---
title: 'Manager, External Manufacturing Operations at Immunome, Inc.'
canonical: 'https://feeny.ai/job/manager-external-manufacturing-operations-immunome-inc-bothell-washington-344kbygcy4af'
type: 'job'
last_seen: '2026-09-05'
---

# Manager, External Manufacturing Operations at Immunome, Inc.

- **Company:** Immunome, Inc.
- **Location:** Bothell Washington, United States
- **Compensation:** $109k–$138k
- **Posted:** 2026-09-02
- **Last confirmed live:** 2026-09-05
- **Apply:** https://job-boards.greenhouse.io/immunomeinc/jobs/5414342008

## Job description

Company Overview

Immunome is a clinical-stage targeted oncology company committed to developing first-in-class and best-in-class targeted cancer therapies. We are advancing an innovative portfolio of therapeutics, supported by a leadership team with deep experience in the design, development, and commercialization of cutting-edge therapies, including antibody-drug conjugates. Our pipeline includes varegacestat, an investigational gamma secretase inhibitor for which an NDA has been accepted by the U.S. FDA; IM-1021, a clinical-stage ROR1 ADC; IM-1617, a clinical-stage solid tumor ADC; and IM-3050, a clinical-stage FAP-targeted radioligand therapy. We are also advancing a broad portfolio of early-stage ADCs pursuing undisclosed solid tumor targets.

Position Overview

The Manager, External Manufacturing Operations, is responsible for ensuring Immunome’s supply requirements are met through the coordination and oversight of activities performed by external suppliers, including Contract Development and Manufacturing Organizations (CDMOs) and other third-party service providers. The Manager will serve as a key point of contact for assigned external partners and collaborate cross-functionally to ensure the effective execution of activities in support of clinical and commercial programs.

The role will initially focus on small molecule programs, with the opportunity to support additional modalities as Immunome’s portfolio and external manufacturing network evolve and expand.

## Responsibilities

- Provide day-to-day oversight of assigned suppliers, serving as a primary point of contact and facilitating effective coordination between Immunome and its external partners.
- Participate in and, as appropriate, lead Virtual Management Teams (VMTs) comprising Quality, Product Supply, Technical Development, Regulatory, and other cross-functional stakeholders. Support alignment of priorities, deliverables, and key communications with CDMOs.
- Coordinate and conduct well-organized and documented meetings internally and with assigned external suppliers. Monitor progress against established plans, including pre-campaign preparation, manufacturing operations, release activities, and logistics. Identify potential delays and risks and work with internal and external stakeholders to support timely resolution.
- Develop a thorough understanding of Immunome’s manufacturing processes. Participate in technical reviews of master and executed batch records, specifications, investigations, change controls, and other manufacturing documentation, as required.
- Monitor supplier performance through established Key Performance Indicators (KPIs) and work with internal stakeholders and external partners to identify and implement opportunities for improvement. Participate in periodic Business Review Meetings and other supplier governance forums.
- Maintain understanding of assigned suppliers’ systems, capabilities, capacities, requirements, and business practices. Escalate significant operational, supply, quality, or relationship risks to leadership, as appropriate.
- Collaborate with Legal and External Manufacturing leadership in the development and negotiation of service agreements, statements of work, and other contractual arrangements.
- Partner with External Manufacturing leadership, Finance, and Project Management to monitor spending against budget, review CDMO invoicing for accuracy and alignment with contractual terms and communicate significant cost variances in a timely manner.
- Provide clear and timely updates to External Manufacturing leadership and cross-functional stakeholders regarding manufacturing progress, risks, priorities, and issues requiring attention or decision-making.
- Support technology transfers, supplier sourcing and qualification activities, as required.
- Participate in the development and periodic review of manufacturing and supply risk assessments and support implementation of appropriate risk mitigation plans.
- Contribute to the development and continuous improvement of processes, tools, and ways of working that support effective management of Immunome’s external manufacturing network.
- Support manufacturing data collection, trending, and analysis, including the preparation of continuous process verification (CPV) summaries and report drafts, as required.

## Qualifications

- Bachelor’s degree in biotechnology, biology, chemistry, chemical engineering, pharmaceutical sciences, or a related field required; an advanced degree is preferred.
- A minimum of 7 years of relevant experience in the biotechnology or pharmaceutical industry, or an equivalent combination of work and education experience.
- Hands-on experience in small molecule manufacturing operations, process development, process engineering, or related activities.
- Experience working directly with CDMOs and successfully collaborating in a matrixed, cross-functional environment.
- Position requires domestic and international travel of up to approximately 25%, with occasional evening and/or weekend commitments based on manufacturing activities and business needs.

Knowledge and Skills

- Strong organizational, communication, and collaboration skills, with the ability to effectively coordinate activities across internal functions and external partners.
- Working knowledge of cGMP requirements and pharmaceutical Quality Systems, including deviations, investigations, change controls, CAPAs, and batch disposition activities.
- Strong problem-solving skills, with the ability to identify manufacturing and supply risks, coordinate cross-functional input, and drive issues toward resolution.
- Working knowledge of service agreements, statements of work, and other contractual terms relevant to external manufacturing.
- Ability to operate effectively in a fast-paced and evolving environment, manage multiple priorities, and adapt as business needs change.

Washington State Pay Range $108,969—$138,046 USD

E/E/O

Immunome, Inc. is an equal opportunity employer. We celebrate diversity and are committed to creating an inclusive environment for all employees.

E-Verify

Immunome, Inc. is a participant in E-Verify. Please review the following notices: [E-Verify Participation Poster](https://immunome.box.com/s/bopxukipfidxjscs4bjxt75f90bvpppk) | https://immunome.box.com/s/r51g9subw1wqni9xkutbl6up635sjr8e | https://immunome.box.com/s/r3ekbimwh988my9vzl76tnlbg60zvh9u.

## About Immunome, Inc.

## Company Overview
- **One-liner**: Immunome is a clinical-stage oncology company developing first-in-class and best-in-class targeted cancer therapies, with a primary focus on antibody-drug conjugates (ADCs).
- **Entity Type**: Public (Nasdaq: IMNM)
- **Headquarters**: Bothell, Washington, United States
- **Founded**: The company was formed through a merger of Morphimmune and Immunome in October 2023.
- **Founders**: The company is led by Clay Siegall, Ph.D. (Chairman, CEO, and President), who co-founded Seagen. The original Immunome entity was founded earlier, but the current company structure dates to the 2023 merger.

## Core Business
- Primary industry/industries: Biotechnology, Oncology, Drug Discovery & Development
- Target customers: Patients with cancer, healthcare providers, and clinical trial sites. The company is a B2B/B2C entity in the healthcare and life sciences space.
- Mission or purpose statement: "Our mission is to improve outcomes for cancer patients by advancing and expanding a portfolio of first-in-class and best-in-class therapeutic candidates." [immunome.com](https://immunome.com/)

## Products & Services
- **Varegacestat (formerly AL102)**: A late-clinical stage gamma secretase inhibitor for the treatment of desmoid tumors. The company submitted a New Drug Application (NDA) to the U.S. FDA in April 2026. [investors.immunome.com](https://investors.immunome.com/)
- **IM-1021**: A ROR1-targeted antibody-drug conjugate (ADC) currently in a Phase 1 trial.
- **IM-3050**: A FAP-targeted radioligand which received IND clearance in Q1 2025.
- **Preclinical ADC Pipeline (IM-1617, IM-1340, IM-1335)**: ADCs pursuing undisclosed targets with expression in multiple solid tumors. IM-1617 had its first patient dosed in a Phase 1 trial in June 2026. [investors.immunome.com](https://investors.immunome.com/)

## Market Standing
- **Valuation/Market Cap**: Not publicly available in the search results. As a public company, this fluctuates. (Check recent filings for current data).
- **Key Metric**: The company is pre-revenue (clinical-stage) and has raised significant capital. Since the 2023 merger, CEO Clay Siegall has raised $355 million in equity financings. [immunome.com](https://immunome.com/about/)
- **Notable Investors/Partners**: The company is publicly traded. Key leadership previously worked at Seagen (acquired by Pfizer for $43 billion).
- **Growth Signals**: The company is rapidly advancing its pipeline. Key milestones include the NDA submission for varegacestat, first patient dosed for IM-1617, and positive Phase 3 data presented at ASCO 2026. The company currently lists 32 open positions on its careers page, indicating strong hiring momentum. [job-boards.greenhouse.io](http://job-boards.greenhouse.io/immunomeinc)

## Competitive Advantages
- **World-Class Leadership**: The executive team, led by Seagen co-founder Clay Siegall, has deep experience in designing, developing, and commercializing blockbuster ADCs (ADCETRIS, PADCEV, TIVDAK, TUKYSA). [immunome.com](https://immunome.com/about/)
- **Proprietary ADC Platform**: A systematic, data-driven process for optimizing antibodies, linkers, and payloads to create differentiated ADCs. [immunome.com](https://immunome.com/)
- **Near-Term Catalyst**: The NDA submission for varegacestat provides a potential near-term commercial opportunity.
- **Strong Financial Backing**: Raised $355M in equity since the merger, providing a solid runway for pipeline advancement.

## Strategic Focus
- **Advancing the Pipeline**: The primary focus is on executing clinical trials for varegacestat (Phase 3), IM-1021 (Phase 1), and IM-3050 (Phase 1), and advancing preclinical ADCs into the clinic.
- **Regulatory Filing**: Successfully navigating the FDA NDA submission and potential approval for varegacestat.
- **Discovery & Expansion**: Using their ADC discovery platform to generate new candidates and identify and acquire targeted oncology assets to expand the portfolio. [immunome.com](https://immunome.com/about/)

## Why Work Here
- **Mission-Driven**: The work directly impacts the lives of cancer patients, with a stated goal of developing transformative therapies. [immunome.com](https://immunome.com/about/)
- **High-Impact Team**: Opportunity to work with "some of the brightest and most experienced minds in ADC development," including leaders who have brought multiple drugs to market. [immunome.com](https://immunome.com/careers/)
- **Growth Stage**: With 32 open roles, the company is in a rapid growth phase, offering significant career advancement opportunities. [job-boards.greenhouse.io](http://job-boards.greenhouse.io/immunomeinc)
- **Comprehensive Benefits**: Includes 100% company-paid medical premiums for employees, a 401(k) with employer match, paid parental leave, and a week-long winter break. [immunome.com](https://immunome.com/careers/)
- **Location & Culture**: Based in Bothell, WA. The company describes a culture of "innovative, collaborative environment where employees are empowered to do their best work." [immunome.com](https://immunome.com/careers/)

## Sources
1. [Immunome Official Website](https://immunome.com/)
2. [Immunome About Page](https://immunome.com/about/)
3. [Immunome Investor Relations](https://investors.immunome.com/)
4. [Immunome Careers Page](https://immunome.com/careers/)
5. [Immunome Jobs on Greenhouse](http://job-boards.greenhouse.io/immunomeinc)

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