---
title: 'Operations Manager, HPC at Ossium Health'
canonical: 'https://feeny.ai/job/operations-manager-hpc-ossium-health-indianapolis-gha9s2wvmy47'
type: 'job'
last_seen: '2026-11-09'
---

# Operations Manager, HPC at Ossium Health

- **Company:** Ossium Health
- **Location:** Indianapolis, IN
- **Posted:** 2026-09-30
- **Last confirmed live:** 2026-11-09
- **Apply:** https://ossiumhealth.com/jd?gh_jid=4717710006

## Job description

## About Ossium

Ossium’s mission is to improve the health, vitality, and longevity of human beings through bioengineering. We develop, manufacture, and bank cell therapy products that apply the power of stem cell science to revolutionize treatment for patients with blood, immune, and orthopedic diseases.  At Ossium, we empower our employees, maintain the highest standards of operational excellence, and are a force for good.

## About the Job

The Operations Manager, HPC leads the hematopoietic progenitor cell (HPC) production team that turns organ donor vertebral bodies into bone marrow and other cell therapy products. You will own the HPC value stream at our Indianapolis facility, from donor intake and allocation to cell processing and cryopreservation, and the supervisors and operators who run it across shifts. You will also lead the cross-functional Core Team that ensures reliable production of HPC, Marrow and work closely with Tissue Production, MSAT, Engineering, Quality, and Supply Chain. This is a hands-on leadership role in a cleanroom environment: you will spend real time on the floor, and you will also own the metrics, the investigations, and the plan for scaling the team.

Required Qualifications

- BS/BA in a technical field or equivalent experience
- 5+ years of manufacturing or related experience
- 3+ years in a formal people-leadership role
- Working knowledge of aseptic technique, cleanroom operations, and cGTP/cGMP requirements
- Experience owning deviations, investigations, and CAPAs, including root cause analysis
- Excellent written and oral communication skills, with the ability to present results to cross-functional stakeholders
- High level of attention to detail and the ability to operate with organization and urgency in a dynamic environment

## Preferred Qualifications

- Advanced degree in a relevant scientific discipline
- Direct experience managing teams in an aseptic manufacturing environment
- Trained in statistical process control and continuous improvement tools and methodologies
- Experience supporting FDA or other regulatory and accreditation inspections
- Experience with process validation and technology transfer from development into routine production
- Familiarity with lean or tiered daily management practices

## Key Responsibilities

- Own daily HPC production output from donor intake through cryopreservation and initial inventory, ensuring every gift is used for its authorized purpose
- Manage HPC Production Supervisors across shifts, ensuring processes are scheduled with appropriately trained and qualified personnel
- Serve as operator, verifier, or trainer during clinical production as needed
- Develop and report production metrics such as throughput, yield, right-first-time documentation, deviation rate, and cycle time, and drive action where targets are missed
- Perform technical review of production batch records and ensure traceability of donor products through final disposition
- Write and oversee event reports, investigations, risk assessments, and CAPAs, including effectiveness checks
- Lead operational changes through project management, document creation, batch record revision, and risk assessment
- Serve as hiring manager for HPC production roles and oversee onboarding, qualification, and ongoing training for the team
- Serve as Core Team Leader for HPC, Marrow: own the Core Team charter, lead the daily meeting, set the agenda for weekly meetings, and drive cross-functional alignment across Production, Quality, Engineering, and MSAT
- Accountable for the Core Team balanced scorecard covering safety, quality, process control and capability, variability reduction, throughput, supply chain planning, productivity, training, and equipment reliability
- Keep the HPC process in control, capable, and compliant, prioritizing effectiveness before efficiency, and lead periodic formal process reviews and Annual Product Review feedback
- Establish the Core Team floor presence schedule and ensure development plans are in place for frontline supervisors and staff
- Partner with Tissue Production, MSAT, Engineering, Quality, Supply Chain, and Facilities on shared suites, materials, equipment, and process improvements

Physical Requirements

- Must be able to work in a moderately noisy environment
- Must be able to work around biohazardous materials and chemicals
- Required to work the majority of the shift aseptically in a controlled environment with limited breaks. This environment requires special gowning (ie. over the head, face, hands, feet and body).
- Must be able to lift, push, pull and/or carry up to 50 lbs
- Must have sufficient manual dexterity, hand/finger coordination, wrist mobility, wrist stability, and grip strength to handle, feel, grasp, manipulate, and operate objects, manual and power tools, equipment, and controls safely and accurately.
- Regularly required to sit, stand, walk, squat, balance, climb, stoop, kneel, crouch and reach with arms.

We offer a full slate of employee benefits including:

- Competitive salaries
- Stock options
- 401(k) matching
- Medical, dental and vision coverage
- Four weeks of PTO accrued (vacation & sick time) annually  + 11 company holidays
- Employer paid life insurance and long term disability
- Gym membership/recreational sports reimbursements

Ossium Health provides equal employment opportunities (EEO) to all employees and applicants for employment without regard to race, color, religion, sex, national origin, age, disability, protected veteran status, sexual orientation, gender identity, gender expression, or any other protected characteristic. Our [Equal Employment Opportunity Policy Statement](https://ossiumhealth.com/wp-content/uploads/2025/05/Ossium-Health-2024-Equal-Employment-Opportunity-Policy-Statement.pdf) and the [Know Your Rights: Workplace Discrimination is Illegal Poster](https://www.eeoc.gov/sites/default/files/2023-06/22-088_EEOC_KnowYourRights6.12.pdf) reaffirm this commitment. Pursuant to the San Francisco Fair Chance Ordinance, we will consider for employment qualified applicants with arrest and conviction records.

If reasonable accommodation is needed, please contact our People Team at careers@ossiumhealth.com or 650-285-0603. Ossium Health complies with federal and state disability laws and makes reasonable accommodations for applicants and candidates with disabilities.

Principals / direct applicants only please. Recruiters, please do not contact this job poster.

## Equal Opportunity Employer/Veterans/Disabled

## About Ossium Health

## Company Overview
- **One-liner**: Ossium Health is a clinical-stage bioengineering company that creates life-saving stem cell therapies from deceased donors for use in bone marrow transplants and other blood and immune system diseases.
- **Entity Type**: Private (Series C)
- **Headquarters**: San Francisco, California, USA (with a manufacturing facility in Indianapolis, Indiana, USA)
- **Founded**: 2016
- **Founders**: Kevin Caldwell (CEO, Co-Founder) and Erik Woods (Chief Science Officer, Co-Founder)

## Core Business
- **Industry**: Biotechnology / Cell Therapy
- **Target Customers**: B2B – healthcare providers (transplant centers), life science companies (biopharma partners), and organ procurement organizations (OPOs)
- **Mission**: “To improve human health through bioengineering” and “Establish a new source for life-saving stem cells” by bringing the deceased donor transplant ecosystem into the fight against diseases of the blood and immune systems.

## Products & Services
- **HPC, Marrow (Hematopoietic Progenitor Cells from marrow)**: An allogeneic stem cell product derived from vertebral body donors, used in bone marrow transplants. First patient successfully engrafted at Henry Ford Health in June 2024.
- **OssiGraft**: An orthopedic product (first patient treated November 2023) – marks the company’s entry into orthopedics.
- **CD34+ Product**: A purified hematopoietic stem cell product used in a multivisceral transplant study at Columbia University Medical Center (first patient November 2021).
- **Platform Model**: A proprietary process for recovering, processing, and cryopreserving cells from deceased donors, enabling off-the-shelf cell therapies.

## Market Standing
- **Valuation/Market Cap**: Not disclosed
- **Key Metric**: **Total Funding** – USD 128.9 million across multiple rounds (Seed, Series A, Series B, Series C, and a grant)
- **Notable Investors/Partners**:
  - Lead investors: CPMG (Series C lead), Vivo Capital (Series B co-lead), General Catalyst (Series B co-lead), First Round Capital (Series A lead)
  - Other investors: Manta Ray Ventures, Village Global, Asahi Kasei, Alumni Ventures
  - Federal partner: Biomedical Advanced Research and Development Authority (BARDA) – contract for radiological/nuclear emergency preparedness
- **Growth Signals**:
  - Headcount: ~75 employees, with +13.3% yearly growth (LinkedIn)
  - Active job postings: 14 (as of mid-2025)
  - Recent clinical milestones: first patient engrafted with HPC Marrow (June 2024) and first OssiGraft patient (Nov 2023)
  - Series C closed July 2023 ($52M)
  - Expanded into orthopedics and federal preparedness markets

## Competitive Advantages
- **Unique Cell Source**: Uses deceased donors (vertebral bodies) rather than living donors or iPSCs, leveraging an existing transplant network to produce scalable, off-the-shelf allogeneic cell therapies.
- **Proprietary Processing & Cryopreservation**: Founders have deep expertise in cryobiology; Dr. Woods co-invented the first closed-system cryovial for cell therapy (CellSeal®) and commercial human platelet lysate (Stemulate®).
- **Regulatory & Operational Infrastructure**: CLIA-certified lab, FDA-registered facility, and AABB accreditation; experienced in high-complexity clinical cell manufacturing.
- **Government Partnership**: BARDA contract validates the platform for national emergency preparedness, providing a stable, non-dilutive revenue stream and strategic credibility.

## Strategic Focus
- Advance clinical trials for HPC Marrow in bone marrow transplant (lead indication) and expand into orthopedics with OssiGraft.
- Strengthen partnerships with OPOs and healthcare systems to increase donor tissue access.
- Scale manufacturing capacity at the Indianapolis facility to meet commercial and federal contract demand.
- Continue to develop additional cell therapy programs (e.g., immune effector cells, mesenchymal stromal cells) using the same platform.

## Why Work Here
- **Culture & Values**: Emphasizes Truth (data-driven decision making), Ownership (high accountability), Grit (persistence toward mission), and Impact (improving human health).
- **Mission-Driven**: Employees are motivated by the chance to fight diseases like leukemia and lymphoma, and to contribute to national health security (BARDA partnership).
- **Work Environment**: Two locations – San Francisco HQ (office) and Indianapolis facility (cell manufacturing lab). Roles span clinical production, recovery services, quality assurance, research, and commercial. Likely on-site for lab and manufacturing roles.
- **Growth Opportunity**: Rapidly scaling company with recent clinical wins and a growing headcount; employees can take ownership of impactful projects early in their careers.
- **Notable Perks**: Not detailed in search results, but the company highlights “empowering employees, maintaining the highest standards of excellence, and being a force for good.”

## Sources
1. [Ossium Health – Careers Page](https://ossiumhealth.com/careers/)
2. [Ossium Health – Homepage](https://ossiumhealth.com/)
3. [Ossium Health – Company About](https://ossiumhealth.com/company/)
4. [Ossium Health – Our Team](https://ossiumhealth.com/our-team/)
5. [Ossium Health – LinkedIn Company Profile](https://www.linkedin.com/company/ossiumhealth)

## Other roles at Ossium Health

- [Controller](https://feeny.ai/job/controller-ossium-health-san-francisco-zkeha5vh6e4q) — San Francisco, CA
- [Production Supervisor, HPC, Marrow](https://feeny.ai/job/production-supervisor-hpc-marrow-ossium-health-indianapolis-c7s100bpyqh4) — Indianapolis, IN
- [Chief Financial Officer](https://feeny.ai/job/chief-financial-officer-ossium-health-san-francisco-cra5q8ffrrrs) — San Francisco, CA
- [Regional Manager, Orthopedics](https://feeny.ai/job/regional-manager-orthopedics-ossium-health-e3frwsynacgq)
- [Tissue Recovery Specialist (Contract) - Northern OR Southern Indiana](https://feeny.ai/job/tissue-recovery-specialist-contract-northern-or-southern-indiana-ossium-health-rmvccntaz5r9) — Field Based: Northern, IN / Field Based: Southern, IN