--- title: 'Informatics Engineer at Prime Medicine' canonical: 'https://feeny.ai/job/informatics-engineer-prime-medicine-cambridge-t211ebww167m' type: 'job' last_seen: '2026-09-09' --- # Informatics Engineer at Prime Medicine - **Company:** Prime Medicine - **Location:** Cambridge, MA - **Compensation:** $134k–$163k - **Posted:** 2026-08-11 - **Last confirmed live:** 2026-09-09 - **Apply:** https://job-boards.greenhouse.io/primemedicine/jobs/6140875004 ## Job description Company Overview: Prime Medicine is a leading biotechnology company dedicated to creating and delivering the next generation of gene editing therapies to patients. The Company is leveraging its proprietary Prime Editing platform, a versatile, precise and efficient gene editing technology, to develop a new class of differentiated, one-time, potentially curative genetic therapies. Designed to make only the right edit at the right position within a gene while minimizing unwanted DNA modifications, Prime Editors have the potential to repair almost all types of genetic mutations and work in many different tissues, organs and cell types. Prime Medicine is currently progressing a diversified portfolio of investigational therapeutic programs organized around our core areas of focus: hematology, immunology & oncology, liver and lung. Across each core area, Prime Medicine is focused initially on a set of high value programs, each targeting a disease with well-understood biology and a clearly defined clinical development and regulatory path, and each expected to provide the foundation for expansion into additional opportunities. For more information, please visit [www.primemedicine.com](http://www.primemedicine.com/). ## About the role We're hiring an Informatics Engineer to build the scientific data and computing platform that powers Prime Medicine's gene editing programs. You will work in close partnership with our computational biology team and our cloud infrastructure team. The role suits someone who's comfortable owning a platform end-to-end, building the engineering foundations that scientists across the organization rely on, including data pipelines and APIs through to AI-enabled internal tooling. Your engineering judgment about what to build and how to build it will shape how Prime Medicine works with scientific data day-to-day. ## What you'll do - Design and build the data platform connecting NGS instruments, laboratory informatics systems (Benchling), and AWS cloud compute; covering automated ingestion, provenance tracking, scalable storage, and observability. - Build production-grade APIs, SDKs, and internal tools that bring genomic data and analytical capabilities to scientists across the organization. - Build the orchestration layer for the automated, event-triggered execution of our scientific pipelines. The pipelines themselves (amplicon-seq, off-target analysis, and others) are co-developed with our computational biology team; you'll own how they run, scale, and integrate. - Ship AI-powered and agentic capabilities such as RAG over internal scientific data, agentic workflows with human-in-the-loop review, and internal copilots that streamline routine workflows across the organization connecting both science and business needs. - Build integrations across the scientific tool chain so data moves reliably between ELNs, LIMS, instrument software, and cloud compute. - Translate scientific requirements into reliable, maintainable software, helping bring research prototypes into production-grade systems. - Partner with computational biologists, lab scientists, and our cloud-support team to continuously improve platform performance, cost, and reliability. ## What we're looking for This is an Infrastructure engineering focused role, well suited to candidates whose primary background is software engineering, data engineering, or scientific platform engineering, with a strong interest in applying those skills to scientific problems. Requirements: - 5+ years of full-time engineering experience (3+ for those with an MS or PhD) in production environments. - Strong Python programming skills. - Production AWS experience with depth in event-driven, cloud-native architectures, including AWS Lambda, EventBridge (or comparable event-routing infrastructure), and Infrastructure as Code with Terraform or CDK. - Docker / containerization, Git-based workflows, CI/CD, code review, and testing code in DEV/TEST environments before deploying to production. - A track record of building integrations and automations. Experience in a life-science related industry involving scientific or regulated data, such as biotech, pharma, healthtech, clinical informatics, scientific instrumentation, or agricultural genomics. ## Nice to have - NGS expertise. Knowledge of NGS technology, workflows and pipeline architecture is strongly preferred. - Hands-on workflow orchestration experience. Familiarity with Nextflow/NextFlow Tower/Seqera Platform preferred. - Laboratory informatics experience with Benchling or comparable ELN/LIMS, as an operator, builder, or administrator. - AI / LLM tooling and agentic systems (LangChain, LangGraph, MCPs, RAG architectures). - Gene editing familiarity: CRISPR, base editing, prime editing. - GxP / 21 CFR Part 11 / regulated-software experience. - Plotly Dash, Streamlit, Spotfire, Retool, or similar tools for internal apps and data visualizations. - Experience managing or querying relational databases (PostgreSQL, MSSQL). Interview process The process includes a recruiter conversation, a hiring manager interview, and a small panel that includes computational biology, engineering, and wet lab partners. A Python coding exercise is part of the process Logistics and policy - Hybrid with office in Cambridge, MA. We are not currently able to sponsor visas. US work authorization at the time of application is required. - Competitive base salary, equity, and standard benefits. The pay range reflects the full-time base salary range we expect to pay for this role at the time of posting. Base pay will be determined based on several factors including, but not limited to, relevant experience, skills, and education. This role is eligible for an annual short-term incentive award (e.g., bonus) and an annual long-term incentive award (e.g., equity). Prime Medicine offers a comprehensive Total Rewards package with robust health, financial, and wellness benefits—including medical, dental, vision, life insurance, a 401(k) match, and equity programs—along with generous paid time off, wellness days, and company-wide recharge breaks. Our commitment to employee well-being reflects our belief that when we care for our people, we strengthen our ability to put patients first and make meaningful impact together. U.S. Pay Range $134,000—$163,000 USD Prime Medicine is proud to be an equal opportunity employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, national origin, age, sexual orientation, gender identity, disability, veteran status, or any other classification protected by law. ## About Prime Medicine ## Company Overview - **One-liner**: Prime Medicine is a biotechnology company using prime editing, a next-generation gene editing technology, to “search and replace” disease-causing genetic mutations and restore normal gene function. - **Entity Type**: Public (NASDAQ: PRME, IPO October 2022) - **Headquarters**: Cambridge, Massachusetts, United States - **Founded**: 2019 - **Founders**: David Liu, PhD (Scientific Founder); Andrew Anzalone, MD, PhD (Co-founder) ## Core Business - **Primary industry**: Biotechnology / Gene Editing Therapeutics - **Target customers**: Patients with genetic diseases; partners include pharmaceutical companies (e.g., Bristol Myers Squibb) and foundations (e.g., Cystic Fibrosis Foundation) - **Mission**: “To bring the promise of gene editing to patients” and ultimately “cure, halt, and prevent genetic diseases, providing lifelong benefit to patients.” ## Products & Services - **Prime Editing Platform**: A proprietary gene editing technology that acts like a “DNA word processor” to precisely replace faulty DNA sequences without causing double-strand breaks. Designed to address ~90% of known disease-causing mutations. - **PM359** (Phase 1/2): Ex vivo prime editing therapy for p47phox Chronic Granulomatous Disease (CGD). Received FDA RMAT designation and orphan drug designation. - **PM577a** (Phase 1/2): In vivo prime editing therapy for H1069Q-mutated Wilson Disease. Clinical trial application cleared in New Zealand. - **Alpha-1 Antitrypsin Deficiency (AATD)**: Discovery-stage liver program using LNP delivery. - **Cystic Fibrosis**: Discovery program supported by Cystic Fibrosis Foundation (up to $15M), using PASSIGE™ technology. - **Ex vivo CAR-T** (collaboration with Bristol Myers Squibb): Strategic license and broad collaboration to develop and commercialize ex vivo T-cell prime editor products. ## Market Standing - **Valuation/Market Cap**: $777.8 million (as of mid-2026, per LinkedIn data) - **Key Metric**: Annual revenue $4.6 million; total funding raised ~$1.02 billion (including post-IPO equity) - **Notable Investors/Partners**: ARCH Venture Partners, F-Prime, Bristol-Myers Squibb (corporate round $55M in 2024), Google Ventures (post-IPO equity $5M in 2025), Cystic Fibrosis Foundation - **Growth Signals**: - Clinical data for PM359 published in *The New England Journal of Medicine*; RMAT designation from FDA. - Headcount of 154 (down 29.4% YoY, likely reflecting strategic refocusing). - Active job postings: 7 (as of mid-2026), with recent uptick in quarterly postings (+40%). ## Competitive Advantages - **Prime Editing differentiation**: Unlike CRISPR, prime editing does not require double-strand DNA breaks, enabling more precise and predictable edits with fewer unwanted modifications. - **Broad applicability**: Can theoretically correct ~90% of known disease-causing mutations across many organs and cell types. - **Strong IP and scientific foundation**: Co-invented by David Liu (Broad Institute), a pioneer in gene editing. ## Strategic Focus - **Advancing lead programs** (PM359 for CGD, PM577a for Wilson Disease) through clinical development and regulatory approvals. - **Expanding pipeline** in liver, lung, hematology/immunology/oncology via internal research and strategic partnerships (e.g., BMS for CAR-T). - **Leveraging delivery technologies** (LNP, AAV, ex vivo electroporation) to enable both in vivo and ex vivo applications. ## Why Work Here - **Mission-driven culture**: Opportunity to shape the future of gene editing and directly impact patients with genetic diseases. - **Collaborative environment**: Emphasis on diversity of viewpoints, scientific curiosity, and passion for patient outcomes. - **Location**: Headquarters in Cambridge, MA – a hub for biotech innovation. Presence also in India. - **Career development**: Roles span research, clinical, technical development, finance, HR, and informatics. Recent job postings include AI & Informatics Engineer, Senior Scientist, and Director of People & Culture. - **Perks & culture**: Not explicitly detailed, but the company values “dedicated, scientifically curious individuals” and offers the chance to work with a world-class scientific team. ## Sources 1. [primemedicine.com](https://primemedicine.com/) 2. [primemedicine.com/about/](https://primemedicine.com/about/) 3. [primemedicine.com/careers/](https://primemedicine.com/careers/) 4. [primemedicine.com/pipeline/](https://primemedicine.com/pipeline/) 5. [linkedin.com/company/prime-medicine](https://www.linkedin.com/company/prime-medicine) ## Other roles at Prime Medicine - [Senior Quality Engineering Specialist](https://feeny.ai/job/senior-quality-engineering-specialist-prime-medicine-cambridge-yearqxvgjzt1) — Cambridge, MA - [Senior Scientist / Senior Engineer, LNP Process Development](https://feeny.ai/job/senior-scientist-senior-engineer-lnp-process-development-prime-medicine-h2ma4d77ffav) — Cambridge, MA - [Senior Scientist, mRNA Design & Platform Innovation](https://feeny.ai/job/senior-scientist-mrna-design-platform-innovation-prime-medicine-cambridge-hma82924aerh) — Cambridge, MA - [Senior Director, Biometrics](https://feeny.ai/job/senior-director-biometrics-prime-medicine-cambridge-5b24s6r19ew4) — Cambridge, MA