---
title: 'Manager, Forecasting at Kardigan'
canonical: 'https://feeny.ai/job/manager-forecasting-kardigan-evanston-qvn5b2dgyy11'
type: 'job'
last_seen: '2026-10-17'
---

# Manager, Forecasting at Kardigan

- **Company:** Kardigan
- **Location:** Evanston, IL
- **Compensation:** $142k–$185k
- **Posted:** 2026-09-24
- **Last confirmed live:** 2026-10-17
- **Apply:** https://job-boards.greenhouse.io/kardigan/jobs/5433783008

## Job description

## About Us

Kardigan is a heart health company working to make cardiovascular disease preventable, curable and no longer the leading cause of death in the world.

It is Kardigan’s mission to develop multiple targeted treatments in parallel that bring people with cardiovascular diseases to the cures they deserve.

Led by Tassos Gianakakos, Jay Edelberg, M.D., Ph.D., and Bob McDowell, Ph.D., Kardigan’s co-founders have reunited after leading MyoKardia to discover and develop mavacamten, the first cardiac myosin inhibitor, resulting in an acquisition by Bristol Myers Squibb in 2020.

We have a cutting-edge discovery and translational research platform, a pipeline of late-stage candidates, and an industry-leading team that is driven to improve the lives of patients.

At Kardigan, we are motivated by our values which guide how we work, interact, and achieve our goals. Driven by patients and their families, we are deeply committed to improving the lives of patients and prioritizing their needs above all else. We believe in being authentic—leading with truth to bring out the best in others by creating an environment where every person knows they will be fully accepted. With an eagerness to learn, we encourage the highest levels of curiosity and are open to changing our minds. We are committed to winning as a team with urgency, excellence, and intention, and support each other no matter what role we play or where we sit. Lastly, we strive to enable the impossible because patients are counting on us. We are not afraid to take risks to unlock innovation and advance scientific discoveries.

These values are the foundation of our work, empowering us to make a real difference, every day.

Position Title: Manager, Forecasting

Department: Portfolio Strategy

Reports To: Director, Portfolio Strategy

Location: Evanston, IL – On-site 4 days per week (Mon to Thurs)

Job Overview

Kardigan is hiring a Manager, Forecasting to turn data into the insights that guide strategic and operational decisions across our portfolio. Sitting within the Portfolio Strategy team, you will own how patient / revenue forecasts get built, synthesized and communicated. This position will collaborate closely with Insights & Analytics teams to provide input on key data points to gather from primary and secondary market research across patients, physicians, and payers. The role partners broadly across the organization, including Portfolio Strategy, Corporate Strategy, Product Strategy, Commercial, Clinical Development, Medical Affairs, Regulatory, R&D, Program Management and Business Development. Success here depends on analytical rigor: framing ambiguous questions, pressure-testing the underlying data, and reconciling signals that arrive from very different sources. The position also requires business acumen and a deep understanding of pharmaceutical operations to ensure the successful development, launch and growth of our products. The position is based in Evanston, IL.

Essential Duties and Responsibilities

- Lead forecasting across the portfolio, building the projection models behind both active programs, indication expansions, and prospective candidates
- Partner with Finance and Portfolio Strategy to deliver forecasts for the long-range plan, annual operating plan and budget cycles, ensuring alignment of assumptions across functions
- Ad hoc forecasting and analytics in partnership with investor relations to inform board meetings, earnings calls, and investor discussions
- Support business development activities by forecasting revenue opportunities for prospective asset candidates
- Partner with competitive intelligence to evaluate competitor clinical results and anticipated market dynamics; translate key findings into impacts on internal forecasts
- Own forecast governance, including documentation of assumptions, version control, reconciliation of actuals versus forecast, and tracking and improving forecast accuracy over time
- Analyze secondary data, including patient claims and epidemiology studies, alongside market research findings to characterize patient populations, determine market segmentation and uncover trends
- Build and maintain patient-flow and scenario models, running sensitivity analyses against target product profiles, clinical outcomes and launch timing to quantify risk and upside for decision makers
- Track how pricing, payer behavior and coverage hurdles are shifting, and feed these inputs into pricing and market access strategy
- Provide demand and volume forecasts to support launch readiness, supply planning and manufacturing, and commercial resource decisions such as field force sizing
- Identify emerging trends and areas of unmet need within priority disease areas to inform portfolio prioritization
- Raise the standard for how analytics are completed, choosing the right data assets, vendors and methods for the question at hand and codifying what works
- Present and discuss forecasts, assumptions, insights and recommendations with internal stakeholders and senior leadership; mentor junior analysts as the function grows

## Qualifications and Preferred Skills

- Bachelor’s degree required and a minimum of 5 years of consulting, investment, marketing, consulting, forecasting, or agency experience in healthcare/biopharmaceuticals. MBA or advanced degree preferred.
- Forecasting and Modeling: Proficiency in data analysis and financial modeling, including forecast, valuation and scenario models.
- Data and Market Research: Experience conducting and/or evaluating secondary data sources and primary market research, with the ability to interpret complex scientific and market data, identify key trends and extract meaningful insights.
- Collaboration: Ability to effectively collaborate across multiple functions and with internal and external stakeholders of various backgrounds and skill sets. Skilled in establishing a collaborative and respectful environment.
- Communication: Writes and presents with clarity, and can make a complex analysis land with scientists, commercial leaders, and executives alike.
- Industry Knowledge: Deep familiarity with the healthcare landscape — managed care and payers, patients, providers, biopharma companies, and the technologies and disease-area trends reshaping them.
- Strategic Thinking: Strong strategic thinking with the ability to synthesize market data, customer insights and scientific information into actionable recommendations.
- Business Excellence: Strong project and process management skills including the ability to manage multiple projects, set priorities and meet deadlines.
- Critical Thinking: Strong critical thinking and structured, problem-solving skills.
- Agility: Comfortable operating in a fast-moving, often ambiguous environment, and adapts as priorities shift.

Exact Compensation may vary based on skills, experience and location.

Pay range $142,000—$185,000 USD

## About Kardigan

## Company Overview
- **One-liner**: Kardigan is a publicly traded biopharmaceutical company developing targeted cardiovascular therapies with the aim of transforming treatment from symptom management toward functional cures.
- **Entity Type**: Public (ticker not available from provided sources; IPO closed as per company announcement)
- **Headquarters**: South San Francisco, California, United States (with additional offices in Princeton, New Jersey and Chicago, Illinois)
- **Founded**: Year not specified in available sources
- **Founders**: Tassos Gianakakos (Co-Founder, CEO & Chair), Dr. Jay Edelberg (Co-Founder & Chief Medical Officer), Dr. Bob McDowell (Co-Founder & Scientific Adviser), Brianne Puglisi (Co-Founder)

## Core Business
- **Primary industry**: Biopharmaceuticals – cardiovascular drug discovery and development
- **Target customers**: B2B / B2G – healthcare providers, hospitals, payers, and patients; the company develops prescription medicines for serious cardiovascular conditions
- **Mission or purpose statement**: “To make cardiovascular disease preventable, curable and no longer the leading cause of death in the world.” ([kardigan.bio](https://www.kardigan.bio/))

## Products & Services
- **Tonlamarsen**: A Phase 2/3 candidate for acute severe hypertension (ASH) and uncontrolled hypertension. Positive Phase 2 data presented as a late-breaker at ACC.26 and simultaneously published in JACC. ([kardigan.bio](https://www.kardigan.bio/))
- **Danicamtiv**: A Phase 3 candidate for genetic dilated cardiomyopathy (DCM), targeting the underlying inherited cardiac muscle disease. ([kardigan.bio](https://www.kardigan.bio/))
- **Calcific Aortic Valve Stenosis (CAVS) Program**: A late-stage clinical program addressing calcium deposition that stiffens the aortic valve. ([kardigan.bio](https://www.kardigan.bio/))
- **Prolaio Subsidiary**: An AI and real‑world data platform integrated into Kardigan to generate insights, inform clinical trial design, and reduce time/cost of drug development. ([kardigan.bio](https://www.kardigan.bio/about-us/))
- **Cardiac Intelligence Platform**: A discovery and translational research engine that uses real‑world patient data, AI, and deep cardiovascular expertise to identify disease drivers and design targeted therapies. ([kardigan.bio](https://www.kardigan.bio/))

## Market Standing
- **Valuation/Market Cap**: Not disclosed in provided sources
- **Key Metric**: Public company (IPO closed); annual revenue not disclosed
- **Notable Investors/Partners**: Not explicitly listed in provided sources; company built on the team’s track record from MyoKardia (acquired by Bristol Myers Squibb for $13.1B in 2020)
- **Growth Signals**:
  - Positive Phase 2 pivotal data for Tonlamarsen in hypertension, presented at ACC.26 and published in JACC
  - Three late‑stage clinical programs (CAVS, ASH, DCM) running in parallel
  - Active job postings across 210+ roles in clinical operations, data science, manufacturing, and corporate strategy, indicating scaling ([job-boards.greenhouse.io/kardigan](http://job-boards.greenhouse.io/kardigan))
  - Integration of Prolaio’s AI platform to accelerate R&D

## Competitive Advantages
- **Leadership expertise**: CEO Tassos Gianakakos previously scaled MyoKardia from startup to a $13.1B acquisition; the team includes veterans from MyoKardia, Sanofi, BMS, and Merck.
- **Parallel pipeline strategy**: Multiple late‑stage programs targeting distinct cardiovascular diseases (valve, hypertension, cardiomyopathy) de‑risks development and creates data synergies.
- **Cardiac Intelligence platform**: Proprietary combination of real‑world data, AI, and deep biological insight to move beyond symptom management toward modifying underlying disease.
- **Focus on functional cures**: Each program aims to alter the course of disease rather than merely treat symptoms, creating potential for breakthrough efficacy.

## Strategic Focus
- **Advance late‑stage clinical trials**: Continue Phase 2/3 studies for Tonlamarsen, Danicamtiv, and CAVS while preparing for potential regulatory submissions.
- **Expand platform capabilities**: Leverage Prolaio’s AI and real‑world evidence to design smarter, faster trials and discover new drug targets.
- **Build commercial infrastructure**: Growing corporate strategy, medical affairs, and manufacturing teams in South San Francisco, Princeton, and Chicago signals preparation for launch.

## Why Work Here
- **Culture**: “Everything we do starts with patients – and it’s powered by people.” Emphasis on collaboration, purpose‑driven work, and achieving the impossible together. Mission‑oriented environment focused on curing cardiovascular disease. ([kardigan.bio](https://www.kardigan.bio/job-openings/))
- **Work model**: Roles are listed for South San Francisco, Princeton, NJ, and Chicago, IL; likely on‑site/hybrid given the lab and clinical development nature. Not purely remote.
- **Benefits**:
  - Competitive salaries and annual bonus program
  - Comprehensive medical, dental, and vision coverage
  - 401(k) plan, life and disability insurance
  - Flexible spending and health savings accounts
  - Commuter benefits, cellphone allowance
  - Paid holidays and time off
  - Employee assistance program ([kardigan.bio](https://www.kardigan.bio/job-openings/))
- **Engineering & data science culture**: Active recruitment for data analytics, AI, and clinical data science roles; Executive Director of Data, AI & Collaboration Services is an open position, reflecting a strong tech‑driven R&D approach.

## Sources
1. [kardigan.bio](https://www.kardigan.bio/) – Company homepage and pipeline descriptions
2. [kardigan.bio/about-us](https://www.kardigan.bio/about-us/) – About Us, mission, and Prolaio integration
3. [kardigan.bio/job-openings](https://www.kardigan.bio/job-openings/) – Careers page with benefits and open roles
4. [kardigan.bio/leadership](https://www.kardigan.bio/leadership/) – Leadership team and co‑founder backgrounds
5. [job-boards.greenhouse.io/kardigan](http://job-boards.greenhouse.io/kardigan) – Detailed job listings (32+ postings)

## Other roles at Kardigan

- [Contracts Manager (Prolaio)](https://feeny.ai/job/contracts-manager-prolaio-kardigan-chicago-42r8rkrddx72) — Chicago, IL
- [Medical Director, Clinical Development](https://feeny.ai/job/medical-director-clinical-development-kardigan-princeton-h0r5qrx667b5) — Princeton, NJ
- [Executive Director, Global Program Manager](https://feeny.ai/job/executive-director-global-program-manager-kardigan-princeton-22n8a9rqn2kb) — Princeton, NJ
- [Director, Clinical Quality Lead](https://feeny.ai/job/director-clinical-quality-lead-kardigan-south-san-francisco-california-united-qzg2emd2he5j) — South San Francisco California United States Princeton New Jersey, United States
- [Senior Director, Biostatistics](https://feeny.ai/job/senior-director-biostatistics-kardigan-princeton-vb12pjj1sw78) — Princeton, NJ
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