---
title: 'Manager, Total Rewards at Tango Therapeutics'
canonical: 'https://feeny.ai/job/manager-total-rewards-tango-therapeutics-boston-fywb3xy2sabn'
type: 'job'
last_seen: '2026-09-08'
---

# Manager, Total Rewards at Tango Therapeutics

- **Company:** Tango Therapeutics
- **Location:** Boston, MA
- **Compensation:** $123k–$185k
- **Posted:** 2026-08-27
- **Last confirmed live:** 2026-09-08
- **Apply:** https://job-boards.greenhouse.io/tangotherapeutics/jobs/7979650003

## Job description

Company Overview

Tango Therapeutics is a biotechnology company dedicated to discovering novel drug targets and delivering the next generation of precision medicine for the treatment of cancer.

Using an approach that starts and ends with patients, Tango leverages the genetic principle of synthetic lethality to discover and develop therapies that take aim at critical targets in cancer.

This includes expanding the universe of precision oncology targets into novel areas such as tumor suppressor gene loss and their contribution to the ability of cancer cells to evade immune cell killing.

The Tango labs and offices are located at 201 Brookline Avenue, in the Fenway area of Boston, Massachusetts.

Summary:

Tango Therapeutics is seeking a Manager, Total Rewards to help design, deliver, and continuously enhance our compensation, benefits, and rewards programs. Reporting to the Senior Director, Total Rewards & HR Operations, this role will serve as a strategic partner across the organization, ensuring our programs are competitive, equitable, scalable, and aligned with Tango's mission and growth.

This position will lead key compensation initiatives while also owning the administration and evolution of Tango's health, welfare, retirement, leave, wellness, and recognition programs. The role will partner closely with Talent Acquisition, Finance, and external vendors to deliver best-in-class employee experience that supports our ability to attract, retain, and engage top talent

Your Role:

- Manage and evolve Tango's compensation and job leveling framework
- Conduct market benchmarking and salary surveys to support competitive pay decisions
- Partner with Talent Acquisition on job pricing, offer development, and compensation guidance for new hires
- Partner with annual compensation planning, merit, bonus, equity, and promotion processes
- Manage Tango's employee benefits programs, including medical, dental, vision, retirement, leave of absence, wellness, and other reward offerings
- Partner with brokers and vendors to evaluate plan performance, analyze utilization and cost trends, and recommend enhancements that support employee well-being and business objectives
- Lead benefit renewals, open enrollment, employee communications, and ongoing vendor management
- Ensure compliance with applicable compensation and benefits regulations, including pay transparency and pay equity requirements
- Manage employee recognition and reward programs, including spot awards and milestone recognition
- Leverage market data and compensation tools, including Radford, to provide actionable insights to leaders
- Support and optimize HR systems and Total Rewards processes to improve efficiency and employee experience
- Develop and deliver compensation, benefits, and workforce analytics to support leadership decision-making, measure program effectiveness, identify trends, and inform strategic Total Rewards initiatives

What You Bring:

- Bachelor's degree and 5+ years of Human Resources experience, with a focus on Compensation, Benefits, or Total Rewards
- Experience supporting a fast-paced biotech, life sciences, or high-growth organization
- Strong knowledge of compensation programs, market pricing, salary surveys, and job architecture
- Experience managing employee benefits programs, broker relationships, open enrollment, and vendor partnerships
- Familiarity with regulatory requirements related to compensation and benefits administration
- Proficiency with compensation data sources such as Radford and compensation benchmarking methodologies
- Strong analytical, problem-solving, and communication skills
- Ability to build trusted partnerships across HR, Finance, Talent Acquisition, and business leadership

We are an equal opportunity employer and value diversity at our company. We do not discriminate on the basis of race, religion, color, national origin, gender, sexual orientation, age, marital status, veteran status, or disability status.

## #LI-HYBRID

Salary range $123,000—$184,800 USD

## About Tango Therapeutics

## Company Overview
- **One-liner**: Tango Therapeutics is a clinical-stage biotechnology company leveraging the principle of synthetic lethality to discover and develop next-generation precision cancer medicines for genetically defined patient populations.
- **Entity Type**: Public (NASDAQ: TNGX)
- **Headquarters**: Boston, Massachusetts, United States
- **Founded**: 2017
- **Founders**: Not publicly disclosed (launched by Third Rock Ventures)

## Core Business
- **Primary industry/industries**: Biotechnology, Precision Oncology, Drug Discovery & Development
- **Target customers**: B2B (pharma partnerships, clinical trial sites); ultimate customers are cancer patients with specific genetic tumor profiles
- **Mission or purpose statement**: "Discover transformative drugs for people with cancer by leveraging the classic principles of synthetic lethality in innovative ways… building a road map to cures that will transform the lives of patients and their families." [tangotx.com](https://www.tangotx.com/join-us/)

## Products & Services
- **Vopimetostat (PRMT5 inhibitor)**: A clinical-stage, wholly-owned program targeting MTAP-deleted cancers, including pancreatic, lung, and glioblastoma. Currently in Phase 1/2 trials. [tangotx.com](https://www.tangotx.com/pipeline/)
- **TNG456 (PRMT5 inhibitor)**: A next-generation PRMT5 inhibitor for MTAP-deleted cancers, currently in pre-clinical development.
- **Daraxonrasib (RAS inhibitor)**: A combination therapy (with vopimetostat) for MTAPdel/RASmut pancreatic and lung cancers. Recently reported a 92% objective response rate in pancreatic cancer in a Phase 1/2 trial. [tangotx.com](https://www.tangotx.com/)
- **CRISPR-based Target Discovery Engine**: A proprietary platform for identifying novel synthetic lethal targets, enabling a robust pipeline of wholly-owned programs.

## Market Standing
- **Valuation/Market Cap**: ~$1.05 billion (as of mid-2026) [linkedin.com](https://www.linkedin.com/company/tango-therapeutics)
- **Key Metric**: Annual Revenue of ~$62.4 million; Total Funding raised ~$901 million (including post-IPO). [linkedin.com](https://www.linkedin.com/company/tango-therapeutics)
- **Notable Investors/Partners**: Third Rock Ventures (lead Series A), Boxer Capital (lead Series B), BCTG Acquisition Corp (parent). Strategic partners include pharma and biotech companies (collaborations under active exploration). [linkedin.com](https://www.linkedin.com/company/tango-therapeutics)
- **Growth Signals**: Completed a $600 million upsized public offering in June 2026; strong clinical data (92% ORR in pancreatic cancer); pipeline expanding into glioblastoma; headcount growth in job postings (+400% YoY in active roles). [tangotx.com](https://www.tangotx.com/)

## Competitive Advantages
- **Synthetic Lethality Expertise**: A deep, proprietary understanding of CRISPR-based target discovery to identify novel vulnerabilities in cancers with tumor suppressor gene loss, undruggable oncogenes, and immune evasion mechanisms.
- **Genetically Defined Patient Selection**: All programs are designed for well-defined patient populations with clear biomarkers, increasing the probability of clinical success and reducing trial risk.
- **Wholly-Owned Pipeline**: Unlike many biotechs that license out rights, Tango retains full ownership of its lead programs, capturing maximum value.
- **Strong Financial Position**: With over $1B in market cap and a recent $600M offering, the company is well-capitalized to advance its pipeline through pivotal trials.

## Strategic Focus
- **Current priorities**: Advancing vopimetostat and daraxonrasib into Phase 3 trials for pancreatic and lung cancers; expanding the pipeline into glioblastoma; continuing to discover and validate new synthetic lethal targets; building out commercial manufacturing and clinical operations infrastructure.
- **Direction for growth**: Becoming a fully-integrated biotechnology company capable of bringing its own medicines to market, while selectively pursuing strategic collaborations to expand reach.

## Why Work Here
- **Culture highlights**: Emphasizes "urgency + compassion," "courage + leadership," "spirit + resilience," and "embrace individuality and face challenges together." Described as a team of "passionate problem solvers" who are "all in for exciting science and changing lives." [tangotx.com](https://www.tangotx.com/join-us/)
- **Remote/hybrid/office policy**: Primarily on-site at Boston HQ (201 Brookline Ave, Suite 901, Boston, MA). Roles appear to be Boston-based, though some field-based positions (e.g., Medical Science Liaisons) are remote.
- **Notable perks or engineering culture**: High scientific ambition with a clear patient-first mission; strong leadership team with deep oncology experience; active hiring across clinical operations, biostatistics, medical affairs, and legal/compliance; 15+ active job postings with significant YoY growth in roles. [greenhouse.io](http://job-boards.greenhouse.io/tangotherapeutics)
- **Workforce**: ~129 employees, with a mix of research (26%), medical (12%), and operations roles. Notable alumni from Novartis, Vertex, Takeda, and Broad Institute. [linkedin.com](https://www.linkedin.com/company/tango-therapeutics)

## Sources
1. [Tango Therapeutics Official Website](https://www.tangotx.com/)
2. [Tango Therapeutics Careers Page (Greenhouse)](http://job-boards.greenhouse.io/tangotherapeutics)
3. [Tango Therapeutics LinkedIn Profile](https://www.linkedin.com/company/tango-therapeutics)
4. [Tango Therapeutics Pipeline Page](https://www.tangotx.com/pipeline/)
5. [Tango Therapeutics Join Us Page](https://www.tangotx.com/join-us/)

## Other roles at Tango Therapeutics

- [Vice President, Marketing & Sales](https://feeny.ai/job/vice-president-marketing-sales-tango-therapeutics-boston-ex81335qs4hc) — Boston, MA
- [Executive Director, Insights & Analytics](https://feeny.ai/job/executive-director-insights-analytics-tango-therapeutics-boston-4f5kkx80kztw) — Boston, MA
- [Senior Vice President, Market Access](https://feeny.ai/job/senior-vice-president-market-access-tango-therapeutics-boston-47tt1fw4qxxq) — Boston, MA
- [Senior Manager, Clinical Informatics](https://feeny.ai/job/senior-manager-clinical-informatics-tango-therapeutics-boston-g3pk44zmymam) — Boston, MA
- [Executive Director, FP&A](https://feeny.ai/job/executive-director-fp-a-tango-therapeutics-boston-kph81hnp4jvk) — Boston, MA
- [Associate Director, Pharmacovigilance Scientist](https://feeny.ai/job/associate-director-pharmacovigilance-scientist-tango-therapeutics-boston-5cgk3mmdsprr) — Boston, MA
- [Associate Medical Director, Pharmacovigilance](https://feeny.ai/job/associate-medical-director-pharmacovigilance-tango-therapeutics-boston-4kcjnjy0vpys) — Boston, MA
- [Executive Director, Clinical Development](https://feeny.ai/job/executive-director-clinical-development-tango-therapeutics-boston-xhzk5j65r72k) — Boston, MA
- [Clinical Trials Manager](https://feeny.ai/job/clinical-trials-manager-tango-therapeutics-boston-7yaaz94j244a) — Boston, MA
- [Senior Director, Clinical Sciences](https://feeny.ai/job/senior-director-clinical-sciences-tango-therapeutics-boston-j8hypf1vqq14) — Boston, MA