Opportunity to work at the frontier of AI and biology; direct exposure to major pharma partnerships (J&J, Daiichi Sankyo); early-stage equity potential in a high-growth startup; a mission-driven focus on curing chronic disease. ## Sources 1. [nosisbio.com](https://www.nosisbio.com/) 2. [nosisbio.com/about](https://www.nosisbio.com/about) 3. [nosisbio.com/careers](https://www.nosisbio.com/careers) 4. [linkedin.com/company/nosisbio](https://www.linkedin.com/company/nosisbio) 5. [jobs.ashbyhq.com/nosisbio](https://jobs.ashbyhq.com/nosisbio) ## Other roles at Nosis Bio - [Molecular Biology Research Associate I/II/Snr RA, Pharmacology](https://feeny.ai/job/molecular-biology-research-associate-i-ii-snr-ra-pharmacology-nosis-bio-alameda-vnqw4wpsc5pd) — Alameda, CA - [(Principal) Senior Scientist, Pharmacology](https://feeny.ai/job/principal-senior-scientist-pharmacology-nosis-bio-alameda-j539t9dmcb59) — Alameda, CA