---
title: 'Manager, Development Sciences Operations at Atrium Therapeutics'
canonical: 'https://feeny.ai/job/manager-development-sciences-operations-atrium-therapeutics-san-diego-fkc4aevv610b'
type: 'job'
last_seen: '2026-09-11'
---

# Manager, Development Sciences Operations at Atrium Therapeutics

- **Company:** Atrium Therapeutics
- **Location:** San Diego, CA
- **Employment:** full-time
- **Work type:** onsite
- **Posted:** 2026-08-13
- **Last confirmed live:** 2026-09-11
- **Apply:** https://jobs.lever.co/atrium-therapeutics/7241c38e-c104-4226-ad8d-32184dc00612

## Job description

Atrium is a biopharmaceutical company pioneering delivery of RNA therapeutics to the heart to transform the standard of care for people living with cardiomyopathies. Our proprietary technology leverages the targeted RNA delivery platform initially designed at Avidity, which combines the tissue selectivity of mAbs and other targeted delivery ligands with the precision of oligonucleotides. This unique combination is designed to allow selective targeting of the underlying genetic drivers of disease that were previously undruggable. Through targeted, non-viral delivery of siRNA to cardiac tissues, our approach has the potential to overcome key limitations of nonspecific viral and nanoparticle-based delivery systems, including challenges related to tissue specificity, immunogenicity, and redosing. Position Overview:

Atrium Therapeutics is seeking a dynamic, flexible, and motivated Manager, Development Sciences Operations to help advance multiple programs from development candidate nomination through IND and beyond. Reporting within Development Sciences, this role owns the operational execution of the department’s outsourced nonclinical program — coordinating GLP and non-GLP toxicology and pharmacokinetic studies at contract research organizations (CROs) — and serves as a central steward of the Development Sciences department budget, including forecasting, purchase-order generation, and invoice/billing oversight in partnership with Finance. This role will also provide operational outsourcing and contracting support across Research. The successful candidate is a self-starter who thrives in a fast-paced, cross-functional environment and brings a collaborative, can-do approach. This is a full-time, onsite position based in La Jolla, CA. Responsibilities:

- Coordinate GLP and non-GLP toxicology and PK studies at CROs across start-up, execution, and close-out — including protocol finalization, sample and test-article logistics, data delivery, timelines, milestones, and action items
- Serve as the operational point of contact and sponsor representative for outsourced studies; perform on-site and remote CRO monitoring
- Track study timelines and budgets against program milestones; proactively identify operational risks and drive resolution
- Partner closely with study scientific leads to ensure timely execution and delivery of results that inform program development
- Support study data and report management, quality review, and nonclinical documentation, including regulatory submissions as needed
- Responsible for CRO qualification, contracting, and vendor-performance oversight in partnership with Legal, QA and Procurement
- Facilitate communication across CROs and internal functions — including toxicology, DMPK, bioanalytical, chemistry/CMC, regulatory, finance, legal, and project management
- Serve as a central steward of the Development Sciences department budget — leading tracking, forecasting, and variance monitoring in partnership with Finance, and overseeing purchase-order generation, invoicing, billing, and accruals Education and Experience Requirements:
- BS or MS in Biological Sciences, Toxicology, Pharmacology, Pathology, Life Sciences, or a related discipline.
- 8+ years of relevant experience in the pharmaceutical, biotechnology, or CRO industry, including demonstrated ownership of outsourced nonclinical study operations and departmental budget management.
- Hands-on experience with GLP/non-GLP toxicology study coordination, monitoring, and execution.
- Working knowledge of ICH guidelines, GLP standards, OECD requirements, and the nonclinical drug development process.
- Demonstrated CRO/vendor management, timeline and budget management, and contracting experience.
- Financial operation fluency: budget tracking and forecasting, purchase-order and invoice systems, and accruals.
- Excellent interpersonal skills, with the ability to work in a matrix environment and build relationships with key stakeholders.
- Proven ability to multi-task, work independently, and stay self-motivated.
- Excellent written and oral communication skills.
- Proficiency with Microsoft Word, Excel, PowerPoint, Outlook, Smartsheet, and Adobe Acrobat.
- Experience with project-management tools, databases, or electronic document management systems is preferred. What We Provide:
- The base salary range for this role is $142,000-$158,000. The final compensation will be commensurate with such factors as relevant experience, skillset, internal equity and market factors.
- Atrium offers competitive compensation and benefits which include stock options & RSUs, as well as a 401(k) with an employer match. In addition, the comprehensive wellness program includes coverage for medical, dental, vision, LTD, and unlimited of time off including summer & winter breaks.
- A commitment to learning and development which includes a variety of programming internally developed by and for Atrium employees, opportunities for job-specific training offered by industry, and an education reimbursement program.

## About Atrium Therapeutics

## Company Overview
- **One-liner**: Atrium Therapeutics is a biopharmaceutical company pioneering the delivery of RNA therapeutics directly to the heart muscle to transform the standard of care for people living with cardiomyopathies.
- **Entity Type**: Private (startup stage, not yet publicly traded; no funding rounds publicly disclosed)
- **Headquarters**: San Diego, California, United States
- **Founded**: 2026
- **Founders**: Not explicitly listed; the company was formed by a team of former executives from Avidity Biosciences and other biotech firms, led by CEO Kathleen Gallagher.

## Core Business
- **Primary industry**: Biotechnology – RNA therapeutics for cardiovascular diseases (precision cardiology).
- **Target customers**: Patients with rare cardiomyopathies (PLN cardiomyopathy, PRKAG2 syndrome), healthcare providers, and payers (B2B/B2C through drug development and eventual commercialization).
- **Mission statement**: “Pioneer the delivery of RNA therapeutics to the heart to transform the standard of care for people living with cardiomyopathies.”

## Products & Services
- **ATR 1072**: Development candidate for PRKAG2 syndrome (rare cardiomyopathy). Preclinical/early clinical stage.
- **ATR 1086**: Development candidate for PLN (phospholamban) cardiomyopathy. Preclinical/early clinical stage.
- **Undisclosed pipeline**: Two additional research-stage targets in rare cardiomyopathies.
- **Technology Platform**: Proprietary RNA delivery platform based on the clinically validated AOC (Antibody-Oligonucleotide Conjugate) technology, originally designed at Avidity Biosciences. Combines the tissue selectivity of monoclonal antibodies with the precision of oligonucleotides to deliver siRNA directly to cardiac tissue, overcoming challenges with immunogenicity, cytotoxicity, and redosing limitations.

## Market Standing
- **Valuation/Market Cap**: Not disclosed (private company; no public funding rounds reported).
- **Key Metric**: Headcount of 41 employees (as of mid-2026), with 5.7% monthly growth; 28 employees recruited from Avidity Biosciences.
- **Notable Investors/Partners**: No specific investors or partnerships disclosed publicly. The company’s “Investors” page is a placeholder.
- **Growth Signals**: Founded in 2026; rapid team building with deep expertise from Avidity, Ionis, Biogen, etc.; two lead candidates in development for high‑unmet‑need cardiomyopathies; 4,200+ LinkedIn followers with +4.2% monthly growth.

## Competitive Advantages
- **Proprietary cardiac RNA delivery platform** that targets heart muscle with high specificity – a key differentiator from viral and nanoparticle delivery systems.
- **Clinically validated technology** originally developed at Avidity Biosciences, reducing technical risk.
- **Focus on underserved rare cardiomyopathies** with no approved therapies (PLN, PRKAG2), offering potential for rapid regulatory pathways (orphan drug designation).
- **Experienced leadership team** with track record in RNA therapeutics, rare disease drug development, and commercialization (Akcea, Ionis, Biogen, Avidity).

## Strategic Focus
- **Advance two lead candidates** (ATR 1072, ATR 1086) through preclinical and into clinical trials.
- **Expand the pipeline** with additional undisclosed targets in rare cardiomyopathies.
- **Build out the organization**, particularly in translational medicine, process development, and quality assurance (as evidenced by current job postings).
- **Leverage the AOC platform** to potentially address broader cardiac indications beyond the initial rare disease focus.

## Why Work Here
- **Cutting‑edge science**: Opportunity to work on a novel RNA delivery platform with the potential to transform cardiology.
- **Small, agile team** (~41 employees) allows for high impact and visibility across functions.
- **Founding team from Avidity Biosciences** brings deep domain expertise and a proven track record in RNA therapeutics.
- **Location**: Onsite roles in San Diego, California (Science Center Drive), a major biotech hub.
- **Current open roles** include:
  - Scientist II, Translational Medicine (San Diego, onsite)
  - Senior Director, AOC Process Development & Manufacturing – Oligonucleotide (San Diego)
  - Senior Director, Head of Quality Assurance (San Diego)
  - Manager, Accounting (from LinkedIn)
- **Culture**: The company’s website emphasizes a commitment to patients with high unmet need, a collaborative environment, and a passion for precision medicine.
- **Perks**: Not explicitly stated, but typical biotech early‑stage includes equity, competitive compensation, and the chance to shape a young company’s culture.

## Sources
1. [Atrium Therapeutics - Homepage](https://atriumtherapeutics.com/)
2. [Atrium Therapeutics - About Page](https://atriumtherapeutics.com/about/)
3. [Atrium Therapeutics - Investors Page](https://investors.atriumtherapeutics.com/overview)
4. [Atrium Therapeutics - Careers Page](https://atriumtherapeutics.com/careers/)
5. [LinkedIn - Atrium Therapeutics](https://www.linkedin.com/company/atrium-therapeutics)

## Other roles at Atrium Therapeutics

- [Associate Director, Supply Chain & Logistics](https://feeny.ai/job/associate-director-supply-chain-logistics-atrium-therapeutics-san-diego-31w7rn8e081j) — San Diego, CA
- [Research Associate (Contract)](https://feeny.ai/job/research-associate-contract-atrium-therapeutics-san-diego-84w1pwtnp1nq) — San Diego, CA
- [Associate Director, Translational Medicine](https://feeny.ai/job/associate-director-translational-medicine-atrium-therapeutics-san-diego-ct34y2jzjtwy) — San Diego, CA